Abstract：
BACKGROUND AND OBJECTIVE:Two different pathways for the development of tumor have been described in colorectal carcinoma: the chromosomic instability, raised by suppressor genes and proto-oncogene alterations, and the microsatellite instability (MSI), caused by alterations in DNA repairing genes. PATIENTS AND METHOD:The frequency and the clinical meaning of the microsatellites instability pathway were determined in a consecutive prospective cohort of 106 patients who underwent surgical resection of colorectal carcinoma by a single surgeon. Microsatellite instability determination was established according to the criteria proposed by the National Cancer Institute in 1998. RESULTS:9.4% of patients had a high instability and it was low in 11.3%; both groups displayed different clinico-pathological characteristics (age, sex, tumor site and histologic type). In the multivariant analysis of overall survival and disease free survival, high instability exhibited prognostic value independent of the rest of variables evaluated (p < 0.0001). CONCLUSIONS:The genetic alterations giving rise to microsatellite instability lead to a better prognosis in patients with colorectal cancer.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Vidaurreta M,Sanz-Casla MT,Maestro ML,Rafael S,Jiménez F,Arroyo M,Fernández C,Cerdán Jdoi
10.1157/13071004keywords:
subject
Has Abstractpub_date
2005-02-05 00:00:00pages
121-5issue
4eissn
0025-7753issn
1578-8989pii
S0025-7753(05)71635-3journal_volume
124pub_type
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