Abstract:
:Diabetic dyslipidemia, characterized by the lipid triad (elevated plasma triglycerides, low HDL cholesterol and predominance of small, dense LDL particles), is a significant contributor to the elevated cardiovascular risk of type 2 diabetic patients. Statin monotherapy has shown, in different prospective trials, significant reductions in cardiovascular events and mortality. However, the residual risk in these subjects remains elevated, probably due to the incomplete control of diabetic dyslipidemia. In this review we discuss the global therapeutic approach, underlying the need of combining statins with agents that more effective in reducing triglycerides and elevating HDL cholesterol, even in subjects whose LDL cholesterol values are at target. Available data supports that such combinations contribute to normalize the lipid profile with possible beneficial effects on the cardiovascular risk. Ongoing clinical trials, using different combinations and focusing on cardiovascular morbidity and mortality are also discussed. In our opinion, the future treatment of diabetic dyslipidemia will include the combination of statins and other hypolipidemic agents.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Carmena R,Ascaso JFdoi
10.1016/j.medcli.2009.10.010subject
Has Abstractpub_date
2010-04-03 00:00:00pages
406-11issue
9eissn
0025-7753issn
1578-8989pii
S0025-7753(09)01454-7journal_volume
134pub_type
杂志文章,评审相关文献
MEDICINA CLINICA文献大全abstract::Three cases of encrusted cystitis caused by Corynebacterium group D2 are described. The vesical damage previous to the establishment of this bacteria is noteworthy and the very rapid increase in urease activity explains the pathogenesis of the situation. Thus allowing for its identification and is relevant to treatmen...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1992-03-21 00:00:00
abstract:BACKGROUND:Renal transplantation in children raises numerous diagnostic problems. The renography obtained with diethyltriaminopentaacetic acid marked with (99mTc metastable technetium (99mTc-DTPA) was compared with fine needle aspiration biopsy (FNAB) in search of a better interpretation of post-transplant crisis: reje...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1992-11-07 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with la...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2017.02.025
更新日期:2017-10-11 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Our purpose was to provide information about static and dynamic balance posturographic disorders in elderly people with recurrent falls, and to compare the results with a healthy elderly group. PATIENTS AND METHOD:We included 95 subjects: 57 patients who fell (86% women; age, 78.1 years) and 3...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13071759
更新日期:2005-02-19 00:00:00
abstract::Fifteen reflex tests for the diagnosis of cardiovascular autonomic neuropathy (CAN) were evaluated in 90 controls and 154 diabetic patients. We found that age, baseline heart rate and body position differently influenced the tests. The best parasympathetic indexes were Valsalva, inspiration minus expiration (I-E) and ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1990-09-29 00:00:00
abstract:BACKGROUND:A high prevalence of osteoporosis has been described in patients before and after cardiac transplantation. But clinical factors involved in previous bone loss in this condition are not well known. The purpose has been to study bone mineral density (BMD) in patients subject to cardiac transplantation, analyzi...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(00)71430-8
更新日期:2000-05-27 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To validate four instruments to detect domestic violence in health-care settings against external criteria -Index of Spouse Abuse (ISA), Psychological Maltreatment of Women Inventory short form (PMWI-SF), Woman Abuse Screening Tool (WAST), Partner Violence Screen (PVS)- and to assess the conco...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2010.11.038
更新日期:2011-10-08 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To describe an outbreak of Legionella pneumophila serogroup 1 in Mataró, Catalunya, Spain, in August 2002. The source of the microorganism was a cooling tower. PATIENTS AND METHOD:Prospective and observational study with analysis of epidemiological, clinical, and microbiological data. RESULTS...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(06)71871-1
更新日期:2006-02-11 00:00:00
abstract:BACKGROUND:Nosocomial infection (NI) represents an increase of hospital morbidity and mortality. The data available concerning the hospital expenses due to the prolongation of hospital stay associated to NI are fundamentally derived from American studies. The aim of this study was to evaluate the direct cost of nosocom...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1993-03-06 00:00:00
abstract:BACKGROUND AND OBJECTIVE:We aimed to determine whether measuring the hyperacute lipid profile helps to start a cholesterol-lowering therapy soon after an ischemic stroke. PATIENTS AND METHOD:72 ischemic stroke patients underwent lipid determinations at three times (hyperacute phase or arrival, second day and the third...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13072322
更新日期:2005-03-05 00:00:00
abstract::Most patients with type 2 diabetes have excess adiposity. There is wide consensus that adequate treatment of type 2 diabetes requires a simultaneous approach to overweight/obesity and the remaining cardiovascular risk factors. Non-pharmacological interventions (diet, exercise) represent the cornerstone of the treatmen...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/S0025-7753(17)30620-6
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Hypertension is the most prevalent risk factor in the community. The aim of this study was to describe the risk factors for the progression of blood pressure (BP) from correct values. SUBJECTS AND METHODS:Prospective and observational study with 7 years follow-up. BP>140/90 mmHg was considered...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2012.09.026
更新日期:2013-06-04 00:00:00
abstract::Podoconiosis, mossy foot or endemic non-filarial elephantiasis, is a geochemical disease that causes lower limb lymphedema; it is directly related to walking barefoot over soils of volcanic origin, in areas with a high pluviometric annual index. It has a specific geographical distribution, affecting around 5% populati...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2014.12.020
更新日期:2015-11-20 00:00:00
abstract::Cardiovascular disease is a chronic disorder which is usually already at an advanced stage when the first symptoms develop. The fact that the initial clinical presentation can be lethal or highly incapacitating emphasizes the need for primary and secondary prevention. It is estimated that the ratio of patients with go...
