Abstract：
BACKGROUND:The presence of cagA antibodies constitutes a serum marker of infection caused by virulent strains of Helicobacter pylori. The objective of this study was to determine the risk of peptic ulcer in patients with H. pylori infection, in relation to the detection of CagA and VacA antibodies. PATIENTS AND METHOD:Prospective case-control study including 104 peptic ulcer patients with active H. pylori infection (positive urease test and/or histology, or positive urea breath test) and 104 age- and sex-matched controls, without peptic ulcer history, with active H. pylori infection (positive urea breath test). Serum CagA and VacA antibodies were determined by Western blot. Non-steroidal antiinflamatory drugs (NSAID) use was determined by structured data collection. A multivariate analysis (logistic regression) was carried out to determine the odds ratio (OR). RESULTS:Presence of serum antibodies against CagA was higher in peptic ulcer patients (74%) than in controls (46.2%) (OR = 5.7; 95% CI = 2.1-15.6). However, presence of serum antibodies against VacA in patients (46.2%) was similar to that in controls (36.5%). NSAID use was also more frequent in patients (51.9%) than in controls (21,2%) (OR = 6.5; 95% CI = 2.2-19,5). CONCLUSIONS:Serum antibodies against CagA and use of NSAID are the most important risk factors for peptic ulcer disease.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Santolaria S,Lanas A,Benito R,Piazuelo E,Sáinz Rkeywords:
subject
Has Abstractpub_date
2001-05-12 00:00:00pages
641-4issue
17eissn
0025-7753issn
1578-8989pii
S0025-7753(01)71935-5journal_volume
116pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND AND OBJECTIVE:The aim of our study was to identify the rate of diabetic patients treated for hypothyroidism and compare them with a group without type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:We reviewed the computerized clinical records of 5161 patients. We identified diabetic patients treated with...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2011.08.009
更新日期：2012-04-28 00:00:00
abstract：:A prospective analysis was carried out to evaluate the cost-effectiveness of two alternatives for the treatment of hypo-agammaglobulinemia with intravenous immunoglobulin: the current hospital administration and the administration in the patient's home. 38 patients or relatives were surveyed about their personal or fa...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-01-19 00:00:00
abstract：BACKGROUND:The aim of this study was to determine the risk of active tuberculosis in intravenous drug addict (IVDA) patients seropositive and seronegative for the HIV. METHODS:A retrospective study of a cohort of IVDA males in 2 drug addict detoxication communities was carried out. Patients with tuberculosis, under tr...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-05-15 00:00:00
abstract：BACKGROUND:The elevated incidence of malnutrition in the elderly and its close relation with the prevalence and evolution of determined diseases raises the need for early identification. Despite the existence of numerous indicators, specificity, sensitivity or occasionally both are lacking. METHODS:One hundred fifteen...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-02-22 00:00:00
abstract：:The clinical records of 304 patients with acute respiratory insufficiency were studied in retrospect. All of them had been treated in an Intensive Care Unit during its first year and a half of operation. One hundred and thirty-one patients suffered from chronic obstructive lung disease and acute episodes of chronic re...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-01-25 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To determine the accuracy of clinical gestalt to identify patients with acute symptomatic pulmonary embolism (PE) at low-risk for short-term complications. PATIENTS AND METHODS:This study included a total of 154 consecutive patients diagnosed with acute symptomatic PE in a tertiary university ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2017.11.023
更新日期：2018-08-22 00:00:00
abstract：BACKGROUND:The capacity of stable asthma patients to recognize the presence of air flow obstruction, treatment improvement and daily variations was studied. METHODS:Placebo and 500 micrograms of inhaled terbutaline for two consecutive days were administered to 39 patients. The subjective impressions were compared with...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-11-11 00:00:00
abstract：:The follow-up of the Mediterranean Diet (MD) has been associated with lower mortality and morbidity from cardiovascular diseases. However, it is important to evaluate the scientific evidence provided by published articles. Therefore, in order to analyze the literature on the overall effects of MD on intermediate and f...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2009.01.033
更新日期：2010-01-23 00:00:00
abstract：BACKGROUND:It has been previously reported that an exaggerated response of blood pressure to mental stress tasks is associated to an increased cardiovascular risk. The objective of this cross-sectional study, with sequential inclusion of subjects who met the inclusion criteria, was to asses the relationships between th...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-10-09 00:00:00
abstract：BACKGROUND:The evaluation of the costs of intensive care is a subject of interest at present, due to the high resources required by this area of health care services and the rhythm at which these costs increase. Such an evaluation has rarely been carried out in Spain. The aim of this study was to quantify the cost of m...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1994-06-11 00:00:00
abstract：:We assessed whether theophylline or budesonide (an inhaled corticosteroid) is the most adequate drug to be added to the treatment of patients insufficiently controlled with beta agonists (procaterol). Two comparable groups of nonatopic asthmatic adults (n = 24), aged between 16 and 66 years (42 +/- 17), were investiga...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-11-24 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Our goal was to determine the incidence of infection due to Mycobacterium kansasii in Elche, Spain over the last 10 years and to study the activity of new antibiotics against the strains isolated. MATERIAL AND METHODS:A retrospective study of patients and study of antibiotic susceptibility in ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To study an outbreak of nosocomial colonisation/infection due to multidrug and carbapenem resistant A. baumannii (ABMDR-C). PATIENTS AND METHODS:Prospective study of patients with ABMDR-C colonisation/infection (January 2007-June 2008). Epidemiological and clinical variables and predictors of ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2010.01.033
更新日期：2010-09-18 00:00:00
