Abstract：
:The majority of patients with differentiated thyroid cancer are cured with standard primary treatments including surgery, radioactive iodine and TSH suppression. A small proportion of patients who develop radioactive iodine-refractory metastatic disease have few treatment options. Recent discovery of the molecular mechanisms that contribute to thyroid cancer tumorigenesis and its progression have revealed key targets that are currently being evaluated in clinical trials. In the last decade several novel targeted therapies have shown encouraging results and have brought hope to patients with advanced disease. However, identifying the subpopulation of patients who may benefit from systemic therapies remains a challenge as the use of these therapeutic modalities is associated with high toxicity rates and most patients have a long indolent phase where the tumor is stable or slowly progressive and asymptomatic. The objective of this review is to summarize the management of patients with metastatic, radioactive iodine refractory differentiated thyroid cancer.
journal_name
Minerva Endocrinoljournal_title
Minerva endocrinologicaauthors
Dadu R,Cabanillas MEsubject
Has Abstractpub_date
2012-12-01 00:00:00pages
335-56issue
4eissn
0391-1977issn
1827-1634pii
R07121976journal_volume
37pub_type
杂志文章,评审abstract：BACKGROUND:The aim of this study was to evaluate long-term effectiveness and safety of liraglutide in real world. METHODS:A diabetes clinic in Italy systematically collected data of all patients treated with liraglutide. Generalized hierarchical linear regression models for repeated measures were applied to assess tre...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：:Loss of estrogens or androgens causes bone loss by increasing the rate of bone remodeling, and also causes an imbalance between resorption and formation by prolonging the lifespan of osteoclasts and shortening the lifespan of osteoblasts. Conversely, treatment with androgens, as well as estrogens, maintains cancellous...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
abstract：:Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. Decreased GHRH secretion and/or action leads to impairment of this process and somatotrope hypoplasia in both humans and experimental animals. Excessive GHRH...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：:The treatment of NIDDM patients with secondary failure to sulfonylureas is still a debated problem. In this study we compared in NIDDM patients with secondary failure to glyburide, the effect of adding a single, low-dose bed time either NPH or ultralent insulin injection (0.15-0.2 U/kg) to the previously ineffective s...
journal_title：Minerva endocrinologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-06-01 00:00:00
abstract：:Nodular goiter encompasses a spectrum of diseases from the incidental asyntomatic small solitary nodule to the large intrathoracic goiter causing pressure symptoms as well as functional complaints. The mainstay in the diagnostic evaluation is related to functional and morphological characterization with serum thyroid-...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2010-09-01 00:00:00
abstract：:Medullary thyroid carcinoma arises from the C cells, which produce a characteristic hormone, calcitonin. At present, surgery is the main treatment modality. Medullary thyroid carcinoma is usually treated with total thyroidectomy and with removal of nodes in the central portion of the neck and upper mediastinum. Cervic...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
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更新日期：1998-12-01 00:00:00
abstract：:Diabetological care in pre-gestational (preGDM) and gestational (GDM) pregnant diabetic is an indispensable factor for the reduction of risk of mother, fetus and newborn complications. The adoption of an intensified therapy, aiming at maintaining almost normal glycemic values, and the improvement in fetal monitoring h...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1994-06-01 00:00:00
abstract：:Loss of weight in obese patients, both hypertensive and normotensive, causes a fall in blood pressure (BP) through a mechanism which is still not fully understood. The effects of a low-sodium low-energy diet on BP were assessed in 20 obese subjects (15 M and 5 F; age 26-65 years), 11 of whom were normotensive and 9 hy...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：BACKGROUND:A limited number of human and animal studies suggest that a relationship exists between phthalates and obesity, although this is not supported by all research. The purpose of this study was to investigate the relationship between Body Mass Index (BMI) and the levels of phthalates in human blood and urine sam...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.16.02295-1
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with well-established metabolic abnormalities. In the present study, untargeted metabolomics technology was applied to analyze the serum and follicular fluid samples from women with polycystic ovary syndrome and healthy controls using 1H nuclea...
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pub_type： 杂志文章
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更新日期：2020-10-26 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2003-12-01 00:00:00
abstract：:Steroid hormones mediate pleiotropic cellular processes involved in metabolism, cellular proliferation, and differentiation. The ability of the cell to respond to its hormonal environment is transduced by nuclear receptors (NRs) that bind both hormone and DNA. Hence, NRs represent a link between the external hormonal ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2002-03-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：:The present paper reports our personal data on gonadotropin therapy in patients with idiopathic secretory oligozoospermia due to a low biological activity of LH. In recent years the use of more specific diagnostic procedures, particularly the biological assay of gonadotropins, and a better knowledge of the biological ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：AIM:The aim of this paper was to compare serum high sensitivity C-reactive protein (HsCRP) levels and carotid artery intima-media thickness (CIMT) of patients with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) with that in control subjects. METHODS:Ninety-six subjects with prediabetes, 48 with IFG...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：:Very-low-calorie ketogenic diet (VLCKD) is a promising lifestyle intervention for the management of overweight and obesity. It is characterized by a restriction of both calories and carbohydrates, while assuring the adequate proteins, fats and micronutrients intake. Significant results in terms of excess body weight l...
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pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03356-8
更新日期：2020-11-19 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2012-09-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2012-06-01 00:00:00
abstract：:This review concerns the relation between most frequent thyroid gland diseases and diabetes mellitus in adult patients. Special attention is paid to autoimmune thyroiditis, Graves' disease, thyroid autoimmunity in pregnant diabetic women, and iodine metabolism. We focused on mechanisms leading to coexistence of both e...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2005-12-01 00:00:00
abstract：:Patients and animals with poorly controlled or uncontrolled diabetes present with diurnal hypersecretion of glucocorticoids and altered regulation of the hypothalamo-pituitary-adrenocortical (HPA) axis. Although some of these changes are reversed with insulin replacement therapy, neuroendocrine function is not always ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2003-06-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:To investigate whether inappropriate LH secretion in Polycystic Ovary Syndrome (PCO) was related to a reduction of inhibitory opioid control on the GnRH-LH system, 23 women affected by PCO (12 obese, BMI: 37.1 +/- 3.9 and 11 non obese, BMI: 21.5 + 2.4) and 19 fertile women (10 obese, BMI: 38.8 + 1.8 and 9 non obese, B...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
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更新日期：1992-07-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.17.02610-4
更新日期：2018-03-01 00:00:00
abstract：AIM:An association between Glucagon-Like Peptide-1 Receptor Agonists (GLP1-RA) and risk of pancreatitis and pancreatic cancer has been suggested. Since its first description, several new trials (including three cardiovascular outcome trials) have been published, substantially increasing the available data set. This sug...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03219-8
更新日期：2020-07-23 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2003-03-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2015-03-01 00:00:00
