Abstract：
:Calcified aortic valve disease (CAVD) is a prevalent condition, affecting 25% of people older than 65 years. CAVD and atherosclerosis share common risk factors and pathogenic mechanisms. Nevertheless, they present different pathologic lesions. The main factors involved in the pathogenesis of CAVD are genetic predisposition, the process of valvular calcification, deposition of lipoproteins, and chronic inflammation. Studies have suggested a potential benefit from early treatment with angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers, and particularly with statins. Observational studies on risk factors for the CAVD, and randomized clinical trials on primary and secondary prevention in subjects with high risk for the disease, would be necessary to improve the clinical management of CAVD.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Toro R,Mangas A,Gómez Fdoi
10.1016/j.medcli.2010.02.019subject
Has Abstractpub_date
2011-05-14 00:00:00pages
588-93issue
13eissn
0025-7753issn
1578-8989pii
S0025-7753(10)00285-Xjournal_volume
136pub_type
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