Efficacy of low and high fixed dose radioactive iodine therapy in patients with toxic nodular goiter.

Abstract:

AIM:The efficacy of low and high fixed dose radioactive iodine (RAI) therapy in patients with toxic nodular goiter was investigated. METHODS:Ninety-three patients (25 males, 68 females) were included into the study (32 patients with toxic adenoma, 61 patients with toxic multinodular goiter). Patients were treated with a fixed dose of 370 MBq (10 mCi) or 740 MBq (20 mCi) RAI. The average follow-up period was 17±10 months. RESULTS:The overall cure rate (eutyhroidism and hypothyroidism) was 81% in patients treated with 740 MBq RAI and 51% in patients treated with 370 MBq RAI (p<0.05). RAI therapy with a dose of 370 MBq and 740 MBq provided the cure in 73% and 91% of the patients with toxic adenoma and 42% and 76% of the patients with toxic multinodular goiter, respectively. No significant difference for gender was observed. Hypothyroidism developed in 4 and 15 patients with a dose of 370 MBq and 740 MBq RAI, respectively. CONCLUSION:A dose of 740 MBq RAI was found to be more effective for the treatment of toxic nodular goiter as compared to a dose of 370 MBq RAI.

journal_name

Minerva Endocrinol

journal_title

Minerva endocrinologica

authors

Sonmez B,Erem C,Dogan I,Ersoz HO,Sonmez M

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

117-21

issue

2

eissn

0391-1977

issn

1827-1634

pii

R07111812

journal_volume

36

pub_type

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