Abstract：
:In 51 patients with gastric adenocarcinoma the fasting blood concentrations of hCG, beta hCG, alpha subunits, ADH, calcitonin, enteroglucagon, gastrin, GH, melatonin, somatostatin, estradiol, CEA and pepsinogen I in the peripheral vein were estimated by radioimmunoassay at the time of diagnosis and, in those who underwent surgery, 7 days after the operation, to determine the incidence of the modifications of the above mentioned substances' blood levels and the existence of possible markers. In presence of increases of the examined parameters greater than 50%, considering M +/- 2 SD of 10 control subjects as normal range, the tumours were examined immunohistochemically. In patients with gastric adenocarcinoma, in comparison with normal subjects, we found significant higher blood levels of hCG alpha subunits, gastrin and CEA and lower of melatonin, pepsinogen I and GH. The immunohistological results demonstrated CEA in both examined cases, alpha subunits in 2 of 6 (respectively in dysplasic areas and in surrounding non neoplastic mucosa) and enteroglucagon in 1 of 3 (dysplasic areas). Our results indicate that none of the parameters we examined, because of their non-specificity or of the low incidence of their modifications, can be considered a marker of gastric adenocarcinoma.
journal_name
Minerva Endocrinoljournal_title
Minerva endocrinologicaauthors
Colombo F,Iannotta F,Fachinetti A,Giuliani F,Cornaggia M,Finzi G,Mantero G,Fraschini F,Malesci A,Bersani Msubject
Has Abstract,Author List Incompletepub_date
1991-07-01 00:00:00pages
127-39issue
3eissn
0391-1977issn
1827-1634journal_volume
16pub_type
杂志文章abstract：:Congenital hypogonadotropic hypogonadism (CHH) is a rare disease characterized by delayed/absent puberty and infertility due to an inadequate secretion or action of gonadotrophin-releasing hormone (GnRH), with an otherwise structurally and functionally normal hypothalamic-pituitary-gonadal (HPG) axis. CHH is genetical...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2016-06-01 00:00:00
abstract：:Previous studies have shown a significant but weak correlation between speed of sound (SOS) and broadband ultrasound attenuation (BUA) in bone, and densitometric bone measurements. These findings indicate that these techniques reflect different properties of bone. We measured SOS and BUA in the os calcis (Achilles, Lu...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：: ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.18.02852-3
更新日期：2019-03-01 00:00:00
abstract：:Visualization of cerebral perfusion with Single Photon Emission Computed Tomography (SPET) needs lipophil radiotracers which are able to cross the intact blood-brain-barrier (BBB); moreover local uptake must reflect regional cerebral blood flow. In the last decade many radiopharmaceuticals have been suggested and empl...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：AIM:The efficacy of low and high fixed dose radioactive iodine (RAI) therapy in patients with toxic nodular goiter was investigated. METHODS:Ninety-three patients (25 males, 68 females) were included into the study (32 patients with toxic adenoma, 61 patients with toxic multinodular goiter). Patients were treated with...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:Sex steroids are essential for reproduction and development in animals and humans, and sex steroids also play an important role in neuroprotection following brain injury. New data indicate that sex-specific responses to brain injury occur at the cellular and molecular levels. This review summarizes the current underst...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2010-06-01 00:00:00
abstract：:To investigate whether inappropriate LH secretion in Polycystic Ovary Syndrome (PCO) was related to a reduction of inhibitory opioid control on the GnRH-LH system, 23 women affected by PCO (12 obese, BMI: 37.1 +/- 3.9 and 11 non obese, BMI: 21.5 + 2.4) and 19 fertile women (10 obese, BMI: 38.8 + 1.8 and 9 non obese, B...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:The aim of this study was to compare the diagnostic accuracy of fine needle biopsy (FNB) and intraoperative frozen-section biopsy (FS) regarding the surgical management of thyroid nodules. METHODS:A total of 812 patients with solitary nodule or dominant nodule in a multinodular goiter were evaluated. The pa...
journal_title：Minerva endocrinologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:The present insulin preparations are not ideal for diabetes therapy by subcutaneous administration, subcutaneous insulin absorption is too slow to mimic the normal rapid increments of insulin in blood in response to nutrient intake. The absorption of insulin from subcutaneous tissue is influenced by many factors, amon...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1996-03-01 00:00:00
abstract：:Hyperhomocysteinemia is a well-established risk factor for cardiovascular disease. Various factors, both modifiable and non-modifiable, interact with the homocysteine metabolism and determine the plasma homocysteine concentrations. These include genetic abnormalities, age, sex and various nutritional and hormonal dete...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：:Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. Decreased GHRH secretion and/or action leads to impairment of this process and somatotrope hypoplasia in both humans and experimental animals. Excessive GHRH...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is diabetes that is first diagnosed in the second or third trimester of pregnancy in patients who did not have a history of diabetes before pregnancy. Consequences of GDM include increased risk of macrosomia and birth complications in the infant and an increased risk of maternal typ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03192-2
更新日期：2020-09-01 00:00:00
abstract：:Recent trials have reported sodium-glucose co-transporter 2 (SGLT2) inhibitors to decrease cardiac morbidity and hospitalization in diabetic patients. They have a remarkable ability to modify the cardio-renal axis and have a safer metabolic profile among the existing pharmacotherapy in diabetes. There are multiple pro...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03221-6
更新日期：2020-12-17 00:00:00
abstract：:Familial non-medullary thyroid cancer (FNMTC) constitutes 3-9% of all thyroid cancers and occur in two or more first-degree relatives in the absence of predisposing environmental factors. Out of all FNMTC cases, only 5% are represented by syndromic forms (Gardner's syndrome, familial adenomatous polyposis, Cowden's sy...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03338-6
更新日期：2020-10-12 00:00:00
abstract：BACKGROUND:Mild hypothyroidism (thyroid stimulating hormone [TSH] less than 10 mIU/L) induces reversible cognitive dysfunction, which can be evaluated by event related potentials (ERP). So far, only little is known about the impact of subclinical hypothyroidism on ERP as electrophysiological markers of cognitive activi...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.16.02327-0
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Whether Doppler ultrasonography (DU) may be of help in characterizing thyroid nodes is still under debate: both good and unsatisfactory results have been claimed, either in evaluating the presence of malignancy or in identifying hyperfunctional structures. METHODS:In this paper, the scintigraphic and Dopple...
