Abstract：
:The major issue currently being faced in the management of prostate cancer is the inability to distinguish between indolent prostate tumors that will not present clinically from more aggressive and metastatic prostate cancers that will impact on men's lives. Only a small proportion of prostate cancers can be accounted for by unmistakable hereditary cancer syndromes and the predominant contribution to the progression of most sporadic cancers is thought to be environmental, with nutrition having the greatest influence. Population studies have clearly implicated metabolic factors as contributors to disease progression and poor response to therapy. It is well established that the IGF system is key in regulating growth and metabolism and mediates the effects of nutrition on these processes. It consists of two ligands (IGF-I and IGF-II), two receptors [type 1 IGF-IR and IGF-II/mannose 6-phosphate receptor], and six high affinity IGF-binding proteins (IGFBP-1 to -6). This review provides evidence from in vitro, in vivo, clinical and epidemiology studies that indicates an important role for the IGF axis in the development of prostate cancer and the likely role that it plays in mediating the effects of nutrition on disease progression. We suggest that the IGF axis is central to understanding how lifestyle impacts on prostate cancer and we highlight this by describing numerous strategies being developed to target this axis.
journal_name
Minerva Endocrinoljournal_title
Minerva endocrinologicaauthors
Biernacka KM,Perks CM,Holly JMsubject
Has Abstractpub_date
2012-06-01 00:00:00pages
173-85issue
2eissn
0391-1977issn
1827-1634pii
R07121947journal_volume
37pub_type
杂志文章,评审abstract：UNLABELLED:Anaplastic thyroid cancer (ATC) is a rare aggressive tumor arising from the follicular cells of the thyroid gland (as does well differentiated thyroid cancer, WDTC), but ATC cells do not retain any of the biological features of the original follicular cells, such as uptake of iodine and synthesis of thyroglo...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2008-12-01 00:00:00
abstract：:Bariatric surgery has been found to be very useful in treating established type-2 diabetes in obese persons, as well as in borderline diabetics, besides giving a good weight loss. Various modifications of the primary bariatric procedures have been introduced, with differ advantages and better efficacy. Good incretin r...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2016-12-01 00:00:00
abstract：:We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Acromegaly is a rare and chronic disease that, in the majority of cases, is due to the presence of a benign growth hormone (GH)-producing tumor of the pituitary. In the past, the diagnosis of acromegaly was established basically on physical changes, and only the patients with a severe clinical picture were brought to ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
abstract：:The authors present 6 cases of carotid glomus tumours referred to their attention over the past 10 years. Their experience shows that colour ultrasonography (using both morphological and functional evaluation) is the diagnostic key for defining the treatment of paraganglioma. More recent experience highlights the role...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:Patients and animals with poorly controlled or uncontrolled diabetes present with diurnal hypersecretion of glucocorticoids and altered regulation of the hypothalamo-pituitary-adrenocortical (HPA) axis. Although some of these changes are reversed with insulin replacement therapy, neuroendocrine function is not always ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2003-06-01 00:00:00
abstract：:The treatment of NIDDM patients with secondary failure to sulfonylureas is still a debated problem. In this study we compared in NIDDM patients with secondary failure to glyburide, the effect of adding a single, low-dose bed time either NPH or ultralent insulin injection (0.15-0.2 U/kg) to the previously ineffective s...
journal_title：Minerva endocrinologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:Whether Doppler ultrasonography (DU) may be of help in characterizing thyroid nodes is still under debate: both good and unsatisfactory results have been claimed, either in evaluating the presence of malignancy or in identifying hyperfunctional structures. METHODS:In this paper, the scintigraphic and Dopple...
journal_title：Minerva endocrinologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:The aim of this study was to compare the diagnostic accuracy of fine needle biopsy (FNB) and intraoperative frozen-section biopsy (FS) regarding the surgical management of thyroid nodules. METHODS:A total of 812 patients with solitary nodule or dominant nodule in a multinodular goiter were evaluated. The pa...
