The beta-cell death in long-term type 2 diabetes mellitus: never say never again.

abstract：BACKGROUND:The aim of this study was to evaluate long-term effectiveness and safety of liraglutide in real world. METHODS:A diabetes clinic in Italy systematically collected data of all patients treated with liraglutide. Generalized hierarchical linear regression models for repeated measures were applied to assess tre...

journal_title：Minerva endocrinologica

authors： Ponzani P,Scardapane M,Nicolucci A,Rossi MC

更新日期：2016-03-01 00:00:00

abstract：:To investigate whether inappropriate LH secretion in Polycystic Ovary Syndrome (PCO) was related to a reduction of inhibitory opioid control on the GnRH-LH system, 23 women affected by PCO (12 obese, BMI: 37.1 +/- 3.9 and 11 non obese, BMI: 21.5 + 2.4) and 19 fertile women (10 obese, BMI: 38.8 + 1.8 and 9 non obese, B...

journal_title：Minerva endocrinologica

authors： Barletta C,Vagiri D,Scavo D

更新日期：1992-07-01 00:00:00

abstract：:Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, resulting in hyperglycemia. Reproductive impairment in poorly controlled diabetes mellitus type 1 (T1DM) results from a combined effect of insulin deficiency and hyperglycemia that disrupt the functio...

journal_title：Minerva endocrinologica

authors： Pertynska-Marczewska M,Cypryk K

更新日期：2017-09-01 00:00:00

abstract：:Central adrenal insufficiency (AI) represents a life-threatening disorder that results from a reduced cortisol production due to an impairment production of adrenocorticotropic hormone (ACTH). In particular, secondary AI results from pituitary disease that impedes the release of ACTH, while tertiary AI is caused from ...

journal_title：Minerva endocrinologica

authors： Paragliola RM,Corsello SM

更新日期：2018-06-01 00:00:00

abstract：:The coexistence of Graves' disease and insulin-dependent diabetes mellitus is well known among autoimmune polyglandular syndromes and sustained by common underlying immune pathogenic factors. Hyperthyroidism itself may lead to impaired glucose tolerance in subjects with intact beta-cell function through various not we...

journal_title：Minerva endocrinologica

authors： Pandolfi C,Pellegrini L,Sbalzarini G

更新日期：1992-04-01 00:00:00

abstract：:In health, growth hormone (GH) is secreted in a circadian rhythm with superimposed pulsatility. Temporal fluctuations of hormone concentrations are essential for physiological action, and loss of diurnal rhythm is important in the development of disease. GH feedback occurs through the hypothalamus and involves neurope...

journal_title：Minerva endocrinologica

authors： White HD,Ahmad AM,Vora JP

更新日期：2003-03-01 00:00:00

abstract：:Although diabetes has been known to increase the risk of cancer for over a century, it was not until recently when this area gained momentum and generated a lot of interest. That is in- part because of the rising global diabetes epidemic and the wide spread use of insulin analogues, metformin and other anti-diabetic a...

journal_title：Minerva endocrinologica

authors： Pandey A,Forte V,Abdallah M,Alickaj A,Mahmud S,Asad S,McFarlane SI

更新日期：2011-09-01 00:00:00

abstract：:We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- ...

journal_title：Minerva endocrinologica

authors： Ardizzi A,Guzzaloni G,Grugni G,Moreni G,Sartorio A,Conti A,Morabito F

更新日期：1990-04-01 00:00:00

abstract：:Controversies surround the view that the blood-bone ionic equilibrium is controlled by ionic changes at a so called "bone membrane" that display a pump-leak mechanism able to maintain a concentration gradient for chloride in addition to that for calcium, sodium and potassium. On the other hand it is known that a chlor...

journal_title：Minerva endocrinologica

authors： Rubinacci A,Boniforti F,De Ponti A

更新日期：1992-07-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a biologically aggressive tumor with a low long-term survival rate. SCLC is highly responsive to chemotherapy and surgery has a very limited role in its treatment because the disease is usually widely disseminated at the diagnosis. Good results from surgery have been reported in the sm...

journal_title：Minerva endocrinologica

authors： Puma F,Urbani M,Santoprete S,Ricci F,Sanguinetti A,Vinci D,Ottavi P,Porcaro G,Daddi G

