[New approaches for the treatment of dyslipidemia].

Abstract:

:Reduction in the risk of cardiovascular complications through modification of lipids is currently focused on lowering low density lipoproteins-cholesterol, with statins being the preferred drugs. New agents, under research, such as antibodies neutralizing PCSK9, will have a special place for the management of patients with intolerance to statins of severe dyslipemias. Drugs used to modify the concentration of high density lipoproteins-cholesterol and triglycerides have not been accompanied by the expected reductions in the rate of cardiovascular complications.

journal_name

Med Clin (Barc)

journal_title

Medicina clinica

authors

Mostaza JM,Lahoz C

doi

10.1016/j.medcli.2013.04.026

subject

Has Abstract

pub_date

2014-04-07 00:00:00

pages

306-9

issue

7

eissn

0025-7753

issn

1578-8989

pii

S0025-7753(13)00310-2

journal_volume

142

pub_type

杂志文章,评审
  • [Guidelines for the rational use of endoscopy to improve the detection of relevant lesions in an open-access endoscopy unit: a prospective study].

    abstract:BACKGROUND AND OBJECTIVE:Almost 50% of gastrointestinal endoscopies performed in our Unit correspond to patients coming from primary care. Since resources are finite, adherence to appropriate indications for these procedures is essential. We prospectively assessed the appropriateness of gastrointestinal endoscopies ref...

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    pub_type: 杂志文章

    doi:10.1157/13107917

    authors: Fernández-Esparrach G,Gimeno-García AZ,Llach J,Pellisé M,Ginès A,Balaguer F,Mata A,Castells A,Bordas JM

    更新日期:2007-07-07 00:00:00

  • [Expanded newborn screening in the Region of Murcia, Spain. Three-years experience].

    abstract:BACKGROUND AND OBJECTIVE:The early detection of inborn errors of metabolism by mass spectrometry allows expanding the traditional neonatal screening of phenylketonuria and congenital hypothyroidism to test for aminoacidopathies, fatty acid oxidation disorders and organic acid metabolic disorders. Cystic fibrosis and bi...

    journal_title:Medicina clinica

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    doi:10.1016/j.medcli.2011.10.007

    authors: Juan-Fita MJ,Egea-Mellado JM,González-Gallego I,Moya-Quiles MR,Fernández-Sánchez A

    更新日期:2012-12-01 00:00:00

  • [Fetal microchimerism in patients with primary biliary cirrhosis].

    abstract:BACKGROUND:Fetal microchimerism (FM) has been implicated in the pathogenesis of primary biliary cirrhosis (PBC). The aim of the study was to investigate the presence of FM in PBC patients. PATIENTS AND METHOD:FM was studied in 28 women, 14 with PBC and 14 healthy controls.DNA was extracted from peripheral blood cells,...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(02)73575-6

    authors: Selva O'Callaghan A,Balada Prades E,Castells Fusté L,Vargas Blasco V,Solans Laque R,Vilardell Tarrés M

    更新日期:2002-12-07 00:00:00

  • [Antibiotic sensitivity, serology and typing by pyocine in 154 cultures of Pseudomonas aeruginosa (author's transl)].

    abstract::Pseudomonas infections continue to be an important problem in the hospital environment. Serious infections are always invariably associated with severe underlying conditions or with diminished host resistance. The increasingly resistance of strains and hospital epidemics favour the organism prevalence. During 1978, Ps...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Cantos de la Casa A,García Curiel A,Gómez Fernández MV,Arroyo Trillo A,Díaz Sánchez JA,Dueñas P

    更新日期:1980-07-15 00:00:00

  • [Waldenström's macroglobulinemia, cryoglobulinemia type I and membranous glomerulonephritis].

    abstract::Renal complications in Waldenström's macroglobulinemia (WM) are infrequent and are characterized by the presence of PAS positive amorphous hyaline deposits in the capillary lumen, infiltrated with lymphoplasmatic cells with PAS positive inclusions in the interstices and intratubular hyaline cylinders. Membranous glome...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: González Anglada MI,González García J,del Arco A,Picazo ML,Quevedo E,Vázquez Rodríguez JJ

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  • [A pancreatic pseudotumour of tuberculous etiology].

    abstract:BACKGROUND:To review the clinical findings of pancreatic tuberculosis and to establish a differential diagnosis with pancreatic tumours. PATIENTS AND METHODS:To describe three cases of pancreatic tuberculosis diagnosed in a 850 bed teaching hospital during the last two years. RESULTS:In the three case the imaging pro...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/s0025-7753(00)71592-2

    authors: Martínez-Valle F,Capdevila JA,Ribera E,Pigrau C,Pahissa A

    更新日期:2000-10-14 00:00:00

  • [Low prevalence of the Leu7/Pro polymorphism in the signal peptide of preproneuropeptide Y in the Spanish Mediterranean population].

