Abstract:
:It is known that young female cancer survivors are at higher risk for decreased fertility and early menopause. Because the risk of these outcomes varies by age, cancer type, treatment regimen and other patient-specific characteristics, there is a need for valid tools for measuring and predicting reproductive function in this population. Ovarian reserve tests (ORT) include serum and ultrasound biomarkers used in characterizing healthy ovarian aging and predicting ovarian reserve prior to fertility treatment. This review summarizes efforts to translate ORT to use in female cancer patients. To date, small longitudinal and cross-sectional studies of young cancer patients demonstrate that gonadotoxic chemotherapy impact ORT. While follicle stimulating hormone (FSH), anti-Mullerian hormone (AMH), inhibin B, antral follicle count (AFC) and ovarian volume have all been demonstrated to change with exposure to gonadotoxic therapy, FSH, AMH and AFC appear to be the most sensitive. More data are needed to determine the long-term effect of hormonal agents from tamoxifen to GnRH agonists on ORT. The effect of unilateral oophorectomy acutely or in the long-term on ORT is not known. There are some early data postulating that cancer itself may impair ovarian reserve. Among cancer survivors, ORT correlate with amenorrhea. Even in young survivors with normal menstrual cycles, hormone and ultrasound measures of ovarian reserve suggest decreased underlying ovarian reserve than age-matched healthy women. More studies are needed to determine the optimal time to test ORT in the large number of young survivors on combined estrogen and progesterone contraceptives. A significant utility of ORT would be to be able to predict fertility for young survivors, and there are no data on this outcome to date. The goal of future studies of ORT in young girls and women with cancer is to determine their utility as surrogate measures of ovarian function or predictors of infertility or ovarian failure. To do so, large-scale data need to be collected through cooperative group mechanisms. Epidemiologically, studies need to move from association studies to develop ORT into appropriate screening and predictive tests.
journal_name
Minerva Endocrinoljournal_title
Minerva endocrinologicaauthors
Su HIsubject
Has Abstractpub_date
2010-12-01 00:00:00pages
259-70issue
4eissn
0391-1977issn
1827-1634pii
R07101797journal_volume
35pub_type
杂志文章,评审abstract:BACKGROUND:The aim of this study was to evaluate long-term effectiveness and safety of liraglutide in real world. METHODS:A diabetes clinic in Italy systematically collected data of all patients treated with liraglutide. Generalized hierarchical linear regression models for repeated measures were applied to assess tre...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:
更新日期:2016-03-01 00:00:00
abstract::The present paper reports our personal data on gonadotropin therapy in patients with idiopathic secretory oligozoospermia due to a low biological activity of LH. In recent years the use of more specific diagnostic procedures, particularly the biological assay of gonadotropins, and a better knowledge of the biological ...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:1990-01-01 00:00:00
abstract::Sex steroids are essential for reproduction and development in animals and humans, and sex steroids also play an important role in neuroprotection following brain injury. New data indicate that sex-specific responses to brain injury occur at the cellular and molecular levels. This review summarizes the current underst...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:2010-06-01 00:00:00
abstract::Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. Decreased GHRH secretion and/or action leads to impairment of this process and somatotrope hypoplasia in both humans and experimental animals. Excessive GHRH...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:2002-12-01 00:00:00
abstract::Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, resulting in hyperglycemia. Reproductive impairment in poorly controlled diabetes mellitus type 1 (T1DM) results from a combined effect of insulin deficiency and hyperglycemia that disrupt the functio...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:10.23736/S0391-1977.16.02477-9
更新日期:2017-09-01 00:00:00
abstract::Surgical intervention for breast cancer has continually evolved. The current review reports on updates from the pivotal trials, examines areas of controversy, and explores possible future directions. ...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:2009-12-01 00:00:00
abstract::The Authors report a case of left adrenal mass incidentally discovered by upper abdominal echogram in a 40 year old man. Physical examination showed no signs of hypercortisolism and plasma cortisol and ACTH levels were in the normal range as well as urinary free cortisol. After adrenalectomy, 4 and 8 month follow-up w...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::Obesity has become a national epidemic and a disease of global magnitude. The numbers of patients with obesity have grown exponentially in the last 10 years to the degree that the Centers for Disease Control and Prevention reports that one third of the US population is obese. The prevalence of diabetes has grown by mo...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:2013-06-01 00:00:00
abstract::Gestational diabetes mellitus (GDM) is diabetes that is first diagnosed in the second or third trimester of pregnancy in patients who did not have a history of diabetes before pregnancy. Consequences of GDM include increased risk of macrosomia and birth complications in the infant and an increased risk of maternal typ...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:10.23736/S0391-1977.20.03192-2
更新日期:2020-09-01 00:00:00
abstract::Loss of weight in obese patients, both hypertensive and normotensive, causes a fall in blood pressure (BP) through a mechanism which is still not fully understood. The effects of a low-sodium low-energy diet on BP were assessed in 20 obese subjects (15 M and 5 F; age 26-65 years), 11 of whom were normotensive and 9 hy...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::The authors take the case of a neuroendocrine tumour of the cecum as the starting point for an analysis of the anatomopathological and diagnostic-therapeutic aspects of these neoplasms. Furthermore, the authors underline that neuroendocrine tumours (NET) of the colon represent an extremely rare nosological entity and ...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:This study evaluates the effectiveness of continuous glucose monitoring (CGM) in diabetes patients who were on routine dialysis. METHODS:Literature search was conducted in electronic databases and studies were selected by following precise eligibility criteria. Random-effects meta-analyses were performed to...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:10.23736/S0391-1977.20.03284-8
