[Current state of anti-tumor necrosis factor therapy in autoimmune diseases].

Abstract:

:Tumor necrosis factor (TNF) alpha plays a central role in both the inflammatory response and that of the immune system. Thus, its blockade with the so-called anti-TNF agents (infliximab, etanercept and adalimumab) represents an important tool for the management of a variety of disorders, such as rheumatoid arthritis, the spondyloarthropathies, inflammatory bowel disease and psoriasis. Nonetheless, theoretically, some other autoimmune and inflammatory disorders may benefit from these agents. We intend to update on these off-label uses of anti-TNF blockers in this review.

journal_name

Med Clin (Barc)

journal_title

Medicina clinica

authors

Sánchez Cano D,Callejas Rubio JL,Ortego Centeno N

doi

10.1157/13126958

subject

Has Abstract

pub_date

2008-10-11 00:00:00

pages

471-7

issue

12

eissn

0025-7753

issn

1578-8989

pii

S0025-7753(08)72455-2

journal_volume

131

pub_type

杂志文章,评审
  • [Chronic hepatitis E].

    abstract::The hepatitis E virus is an RNA virus with 4 genotypes. Genotypes 1 and 2 only affect humans and produce epidemic acute hepatitis in endemic regions (Asia and Africa). Genotypes 3 and 4 are considered a zoonosis and produce episodic acute hepatitis in non-endemic areas (America and Europe). However, in the last 3 year...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2011.02.003

    authors: González Tallón AI,Moreira Vicente V,Mateos Lindemann ML

    更新日期:2012-02-04 00:00:00

  • Effect of alcohol and its metabolites in lung cancer: CAPUA study.

    abstract:BACKGROUND AND OBJECTIVE:Alcohol and its metabolites play an important role in carcinogenesis. This effect could be modulated by polymorphisms in genes encoding enzymes involved in the metabolism of alcohol and folate. Therefore, we analyzed the effect of alcohol consumption and ADH1B Arg48His, ADH1B Arg370Cys, ADH1C I...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2016.12.033

    authors: Álvarez-Avellón SM,Fernández-Somoano A,Navarrete-Muñoz EM,Vioque J,Tardón A

    更新日期:2017-06-21 00:00:00

  • Relationship between diffuse idiopathic skeletal hyperostosis, abdominal aortic calcification and associated metabolic disorders: Data from the Camargo Cohort.

    abstract:BACKGROUND AND OBJECTIVE:Diffuse idiopathic skeletal hyperostosis (DISH) and abdominal aortic calcification (AAC) are related to an increased cardiovascular risk. The aim of this study was to analyse a possible relationship between both entities and also the association between metabolic disorders and DISH. PATIENTS A...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2017.01.030

    authors: Pariente-Rodrigo E,Sgaramella GA,Olmos-Martínez JM,Pini-Valdivieso SF,Landeras-Alvaro R,Hernández-Hernández JL

    更新日期:2017-09-08 00:00:00

  • Infections in inflammatory bowel disease.

    abstract::Patients with inflammatory bowel disease constitute a population with a special predisposition to develop bacterial, viral and fungal infections. Iatrogenic immunosuppression, frequent contact with healthcare facilities and surgical interventions are some of the risk factors that explain why these infections are one o...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2016.12.041

    authors: Rodríguez de Santiago E,Albillos Martínez A,López-Sanromán A

    更新日期:2017-05-10 00:00:00

  • [Predictive factors of ESBL versus non-ESBL Escherichia coli bacteraemia and influence of resistance on the mortality of the patients].

    abstract:BACKGROUND AND OBJECTIVES:To analyze predictor factors of extended-spectrum betalactamasa (ESBL)-producing E. coli and its repercussion in mortality. PATIENTS AND METHODS:Observational and comparative study of a cohort of non-paediatric admitted patients with E. coli bacteraemia (EB). RESULTS:153 EB (22% ESBL-produci...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2010.05.014

    authors: García Hernández A,García-Vázquez E,Gómez Gómez J,Canteras M,Hernandez-Torres A,Ruiz Gómez J

    更新日期:2011-01-29 00:00:00

  • Anti-neutrophil cytoplasmic antibody-associated vasculitis with renal involvement: Analysis of 89 cases.

    abstract:INTRODUCTION:The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis with renal involvement are associated with high morbi-mortality. In this study we analyse if the prognosis of these diseases have improved in recent years, and which factors influence the outcomes. MATERIAL AND METHODS:Retrospective sin...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2016.09.015

    authors: Caravaca-Fontán F,Yerovi E,Delgado-Yagu E M,Galeano C,Pampa-Saico S,Tenorio MT,Liaño F