    abstract:BACKGROUND AND OBJECTIVE:A common Leu7Pro polymorphism in the signal peptide of neuropeptide Y has been associated with increased plasma cholesterol and accelerated atherosclerosis in the Finnish population. SUBJECTS AND METHOD:A cross-sectional design was carried out in 1,000 individuals from the Mediterranean Spanis...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(03)73695-1

    authors: Portolés O,Sorlí JV,González JI,Ruiz de la Fuente S,Ramírez JB,Corella D

    更新日期:2003-03-15 00:00:00

  • [Calcified aortic valve disease: association with atherosclerosis].

    abstract::Calcified aortic valve disease (CAVD) is a prevalent condition, affecting 25% of people older than 65 years. CAVD and atherosclerosis share common risk factors and pathogenic mechanisms. Nevertheless, they present different pathologic lesions. The main factors involved in the pathogenesis of CAVD are genetic predispos...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2010.02.019

    authors: Toro R,Mangas A,Gómez F

    更新日期:2011-05-14 00:00:00

  • [Clinical and epidemiological characteristics of persons newly diagnosed of HIV infection].

    abstract:BACKGROUND:We describe the characteristics of people with a recent diagnosis of HIV infection. PATIENTS AND METHOD:Series of 126 new cases of HIV infection diagnosed in an infectious diseases Service. RESULTS:Sexual transmission was the commonest form of infection (74%). Fifteen percent of individuals were aged over ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(01)72211-7

    authors: López De Munain J,Cámara MM,Santamaría JM,Zubero Z,Baraia-Etxaburu J,Muñoz J

    更新日期:2001-11-24 00:00:00

  • [Effects of simvastatin on acute-phase protein levels after cardiac surgery].

    abstract:BACKGROUND AND OBJECTIVE:There is contradictory evidence as to whether the pleiotropic effects of statins improve morbidity/mortality rates in coronary artery bypass grafting with extracorporeal circulation, as they reduce the protein plasma levels in the acute phase. PATIENTS AND METHOD:This randomized prospective st...

    journal_title:Medicina clinica

    pub_type: 杂志文章,随机对照试验

    doi:10.1157/13121102

    authors: Tamayo E,Alonso O,Alvarez FJ,Castrodeza J,Flórez S,di Stefano S

    更新日期:2008-05-31 00:00:00

  • [Prevalence of hepatitis B and hepatitis A virus infection among health sciences students in Catalonia, Spain].

    abstract:BACKGROUND:To know current hepatitis B (HBV) and hepatitis A (HAV) infection status among a group of health sciences students during 1990-1993 period. SUBJECTS AND METHODS: SUBJECTS:1,734 health sciences students during 1990-1991, 1992-1993 and 1993-1994 academic years. MAIN OUTCOME MEASURES:demographic variables, v...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Bayas JM,Bruguera M,Vilella A,Carbó JM,Vidal J,Navarro G,Nebot X,Prat A,Salleras L

    更新日期:1996-09-14 00:00:00

  • [Biases in the study of prognostic factors].

    abstract::The main objective is to detail the main biases in the study of prognostic factors. Confounding bias is illustrated with social class, a prognostic factor still discussed. Within selection bias several cases are commented: response bias, specially frequent when the patients of a clinical trial are used; the shortcomin...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:

    authors: Delgado-Rodríguez M

    更新日期:1999-01-01 00:00:00

  • [Prognostic impact of anthracyclines in the treatment of aggressive lymphoma in patients over 70 years].

    abstract:BACKGROUND AND OBJECTIVE:The optimal treatment of aggressive non-Hodgkin lymphoma (NHL) in elderly patients remains controversial. We aimed to evaluate the impact of age and use of anthracyclines. PATIENTS AND METHOD:Retrospective analysis of patients with aggressive NHL aged over 70 years old. RESULTS:One hundred an...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2014.04.026

    authors: Ancochea Á,Salar A,García-Pallarols F,Gimeno E,Fernández-Rodriguez C,Sánchez-González B

    更新日期:2015-06-22 00:00:00

  • [Incrusted cystitis with isolation of Corynebacterium group D2].

    abstract::Three cases of encrusted cystitis caused by Corynebacterium group D2 are described. The vesical damage previous to the establishment of this bacteria is noteworthy and the very rapid increase in urease activity explains the pathogenesis of the situation. Thus allowing for its identification and is relevant to treatmen...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Fernández Natal MI,García Díez F,Salas Valién JS,Cachón García F,Soriano García F

