Abstract：
BACKGROUND AND OBJECTIVE:A common Leu7Pro polymorphism in the signal peptide of neuropeptide Y has been associated with increased plasma cholesterol and accelerated atherosclerosis in the Finnish population. SUBJECTS AND METHOD:A cross-sectional design was carried out in 1,000 individuals from the Mediterranean Spanish population to estimate its prevalence. Two independently collected samples consisting of 486 subjects (sample 1) and 514 subjects (sample 2) were studied. The Leu7Pro polymorphism was determined. RESULTS:We found only one individual carrying the Leu7Pro variant (0.1%). The allele frequency of the Pro7 allele was extremely low: 0.005 (95% CI,0.0001-0.0015). CONCLUSIONS:This low prevalence suggests that the Pro7 allele is not one of the genetic determinant factors affecting obesity, plasma lipids or alcoholism in this population.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Portolés O,Sorlí JV,González JI,Ruiz de la Fuente S,Ramírez JB,Corella Ddoi
10.1016/s0025-7753(03)73695-1keywords:
subject
Has Abstractpub_date
2003-03-15 00:00:00pages
337-9issue
9eissn
0025-7753issn
1578-8989pii
S0025-7753(03)73695-1journal_volume
120pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND:In this study the prescription of drugs in an outpatients geriatric population was evaluated in terms of age and body weight. METHODS:From a wide survey carried out on 500 geriatric outpatients, all the prescriptions corresponding to H-2 antagonists, digoxin, theophylline, bromazepam, diazepam, lorazepam an...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-03-07 00:00:00
abstract：:Out of 110 cases of fever of unknown origin (FUO) that met Petersdorf and Beeson's criteria 15 patients were selected because of prolonged FUO with more than six months elapsed between admission and the final diagnosis. In this group of chronic FUO an etiological diagnosis was reached in 11 cases, distributed as follo...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-05-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Alcohol and its metabolites play an important role in carcinogenesis. This effect could be modulated by polymorphisms in genes encoding enzymes involved in the metabolism of alcohol and folate. Therefore, we analyzed the effect of alcohol consumption and ADH1B Arg48His, ADH1B Arg370Cys, ADH1C I...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2016.12.033
更新日期：2017-06-21 00:00:00
abstract：BACKGROUND:It has been previously reported that an exaggerated response of blood pressure to mental stress tasks is associated to an increased cardiovascular risk. The objective of this cross-sectional study, with sequential inclusion of subjects who met the inclusion criteria, was to asses the relationships between th...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-10-09 00:00:00
abstract：OBJECTIVE:Patient perception of clinical safety has been scantly studied. This study describes the frequency of clinical errors from a patient point of view, their perception of safety and its relationship with the information received. MATERIAL AND METHODS:Descriptive study based on a postal survey to 336 surgical pa...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(08)76458-3
更新日期：2008-12-01 00:00:00
abstract：:Giant cell myocarditis is a rare disease of unknown etiology, which develops as a myocardial isolated affection or associated to different diseases. Its characteristics are such as necrosis, inflammation and giant cell presence in the myocardium. We present the case of a woman who suffered of giant cell myocarditis, t...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1993-10-16 00:00:00
abstract：BACKGROUND:Lateral chest X-rays may be helpful in the early detection of osteoporotic patients. We studied the proportion of chest X-ray reports in which the radiologist highlighted the presence of vertebral osteoporotic signs, as well as the proportion of patients with such records who were further studied by their ph...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)72241-5
更新日期：2001-12-08 00:00:00
abstract：BACKGROUND:Acarbose is a reversible inhibitor of the intestinal alpha-glucosidases, the oral administration of which delays or diminishes the postprandial increase of glucose and insulin. METHODS:A multicentric double-blind clinical trial (11 centers), controlled versus placebo, crossed and randomized, was carried out...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1993-04-03 00:00:00
abstract：BACKGROUND:The presence of cagA antibodies constitutes a serum marker of infection caused by virulent strains of Helicobacter pylori. The objective of this study was to determine the risk of peptic ulcer in patients with H. pylori infection, in relation to the detection of CagA and VacA antibodies. PATIENTS AND METHOD...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2001-05-12 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Anxiety and depression are common among medical inpatients. While their relation to the severity of illness is often discussed, the feeling of such severity by the patient and his/her prospects of improvement can be influenced by anxiety and depression. PATIENTS AND METHOD:Patients admitted in...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2003-03-22 00:00:00
abstract：BACKGROUND:To know the clinical and epidemiologic characteristics, the evolution and the rate of adequate empiric antibiotic treatment in adult patients with a bacteremia discovered after discharge from an emergency unit. PATIENTS AND METHOD:During 10 years (1989-1998), we registered the clinical and epidemiological d...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)71954-9
更新日期：2001-05-19 00:00:00
abstract：BACKGROUND:There is no detailed information on the scientific production in biomedicine from the perspective of the centers which make up the National Health Care System. Nor has any analysis on productivity by specialties compared with that of other countries of the European Community (EC) been carried out. METHODS:T...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-12-04 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Though there is a general agreement on the need of influenza vaccination (IV), very different results have been published about the magnitude of its effect. We evaluated the effectiveness of IV in the reduction of mortality in individuals over 65 years of age. PATIENTS AND METHOD:Prospective c...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(05)72156-4
更新日期：2005-11-19 00:00:00
abstract：:Bipolar disorder is a chronic and recurrent mood disorder, which may severely impact on the patient's global functioning. It has been estimated that approximately 1.6% of the population is affected. A long delay in diagnosis and an excessive disparity in the treatment of these patients have been detected. Within the Q...
