Abstract：
BACKGROUND AND OBJECTIVE:The optimal treatment of aggressive non-Hodgkin lymphoma (NHL) in elderly patients remains controversial. We aimed to evaluate the impact of age and use of anthracyclines. PATIENTS AND METHOD:Retrospective analysis of patients with aggressive NHL aged over 70 years old. RESULTS:One hundred and twenty-eight patients with a median age of 76 years (70-91). Eighty-eight percent received chemotherapy, and 72% received anthracyclines. The overall response rate was 70%, 51% with a complete response (CR)/uncertain complete response and 19% with a partial response (PR). Overall survival (OS) was 28 months (95% confidence interval 18-78). In the diffuse large B-cell lymphoma group, progression-free survival (PFS) and OS were significantly better in patients who achieved CR versus PR. The use of anthracyclines was associated with CR, the international prognostic index (IPI) was associated with both survival and response, and age showed no association. CONCLUSIONS:In patients aged ≥ 70 years with aggressive lymphoma who received chemotherapy, the IPI but not age and the use of anthracyclines showed a prognostic impact. Therefore, in elderly patients with aggressive lymphomas, the use of anthracyclines should be considered and therapeutic decisions should not be based on age exclusively.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Ancochea Á,Salar A,García-Pallarols F,Gimeno E,Fernández-Rodriguez C,Sánchez-González Bdoi
10.1016/j.medcli.2014.04.026subject
Has Abstractpub_date
2015-06-22 00:00:00pages
544-7issue
12eissn
0025-7753issn
1578-8989pii
S0025-7753(14)00466-7journal_volume
144pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：:The usefulness of two alpha-2 adrenergic agonists (clonidine and guanfacine) and their comparative effectiveness were evaluated regarding the control of the opiates abstinence syndrome and the secondary effects, including development of cardiovascular abnormalities, in 88 parenteral heroin abusers admitted to two hosp...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-02-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Patients identified as risk drinkers usually fill a questionnaire in order to assess their alcohol dependence. In our setting, the Münchner Alkoholismus Test (MALT) has been recommended, but there are not enough data about its validity and accuracy, particularly in women. The aim of this study ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13079611
更新日期：2005-10-08 00:00:00
abstract：BACKGROUND:Recent studies have suggested that women with ischemic heart disease receive lesser therapeutic care than males. The aim of this study was to verify the hypothesis that sex is an independent predictive factor in therapeutic care upon admission in patients with acute myocardial infarction. METHODS:Secondary ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1994-03-19 00:00:00
abstract：:Meningitis and other infectious diseases of the central nervous system are predisposing causes of the inadequate secretion syndrome of the antidiuretic hormone (ISADH). The association between the acquired immunodeficiency syndrome (AIDS) and ISADH is recognized but little studied. In AIDS patients hyponatremia is a f...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1993-03-20 00:00:00
abstract：BACKGROUND AND OBJECTIVES:To compare the efficacy of a self-monitoring programme vs. the conventional method used before the intervention in maintaining the international normalised ratio (INR) in the therapeutic range in patients receiving oral anticoagulants, as well as complications, quality of life and the time inv...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2019.06.016
更新日期：2020-05-22 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Diffuse idiopathic skeletal hyperostosis (DISH) and abdominal aortic calcification (AAC) are related to an increased cardiovascular risk. The aim of this study was to analyse a possible relationship between both entities and also the association between metabolic disorders and DISH. PATIENTS A...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2017.01.030
更新日期：2017-09-08 00:00:00
abstract：BACKGROUND:To evaluate the efficacy of methotrexate in patients with systemic lupus erythematosus (SLE) without major organ involvement resistant to medium-high doses of prednisone. METHODS:Crossover, open clinical trial with two treatment periods, the first of 3 months and the second of 6 months, an intermediate cont...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章
doi：
更新日期：1993-10-02 00:00:00
abstract：:Nausea and vomiting are considered one of the most distressing side-effects of chemotherapy. Complete control of acute and delayed emesis improves quality of life and increases adherence to treatment. The frequency of nausea and vomiting depends primarily on the emetogenic potential of the chemotherapeutic agents used...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1157/13084022
更新日期：2006-02-04 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate the risk factors of complications in lower limbs in diabetic patients. PATIENTS AND METHODS:We evaluated 270 patients with diabetes followed in Hospital la Paz from 2000 to 2008.We measured the ankle-brachial index (ABI), toe-brachial index (TBII), and toe blood pressure (BP). We d...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2010.05.032
更新日期：2011-04-09 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To assess the usefulness of a risk scale based on serum procalcitonin (PCT) compared to the Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) scale in the early discrimination between necrotising fasciitis (NF) and cellulitis of the extremities. MATERIALS AND METHODS:Retrospective s...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2019.01.032
更新日期：2019-11-15 00:00:00
abstract：BACKGROUND:Sentinel-node biopsy is meant to excise the first-echelon node from a primary tumor, which is the one that most probably harbors early metastases. PATIENTS AND METHODS:We report our results in 35 patients with breast cancer, using a radiotracer by peri-tumoral injection, pre-surgical scintigraphy and intrao...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-06-19 00:00:00
abstract：BACKGROUND:In this study we introduce a new view of hospital infection, to apply time series techniques to it. Our objective is to complement hospital infection's epidemiological surveillance by means of obtaining alert and alarm thresholds that make easy to the epidemiologist the decision of intervention, in case they...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-06-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Leptin is an hormone resulting from the obesity gene. Their actions could be important in the pathogenesis of the osteoporosis. The aim of this study is to analyse the influence of tobacco on serum leptin levels, and its relationship with bone mineral density (BMD) and steroid hormones. SUBJEC...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13094819
