Abstract:
:Growth hormone (GH) has previously been implicated in T-cell development, and here we test its efficacy in promoting T-lymphocyte engraftment in mice with severe combined immune deficiency (SCID). SCID mice receiving syngeneic thymocytes and treated with recombinant human GH (rhGH) had significantly better T-cell engraftment in their lymph nodes. Human T-cell engraftment was also strongly promoted by rhGH in SCID recipients receiving human peripheral blood lymphocytes. Additionally, although mature human cells have not been thought to enter the murine thymus, human T cells were detected in the SCID thymus after rhGH treatment. Thus, rhGH can be used to optimize long-term peripheral T-cell engraftment in these human-mouse chimeras and may also be useful clinically in treating T-cell deficiencies.
journal_name
Proc Natl Acad Sci U S Aauthors
Murphy WJ,Durum SK,Longo DLdoi
10.1073/pnas.89.10.4481keywords:
subject
Has Abstractpub_date
1992-05-15 00:00:00pages
4481-5issue
10eissn
0027-8424issn
1091-6490journal_volume
89pub_type
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