Abstract：
:There are a great number of polymorphic genes in the human genome. Many of them codify enzymes that metabolizes drugs and xenobiotic agents, including carcinogens. Among the better known of them, there are a number of isozymes of the microsomal oxidative system (CYP3A4, CYP2C9, CYP2C19 y CYP2D6). This article reviews the following issues: a) frequency of presentation of the "poor metabolizer" genotype and/or phenotype for substrates of CYP2C19; b) role of CYP2C19 polymorphism on the metabolism of some drugs (mephenytoine and other antiepileptic drugs, proton pump inhibitors, several antidepressants and anxyolitics, the antimalaria aggent proguanyl, and propranolol, among others, use this metabolic pathway), and c) possible role of CYP2C19 polymorphism in the risk for development of neoplasia and other diseases (systemic lupus erythematosus, psoriasis, hip osteonecrosis, Alzheimer's disease, amyotrophic lateral sclerosis, essential tremor).
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Alonso-Navarro H,Jiménez-Jiménez FJ,García-Agúndez JAdoi
10.1157/13088772subject
Has Abstractpub_date
2006-05-13 00:00:00pages
697-706issue
18eissn
0025-7753issn
1578-8989pii
S0025-7753(06)72065-6journal_volume
126pub_type
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