journal_title：Minerva endocrinologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Acromegaly is a rare and chronic disease that, in the majority of cases, is due to the presence of a benign growth hormone (GH)-producing tumor of the pituitary. In the past, the diagnosis of acromegaly was established basically on physical changes, and only the patients with a severe clinical picture were brought to ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
abstract：:Notwithstanding recent neuroendocrinological and neuroradiological findings, about 40% of carriers of pituitary adenoma still reach clinical observation and, consequently, the surgeon, in the stage of suffering from extrasellar extension to a varying degree, especially when the volumetric growth of the lesion is not a...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Hyponatremia is common in neurosurgical patients and is associated with significant morbidity and mortality. Despite significant research efforts to date, we still lack a complete understanding of the pathophysiological mechanisms underlying hyponatremia in this patient setting. The purpose of this narrative review is...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
abstract：:A 49 year-old woman with anaplastic thyroid carcinoma came, for the first time, to our clinic with an enlarged supraclavicular lymph node. Ten years earlier she received a diagnosis of benign nodular goiter and has been followed up with ultrasonography, which never demonstrated any enlargement of her thyroid nodule an...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:As it's well known from the clinic, human syndromes depending on pituitary GH, ACTH and PRL secreting tumors are associated with alteration of glucose homeostasis. There is an hypothetical but convincing explanation for this, based on a number of concrete observations and experiments. The main mechanism for glucose in...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND:The surgical approach to Differentiated Thyroid Carcinoma (DTC) is controversial. Aim of this study is to evaluate the opportunity of total thyroidectomy as treatment of choice for DTC in children. METHODS:We examined the tumor features at diagnosis, the complications of surgery and the clinical outcome in ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:We treated with PEI 81 patients carriers of autonomous thyroid nodule, 65 toxic and 16 non toxic, all with undetectable serum TSH and suppressed extranodular tissue on scintigraphy. The treatment schedule was: 1-2 sessions per week, 1-8 ml per session, 3-13 sessions in total, In relation to the size and the therapeuti...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:Loss of estrogens or androgens causes bone loss by increasing the rate of bone remodeling, and also causes an imbalance between resorption and formation by prolonging the lifespan of osteoclasts and shortening the lifespan of osteoblasts. Conversely, treatment with androgens, as well as estrogens, maintains cancellous...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
abstract：:Controversies surround the view that the blood-bone ionic equilibrium is controlled by ionic changes at a so called "bone membrane" that display a pump-leak mechanism able to maintain a concentration gradient for chloride in addition to that for calcium, sodium and potassium. On the other hand it is known that a chlor...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Acromegaly is a rare disease characterized by high levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). The excess of GH leads to the development of different manifestations in different organs, from subtle signs in the bones and soft tissues to the development of respiratory and cardiac insufficien...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：10.23736/S0391-1977.18.02930-9
更新日期：2019-06-01 00:00:00
abstract：:Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, resulting in hyperglycemia. Reproductive impairment in poorly controlled diabetes mellitus type 1 (T1DM) results from a combined effect of insulin deficiency and hyperglycemia that disrupt the functio...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：10.23736/S0391-1977.16.02477-9
更新日期：2017-09-01 00:00:00
abstract：:The authors present 6 cases of carotid glomus tumours referred to their attention over the past 10 years. Their experience shows that colour ultrasonography (using both morphological and functional evaluation) is the diagnostic key for defining the treatment of paraganglioma. More recent experience highlights the role...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:The normal growth and development of the prostate requires the presence and action of androgens, which are also known risk factors in the origins of benign and malignant prostate disease. Paradoxically, the incidence of prostate disease increases with age when serum androgen levels are in decline and emerging evidence...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2006-03-01 00:00:00
abstract：:The authors take the case of a neuroendocrine tumour of the cecum as the starting point for an analysis of the anatomopathological and diagnostic-therapeutic aspects of these neoplasms. Furthermore, the authors underline that neuroendocrine tumours (NET) of the colon represent an extremely rare nosological entity and ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
