Abstract:
BACKGROUND AND OBJECTIVE:Though there is a general agreement on the need of influenza vaccination (IV), very different results have been published about the magnitude of its effect. We evaluated the effectiveness of IV in the reduction of mortality in individuals over 65 years of age. PATIENTS AND METHOD:Prospective cohort study of all individuals over 65 attended in 8 urban primary care centers (n = 11,241). We assessed IV in autumn 2001 and considered the death from all causes during 2002 as a response variable. We calculated the global effectiveness (1-relative risk) and the necessary number of vaccinations in order to prevent 1 death (NNT = 1/attributable risk). RESULTS:Global effectiveness of IV was 2%, considering an NNT of 1667. No vaccination benefit among the 65-74 years-old group was observed, but IV proved 22% effectiveness (95% confidence interval, 3-38%) in individuals over 75, with an estimated NNT of 66 vaccinations (95% confidence interval, 38-435). CONCLUSIONS:Within a year with a moderate incidence of influenza, IV had a small effectiveness in preventing general mortality in our area, though it was especially effective among those at higher risk (over 75 and suffering from chronic pathologies).
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Vila-Córcoles A,Ochoa-Gondar O,Ansa-Echeverría X,Gómez-Sorribes A,Espelt-Aluja P,Pascual-Morón Idoi
10.1016/s0025-7753(05)72156-4keywords:
subject
Has Abstractpub_date
2005-11-19 00:00:00pages
689-91issue
18eissn
0025-7753issn
1578-8989pii
S0025-7753(05)72156-4journal_volume
125pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract:BACKGROUND AND OBJECTIVE:The proportion of elderly patients hospitalized in acute care wards has progressively increased. Patients with a decreased functional status are prone to have malnutrition which negatively affects their prognosis and increases mortality. However, it is unclear whether functional and nutritional...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(04)74521-2
更新日期:2004-09-25 00:00:00
abstract::We have evaluated the close contacts of 191 patients diagnosed of tuberculosis in our center between 1984 and 1987. The overall number of evaluated contacts was 666, and the mean number of contacts for each index case was 3.7. In 55% of the evaluated population PPD reaction was positive, and their mean age was 33.3 ye...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1989-04-22 00:00:00
abstract::Due to a combination of ingested ethanol and inhaled trichloroethylene (Tri) a 28 year old man developed toxic hepatitis and acute oliguric renal failure, both of which had a favorable evolution. Tri has been described as a cause of hepatic disfunction and acute renal failure due to acute tubular necrosis, although so...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1981-06-25 00:00:00
abstract:UNLABELLED:Most experts, specially from Anglo-Saxon countries, recommend a low fat diet in order to prevent cardiovascular diseases. However, mortality rate by ischemic cardiopathy is low in Mediterranean countries, probably because of the consumption of a Mediterranean diet, with a high level of monounsaturated fats p...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(00)71561-2
更新日期:2000-09-30 00:00:00
abstract:BACKGROUND:The aim of this study is to assess the prevalence of Parvovirus B19 infection in a group of patients affected by congenital coagulation disorders and its association with epidemiological aspects. PATIENTS AND METHODS:We have analyzed a group of 50 patients (median age 28) diagnosed with haemophilia or any o...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1997-05-03 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The association between the presence of the allele APOE*epsilon4 (apolipoprotein E) and sporadic Alzheimer disease (AD) has been long established. However, the possible influence of other genetic factors is still under debate. This study investigated the role of the a 1-antichymotrypsin (ACT) g...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(04)74479-6
更新日期:2004-09-04 00:00:00
abstract:BACKGROUND:The main goal of the study is to investigate in the Spanish population the value of searching for the Gly380Arg mutation in the transmembrane domain of fibroblast growth factor receptor-3 (FGFR3#) as the basis for the molecular diagnosis of achondroplasia. PATIENTS AND METHODS:Twenty eight achondroplastic p...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1998-04-18 00:00:00
abstract::Weight loss can improve metabolic control in patients with type 2 diabetes mellitus but the results of conventional therapy in this respect have been discouraging. Besides achieving significant and sustained weight loss, bariatric surgery can improve or resolve type 2 diabetes mellitus in the majority of patients. Ana...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2011.04.009
更新日期:2012-04-14 00:00:00
abstract::The usefulness of two alpha-2 adrenergic agonists (clonidine and guanfacine) and their comparative effectiveness were evaluated regarding the control of the opiates abstinence syndrome and the secondary effects, including development of cardiovascular abnormalities, in 88 parenteral heroin abusers admitted to two hosp...
