Abstract:
:The measurement of health-related quality of life (HRQOL) plays a very important role in the study of health outcomes, particularly in effectiveness studies. Nevertheless, the nature of these studies implies a series of challenges in the use of HRQOL instruments, due to the type of comparisons made, the heterogeneity of subjects included in terms of both the presence of comorbid conditions and the ability to understand and complete questionnaires, and because there is a need to collect the data in conditions of usual clinical practice. The aim of this paper is to discuss some of these issues, as well as other topics of current interest in the field, such as the use of individualized measures, applications of Item Response Theory, and response shift phenomenon research. With regard to the use of HRQOL measures in effectiveness studies, the main conclusions are that: a) instrument selection probably needs to be even more careful than in controlled clinical trials, and needs to take into account time pressures and variability in patients' ability to respond; b) that instrument selection should centre on the use of disease-specific measures; c) that generic measures may play an important role in capturing the broader effects of co-morbidity, and may be useful in controlling certain types of bias, and d) that more comparisons are required between disease-specific instruments for the same condition, particularly with respect to their discriminative power and their sensitivity to change.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Herdman Mkeywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
22-5eissn
0025-7753issn
1578-8989journal_volume
114 Suppl 3pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract::Gaucher's disease (GD) is an inherited metabolic disease due to lack of activity of the enzyme betaglucocerebrosidase. The diagnosis of GD is usually performed by fluorimetric analysis of the enzyme betaglucocerebrosidase. It can also be done by measuring the activity of tandem mass spectrometry. This enzyme can be an...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/S0025-7753(11)70011-2
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The myocardial infarction (MI) with ST elevation and angiographically normal coronary arteries isn't frequent. The aim of this study is to describe clinical characteristic and mid-term follow-up of those patients. PATIENTS AND METHOD:Between January 1997 and December 2004 we identified 75 pati...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13112511
更新日期:2007-11-17 00:00:00
abstract:BACKGROUND AND OBJECTIVE:High levels of daily physical activity have been shown to be linked to decreased functional impairment in peripheral artery disease (PAD) patients and positively related to the ankle brachial index (ABI) in subjects without PAD. The aim of this study was to examine the relationship between leis...
journal_title:Medicina clinica
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medcli.2015.01.015
更新日期:2015-11-20 00:00:00
abstract::The authors report a case of hepatorenal polycystic disease discovered in the course of a routine physical examination. The patient was asymptomatic and the progression of the disease was extremely low. The existence of the disorder, however, was confirmed in the autopsy. Although hepatorenal polycystic disease is a r...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1980-02-10 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Liver re-transplantation (re-LT) is an accepted indication for some (technical problems, primary non-function [PNF]) but not all indications, particularly recurrence of the original disease, such as hepatitis C. We aimed to determine in our center: a) the rate of survival following re-transplan...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13075442
更新日期:2005-05-21 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Our objective was to assess the activity of thiopurine methyltransferase (TPMT) in a very large number of Spanish patients with inflammatory bowel disease (IBD), to evaluate the influence of several variables (including azathioprine or 6-mercaptopurine) on that activity, and to know the proport...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13078420
更新日期:2005-09-10 00:00:00
abstract::Amebian hepatic abscess (AHA) is the most frequent extraintestinal localization of infection by Entamoeba histolytica. Despite being a disease mainly of tropical zones, it is currently also observed with higher frequency in Spain. Thirteen cases of AHA diagnosed in the authors' hospital over the last 11 years were ret...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1995-10-28 00:00:00
abstract:BACKGROUND:The empiric antibiotic treatment of intraabdominal infections is in constant evolution. Monotherapy appears to be a desirable goal because of the simplicity of its administration, lack of toxic effects and wide spectrum. PATIENTS AND METHODS:A multicentre, prospective, randomized, open study was carried out...
journal_title:Medicina clinica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1998-06-27 00:00:00
abstract::The association of celiac disease, epilepsy and occipital calcifications with initial clinical manifestations of epilepsy during the first two decades of life with an often progressive and variable course and clinical expression of malabsorption has recently been described. Two cases of celiac disease with occipital c...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1995-12-08 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The aims of the GEMM Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in individuals born and living in Mexico. The authors evaluate the heritabilities (h2) of CVD risk factors in Mexicans from a preliminary cohort already studied. Heritabilities for CVD...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13106675
更新日期:2007-06-02 00:00:00
abstract::A prospective clinical and electrophysiologic study was performed in 50 alcoholic patients in order to assess the incidence and clinical manifestations of alcoholic polyneuropathy, the value of the electrophysiologic parameters studied, and the influence of liver disease on the appearance of neuropathy. The proposed c...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1981-03-10 00:00:00
abstract:BACKGROUND:Group therapy is a widely used technique for the treatment of tobacco, alcohol and other toxic addictions. Nevertheless, its effectiveness for smoking cessation remains to be established. Our objective was to evaluate the relative effectiveness of a group intervention versus an individual intervention for sm...
