Abstract：
BACKGROUND:Loss of heterozygosity (LOH) at 5q21, where the APC/MCC genes reside, is one of the genetic alterations that characterizes lung cancer. The aim of this study was to analyse LOH frequency on chromosome 5q21 in patients with non-small cell lung cancer and its relationship with TNM staging and histological subtypes. PATIENTS AND METHODS:Tumor and corresponding normal DNA were isolated from 60 patients with non-small cell lung cancer and a subsequent polymerase chain reaction (PCR) with microsatellite markets within the APC/MCC region was performed. The PCR products were resolved by electrophoresis. The comparison between the normal and tumor DNA patterns allowed us to detect the samples harboring LOH. RESULTS:LOH at 5q21 was detected in 20% of the patients. LOH at 5q21 was found in 16% of stage I patients, 8% in stage II patients and 40% in stage IIIA patients. A trend towards worse survival was detected in stage IIIA patients with LOH at 5q21 (9 months median time survival) in comparison with patients with LOH (21 months), although the difference was not statistically significant (p = 0.11). No significant differences in LOH were observed among histological types. In addition, we found no correlation between LOH and higher frequency of mutations rate affecting K-ras and p53 genes. CONCLUSIONS:LOH at 5q21 is a frequent genetic alteration in non-small cell lung cancer and correlates with locally advanced disease (stage IIIA). Our results suggest that LOH at the 5q21 region could be a prognostic factor in non-small cell lung cancer.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Sánchez Céspedes M,López Cabrerizo MP,Moreno I,Ariza A,Monzó M,Rosell Rsubject
Has Abstractpub_date
1997-05-31 00:00:00pages
1-5issue
1eissn
0025-7753issn
1578-8989journal_volume
109pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：:The clinical records of 304 patients with acute respiratory insufficiency were studied in retrospect. All of them had been treated in an Intensive Care Unit during its first year and a half of operation. One hundred and thirty-one patients suffered from chronic obstructive lung disease and acute episodes of chronic re...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-01-25 00:00:00
abstract：:The presence of antibodies (Abs) against hepatitis C virus (HCV) was analyzed in 26 haemophiliac patients; a prevalence of 38% was found in the total series and 56% in the treated patients. There were no cases with a positive serology among the three patients who had only received pasteurized factor. The frequency of ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-01-26 00:00:00
abstract：BACKGROUND:To determine the risk factors for the development of atopy in Spanish young adults. SUBJECTS AND METHODS:Case-control study over prevalent cases. Carried out in general population between the ages of 20 to 44 years old. Spanish participants of the ECRHS, a random representative sample of Spanish young adult...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71231-0
更新日期：2000-02-12 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The smoke fume, principal factor in the development of lung cancer, causes the expression of certain cytokines, including interleukin 4, 6, 8 and 10, which may act by inhibiting apoptosis and interfere cellular repair mechanisms and angiogenesis. To determine the possible relationship between g...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.07.034
更新日期：2014-08-04 00:00:00
abstract：:We present the two first Spanish cases about the endodermic heterotopia of the atrioventricular node. This is an infrequent and probably congenital lesion, with a not well known histogenesis and associated with heart blocks and sudden death, which affects women in most cases. The first observation attaches a 55 years-...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1995-02-25 00:00:00
abstract：:Bipolar disorder is a chronic and recurrent mood disorder, which may severely impact on the patient's global functioning. It has been estimated that approximately 1.6% of the population is affected. A long delay in diagnosis and an excessive disparity in the treatment of these patients have been detected. Within the Q...
journal_title：Medicina clinica
pub_type： 杂志文章,实务指引
doi：10.1016/j.medcli.2013.05.023
更新日期：2013-10-05 00:00:00
abstract：:Coronary heart disease is one of the major causes of death in developed countries. The hypothesis that peroxidation of low density lipoproteins (LDL) may be the initial step of the atherosclerotic process has promoted numerous studies aimed at investigating the mechanisms by which the body protects itself from such ox...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/s0025-7753(03)74011-1
更新日期：2003-10-25 00:00:00
abstract：BACKGROUND:Anal intraepithelial neoplasia is considered a precursor lesion of anal squamous carcinoma. The population with increased risk of this conditions are immunocompromised individuals, especially HIV-infected, with anal sex practices. The aim of this study was to describe the sexual habits of patients who were s...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.05.047
更新日期：2014-02-20 00:00:00
abstract：OBJECTIVE:To compare the occurrence of haemorrhages among the different oral anticoagulants (OAC) and to analyse factors that influence it. MATERIAL AND METHODS:Single-centre, observational, retrospective study. After studying the total population treated with OAC, patients who were treated with an OAC from July 2015 ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2018.10.006
更新日期：2019-06-21 00:00:00
abstract：:Meningitis and other infectious diseases of the central nervous system are predisposing causes of the inadequate secretion syndrome of the antidiuretic hormone (ISADH). The association between the acquired immunodeficiency syndrome (AIDS) and ISADH is recognized but little studied. In AIDS patients hyponatremia is a f...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1993-03-20 00:00:00
abstract：:Amyotrophic neuralgia is an uncommon neuropathy characterized by severe unilateral shoulder pain. Isolated or concomitant involvement of other peripheral motor nerves depending on the brachial plexus such as phrenic or laryngeal nerves is unusual(1). Its etiology is unknown, yet several explanatory factors have been p...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2015.03.016
更新日期：2015-09-07 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Anxiety and depression are common among medical inpatients. While their relation to the severity of illness is often discussed, the feeling of such severity by the patient and his/her prospects of improvement can be influenced by anxiety and depression. PATIENTS AND METHOD:Patients admitted in...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2003-03-22 00:00:00
abstract：:Renal complications in Waldenström's macroglobulinemia (WM) are infrequent and are characterized by the presence of PAS positive amorphous hyaline deposits in the capillary lumen, infiltrated with lymphoplasmatic cells with PAS positive inclusions in the interstices and intratubular hyaline cylinders. Membranous glome...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-10-26 00:00:00
abstract：INTRODUCTION:Neurosarcoidosis is a rare complication of sarcoidosis. There are small series on the condition and very few from Spain. We conducted a retrospective study of neurosarcoidosis in Virgen de la Victoria Hospital over the last 10 years. PATIENTS AND METHOD:the medical records of patients diagnosed with sarco...
