[Influence of plasma lipids, APOE genotype and type of LDL receptor gene mutations on myocardial infarction in subjects with familial hypercholesterolemia].


BACKGROUND:Our goal was to analyze the relationship of lipids and lipoproteins, APOE genotype and mutations of the LDL receptor gene with the prevalence of myocardial infarction (MI) in patients with familial hypercholesterolemia (FH) from a Southern European FH population. PATIENTS AND METHOD:We studied 108 heterozygous FH subjects aged > 35 years (41 males). It was a cross-sectional study comparing individuals with FH and MI with individuals with FH without MI. In 88 FH subjects, a mutation of the LDL receptor gene was detected. These FH subjects were divided in carriers of null mutation or no null mutations. We compared lipids and lipoproteins and prevalences of LDL receptor type mutation and APOE genotype. RESULTS:Parameters associated with MI were: age, presence of xanthomas and arcus cornealis, plasma concentrations of total cholesterol (TC), LDLc, TC/HDLc ratio > 5.3 and *4 genotype of the APOE gene. Odds ratio for MI were as follows: presence of xanthomas and arcus cornealis, 1.36 (CI 95%, 1.08-1.71; P = 0.01), age > 54 years (50 th of FH group), 1.56 (CI 95%, 1.19-2.04; P = 0.001) and plasma TC values > 332 mg/dl (50 th of FH group), 1.34 (CI 95%, 1.05-1.71; P = 0.019). In the logistic regression model, only age and TC were significantly associated with MI. CONCLUSIONS:In FH subjects aged over 35 years from a Southern European population, MI is associated with age, plasma TC and LDLc values, TC/HDLc ratio and the *4 genotype. In addition, MI is related with age and TC plasma levels on an independent basis.


Med Clin (Barc)


Medicina clinica


Real JT,Ascaso JF,Chaves FJ,González C,Puig O,Armengod ME,Carmena R





Has Abstract


2002-05-18 00:00:00














  • [LDL concentration and particle size after treatment with rosiglitazone in patients with diabetes mellitus type 2].

    abstract:BACKGROUND AND OBJECTIVE:The effects of rosiglitazone on the lipid profile are controversial, with related increases in the concentration of total and LDL cholesterol. Our objective is to evaluate the evolution of the concentration and size of LDL particles in a group of patients with type 2 diabetes mellitus taking ro...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Albaladejo Otón MD,Calle Luna JG,Granero Fernández E,Hernández Martínez AM,Parra Pallarés S,Martínez Hernández P

    更新日期:2009-01-31 00:00:00

  • [The follow-up of the mobilization of circulating hematopoietic progenitor cells by granulocyte growth factor (G-CSF) using flow cytometry].

    abstract:BACKGROUND:The aim of the present study was to investigate the characteristics of the mobilization of hematopoietic precursor cells CD34+ in peripheral blood following stimulation with recombinant granulocytic colony stimulating factor (G-CSF). METHODS:Fourteen patients (10 males, 4 females: mean age 33 years; range 1...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: De Arriba F,Ortuño F,Rivera J,Heras I,Funes C,Moraleda JM,Vicente V

    更新日期:1995-01-21 00:00:00

  • [Global therapy of diabetic dyslipidemia: benefits and new therapeutic approaches].

    abstract::Diabetic dyslipidemia, characterized by the lipid triad (elevated plasma triglycerides, low HDL cholesterol and predominance of small, dense LDL particles), is a significant contributor to the elevated cardiovascular risk of type 2 diabetic patients. Statin monotherapy has shown, in different prospective trials, signi...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审


    authors: Carmena R,Ascaso JF

    更新日期:2010-04-03 00:00:00

  • [Acute myocardial infarction of the right ventricle: hemodynamic and electrocardiographic correlation (author's transl)].

    abstract::The electrocardiogram as a diagnostic aid in acute myocardial infarction of the right ventricle (AMI-RV) was studied prospectively in a group of 66 patients in our coronary unit. Diagnosis was AMI in all cases, divided into 29 (44%) with posterior-descending and 35 (53%) with anterior location. Electrocardiography was...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Fiol Sala M,Jaume Tomás G,Orellana Mas J,Ibáñez Juvé J,Guardiola Navarro F,García Moris S

    更新日期:1981-09-25 00:00:00

  • [Sociosanitary impact on patients with rare diseases (ERES study)].

    abstract:BACKGROUND AND OBJECTIVE:The impact and burden of disease of the rare diseases (RD) is not known, also the type of disability that entail. The objective of the work is to analyze the socio-sanitary impact of the RD in Spain. PATIENTS AND METHOD:This is a nationwide study. The dimensions used were mobility, personal ca...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Avellaneda Fernández A,Layola M,Izquierdo Martínez M,Guilera M,Badia Llach X,Ramón JR