    更新日期:2017-01-06 00:00:00

  • Evaluation of the activity of rheumatoid arthritis in clinical practice. Agreement between self-rated clinimetric evaluation and clinical evaluation with activity indexes: DAS28, CDAI and SDAI.

    abstract:INTRODUCTION AND OBJECTIVE:To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with la...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2017.02.025

    authors: Horta-Baas G,Pérez Bolde-Hernández A,Hernández-Cabrera MF,Vergara-Sánchez I,Romero-Figueroa MDS

    更新日期:2017-10-11 00:00:00

  • Usefulness of bronchoalveolar lavage and flow cytometry in patients with hematological malignancies and respiratory failure.

    abstract:BACKGROUND AND OBJECTIVES:Strategies to improve the efficiency of bronchoalveolar lavage (BAL) are needed. We conducted a study to establish the diagnostic value of BAL in patients with hematological malignancies and pulmonary infiltrates. PATIENTS AND METHODS:The correlation of cytologic and flow cytometric study of ...

    journal_title:Medicina clinica

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.medcli.2016.10.045

    authors: Ferrà C,Xicoy B,Castillo N,Morgades M,Juncà J,Andreo F,Millá F,Feliu E,Ribera JM

    更新日期:2017-04-07 00:00:00

  • [Role of cardiac magnetic resonance in cardiac involvement of Fabry disease].

    abstract:BACKGROUND AND OBJECTIVES:Fabry disease is a hereditary disorder. Clinical manifestations are multisystemic. The majority of the patients remain undiagnosed until late in life, when alterations could be irreversible. Early detection of cardiac symptoms is of major interest in Fabry's disease (FD) in order to gain acces...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2009.11.044

    authors: Serra VM,Barba MA,Torrá R,Pérez De Isla L,López M,Calli A,Feltes G,Torras J,Valverde V,Zamorano JL

    更新日期:2010-09-04 00:00:00

  • Consensus document for the use of the Polypill in the secondary prevention of cardiovascular disease.

    abstract::Cardiovascular disease is a chronic disorder which is usually already at an advanced stage when the first symptoms develop. The fact that the initial clinical presentation can be lethal or highly incapacitating emphasizes the need for primary and secondary prevention. It is estimated that the ratio of patients with go...

    journal_title:Medicina clinica

    pub_type: 共识发展会议,杂志文章

    doi:10.1016/j.medcli.2016.10.031

    authors: González-Juanatey JR,Mostaza JM,Lobos JM,Abarca B,Llisterri JL,Baron-Esquivias G,Galve E,Lidón RM,Garcia-Moll FX,Sánchez PL,Suárez C,Millán J,Pallares V,Alemán JJ,Egocheaga I

    更新日期:2017-02-09 00:00:00

  • [Evaluation on the compliance of the metabolic control aims in outpatients with type 2 diabetes mellitus in Spain. The TranSTAR study].

    abstract:BACKGROUND AND OBJECTIVE:A good metabolic control of patients with type 2 diabetes mellitus (DM2) will likely contribute to a decrease of their cardiovascular (CV) risk. Our aim was (1) to evaluate the degree of metabolic control with regard to glycemia, lipidemia and blood pressure (BP) and (2) to describe the prevale...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(03)73735-x

    authors: de la Calle H,Costa A,Díez-Espino J,Franch J,Goday A

    更新日期:2003-04-05 00:00:00

  • Crucial laboratory parameters in COVID-19 diagnosis and prognosis: An updated meta-analysis.

    abstract:INTRODUCTION AND OBJECTIVES:Common laboratory parameters are crucial in aiding coronavirus disease 2019 (COVID-19) case detection. This study aimed to determine the differences between laboratory parameters in (1) COVID-19 versus non-COVID-19 pneumonia, and (2) severe versus non-severe COVID-19 cases. METHODS:Studies ...

    journal_title:Medicina clinica

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.medcli.2020.05.017

    authors: Soraya GV,Ulhaq ZS

    更新日期:2020-08-28 00:00:00

  • Prognostic value of the increase in systolic blood pressure with exercise in patients with hypertension and known or suspected coronary artery disease.

    abstract:BACKGROUND AND OBJECTIVE:The association of an exaggerated systolic blood pressure increase with exercise (EBPIE) with cardiovascular events remains controversial. Our aim was to determine the possible association of an EBPIE with survival and risk of serious cardiac events in patients with hypertension and known or su...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2016.09.016

    authors: Bouzas-Mosquera C,Bouzas-Mosquera A,Peteiro J

    更新日期:2017-01-20 00:00:00

  • [DNA prints instead of plantar prints in neonatal identification].