abstract：BACKGROUND:A low folic acid (FA) intake may increase the risk of neural tube defects (NTD). We estimated the proportion of women with a FA intake < 400 micrograms/day, at the Valencian Region, exploring those factors associated with a FA intake < 400 micrograms/day. SUBJECTS AND METHOD:Daily FA intake was estimated fo...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71316-9
更新日期：2000-03-25 00:00:00
abstract：BACKGROUND:Loss of heterozygosity (LOH) at 5q21, where the APC/MCC genes reside, is one of the genetic alterations that characterizes lung cancer. The aim of this study was to analyse LOH frequency on chromosome 5q21 in patients with non-small cell lung cancer and its relationship with TNM staging and histological subt...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1997-05-31 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Alcohol and its metabolites play an important role in carcinogenesis. This effect could be modulated by polymorphisms in genes encoding enzymes involved in the metabolism of alcohol and folate. Therefore, we analyzed the effect of alcohol consumption and ADH1B Arg48His, ADH1B Arg370Cys, ADH1C I...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2016.12.033
更新日期：2017-06-21 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The influence of homocysteine metabolism on the prognosis of acute coronary syndrome without ST elevation is controversial. PATIENTS AND METHOD:Prospective study of 109 patients admitted because of acute coronary syndrome without ST elevation. Basal plasmatic levels of homocysteine and folates...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13109705
更新日期：2007-09-08 00:00:00
abstract：BACKGROUND:To study the evolution of the diet and the nutritional intake between 1983 and 1999, by age and sex. SUBJECTS AND METHODS:We performed a series of analysis of the food intake on a representative sample of the population of Reus (aged 10-69 years). Dietary intake was estimated using the 24-hours recall metho...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71448-5
更新日期：2000-06-03 00:00:00
abstract：BACKGROUND:There is poor information for isolated clinical tachycardia (ICT), that is to say, office tachycardia but normal ambulatory heart rate (HR). Our objective was to describe it and to know differences between hypertensive subjects with and without ICT. PATIENTS AND METHOD:Comparative study after a diagnostic i...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71627-7
更新日期：2000-11-04 00:00:00
abstract：:It is the aim of this manuscript to take into account the peculiarities and specific characteristics of elderly patients with chronic ischaemic heart disease from a multidisciplinary perspective, with the participation of the Spanish Society of Cardiology (sections of Geriatric Cardiology and Ischaemic Heart Disease/A...
journal_title：Medicina clinica
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.medcli.2016.01.014
更新日期：2016-04-15 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Hypertension is highly prevalent in the very elderly. We studied control rates of hypertension according to clinic blood pressure (BP) and ambulatory BP monitoring (ABPM) in treated hypertensives aged > or =80 years. PATIENTS AND METHOD:Data came from the Spanish Society of Hypertension ABPM R...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2009.04.056
更新日期：2009-11-28 00:00:00
abstract：:Systemic lupus erythematosus is an autoimmune disease associated with an aberrant production of autoantibodies by self-reactive B lymphocytes. The study of the phenotypic characteristics of B lymphocytes and the identification of their surface receptors such as BAFF-R, TACI and BCMA, which are responsible of their sur...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2014.08.008
更新日期：2015-09-07 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate the management of phenylketonuria (PKU) in Spanish metabolic units and to develop a patients registry. PATIENTS AND METHODS:PKU patients diagnosed and/or followed up in Spain, with phenylalanine values before treatment > 360 μmol/L. Registered anonymous data are those yielded by th...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2011.03.037
更新日期：2012-03-03 00:00:00
abstract：BACKGROUND:Autopsies may be used to know the causes of death in population. In Navarra, the number of patients who died by cancer and were autopsied has increased. A similar pattern appeared in other communities. METHODS:We reviewed 2,643 autopsies performed in the main hospitals of Navarra. In each autopsy, age, sex,...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-04-06 00:00:00
abstract：UNLABELLED:Most experts, specially from Anglo-Saxon countries, recommend a low fat diet in order to prevent cardiovascular diseases. However, mortality rate by ischemic cardiopathy is low in Mediterranean countries, probably because of the consumption of a Mediterranean diet, with a high level of monounsaturated fats p...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71561-2
更新日期：2000-09-30 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We decided to assess the overall prevalence of exposure to environmental tobacco smoke (ETS) both in general and according to the settings of exposure (home, workplace and leisure time). SUBJECTS AND METHOD:We analyzed cross-sectional data of ETS exposure in 1,059 non-smokers included in the C...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(04)74570-4
更新日期：2004-10-16 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The B-type natriuretic peptide (BNP) has recently emerged as a prognostic marker in acute coronary syndromes (ACS). This role is based on results from randomized trials and other high selected population studies. The aim of this study was to determine the prognostic value of BNP in unselected p...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2009.04.057
更新日期：2009-10-24 00:00:00
abstract：BACKGROUND:B-mode ultrasonography is a simple and valid method to evaluate subclinical atherosclerosis of the major superficial arteries. The aim of this study was toknow by this technique the prevalence of carotid atherosclerosisin patients with coronary disease and related factors. PATIENTS AND METHOD:In 232patients...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)71864-7
更新日期：2001-03-31 00:00:00
abstract：BACKGROUND AND OBJECTIVE:This study was aimed to verify whether it is possible to detect at hospital admission, by means of INTERMED, pneumonology patients at risk of "complexity" and of specialized psychosocial intervention. PATIENTS AND METHOD:With the Spanish version of INTERMED (for detection of risk for complexit...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(08)75487-3
更新日期：2008-11-29 00:00:00
abstract：BACKGROUND AND OBJECTIVE:More information is needed on hypertension control in clinical practice, which includes taking at least two blood pressure (BP) readings and taking into account surgery times and previous antihypertensive drug intake. Our study aimed to assess the optimum degree of BP control in a broad sample ...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/s0025-7753(04)74183-4
更新日期：2004-02-14 00:00:00