    更新日期:1992-03-21 00:00:00

  • [Emergency hospital admission in medical services: causes, justification, social factors, and their differences in function of age].

    abstract:BACKGROUND:Increasing attention has been given to the care to elderly patients in emergency departments (ED). Moreover, few data are available about final phase of the process, that is hospital admission from ED. This study was conducted to establish appropriateness, reasons and social factors related to hospital admis...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: González-Montalvo JI,Baztán JJ,Rodríguez-Mañas L,San Cristóbal E,Gato A,Ballesteros P,Salgado A

    更新日期:1994-10-15 00:00:00

  • [Risk factors for nosocomial sepsis: a case-control study].

    abstract:BACKGROUND:The objective of this study was to identify the risk factors associated with the nosocomial sepsis syndrome according to the criteria of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. PATIENTS AND METHOD:A 1-year prospective case-control study matched for se...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Fariñas Alvarez C,Carmen Fariñas M,Llorca J,Delgado Rodríguez M

    更新日期:2001-06-02 00:00:00

  • [Number needed to treat: Interpretation and estimation in multivariable analyses and censored data].

    abstract::Number needed to treat has been recommended as an easy way to transmit results from a trial, especially controlled clinical trials. Most articles estimate it from a 2×2 table, as the inverse of the absolute risk reduction. However, some limitations have been pointed out: The interpretation is not as easy as claimed, c...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2013.05.003

    authors: Gómez-Acebo I,Dierssen-Sotos T,Llorca J

    更新日期:2014-05-20 00:00:00

  • [Chronic myeloproliferative syndromes and tuberculosis: apropos of 3 cases].

    abstract::We report 3 patients with chronic myeloproliferative syndromes and active tuberculous infection. The first patient had chronic myelocytic leukemia. In this patient, primary tuberculosis was localized in the lung. In spite of tuberculostatic treatment, he developed laterocervical lymphadenopathy and a tuberculous absce...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Peró Silva A,García Saavedra V,Llorente Cabrera A

    更新日期:1990-04-21 00:00:00

  • [Medical decisions in patients with chronic obstructive pulmonary disease].

    abstract:BACKGROUND:A right information about illness is essential if a patient has to take ethically autonomous medical decisions. We assessed whether a group o patients with chronic obstructive pulmonary disease (COPD) had enough information about their illness to take medical decisions. PATIENTS AND METHOD:Structured interv...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(01)71896-9

    authors: Miró Andreu G,Félez Flor M,Solsona Durán JF

    更新日期:2001-04-21 00:00:00

  • [Lipid profile in the hyperacute phase of ischemic stroke allows to decide cholesterol-lowering therapy].

    abstract:BACKGROUND AND OBJECTIVE:We aimed to determine whether measuring the hyperacute lipid profile helps to start a cholesterol-lowering therapy soon after an ischemic stroke. PATIENTS AND METHOD:72 ischemic stroke patients underwent lipid determinations at three times (hyperacute phase or arrival, second day and the third...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13072322

    authors: Delgado Martínez P,Montaner Villalonga J,Chacón P,Purro F,Ribó M,Alvarez-Sabín J

    更新日期:2005-03-05 00:00:00

  • [Influenza vaccination and mortality in the elderly].

    abstract:BACKGROUND AND OBJECTIVE:Though there is a general agreement on the need of influenza vaccination (IV), very different results have been published about the magnitude of its effect. We evaluated the effectiveness of IV in the reduction of mortality in individuals over 65 years of age. PATIENTS AND METHOD:Prospective c...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(05)72156-4

    authors: Vila-Córcoles A,Ochoa-Gondar O,Ansa-Echeverría X,Gómez-Sorribes A,Espelt-Aluja P,Pascual-Morón I

    更新日期:2005-11-19 00:00:00

  • [Hyporeninemic hypoaldosteronism. Case report and attempt at pathophysiological classification (author's transl)].

    abstract::A 75 year-old male presented with hyperkalemia unexplained by a moderate renal insufficiency, low basal levels of aldosterone and renin with a subnormal response to walking and saline depletion, and normal glucocorticoid function. The hyperkalemia was corrected by fluorocortisone administration. The concept of hypoald...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Cuervas-Mons V,Moya Mir MS,Martín Martín F,Barbadillo García de Velasco R,Sánchez Miró I,Martín Jiménez T,Lorenz Pérez P

    更新日期:1980-11-10 00:00:00

  • Crucial laboratory parameters in COVID-19 diagnosis and prognosis: An updated meta-analysis.