    abstract:BACKGROUND:To check the possible usefulness in studying DNA in dried blood spots taken on filter paper blotters for newborn identification. It set out to establish: 1. The validity of the method for analysis; 2. The validity of all stored samples (such as those kept in clinical records); 3. Guarantee of non-intrusion i...

    journal_title:Medicina clinica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Rodríguez-Alarcón Gómez J,Martińez de Pancorbo Gómez M,Santillana Ferrer L,Castro Espido A,Melchor Maros JC,Linares Uribe MA,Fernández-Llebrez del Rey L,Aranguren Dúo G

    更新日期:1996-06-22 00:00:00

  • [Future challenges in multiple sclerosis].

    abstract::Multiple sclerosis occurs in genetically susceptible individuals, in whom an unknown environmental factor triggers an immune response, giving rise to a chronic and disabling autoimmune disease. Currently, significant progress is being made in our knowledge of the frequency and distribution of multiple sclerosis and it...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/S0025-7753(15)30010-5

    authors: Fernández Ó

    更新日期:2014-12-01 00:00:00

  • [Transforming growth factor beta (TGF-beta) in Gaucher's disease. Preliminary results in a group of patients and their carrier and non-carrier relatives].

    abstract:BACKGROUND:The poor phenotype/genotype correlation in Gaucher's disease makes difficult therapy-decision-making and prevention of complications. Gaucher's cells and tissue fibrosis are the earliest findings of the disease. Transforming growth factor ss (TGF-beta1) is the key cytokine involved in the regulation of tissu...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(00)71637-x

    authors: Pérez Calvo JI,Iñigo Gil P,Giraldo Castellano P,Torralba Cabeza MA,Civeira F,Lario García S,Pocoví M

    更新日期:2000-11-11 00:00:00

  • Translation and adaptation of the Disability Assessment for Dementia scale in the Spanish population.

    abstract:BACKGROUND AND OBJECTIVE:Functional assessment is especially relevant in patients with cognitive impairment (CI). The Disability Assessment for Dementia (DAD) scale assesses functional ability and its use is becoming increasingly popular. This study aims to perform the translation and cultural adaptation of the DAD sca...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2017.03.029

    authors: Sánchez-Pérez A,López-Roig S,Pampliega Pérez A,Peral Gómez P,Pastor MÁ,Hurtado-Pomares M

    更新日期:2017-09-20 00:00:00

  • [Risk factors of the hepatic dysfunction associated with parenteral nutrition].

    abstract:BACKGROUND AND OBJECTIVE:The objective of this study is to describe the incidence of hepatic dysfunction (HD) in our hospital and evaluate the possible risk factors associated with HD development as an improvement of the caring process received by patients treated with parenteral nutrition (PN). PATIENTS AND METHOD:A ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2008.02.003

    authors: Servia L,Schoenenberger JA,Trujillano J,Badia M,Rodríguez-Pozo A

    更新日期:2009-02-07 00:00:00

  • [Estimate of the costs of osteoporotic fractures of the femur in Spain].

    abstract::To evaluate the economic impact of osteoporosis, the cost of acute attention to the osteoporotic hip fractures recorded in Barcelona during one year was investigated. The hospital records of 8637 beds (85.64% of the overall number in the city) were reviewed and the cases seen in inhabitants aged 45 years or more durin...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Díez Pérez A,Puig Manresa J,Martínez Izquierdo MT,Guelar Grimberg AM,Cucurull Canosa J,Mellibovsky Saidler L,Vivancos Lleida J

    更新日期:1989-05-20 00:00:00

  • [New approaches for the treatment of dyslipidemia].

    abstract::Reduction in the risk of cardiovascular complications through modification of lipids is currently focused on lowering low density lipoproteins-cholesterol, with statins being the preferred drugs. New agents, under research, such as antibodies neutralizing PCSK9, will have a special place for the management of patients...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2013.04.026

    authors: Mostaza JM,Lahoz C

    更新日期:2014-04-07 00:00:00

  • ["Stroke code". Shortening the delay in reperfusion treatment of acute ischemic stroke].

    abstract:BACKGROUND:"Stroke Code" is a system for the rapid identification, pre-notification and transport of acute ischemic stroke patients. The objective of this study was to evaluate the impact of delay reduction for thrombolytic therapy in these patients. SUBJECTS AND METHODS:We evaluated acute ischemic stroke patients adm...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Alvarez Sabín J,Molina C,Abilleira S,Montaner J,García F,Alijotas J

    更新日期:1999-10-23 00:00:00

  • [Rituximab for treatment of patients with systemic autoimmune diseases].