journal_title:Medicina clinica
pub_type: 共识发展会议,杂志文章
doi:10.1016/j.medcli.2016.10.031
更新日期:2017-02-09 00:00:00
abstract::The health information system in Catalonia has experienced an important evolution but obtaining integrated data to evaluate the health services is still difficult. At the end of 2008 the basis of the information system of the "Center of Results" and a first set of indicators has been approved by the health system stak...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/S0025-7753(10)70006-3
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To assess the usefulness of a risk scale based on serum procalcitonin (PCT) compared to the Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) scale in the early discrimination between necrotising fasciitis (NF) and cellulitis of the extremities. MATERIALS AND METHODS:Retrospective s...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2019.01.032
更新日期:2019-11-15 00:00:00
abstract::In the present article we describe the activity of the admissions service on the day of the terrorist attacks, 11 March, 2004. Firstly, we try to describe the objectives and lines of intervention that we believe should be covered by our service. Subsequently, we describe how we organized ourselves into teams in order ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13072650
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To study an outbreak of nosocomial colonisation/infection due to multidrug and carbapenem resistant A. baumannii (ABMDR-C). PATIENTS AND METHODS:Prospective study of patients with ABMDR-C colonisation/infection (January 2007-June 2008). Epidemiological and clinical variables and predictors of ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2010.01.033
更新日期:2010-09-18 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The influence of homocysteine metabolism on the prognosis of acute coronary syndrome without ST elevation is controversial. PATIENTS AND METHOD:Prospective study of 109 patients admitted because of acute coronary syndrome without ST elevation. Basal plasmatic levels of homocysteine and folates...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13109705
更新日期:2007-09-08 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Although constipation affects quality of life, questionnaires hardly exist for its evaluation. We aimed to develop and validate a questionnaire able to measure the quality of life in patients with constipation. PATIENTS AND METHOD:A Spanish multicenter study was performed in 2 stages: a) quest...
journal_title:Medicina clinica
pub_type: 杂志文章,多中心研究
doi:10.1016/s0025-7753(08)72285-1
更新日期:2008-09-27 00:00:00
abstract::Amebian hepatic abscess (AHA) is the most frequent extraintestinal localization of infection by Entamoeba histolytica. Despite being a disease mainly of tropical zones, it is currently also observed with higher frequency in Spain. Thirteen cases of AHA diagnosed in the authors' hospital over the last 11 years were ret...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1995-10-28 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Leptin is an hormone resulting from the obesity gene. Their actions could be important in the pathogenesis of the osteoporosis. The aim of this study is to analyse the influence of tobacco on serum leptin levels, and its relationship with bone mineral density (BMD) and steroid hormones. SUBJEC...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13094819
更新日期:2006-11-04 00:00:00
abstract::A prospective clinical and electrophysiologic study was performed in 50 alcoholic patients in order to assess the incidence and clinical manifestations of alcoholic polyneuropathy, the value of the electrophysiologic parameters studied, and the influence of liver disease on the appearance of neuropathy. The proposed c...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1981-03-10 00:00:00
abstract::Epstein-Barr virus (EBV) infection is ubiquitous and may result in multiple and widely different clinical features; the most common of these is infectious mononucleosis (IM). Recently, a group of patients has been included in the chronic EBV infection syndrome (EBVIS), with a sustained nonspecific syndrome consisting ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1989-04-29 00:00:00
abstract:BACKGROUND:To relate the renal hemodynamic changes, as assessed by Doppler ultrasonography,with the development of ascites, renal function, and endogenous vasoactive systems in patients with liver cirrhosis. PATIENTS AND METHODS:60 cirrhotic patients were studied prospectively, 31 of these compensated and 29 with asci...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(01)71906-9
更新日期:2001-04-28 00:00:00
abstract:BACKGROUND:The aim of the present study was to follow for a year all the osteoporotic proximal femoral fractures that happened in the island of Gran Canaria during 1990 and to analyze: a) mortality; b) the degree of functional capacity; c) their destination after being attended from the fracture. METHODS:Personal inte...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1993-10-23 00:00:00
abstract:BACKGROUND:To review the series of patients with pheochromocytoma diagnosed in this institution from 1976 to 1990. METHODS:The main clinical features and presentation of 21 patients (13 women and 8 males) with mean age 40 +/- 13 years were reviewed. Urinary excretion of vanillylmandelic acid (VMA) and total catecholam...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1991-11-02 00:00:00
abstract:BACKGROUND:The elevated incidence of malnutrition in the elderly and its close relation with the prevalence and evolution of determined diseases raises the need for early identification. Despite the existence of numerous indicators, specificity, sensitivity or occasionally both are lacking. METHODS:One hundred fifteen...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1992-02-22 00:00:00
abstract:FOUNDATIONS AND AIM:The aim of this study is to analyze the CHADS2 score as a marker of the risk of mortality in hypertensive patients, with and without the presence of atrial fibrillation. METHODS:We included 1,003 hypertensive patients≥65 years. Risk factors, and CHADS2 score were recorded among other factors, as we...
journal_title:Medicina clinica
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medcli.2016.03.015
更新日期:2016-06-03 00:00:00
abstract:OBJECTIVE:To describe the secular trend of cancer incidence in Catalonia and to compare it with that observed in European regions. MATERIAL AND METHOD:Using data from the Tarragona and Gerona cancer registries, the number of cases, adjusted rates, and the annual percentages of change in cancer incidence in Catalonia f...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(08)76428-5
更新日期:2008-10-01 00:00:00