journal_title:Medicina clinica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0025-7753(02)73312-5
更新日期:2002-06-15 00:00:00
abstract:BACKGROUND:Erythema induratum of Bazin (BEI), is included in the group of cutaneous granulomatous lobulillar panniculitis. The aethiopathogenic association between EI and tuberculosis can not rely on the clinicohistological features of these panniculitis and M. tuberculosis has never been isolated from BEI lesions. Det...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1996-11-30 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The optimal treatment of aggressive non-Hodgkin lymphoma (NHL) in elderly patients remains controversial. We aimed to evaluate the impact of age and use of anthracyclines. PATIENTS AND METHOD:Retrospective analysis of patients with aggressive NHL aged over 70 years old. RESULTS:One hundred an...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2014.04.026
更新日期:2015-06-22 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The effectiveness of the treatment of latent tuberculosis infection depends on its efficacy, the adherence to treatment and patient's risk of tuberculosis. The objective of this study was to evaluate the adherence to treatment with daily isoniazid for 9 months, its effectiviness and equivalent ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13116320
更新日期:2008-02-16 00:00:00
abstract::Difficulties derived from the big complexity of the human genome (because of the great amount of genes) and difficulties at the time of performing a correct molecular diagnosis have led to the utilization of advanced technologies such as DNA arrays. By this technique, it is possible to analyze in a single experiment g...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1157/13119504
更新日期:2008-04-12 00:00:00
abstract:BACKGROUND:Advanced atrioventricular block (AB) during acute myocardial infarction (AMI), characterizes a high-risk subgroup of patients. Our aim was to determine the prognostic significance of AB and its possible peculiarities in relation to infarction localization and/or the thrombolytic therapy. PATIENTS AND METHOD...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(00)71282-6
更新日期:2000-03-11 00:00:00
abstract::Neutrophils play a key role in the innate immune system, providing the first line of host defense. In addition to their ability to eliminate pathogens by phagocytosis and antimicrobial secretions, it has recently been shown that neutrophils can trap and kill microorganisms by the release of extracellular structures co...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2012.04.022
更新日期:2013-01-19 00:00:00
abstract:BACKGROUND AND OBJECTIVE:We aimed to know the prevalence of classical cardiovascular risk factors, hyperinsulinism, insulin resistance and metabolic syndrome (MS) in a population with coronary heart disease (CHD) as compared with a population without personal or familial history of cardiovascular risk factors. SUBJECT...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(03)73907-4
更新日期:2003-07-12 00:00:00
abstract:BACKGROUND:Acarbose is a reversible inhibitor of the intestinal alpha-glucosidases, the oral administration of which delays or diminishes the postprandial increase of glucose and insulin. METHODS:A multicentric double-blind clinical trial (11 centers), controlled versus placebo, crossed and randomized, was carried out...
journal_title:Medicina clinica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1993-04-03 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The association of an exaggerated systolic blood pressure increase with exercise (EBPIE) with cardiovascular events remains controversial. Our aim was to determine the possible association of an EBPIE with survival and risk of serious cardiac events in patients with hypertension and known or su...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2016.09.016
更新日期:2017-01-20 00:00:00
abstract::Since its inception in 2006, the Alliance for Patient Safety in Catalonia has played a major role in promoting and shaping a series of projects related to the strategy of the Ministry of Health, Social Services and Equality, for improving patient safety. One such project was the creation of functional units or committ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2014.07.011
更新日期:2014-07-01 00:00:00
abstract::We describe the experience of the Maxillofacial Surgery Service of the Gregorio Maranon University Hospital in attending the victims of the terrorist attack of 11 March, 2004 in Madrid. The most important types of cranio-maxillofacial injury treated that day, their mechanisms of production, and the organization of the...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13072640
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:We aimed to determine whether measuring the hyperacute lipid profile helps to start a cholesterol-lowering therapy soon after an ischemic stroke. PATIENTS AND METHOD:72 ischemic stroke patients underwent lipid determinations at three times (hyperacute phase or arrival, second day and the third...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13072322
更新日期:2005-03-05 00:00:00
abstract:BACKGROUND:The aim of the present was to determine the levels of the tumor necrosis factor (TNF)-alpha in patients with HIV infection to study the relationship with the concentration of triglycerides (TG), CD4 lymphocyte count and clinical diagnosis. METHODS:Seventy-eight HIV-infected patients (58 males, 20 females); ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1995-03-18 00:00:00
abstract::The association of deep vein thrombosis with systemic necrotizing vasculitis is infrequent. Herein are referred two patients with microscopic polyarteritis and one patient with overlap syndrome who developed deep vein thrombosis which complicated in two cases with pulmonary embolism. The clinical features and the path...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1993-12-11 00:00:00
abstract::The case of a 19 year old patient with Takayasu arteritis with exclusive involvement of the abdominal aorta and without involvement of the renal arteries who presented severe arterial hypertension during the acute phase of the disease is referred. The administration of a dose of 20 mg of enalapril maleate was followed...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-22 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Though there is a general agreement on the need of influenza vaccination (IV), very different results have been published about the magnitude of its effect. We evaluated the effectiveness of IV in the reduction of mortality in individuals over 65 years of age. PATIENTS AND METHOD:Prospective c...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(05)72156-4
更新日期:2005-11-19 00:00:00
abstract:BACKGROUND AND OBJECTIVE:For the treatment of obesity, an adecuate control of associated cardiovascular risk factors (CRF) is fundamental. The objective of this study was to assess the relationship between body mass index (BMI) and CRF, and the effect of a weight loss program on overweight subjects. PATIENTS AND METHO...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(03)73997-9
更新日期:2003-10-18 00:00:00
abstract::Currently, pharmacological thromboprophylaxis is frequently required in patients undergoing surgery, due to the high risk of deep venous thrombosis in the perioperative period. The administration of these anticoagulant agents (in Spain, usually low molecular weight heparins or fondaparinux, and in future, probably als...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/s0025-7753(08)76448-0
更新日期:2008-11-01 00:00:00