[Gastric emptying in reflux esophagitis. Effect of metoclopramide and cinitapride].

Abstract:

:The gastric emptying of solids was evaluated with radionuclide techniques in 16 patients with reflux esophagitis, demonstrated by two of the following methods: endoscopy, pathology, and/or pH measurement. The percentage of radionuclide remaining within the stomach was 80.8 +/- 17% after 45 minutes, 63.3 +/- 10% after 75 minutes, and 48.8 +/- 19% after 105 minutes, with a half time (T1/2) of gastric emptying of 103.4 +/- 6 minutes. These results showed significant differences in T1/2 with those from a control group of healthy individuals, the gastric emptying being slower in patients with esophagitis (103.4 min vs 85.3 min; p less than 0.01). Subsequently, a double blind study to assess the effect of metoclopramide and cinitapride on gastric emptying in patients with reflux esophagitis was carried out. Cinitapride accelerated the gastric emptying of solids with statistically significant differences when compared with placebo (84 min vs 104 min, p less than 0.05). In this study, metoclopramide showed a tendency to accelerate gastric emptying, although it did not achieve a significant difference with placebo.

journal_name

Med Clin (Barc)

journal_title

Medicina clinica

authors

Monés J,Espinós JC,Carrió I,Calabuig R,Vilardell F

subject

Has Abstract

pub_date

1989-09-30 00:00:00

pages

331-4

issue

9

eissn

0025-7753

issn

1578-8989

journal_volume

93

pub_type

临床试验,杂志文章,随机对照试验
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    doi:

    authors: Rico Lenza H,de la Fuente López A,Marañes Pallardo P,Charro Salgado A

    更新日期:1980-04-10 00:00:00

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    abstract::A series of eight patients with cerebral tuberculoma seen between 1980 and 1990 is reported. Headache was the leading clinical finding, followed by focal neurological findings and seizures. Papilledema was the most uniform examination finding associated with intracranial hypertension. Five patients had another localiz...

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    doi:

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    doi:

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    更新日期:1999-06-19 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Montoliu J,Darnell A,Torras A,Botey A,Revert L

    更新日期:1980-01-10 00:00:00

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    doi:

    authors: Ponz E,Graus F,Alvarez R,Sarmiento X,Vidal J,Grau JM

    更新日期:1989-09-09 00:00:00

  • [Morbidity, mortality and the potential years of life lost attributable to tobacco].

    abstract:BACKGROUND:The aim of this study was to evaluate the morbidity and mortality attributable to smoking. MATERIAL AND METHODS:A transversal study was performed in a reference population of residents of the province of Granada (Spain). The number of deaths in 1985, the number of patients admitted to public hospitals in 19...

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    doi:

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  • [Prevalence of metabolic syndrome in patients with coronary heart disease].

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  • [Estimate of the costs of osteoporotic fractures of the femur in Spain].

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    pub_type: 杂志文章

    doi:

    authors: Díez Pérez A,Puig Manresa J,Martínez Izquierdo MT,Guelar Grimberg AM,Cucurull Canosa J,Mellibovsky Saidler L,Vivancos Lleida J

    更新日期:1989-05-20 00:00:00

  • [Lipid profile in the hyperacute phase of ischemic stroke allows to decide cholesterol-lowering therapy].

    abstract:BACKGROUND AND OBJECTIVE:We aimed to determine whether measuring the hyperacute lipid profile helps to start a cholesterol-lowering therapy soon after an ischemic stroke. PATIENTS AND METHOD:72 ischemic stroke patients underwent lipid determinations at three times (hyperacute phase or arrival, second day and the third...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13072322

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  • [Antibiotic sensitivity, serology and typing by pyocine in 154 cultures of Pseudomonas aeruginosa (author's transl)].

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    authors: Cantos de la Casa A,García Curiel A,Gómez Fernández MV,Arroyo Trillo A,Díaz Sánchez JA,Dueñas P

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  • [Tropical spastic paraparesis and HTLV-I. The first case in Spain].

    abstract::The first patient with myelopathy associated with T-cell leukemia/lymphoma virus infection (HTLV-I) in Spain is reported. Although this condition is endemic in several areas from the Caribbean Sea, South America, Africa and Japan, some cases have been reported in European countries, generally in immigrant patients, re...

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  • [Bone metabolism in non-cholestatic chronic hepatopathy].

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  • [Economic evaluation studies in health].

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  • [Megadosage of 6-methylprednisolone in systemic vasculitis with renal involvement. A prospective study].

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    journal_title:Medicina clinica

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    doi:

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  • [Effect on quality of life of nCPAP treatment in patients with obstructive sleep apnea].

    abstract:BACKGROUND AND OBJECTIVE:The standard treatment of the obstructive sleep apnea syndrome (OSAS) is the nCPAP. There is evidence that its use improves the quality of life of patients. The objective of the study is to measure the effect of nCPAP on the quality of life of patients in a Spanish cohort. PATIENTS AND METHOD:...

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  • [Blood pressure control in Spanish hypertensive patients in Primary Health Care Centres. PRESCAP 2002 Study].

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    pub_type: 杂志文章,多中心研究

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  • [The measurement of health related quality of life].

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    doi:

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  • [High prevalence of left ventricular hypertrophy in patients with hypertension of long course].

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    pub_type: 杂志文章,多中心研究

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    doi:

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