更新日期：2001-12-01 00:00:00

abstract：:Hyperhomocysteinemia is a well-established risk factor for cardiovascular disease. Various factors, both modifiable and non-modifiable, interact with the homocysteine metabolism and determine the plasma homocysteine concentrations. These include genetic abnormalities, age, sex and various nutritional and hormonal dete...

journal_title：Minerva endocrinologica

authors： Asnani S,Desouza C,Homan J,Murthy SN,McNamara DB,Fonseca V

更新日期：2002-09-01 00:00:00

abstract：:Adrenal scintigraphy using 131I-6-beta-iodomethyl-19-norcholesterol or 6-methyl-75Se-methyl-19-norcholesterol is a function-dependent imaging method which, in association with high-resolution spatial imaging techniques, plays an essential role in the study of adrenocortical hyperfunction. It can distinguish between bi...

journal_title：Minerva endocrinologica

authors： Gregianin M,Bui F,Varotto L,Zucchetta P,Macri C

更新日期：1995-03-01 00:00:00

abstract：:Familial non-medullary thyroid cancer (FNMTC) constitutes 3-9% of all thyroid cancers and occur in two or more first-degree relatives in the absence of predisposing environmental factors. Out of all FNMTC cases, only 5% are represented by syndromic forms (Gardner's syndrome, familial adenomatous polyposis, Cowden's sy...

journal_title：Minerva endocrinologica

authors： Cirello V

更新日期：2020-10-12 00:00:00

abstract：:Notwithstanding recent neuroendocrinological and neuroradiological findings, about 40% of carriers of pituitary adenoma still reach clinical observation and, consequently, the surgeon, in the stage of suffering from extrasellar extension to a varying degree, especially when the volumetric growth of the lesion is not a...

journal_title：Minerva endocrinologica

authors： Russo A

更新日期：2006-09-01 00:00:00

abstract：:Surgical intervention for breast cancer has continually evolved. The current review reports on updates from the pivotal trials, examines areas of controversy, and explores possible future directions. ...

journal_title：Minerva endocrinologica

authors： Rao R,Wiechmann L

更新日期：2009-12-01 00:00:00

abstract：:A number of studies have been carried out over the past year to characterise the physiological functions and possible therapeutic applications of somatostatin (sst). Somatostatin is one of the most widespread peptides in the body and it fulfils a very wide spectrum of actions in the various organs and tissues. The aim...

journal_title：Minerva endocrinologica

authors： Florio T,Schettini G

更新日期：2001-09-01 00:00:00

abstract：UNLABELLED:Anaplastic thyroid cancer (ATC) is a rare aggressive tumor arising from the follicular cells of the thyroid gland (as does well differentiated thyroid cancer, WDTC), but ATC cells do not retain any of the biological features of the original follicular cells, such as uptake of iodine and synthesis of thyroglo...

journal_title：Minerva endocrinologica

authors： Chiacchio S,Lorenzoni A,Boni G,Rubello D,Elisei R,Mariani G

更新日期：2008-12-01 00:00:00

abstract：:New-onset diabetes after transplantation (NODAT) or posttransplant diabetes mellitus is a frequent metabolic complication of organ transplantation. Diabetes incidence rates among transplant recipients are higher than in the general population. The estimated rates are 9-18% after kidney, 20-33% after liver, 26-40% afte...

journal_title：Minerva endocrinologica

authors： Gosmanov AR,Dagogo-Jack S

更新日期：2012-09-01 00:00:00

abstract：:Medullary thyroid carcinoma arises from the C cells, which produce a characteristic hormone, calcitonin. At present, surgery is the main treatment modality. Medullary thyroid carcinoma is usually treated with total thyroidectomy and with removal of nodes in the central portion of the neck and upper mediastinum. Cervic...

journal_title：Minerva endocrinologica

authors： Vitale G,Cascone E,Lupoli G Jr,Ciccarelli A,Barone C,Lupoli G

更新日期：1998-12-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the developed world and its pathogenesis is complex and multifactorial. It is considered the hepatic manifestation of the metabolic syndrome and is the leading cause of hepatic cirrhosis. This review aims to present current knowledge on the ...