更新日期:2020-12-03 00:00:00
abstract::Thyroid nodule is extremely common. Its prevalence has been estimated to be more than 5% in the adult population. If thyroid nodule is a rare condition, 0.004% a year, identifying those nodules, which are likely to be malignant, is very important for physicians. The evaluation of thyroid is carried out using the fine ...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:1993-09-01 00:00:00
abstract::One hundred children (4.1 +/- 1.9 years) were examined: 31 of type I diabetic mothers, 25 of type II diabetic mothers and 44 of gestational diabetic mothers. The fetal body weight index at delivery was determined according to Babson. The weight/height index was determined according to Tunner's Centiles, when the child...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Growth hormone (GH) has been recently approved by the Italian Health Authorities for use in transition patients with childhood onset-growth hormone deficiency (CO-GHD). GH in addition to promote linear growth influences several key metabolic processes. In particular, in the transition period, from late adolescent to e...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:2015-03-01 00:00:00
abstract::The majority of patients with differentiated thyroid cancer are cured with standard primary treatments including surgery, radioactive iodine and TSH suppression. A small proportion of patients who develop radioactive iodine-refractory metastatic disease have few treatment options. Recent discovery of the molecular mec...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The surgical approach to Differentiated Thyroid Carcinoma (DTC) is controversial. Aim of this study is to evaluate the opportunity of total thyroidectomy as treatment of choice for DTC in children. METHODS:We examined the tumor features at diagnosis, the complications of surgery and the clinical outcome in ...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::The coexistence of Graves' disease and insulin-dependent diabetes mellitus is well known among autoimmune polyglandular syndromes and sustained by common underlying immune pathogenic factors. Hyperthyroidism itself may lead to impaired glucose tolerance in subjects with intact beta-cell function through various not we...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Primary hyperparathyroidism is a not uncommon disease in the elderly. A prevalence of 3% for women and 1% for men is reported in subjects aged 65 years and over. Routine serum calcium determination and parathyroid hormone radioimmuno-assay allow to make an early diagnosis in still asymptomatic subjects. In the elderly...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::Subclinical hypothyroidism - i.e., a condition characterized by serum TSH concentrations above the normal reference range in the presence of normal serum T4 levels - affects 4 to 20% of the population living in iodine-sufficient areas. The present work reviews the clinical challenges regarding, on the one hand, the si...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:10.23736/S0391-1977.20.03176-4
更新日期:2020-08-03 00:00:00
abstract::Medullary thyroid carcinoma arises from the C cells, which produce a characteristic hormone, calcitonin. At present, surgery is the main treatment modality. Medullary thyroid carcinoma is usually treated with total thyroidectomy and with removal of nodes in the central portion of the neck and upper mediastinum. Cervic...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the diagnostic accuracy of fine needle biopsy (FNB) and intraoperative frozen-section biopsy (FS) regarding the surgical management of thyroid nodules. METHODS:A total of 812 patients with solitary nodule or dominant nodule in a multinodular goiter were evaluated. The pa...
journal_title:Minerva endocrinologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract::Loss of estrogens or androgens causes bone loss by increasing the rate of bone remodeling, and also causes an imbalance between resorption and formation by prolonging the lifespan of osteoclasts and shortening the lifespan of osteoblasts. Conversely, treatment with androgens, as well as estrogens, maintains cancellous...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:2005-03-01 00:00:00
abstract::Diabetological care in pre-gestational (preGDM) and gestational (GDM) pregnant diabetic is an indispensable factor for the reduction of risk of mother, fetus and newborn complications. The adoption of an intensified therapy, aiming at maintaining almost normal glycemic values, and the improvement in fetal monitoring h...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:1994-06-01 00:00:00
abstract::Pregnancy in women with a diagnosis of Cushing' syndrome (CS) is an extremely rare event and its diagnosis and treatment are a real medical challenge. During pregnancy, the hypothalamus-pituitary-adrenal axis undergoes major changes leading to a significant increase in plasma cortisol levels throughout gestation. The ...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:10.23736/S0391-1977.18.02803-1
更新日期:2018-12-01 00:00:00
abstract::Recent trials have reported sodium-glucose co-transporter 2 (SGLT2) inhibitors to decrease cardiac morbidity and hospitalization in diabetic patients. They have a remarkable ability to modify the cardio-renal axis and have a safer metabolic profile among the existing pharmacotherapy in diabetes. There are multiple pro...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:10.23736/S0391-1977.20.03221-6
更新日期:2020-12-17 00:00:00
abstract:: ...
journal_title:Minerva endocrinologica
pub_type: 杂志文章
doi:10.23736/S0391-1977.18.02852-3
更新日期:2019-03-01 00:00:00
abstract:UNLABELLED:Anaplastic thyroid cancer (ATC) is a rare aggressive tumor arising from the follicular cells of the thyroid gland (as does well differentiated thyroid cancer, WDTC), but ATC cells do not retain any of the biological features of the original follicular cells, such as uptake of iodine and synthesis of thyroglo...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Whether Doppler ultrasonography (DU) may be of help in characterizing thyroid nodes is still under debate: both good and unsatisfactory results have been claimed, either in evaluating the presence of malignancy or in identifying hyperfunctional structures. METHODS:In this paper, the scintigraphic and Dopple...
journal_title:Minerva endocrinologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::Although diabetes has been known to increase the risk of cancer for over a century, it was not until recently when this area gained momentum and generated a lot of interest. That is in- part because of the rising global diabetes epidemic and the wide spread use of insulin analogues, metformin and other anti-diabetic a...
journal_title:Minerva endocrinologica
pub_type: 杂志文章,评审
doi:
更新日期:2011-09-01 00:00:00