journal_title：Medicina clinica
pub_type：
doi：10.1016/j.medcli.2020.04.027
更新日期：2020-10-09 00:00:00
abstract：:We analyzed the tissue oxygen extraction in 25 patients with acute respiratory failure. Fourteen met the clinical criteria for the adult respiratory distress syndrome (ARDS). The 11 remaining patients had acute respiratory failure with causes different from ARDS. In all cases the changes in the oxygen extraction ratio...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-01-26 00:00:00
abstract：:Patients with inflammatory bowel disease constitute a population with a special predisposition to develop bacterial, viral and fungal infections. Iatrogenic immunosuppression, frequent contact with healthcare facilities and surgical interventions are some of the risk factors that explain why these infections are one o...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2016.12.041
更新日期：2017-05-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Pulmonary arterial hypertension associated with systemic lupus erythematosus (PAH-SLE) is a rare disease with a low incidence rate. In this study, PAH related genes and genetic modifiers were characterised molecularly in patients with PAH-SLE. PATIENTS AND METHODS:Three patients diagnosed with...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2018.01.023
更新日期：2018-08-10 00:00:00
abstract：BACKGROUND:The identification of high risk groups for genital human papillomavirus (HPV) infection may contribute to cervical cancer prevention. The study was designed to estimate the prevalence of HPV infection and the related risk of cervical cancer among imprisoned women. PATIENTS AND METHODS:157 women were visited...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71472-2
更新日期：2000-06-17 00:00:00
abstract：:Three cases of encrusted cystitis caused by Corynebacterium group D2 are described. The vesical damage previous to the establishment of this bacteria is noteworthy and the very rapid increase in urease activity explains the pathogenesis of the situation. Thus allowing for its identification and is relevant to treatmen...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-03-21 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with la...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2017.02.025
更新日期：2017-10-11 00:00:00
abstract：BACKGROUND AND OBJECTIVE:For the treatment of obesity, an adecuate control of associated cardiovascular risk factors (CRF) is fundamental. The objective of this study was to assess the relationship between body mass index (BMI) and CRF, and the effect of a weight loss program on overweight subjects. PATIENTS AND METHO...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(03)73997-9
更新日期：2003-10-18 00:00:00
abstract：BACKGROUND:The sleep apnea syndrome (SAS) and high blood pressure (HBP) present multiple relations. Apnea culminates with an increase in arterial pressure, and a high percentage of apneic patients have HBP. It has also been reported that SAS is more frequent among hypertensive patients than among the general population...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-02-27 00:00:00
abstract：INTRODUCTION:a description of infective left endocarditis at the turn of the millennium. METHOD:A multicentre prospective study into the left endocarditis using data collected from the Andalusian cohort for the study of cardiovascular infections during 1984-2014. RESULTS:Of the 1,604 endocarditis cases collected, 382...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2018.04.018
更新日期：2019-07-19 00:00:00
abstract：BACKGROUND:The aim of the current study is to show the prevalence of atopy in five Spanish areas, and its variability according to area, age and gender. PATIENTS AND METHODS:From a populational based sample of 16,884 individuals aged 20 to 44 years-old, we obtained a randomized 20% subsample (n = 3,310). Participants ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1998-11-07 00:00:00
abstract：BACKGROUND:The aim of this study was to assess the familial aggregation of lipid levels in schoolchildren of Cuenca city, Spain. SUBJECTS AND METHODS:A cross sectional study was made including 307 both sexes schoolchildren 9-12 years old recruited in three schools of Cuenca city, and 346 of their parents. Sociodemogra...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1997-10-04 00:00:00
abstract：:Since Perrinaud in 2006 first described three patients with hemorrhagic bullae in relation to the use of heparins, numerous cases have been published. Currently, this entity has been established as a clearly defined pathology. We review all reported cases, diagnostic features and features that differentiate it from ot...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2015.10.017
更新日期：2016-05-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The association of an exaggerated systolic blood pressure increase with exercise (EBPIE) with cardiovascular events remains controversial. Our aim was to determine the possible association of an EBPIE with survival and risk of serious cardiac events in patients with hypertension and known or su...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2016.09.016
更新日期：2017-01-20 00:00:00
abstract：BACKGROUND:To evaluate the fat consumption and main sources of specific fatty acids in adults from the south and north of Spain. SUBJECTS AND METHODS:Dietary data from 25,816 women and 15,635 men, aged 29-69 years, participants in the European Prospective Study on Cancer and Nutrition (EPIC) recruited in the north (As...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-02-06 00:00:00
abstract：BACKGROUND:To carry out a study on the prognostic factors in large cell lymphomas (LCL) treated during the last decade and validate the international prognostic index (IPI). METHODS:One hundred twenty-four cases of newly diagnosed LCL, treated from 1978 to 1990, with a mean follow up of 27 months (1-142) were included...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-04-29 00:00:00
abstract：BACKGROUND AND AIMS:It has been recently shown that psychiatric disorders are associated with obesity. However this association has not been studied in overweight/obese patients at a hospital setting in our country. PATIENTS AND METHODS:We have studied 333 consecutive patients who were referred to our hospital outpati...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13115025
更新日期：2008-01-26 00:00:00