journal_title:Medicina clinica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-02-10 00:00:00
abstract::Autoinflammatory syndromes are characterised by recurrent or persistent inflammation with no increase in the antibody titers or antigen-specific T lymphocytes, and absence of infection. Initially, they included the hereditary periodic fever syndromes, a group of innate immune system monogenic diseases characterised by...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/S0025-7753(11)70002-1
更新日期:2011-01-01 00:00:00
abstract::The plasma level of neuron-specific enolase (NSE) was measured in 55 patients with small cell bronchial carcinoma (SCC) with cytohistological confirmation to evaluate its diagnostic usefulness. As a control group, 132 patients with non-small cell bronchial carcinoma, 81 with non-neoplastic disease and 37 healthy indiv...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1990-06-02 00:00:00
abstract:BACKGROUND:Evaluation of the therapy with high-dose 131I in solitary toxic thyroid adenoma, with particular attention to the effects on thyroid function and on the nodular size. METHODS:A retrospective study of 43 patients with solitary thyroid nodule treated with radioactive iodine (mean dose 26.6 mCi, range 10-35) a...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:
更新日期:1991-05-18 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Gaucher disease is an inherited disorder caused by deficit of acid β-glucocerebrosidase, responsible for the degradation of glucosylceramide to ceramide and glucose. Although the disorder is primarily hematologic, bone is the second most commonly affected structure. Cathepsin K (CATK) is an enz...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2014.11.018
更新日期:2015-10-05 00:00:00
abstract:BACKGROUND:Primary pulmonary hypertension is a poorly understood disease with a difficult treatment. PATIENTS AND METHOD:Retrospective study of a series of 44 patients suffering from pulmonary hypertension who were studied in our center between 1992 and 2000. RESULTS:At diagnosis, 6 (13%) patients were classified as ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(02)72524-4
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To determine the prevalence of health care workers (HCW) susceptibility to varicella zoster virus (VZV). As a secondary objective, we describe the immunogenicity and reactogenicity of the vaccine. SUBJECTS AND METHODS:A multicenter analytic cross-sectional study was conducted in 5 hospitals in...
journal_title:Medicina clinica
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medcli.2010.11.035
更新日期:2011-09-24 00:00:00
abstract::Pulmonary thromboembolism (PE) is a common cause of morbidity and mortality in patients with cancer. Having cancer is an independent risk factor for death in the general series of patients with PE and is included as a variable in the prognostic scales of acute symptomatic PE. This fact limits the discriminatory power ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/S0025-7753(15)30016-6
更新日期:2015-01-01 00:00:00
abstract::Hypertension represents a relative risk of stroke up to 5 times. It is associated to ischaemic and haemorrhagic stroke. Hypertension produces an increase in brain vessels resistance and loss of the physiological mechanism of autoregulation, and it can be measured with transcranial doppler. Clinical trials have establi...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1157/13094428
更新日期:2006-10-28 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To establish the seroprevalence of infection by Borrelia burgdorferi in Navarre (Spain). PATIENTS AND METHOD:Serum samples of 1,429 individuals considered representative of the population of Navarre were analyzed. The individuals were recruited from a list issued by the government of Navarre. ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2010.06.008
更新日期:2011-03-26 00:00:00
abstract:BACKGROUND:Pleural mesothelioma is a tumor of low incidence whose relation with the exposure to asbestos has been widely demonstrated. This exposure is generally occupational, but may also be domestic and there is the possibility of environmental exposure. METHODS:By death certifications all the cases of death by pleu...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1993-11-06 00:00:00