journal_title：Minerva endocrinologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:The present insulin preparations are not ideal for diabetes therapy by subcutaneous administration, subcutaneous insulin absorption is too slow to mimic the normal rapid increments of insulin in blood in response to nutrient intake. The absorption of insulin from subcutaneous tissue is influenced by many factors, amon...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1996-03-01 00:00:00
abstract：AIM:An association between Glucagon-Like Peptide-1 Receptor Agonists (GLP1-RA) and risk of pancreatitis and pancreatic cancer has been suggested. Since its first description, several new trials (including three cardiovascular outcome trials) have been published, substantially increasing the available data set. This sug...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03219-8
更新日期：2020-07-23 00:00:00
abstract：:Visualization of cerebral perfusion with Single Photon Emission Computed Tomography (SPET) needs lipophil radiotracers which are able to cross the intact blood-brain-barrier (BBB); moreover local uptake must reflect regional cerebral blood flow. In the last decade many radiopharmaceuticals have been suggested and empl...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：AIM:The efficacy of low and high fixed dose radioactive iodine (RAI) therapy in patients with toxic nodular goiter was investigated. METHODS:Ninety-three patients (25 males, 68 females) were included into the study (32 patients with toxic adenoma, 61 patients with toxic multinodular goiter). Patients were treated with...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:Adrenals are a common site of metastasis for many solid tumors. Adrenal metastases, and related symptoms of adrenal failure, are usually overlooked in clinical practice. This is probably due to the functional compensation of the adrenal glands and to the fact that signs and symptoms of adrenal insufficiency are aspeci...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：:Cushing's syndrome is a serious endocrine condition for which no treatment has been proven fully satisfactory at least for its pituitary dependent form (Cushing's disease). Indeed, despite some advances in pharmacology (cyproheptadine, bromocriptine, lisuride) and in surgical and radiation procedures at pituitary leve...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:We treated with PEI 81 patients carriers of autonomous thyroid nodule, 65 toxic and 16 non toxic, all with undetectable serum TSH and suppressed extranodular tissue on scintigraphy. The treatment schedule was: 1-2 sessions per week, 1-8 ml per session, 3-13 sessions in total, In relation to the size and the therapeuti...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:Obesity has become a national epidemic and a disease of global magnitude. The numbers of patients with obesity have grown exponentially in the last 10 years to the degree that the Centers for Disease Control and Prevention reports that one third of the US population is obese. The prevalence of diabetes has grown by mo...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2013-06-01 00:00:00
abstract：:A 54-year-old woman presented with an expansive mass in the anterior cervical region (front of the neck) with abscess. Laboratory tests and thyroid profile proved normal. Surgical exploration revealed a hydatid cyst in the left lobe of the thyroid gland with parasitic metastasis of the left lateral cervical lymph node...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：:Thyroid nodule is extremely common. Its prevalence has been estimated to be more than 5% in the adult population. If thyroid nodule is a rare condition, 0.004% a year, identifying those nodules, which are likely to be malignant, is very important for physicians. The evaluation of thyroid is carried out using the fine ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1993-09-01 00:00:00
abstract：AIM:Patients with differentiated thyroid carcinoma (DTC) are closely monitored during the first decade after diagnosis. At intervals of 1-2 years withdrawal of suppressive doses of T(4) is recommended in order to check thyroglobulin (Tg) levels under increased TSH. T(4) therapy is usually withdrawn for 5 weeks (during ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：:A 49 year-old woman with anaplastic thyroid carcinoma came, for the first time, to our clinic with an enlarged supraclavicular lymph node. Ten years earlier she received a diagnosis of benign nodular goiter and has been followed up with ultrasonography, which never demonstrated any enlargement of her thyroid nodule an...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Primary hyperparathyroidism is a not uncommon disease in the elderly. A prevalence of 3% for women and 1% for men is reported in subjects aged 65 years and over. Routine serum calcium determination and parathyroid hormone radioimmuno-assay allow to make an early diagnosis in still asymptomatic subjects. In the elderly...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with well-established metabolic abnormalities. In the present study, untargeted metabolomics technology was applied to analyze the serum and follicular fluid samples from women with polycystic ovary syndrome and healthy controls using 1H nuclea...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03199-5
更新日期：2020-10-26 00:00:00
abstract：:The majority of patients with differentiated thyroid cancer are cured with standard primary treatments including surgery, radioactive iodine and TSH suppression. A small proportion of patients who develop radioactive iodine-refractory metastatic disease have few treatment options. Recent discovery of the molecular mec...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2012-12-01 00:00:00
abstract：:The normal growth and development of the prostate requires the presence and action of androgens, which are also known risk factors in the origins of benign and malignant prostate disease. Paradoxically, the incidence of prostate disease increases with age when serum androgen levels are in decline and emerging evidence...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2006-03-01 00:00:00
abstract：:The Authors report a case of left adrenal mass incidentally discovered by upper abdominal echogram in a 40 year old man. Physical examination showed no signs of hypercortisolism and plasma cortisol and ACTH levels were in the normal range as well as urinary free cortisol. After adrenalectomy, 4 and 8 month follow-up w...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is diabetes that is first diagnosed in the second or third trimester of pregnancy in patients who did not have a history of diabetes before pregnancy. Consequences of GDM include increased risk of macrosomia and birth complications in the infant and an increased risk of maternal typ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03192-2
更新日期：2020-09-01 00:00:00
abstract：:Controversies surround the view that the blood-bone ionic equilibrium is controlled by ionic changes at a so called "bone membrane" that display a pump-leak mechanism able to maintain a concentration gradient for chloride in addition to that for calcium, sodium and potassium. On the other hand it is known that a chlor...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Notwithstanding recent neuroendocrinological and neuroradiological findings, about 40% of carriers of pituitary adenoma still reach clinical observation and, consequently, the surgeon, in the stage of suffering from extrasellar extension to a varying degree, especially when the volumetric growth of the lesion is not a...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:The presence of islet cell autoantibodies (ICA), and especially of glutamic acid decarboxylase autoantibodies (GAD65Ab), in patients with non-insulin-dependent diabetes mellitus identifies the so-called latent autoimmune diabetes in the adult (LADA). LADA patients have an increased risk for developing insulin deficien...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2003-12-01 00:00:00