journal_title：Medicina clinica
pub_type： 杂志文章,实务指引
doi：10.1016/j.medcli.2013.05.023
更新日期：2013-10-05 00:00:00
abstract：:Hereditary angioedema (HAE) is due to a deficit of the C1 inhibitor (C1 INH) of a dominant autosomic inheritance. Seven patients are presented from a family with HAE, four of whom with poor prognosis due to the frequency and site of the angioedema. Prophylaxis was obtained with long-term danazol since antifibrinolytic...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-03-14 00:00:00
abstract：:It is the aim of this manuscript to take into account the peculiarities and specific characteristics of elderly patients with chronic ischaemic heart disease from a multidisciplinary perspective, with the participation of the Spanish Society of Cardiology (sections of Geriatric Cardiology and Ischaemic Heart Disease/A...
journal_title：Medicina clinica
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.medcli.2016.01.014
更新日期：2016-04-15 00:00:00
abstract：:The authors report a patient who developed a mononucleotic syndrome after 2 months treatment with diphenylhydantoin. The clinical and biological criteria needed to establish the diagnosis of pseudomononucleosis are listed, while other possible causes described in the literature have been excluded. Complications which ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-10-10 00:00:00
abstract：:The authors study the usefulness of the measurement of the negative area of P in V1 (Morris' index) in patients with acute myocardial infarction. The study was carried out prospectively in 70 patients, 31 of them having a Swan-Ganz catheter inserted permitting simultaneous hemodynamic and electrocardiographic measurem...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-03-10 00:00:00
abstract：:Community-acquired pneumonia (CAP) is an infectious respiratory disease with an incidence that ranges from 3 to 8 cases per 1,000 inhabitants per year. This incidence increases with age and comorbidities. Forty per cent of CAP patients require hospitalization and around 10% of these patients are admitted in an Intensi...
journal_title：Medicina clinica
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.medcli.2012.09.034
更新日期：2013-03-02 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We decided to assess the overall prevalence of exposure to environmental tobacco smoke (ETS) both in general and according to the settings of exposure (home, workplace and leisure time). SUBJECTS AND METHOD:We analyzed cross-sectional data of ETS exposure in 1,059 non-smokers included in the C...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(04)74570-4
更新日期：2004-10-16 00:00:00
abstract：BACKGROUND:The sleep apnea syndrome (SAS) and high blood pressure (HBP) present multiple relations. Apnea culminates with an increase in arterial pressure, and a high percentage of apneic patients have HBP. It has also been reported that SAS is more frequent among hypertensive patients than among the general population...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-02-27 00:00:00
abstract：:Pulmonary complications in HIV-infected patients are at present a first-rate problem. They are the main cause of hospital admission of these patients in our country. Most HIV-patients have a pulmonary complication during the evolution of the infection. The main etiologic diagnosis is bacterial pneumonia, especially pn...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1157/13080461
更新日期：2005-10-22 00:00:00
abstract：BACKGROUND:Using the data available from the Cancer Registry of Zaragoza, the incidence of breast cancer in women from 1961 to 1985 was analyzed with future evolution being predicted up to the year 2000. METHODS:The age, period and birth cohort effects, in addition to the place of residence (capital/rest of province) ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-05-29 00:00:00
abstract：:Osteoarthritis and osteoporosis are both common conditions in the elderly but their association has long remained obscure. Recently published studies show that patients with osteoarthritis have higher bone mass but no corresponding decrease in fracture risk. This has been proposed to be due to an increased rate of fal...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2013.01.036
更新日期：2013-09-07 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Forced respiratory volume in first second spirometry is currently used to diagnose chronic obstructive pulmonary disease. However, this technique does not always provide a reliable short-term prognosis, especially in patients with associated morbidity. We propose that specific health-related qu...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13058683
更新日期：2004-03-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Leptin is an hormone resulting from the obesity gene. Their actions could be important in the pathogenesis of the osteoporosis. The aim of this study is to analyse the influence of tobacco on serum leptin levels, and its relationship with bone mineral density (BMD) and steroid hormones. SUBJEC...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13094819
更新日期：2006-11-04 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Urban air pollutants are composed of a heterogeneous mixture of substances in gas and aerosol states. The aim of this study was to compare the effects caused by exposure to contaminants in the gas phase and atmospheric particles in ambient air in patients hospitalized for acute coronary syndro...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.05.040
更新日期：2013-06-18 00:00:00
abstract：:We analyzed the tissue oxygen extraction in 25 patients with acute respiratory failure. Fourteen met the clinical criteria for the adult respiratory distress syndrome (ARDS). The 11 remaining patients had acute respiratory failure with causes different from ARDS. In all cases the changes in the oxygen extraction ratio...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-01-26 00:00:00
abstract：BACKGROUND:The objective of this study was to identify the risk factors associated with the nosocomial sepsis syndrome according to the criteria of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. PATIENTS AND METHOD:A 1-year prospective case-control study matched for se...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2001-06-02 00:00:00
abstract：BACKGROUND:Fetal microchimerism (FM) has been implicated in the pathogenesis of primary biliary cirrhosis (PBC). The aim of the study was to investigate the presence of FM in PBC patients. PATIENTS AND METHOD:FM was studied in 28 women, 14 with PBC and 14 healthy controls.DNA was extracted from peripheral blood cells,...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)73575-6
更新日期：2002-12-07 00:00:00