更新日期：2006-11-04 00:00:00
abstract：:Pulmonary thromboembolism (PE) is a common cause of morbidity and mortality in patients with cancer. Having cancer is an independent risk factor for death in the general series of patients with PE and is included as a variable in the prognostic scales of acute symptomatic PE. This fact limits the discriminatory power ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/S0025-7753(15)30016-6
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate the adherence to the recommendations in clinical practice performed by the Therapeutic Positioning Report (TPR) of the Spanish Agency of Medicines and Sanitary Products about the treatment with oral anticoagulants in patients aged≥75 years old with nonvalvular atrial fibrillation (N...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2017.07.025
更新日期：2018-07-13 00:00:00
abstract：:A 52 year old male presenting chronic myeloid leukemia (CML) Philadelphia chromosome positive (Ph) four years after the diagnosis of a non Hodgkin's lymphoma is described. The patient had received high total doses of alkylating drugs (cyclophosphamide and chlorambucil) as part of chemotherapy treatment for a diffuse m...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-06-20 00:00:00
abstract：BACKGROUND:The aim of this study was to determine the risk of active tuberculosis in intravenous drug addict (IVDA) patients seropositive and seronegative for the HIV. METHODS:A retrospective study of a cohort of IVDA males in 2 drug addict detoxication communities was carried out. Patients with tuberculosis, under tr...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-05-15 00:00:00
abstract：:Hemolytic disease by cold-reacting antibodies is a rare form of hemolytic anemia. In most cases a subjacent cause is found. This disease is generally related with reactive lymphoproliferative processes (infections by the Epstein-Barr virus and cytomegalovirus) or uncontrolled lymphoproliferative disorders (lymphomas, ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-04-04 00:00:00
abstract：BACKGROUND:The use of monoclonal antibodies against tumoral antigens marked with radioactive isotopes is the basis of immunoscintigraphy. The specificity of the technique is high owing to its intrinsic characteristics. METHODS:40 patients with colorectal cancer who were awaiting surgery were evaluated by immunoscintig...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-03-02 00:00:00
abstract：BACKGROUND AND OBJECTIVE:White coat effect (WCE) (i.e., the difference between office blood pressure [OBP] and awake ambulatory blood pressure monitoring [ABPM]) may be present in hypertensive individuals. The relationship between occurrence of WCE and target organ damage (TOD) has not yet been assessed in true resista...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.04.031
更新日期：2013-01-05 00:00:00
abstract：:The first patient with myelopathy associated with T-cell leukemia/lymphoma virus infection (HTLV-I) in Spain is reported. Although this condition is endemic in several areas from the Caribbean Sea, South America, Africa and Japan, some cases have been reported in European countries, generally in immigrant patients, re...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-02-23 00:00:00
abstract：BACKGROUND:In 2001 an outbreak of Legionnaires' diseases occurred in Murcia, Spain, with one of the lowest known rates of associated mortality. We describe the clinical data of a subgroup of patients, and present the results from molecular and virulence studies to correlate the lower mortality of the overall series wit...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2009.05.016
更新日期：2009-09-12 00:00:00
abstract：BACKGROUND:Myotonic dystrophy (DM) is an inherited autosomal dominant disorder. The molecular defect responsible for the disease is the expansion of a CTG triplet at the 3' end of the DM gene. We report the analysis of the gene expansion, its correlation with the clinical severity and with the phenomenon of anticipatio...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-03-13 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Multiple chemical sensitivity (MCS) is characterized by a loss of tolerance to various environmental chemicals. The objective of this study was to describe patients with MCS seen in our hospital. PATIENTS AND METHOD:Patients consecutively seen by the Toxicology and Chronic Fatigue Units who pr...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13107370
更新日期：2007-06-16 00:00:00
abstract：BACKGROUND:Self-care of health problems including self-medication, constitutes the most frequent response to the most common acute symptoms in several studies carried out in other countries. Indeed there are few data concerning the scope of self-care in Spain. METHODS:A telephone survey was carried out by a questionna...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-10-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The effectiveness of the treatment of latent tuberculosis infection depends on its efficacy, the adherence to treatment and patient's risk of tuberculosis. The objective of this study was to evaluate the adherence to treatment with daily isoniazid for 9 months, its effectiviness and equivalent ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13116320
更新日期：2008-02-16 00:00:00
abstract：:We analyzed the tissue oxygen extraction in 25 patients with acute respiratory failure. Fourteen met the clinical criteria for the adult respiratory distress syndrome (ARDS). The 11 remaining patients had acute respiratory failure with causes different from ARDS. In all cases the changes in the oxygen extraction ratio...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-01-26 00:00:00
abstract：BACKGROUND:The aim of this study was to know the opinion of the professionals (physicians and nursing staff) of intensive medicine concerning aspects such as informed consent, family participation in health care decisions, the possibility of not undertaking resuscitation manoeuvers and limiting care in determined cases...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1994-04-16 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of this cross-sectional study was to compare the prevalence of target organ damage (TOD) and established cardiovascular disease (CVD) in a cohort of nondiabetic hypertensive patients with 3 or more cardiovascular risk factors (CVRF) against a group of hypertensives with type 2 diabetes....
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.05.032
更新日期：2013-10-05 00:00:00
abstract：BACKGROUND:To evaluate the diagnostic power of serum myoglobin (Mgb) by latex agglutination as a marker in the first hours of acute myocardial infarction (AMI). METHODS:Two hundred forty-eight serum samples from 53 patients admitted to the Coronary Unit (CU) from the Emergency Department (ED) for suspected AMI were st...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-07-04 00:00:00
