Abstract：
:The presence of antibodies (Abs) against hepatitis C virus (HCV) was analyzed in 26 haemophiliac patients; a prevalence of 38% was found in the total series and 56% in the treated patients. There were no cases with a positive serology among the three patients who had only received pasteurized factor. The frequency of detection of anti-HCV was higher in the patients who had a positive serology for HIV (67%) and hepatitis B virus (56%) than in the seronegative patients (24 and 29%, respectively). The patients with HCV Abs showed a decrease in the helper (CD4+) lymphocytic population, mainly due to the decrease in the helper inducer (CD4+/Leu8-) cells, such alterations being more evident in the patients who also were HIV+ who showed as well an increase in the T-cell activated lymphocytes (CD3+/la+) and a decrease in CD16+ natural killer cells. These results suggest that the lymphocytic alterations found in the patients with anti-HCV Abs are not specific and would rather be related to the presence or not of HIV infection.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Gómez E,Alberca I,Vicente V,González M,Martín AM,Corral M,Cordero M,López Borrasca Asubject
Has Abstractpub_date
1991-01-26 00:00:00pages
81-4issue
3eissn
0025-7753issn
1578-8989journal_volume
96pub_type
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