    abstract:INTRODUCTION AND OBJECTIVES:Common laboratory parameters are crucial in aiding coronavirus disease 2019 (COVID-19) case detection. This study aimed to determine the differences between laboratory parameters in (1) COVID-19 versus non-COVID-19 pneumonia, and (2) severe versus non-severe COVID-19 cases. METHODS:Studies ...

    journal_title:Medicina clinica

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.medcli.2020.05.017

    authors: Soraya GV,Ulhaq ZS

    更新日期:2020-08-28 00:00:00

  • [Future challenges in multiple sclerosis].

    abstract::Multiple sclerosis occurs in genetically susceptible individuals, in whom an unknown environmental factor triggers an immune response, giving rise to a chronic and disabling autoimmune disease. Currently, significant progress is being made in our knowledge of the frequency and distribution of multiple sclerosis and it...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/S0025-7753(15)30010-5

    authors: Fernández Ó

    更新日期:2014-12-01 00:00:00

  • [Hemolytic-uremic syndrome in the adult (author's transl)].

    abstract::This article presents six cases of hemolytic-uremic syndrome, defined as the combination of acute renal insufficiency, microangiopathic hemolytic anemia, and thrombocytopenia, in six adult patients, two men and four women, between 20 and 52 years old. Three of the cases were considered idiopathic, two secondary to the...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Montoliu J,Darnell A,Torras A,Botey A,Revert L

    更新日期:1980-01-10 00:00:00

  • Post-colonoscopy colorectal cancer: Characteristics and predictive factors.

    abstract:INTRODUCTION AND AIMS:A high quality colonoscopy is key in preventing colorectal cancer, but the risk of colorectal cancer (CRC) exists. The aims of the study were to investigate the incidence, characteristics and predictive factors of post-colonoscopy colorectal cancer (PCCRC). MATERIAL AND METHOD:A retrospective and...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2017.04.015

    authors: Muñoz García-Borruel M,Hervás Molina AJ,Rodríguez Perálvarez ML,Moreno Rincón E,Pérez Medrano I,Serrano Ruiz FJ,Casáis Juanena LL,Pleguezuelo Navarro M,Naranjo Rodríguez A,Villar Pastor C

    更新日期:2018-01-12 00:00:00

  • [Current state of anti-tumor necrosis factor therapy in autoimmune diseases].

    abstract::Tumor necrosis factor (TNF) alpha plays a central role in both the inflammatory response and that of the immune system. Thus, its blockade with the so-called anti-TNF agents (infliximab, etanercept and adalimumab) represents an important tool for the management of a variety of disorders, such as rheumatoid arthritis, ...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1157/13126958

    authors: Sánchez Cano D,Callejas Rubio JL,Ortego Centeno N

    更新日期:2008-10-11 00:00:00

  • [Use of screening mammography and its demographic and risk determinants in women 25 to 65 years of age].

    abstract:BACKGROUND:To know the utilization of the screening mammography among women from 25 to 65 years old in an urban health zone, where there is not an specific screening program for breast cancer. To detect the demographic and risk determinants that are involved in the mammography screening use. SUBJECTS AND METHODS:A sam...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Simó Miñana J,Gaztambide Ganuza M,Morote Sanchís MV,Palazón Ferrer G,Gálvez Candel J,Salto Sánchez ML,Peñarroja González D,Hernández Aguado I

    更新日期:1997-05-24 00:00:00

  • [Heart rate and isolated clinical tachycardia in hypertensive patients].

    abstract:BACKGROUND:There is poor information for isolated clinical tachycardia (ICT), that is to say, office tachycardia but normal ambulatory heart rate (HR). Our objective was to describe it and to know differences between hypertensive subjects with and without ICT. PATIENTS AND METHOD:Comparative study after a diagnostic i...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(00)71627-7

    authors: Vinyoles E,de la Figuera M,Bosom M,González C,Moreno N,Pacheco V

    更新日期:2000-11-04 00:00:00

  • [Spanish scientific production in biomedicine and health sciences during the period 1990-1993 (Science Citation Index and Social Science Citation Index) and comparison to period 1986-1989].

    abstract:BACKGROUND:In 1993 a first study on the scientific production of Spain in 1986-1989 on Biomedicine and Health Sciences, through the Science Citation Index (SCI) was published. The analysis attained the level of centres, with special emphasis in those related to the Health Care System. This paper analyses the period 199...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Camí J,Zulueta MA,Fernández MT,Bordons M,Gómez I

    更新日期:1997-10-18 00:00:00