abstract::A woman who had recently become infected with HIV-1 after sexual relations with a seropositive subject presented a rapid fall in CD4+ T lymphocytes and evolved to AIDS 13 months after primoinfection. The most plausible cause for the rapid disease progression in this patient was the observation of a viral syncytium for...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1995-06-17 00:00:00
abstract::Chronic kidney disease is common in people >65years of age. The development and improvement of dialysis techniques has allowed its generalisation to the entire population, when there is a situation of terminal nephropathy, without limit of use due to chronological age. Decision making in elderly patients with advanced...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2018.07.011
更新日期:2019-03-01 00:00:00
abstract::Uterine fibroids are the most common benign tumours that affect women of reproductive age and they represent the main indication for surgery for benign uterine pathology. In 25% of cases, they become clinically apparent, causing heavy menstrual bleeding, pelvic pain and/or infertility. Therefore, fibroids have a notab...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/S0025-7753(13)70045-9
更新日期:2013-07-01 00:00:00
abstract::Fosfosal or 2-phosphonoxybenzoic acid is a new analgesic drug, whose analgesic activity and side effects have been determined in a double blind clinical study in comparison with placebo. The study has been done with 60 outpatients, of both sexes, which suffered musculoskeletal and arthritic pains. Patients were treate...
journal_title:Medicina clinica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1981-01-10 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The objective of this study is to describe the incidence of hepatic dysfunction (HD) in our hospital and evaluate the possible risk factors associated with HD development as an improvement of the caring process received by patients treated with parenteral nutrition (PN). PATIENTS AND METHOD:A ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2008.02.003
更新日期:2009-02-07 00:00:00
abstract:BACKGROUND:B-mode ultrasonography is a simple and valid method to evaluate subclinical atherosclerosis of the major superficial arteries. The aim of this study was toknow by this technique the prevalence of carotid atherosclerosisin patients with coronary disease and related factors. PATIENTS AND METHOD:In 232patients...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(01)71864-7
更新日期:2001-03-31 00:00:00
abstract::Renal complications in Waldenström's macroglobulinemia (WM) are infrequent and are characterized by the presence of PAS positive amorphous hyaline deposits in the capillary lumen, infiltrated with lymphoplasmatic cells with PAS positive inclusions in the interstices and intratubular hyaline cylinders. Membranous glome...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1991-10-26 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To validate four instruments to detect domestic violence in health-care settings against external criteria -Index of Spouse Abuse (ISA), Psychological Maltreatment of Women Inventory short form (PMWI-SF), Woman Abuse Screening Tool (WAST), Partner Violence Screen (PVS)- and to assess the conco...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2010.11.038
更新日期:2011-10-08 00:00:00
abstract:BACKGROUND:We describe the cytogenetic results of 93 patients with myelodysplastic syndromes (MDS). The main object of this report is to analyze the prognostic value of the karyotype in patients with MDS, in relation to the evolution to acute leukemia and the survival time. PATIENTS AND METHODS:Cytogenetic studies wer...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1998-01-31 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Fibromyalgia is considered as a combination of physical, psychological and social disabilities. The purpose of the present study was to determine the benefits of aerobic exercise program and progressive relaxation techniques on anxiety, quality of sleep, depression and quality of life in patien...
journal_title:Medicina clinica
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.medcli.2010.09.045
更新日期:2011-10-08 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Growth hormone binding protein (GHBP), insuline-like growth factor 1 (IGF-1) and insuline-like growth factor binding protein 3 (IGFBP-3) serum concentrations were studied in familial short-statured patients (FSS) and age-matched normal-statured subjects. The aim of the study was to ascertain wh...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13067086
更新日期:2004-10-09 00:00:00