journal_title：Minerva endocrinologica

authors： Papanastasiou L,Fountoulakis S,Vatalas IA

更新日期：2017-06-01 00:00:00

abstract：:Diabetological care in pre-gestational (preGDM) and gestational (GDM) pregnant diabetic is an indispensable factor for the reduction of risk of mother, fetus and newborn complications. The adoption of an intensified therapy, aiming at maintaining almost normal glycemic values, and the improvement in fetal monitoring h...

journal_title：Minerva endocrinologica

authors： Dradi Maraldi C,Santini C

更新日期：1994-06-01 00:00:00

abstract：:Very-low-calorie ketogenic diet (VLCKD) is a promising lifestyle intervention for the management of overweight and obesity. It is characterized by a restriction of both calories and carbohydrates, while assuring the adequate proteins, fats and micronutrients intake. Significant results in terms of excess body weight l...

journal_title：Minerva endocrinologica

authors： Castellana M,Biacchi E,Procino F,Casanueva FF,Trimboli P

更新日期：2020-11-19 00:00:00

abstract：:The present paper reports our personal data on gonadotropin therapy in patients with idiopathic secretory oligozoospermia due to a low biological activity of LH. In recent years the use of more specific diagnostic procedures, particularly the biological assay of gonadotropins, and a better knowledge of the biological ...

journal_title：Minerva endocrinologica

authors： Conte D,Romanelli F,Isidori A

更新日期：1990-01-01 00:00:00

abstract：:The majority of patients with differentiated thyroid cancer are cured with standard primary treatments including surgery, radioactive iodine and TSH suppression. A small proportion of patients who develop radioactive iodine-refractory metastatic disease have few treatment options. Recent discovery of the molecular mec...

journal_title：Minerva endocrinologica

authors： Dadu R,Cabanillas ME

更新日期：2012-12-01 00:00:00

abstract：:A 49 year-old woman with anaplastic thyroid carcinoma came, for the first time, to our clinic with an enlarged supraclavicular lymph node. Ten years earlier she received a diagnosis of benign nodular goiter and has been followed up with ultrasonography, which never demonstrated any enlargement of her thyroid nodule an...

journal_title：Minerva endocrinologica

authors： Vescini F,Di Gaetano P,Vigna E,Pascoli A,Cacciari M

更新日期：2000-09-01 00:00:00

abstract：:Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. Decreased GHRH secretion and/or action leads to impairment of this process and somatotrope hypoplasia in both humans and experimental animals. Excessive GHRH...

journal_title：Minerva endocrinologica

authors： Frohman LA,Kineman RD

更新日期：2002-12-01 00:00:00

abstract：:The pathogenesis of Polycystic Ovary Syndrome (PCOs) is not well known till now. Previous reports indicated an hyperinsulinemia and insulin resistance in obese and non obese PCOs. However the role of hyperinsulinemia in PCOs pathogenesis is not completely understood. In this study we evaluated the glycemic and insulin...

journal_title：Minerva endocrinologica

authors： Vagiri D,Barletta C,Cioli I,Scavo D

更新日期：1994-03-01 00:00:00

abstract：:The characterisation of adrenal lesions is a common radiological dilemma. Incidental adrenal lesions are commonly detected with computed tomography (CT), and lesion characterisation is critical. The prevalence of incidental adrenal lesions has been reported to be 2.3% at autopsy and 0.5-2% with abdominal CT. Such lesi...

journal_title：Minerva endocrinologica

authors： Welsh SJ,Khan S

更新日期：2009-06-01 00:00:00

abstract：:Steroid hormones mediate pleiotropic cellular processes involved in metabolism, cellular proliferation, and differentiation. The ability of the cell to respond to its hormonal environment is transduced by nuclear receptors (NRs) that bind both hormone and DNA. Hence, NRs represent a link between the external hormonal ...

journal_title：Minerva endocrinologica

authors： Amanatullah DF,Zafonte BT,Pestell RG

更新日期：2002-03-01 00:00:00

abstract：:Breast cancer is the second most frequent type of cancer worldwide and the most commonly occurring malignancy in women, and its incidence is increasing in most developed and developing countries. There is growing evidence that lifestyle factors, in particular diet may be associated with higher Breast Cancer risk. Some...

journal_title：Minerva endocrinologica

authors： Laudisio D,Castellucci B,Barrea L,Pugliese G,Savastano S,Colao A,Muscogiuri G

更新日期：2020-09-24 00:00:00