Abstract：
:New-onset diabetes after transplantation (NODAT) or posttransplant diabetes mellitus is a frequent metabolic complication of organ transplantation. Diabetes incidence rates among transplant recipients are higher than in the general population. The estimated rates are 9-18% after kidney, 20-33% after liver, 26-40% after lung, and 29% after heart transplants, respectively. In retrospective studies, NODAT was associated with higher costs of posttransplant care and increased risks of graft failure, infection, cardiovascular disease, and death. The incidence of NODAT is influenced by both traditional risk factors for type 2 diabetes (age, family history, obesity, hepatitis C infection, and ethnicity) and transplant-specific risk factors. Managing NODAT is challenging because posttransplant care is complex and characterized by multiple variables including immunosuppressive regimens, choice of antidiabetes agents, and optimal use of insulin therapy. Therefore, predicting and preventing NODAT would be a compelling objective for improving care of posttransplant patients. During the pretransplant period, lifestyle modifications in patients at risk for NODAT should be considered, recognizing that no randomized controlled trials exist to inform specific modalities or cost-effectiveness of such an approach. After hospital discharge, close monitoring of blood glucose during the first month, and every 3 months thereafter for the first year, is recommended for those without prior history of diabetes mellitus. Future areas of investigation include clinical validation of NODAT risk score engines, validation of interventions for primary prevention of NODAT, the development of immunosuppressive regimens with minimal diabetogenic effects, and prospective determination of the role of glycemic control on graft survival and cardiovascular outcomes.
journal_name
Minerva Endocrinoljournal_title
Minerva endocrinologicaauthors
Gosmanov AR,Dagogo-Jack Ssubject
Has Abstractpub_date
2012-09-01 00:00:00pages
233-46issue
3eissn
0391-1977issn
1827-1634pii
R07121942journal_volume
37pub_type
杂志文章,评审abstract：:Although diabetes has been known to increase the risk of cancer for over a century, it was not until recently when this area gained momentum and generated a lot of interest. That is in- part because of the rising global diabetes epidemic and the wide spread use of insulin analogues, metformin and other anti-diabetic a...
journal_title：Minerva endocrinologica
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journal_title：Minerva endocrinologica
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journal_title：Minerva endocrinologica
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journal_title：Minerva endocrinologica
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更新日期：1990-04-01 00:00:00
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journal_title：Minerva endocrinologica
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更新日期：2002-03-01 00:00:00
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更新日期：1990-01-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
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更新日期：2004-12-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章
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journal_title：Minerva endocrinologica
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doi：
更新日期：2016-03-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
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更新日期：2006-03-01 00:00:00
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journal_title：Minerva endocrinologica
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更新日期：1990-01-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
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更新日期：2009-03-01 00:00:00
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journal_title：Minerva endocrinologica
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更新日期：2015-03-01 00:00:00
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更新日期：2008-09-01 00:00:00
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更新日期：2017-12-01 00:00:00
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更新日期：2002-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-09-24 00:00:00
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pub_type： 临床试验,杂志文章
doi：
更新日期：1997-03-01 00:00:00
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journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2010-09-01 00:00:00