    abstract:BACKGROUND AND OBJECTIVE:To assess the value of rituximab in systemic autoimmune diseases which are refractory to others treatments. PATIENTS AND METHOD:Prospective study on 12 patients -7 with systemic lupus erythematosus (SLE), 4 with Wegener's granulomatosis (WG), and 1 with overlapping connective disease and autoi...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13100563

    authors: García Hernández FJ,Ocaña Medina C,González León R,Garrido Rasco R,Colorado Bonilla R,Castillo Palma MJ,Sánchez Román J

    更新日期:2007-03-31 00:00:00

  • [Value of pulse pressure as a cardiovascular risk marker].

    abstract::Pulse pressure is calculated as the difference between the systolic and diastolic components of arterial blood pressure. Epidemiological studies have demonstrated that pulse pressure elevation directly correlates with cardiovascular mortality and morbidity, as well as with target organ damage. From a pathophysiologica...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1157/13086050

    authors: de la Sierra A

    更新日期:2006-03-18 00:00:00

  • [Prediction of patient outcome].

    abstract::Monitoring biomedical signals obtained from a patient generates information that processed conveniently, it has to allow detecting as soon as possible changes in the predicted evolution. The systematic register of one of these biomedical signals is named a time series. In this paper, a brief introduction appears to th...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1157/13057547

    authors: Muñoz Gracia MP

    更新日期:2004-01-01 00:00:00

  • [Early detection of tuberculosis by the evaluation of contacts].

    abstract::We have evaluated the close contacts of 191 patients diagnosed of tuberculosis in our center between 1984 and 1987. The overall number of evaluated contacts was 666, and the mean number of contacts for each index case was 3.7. In 55% of the evaluated population PPD reaction was positive, and their mean age was 33.3 ye...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Ruiz Manzano J,Parra O,Roig J,Manterola J,Abad J,Morera J

    更新日期:1989-04-22 00:00:00

  • [Elderly patients with recurrent falls. Role of posturographic studies].

    abstract:BACKGROUND AND OBJECTIVE:Our purpose was to provide information about static and dynamic balance posturographic disorders in elderly people with recurrent falls, and to compare the results with a healthy elderly group. PATIENTS AND METHOD:We included 95 subjects: 57 patients who fell (86% women; age, 78.1 years) and 3...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13071759

    authors: Lázaro M,Cuesta F,León A,Sánchez C,Feijoo R,Montiel M,Ribera JM

    更新日期:2005-02-19 00:00:00

  • [Hormonal alterations on young morbid obese women].

    abstract:BACKGROUND:Human obesity is a widespread disease with considerable variability as to its severity, metabolic and endocrine manifestations and etiology. In the present study we have determined whether the alterations of uncomplicated severe obesity in adult young women affect with different intensity the circulating lev...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(01)71815-5

    authors: Vilà R,Gutiérrez R,Luisa Granada M,María Masanés R,del Mar Grasa M,Antonio Fernández López J,Remesar X,Formiguera X,Foz M,Alemany M

    更新日期:2001-03-10 00:00:00

  • [Infectious endocarditis in patients with liver cirrhosis].

    abstract::To evaluate the clinical and microbiological features of infective endocarditis in patients with cirrhosis we compared 18 episodes of endocarditis in these patients with a control group of patients without liver disease. In 61% of patients with cirrhosis the origin of infection was unknown. Four patients developed end...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Otones J,Fernández Clúa MA,Castrillo JM,Fernández Guerrero ML

    更新日期:1989-11-11 00:00:00

  • [Telerehabilitation to treat stress urinary incontinence. Pilot study].

    abstract:BACKGROUND AND OBJECTIVE:We aimed to test a new telerehabilitation device for stress urinary incontinence (SUI) in order to make an initial assessment of its effectiveness. PATIENTS AND METHOD:Randomized, controlled pilot study. INTERVENTION:experimental group (10 patients): pelvic floor muscle training, device train...

    journal_title:Medicina clinica

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.medcli.2014.05.036

    authors: Carrión Pérez F,Rodríguez Moreno MS,Carnerero Córdoba L,Romero Garrido MC,Quintana Tirado L,García Montes I

    更新日期:2015-05-21 00:00:00

  • [The fibroid as clinical problem].

    abstract::Uterine fibroids are the most common benign tumours that affect women of reproductive age and they represent the main indication for surgery for benign uterine pathology. In 25% of cases, they become clinically apparent, causing heavy menstrual bleeding, pelvic pain and/or infertility. Therefore, fibroids have a notab...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/S0025-7753(13)70045-9

    authors: Calaf J,Arqué M,Porta O,D'Angelo E

    更新日期:2013-07-01 00:00:00