    更新日期:2007-11-10 00:00:00

  • [Morbidity, mortality and the potential years of life lost attributable to tobacco].

    abstract:BACKGROUND:The aim of this study was to evaluate the morbidity and mortality attributable to smoking. MATERIAL AND METHODS:A transversal study was performed in a reference population of residents of the province of Granada (Spain). The number of deaths in 1985, the number of patients admitted to public hospitals in 19...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Rodríguez Tapioles R,Bueno Cavanillas A,Pueyos Sánchez A,Espigares García M,Martínez González MA,Gálvez Vargas R

    更新日期:1997-02-01 00:00:00

  • ["Stroke code". Shortening the delay in reperfusion treatment of acute ischemic stroke].

    abstract:BACKGROUND:"Stroke Code" is a system for the rapid identification, pre-notification and transport of acute ischemic stroke patients. The objective of this study was to evaluate the impact of delay reduction for thrombolytic therapy in these patients. SUBJECTS AND METHODS:We evaluated acute ischemic stroke patients adm...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Alvarez Sabín J,Molina C,Abilleira S,Montaner J,García F,Alijotas J

    更新日期:1999-10-23 00:00:00

  • [Scientific evidence of the mediterranean diet effects in determining intermediate and final cardiovascular disease phenotypes].

    abstract::The follow-up of the Mediterranean Diet (MD) has been associated with lower mortality and morbidity from cardiovascular diseases. However, it is important to evaluate the scientific evidence provided by published articles. Therefore, in order to analyze the literature on the overall effects of MD on intermediate and f...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审


    authors: Sotos-Prieto M,Zulet MA,Corella D

    更新日期:2010-01-23 00:00:00

  • [Evolution of serologically confirmed cases of mumps in the Madrid community, Spain, during a period of 7 years (2000--2006)].

    abstract:BACKGROUND AND OBJECTIVE:The aim of this study was to describe the evolution of serologically confirmed cases of mumps in the Madrid Community from 2000 to 2006. PATIENTS AND METHOD:Cases with data about age, sex and with samples obtained < or = 30 days after the onset of symptoms were included. IgM determination was ...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Sanz JC,de Ory F,Fernández M,Herranz N,Méndez N,Ramírez R

    更新日期:2008-03-08 00:00:00

  • [Role of cardiac magnetic resonance in cardiac involvement of Fabry disease].

    abstract:BACKGROUND AND OBJECTIVES:Fabry disease is a hereditary disorder. Clinical manifestations are multisystemic. The majority of the patients remain undiagnosed until late in life, when alterations could be irreversible. Early detection of cardiac symptoms is of major interest in Fabry's disease (FD) in order to gain acces...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Serra VM,Barba MA,Torrá R,Pérez De Isla L,López M,Calli A,Feltes G,Torras J,Valverde V,Zamorano JL

    更新日期:2010-09-04 00:00:00

  • [An analysis of the cardiovascular maneuvers for the diagnosis of cardiovascular autonomic neuropathy].

    abstract::Fifteen reflex tests for the diagnosis of cardiovascular autonomic neuropathy (CAN) were evaluated in 90 controls and 154 diabetic patients. We found that age, baseline heart rate and body position differently influenced the tests. The best parasympathetic indexes were Valsalva, inspiration minus expiration (I-E) and ...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Sánchez Luis A,Vázquez García JA

    更新日期:1990-09-29 00:00:00

  • [Design, implementation and evaluation of a management model of patient safety in hospitals in Catalonia, Spain].

    abstract::Since its inception in 2006, the Alliance for Patient Safety in Catalonia has played a major role in promoting and shaping a series of projects related to the strategy of the Ministry of Health, Social Services and Equality, for improving patient safety. One such project was the creation of functional units or committ...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Saura RM,Moreno P,Vallejo P,Oliva G,Alava F,Esquerra M,Davins J,Vallès R,Bañeres J

    更新日期:2014-07-01 00:00:00

  • [Dysbaric accident in deep sea fishing].

    abstract::The case of a dysbaric accident with occurred in a professional athlete during a national competition is herein reported. The clinical symptoms and response to treatment in a depressurization chamber in addition to CT controls should alert physicians in coastal areas in which this sport is carried out in order to take...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: López Oblaré B,Campos Pascual F

    更新日期:1995-05-20 00:00:00

  • [Influenza vaccination and mortality in the elderly].

    abstract:BACKGROUND AND OBJECTIVE:Though there is a general agreement on the need of influenza vaccination (IV), very different results have been published about the magnitude of its effect. We evaluated the effectiveness of IV in the reduction of mortality in individuals over 65 years of age. PATIENTS AND METHOD:Prospective c...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Vila-Córcoles A,Ochoa-Gondar O,Ansa-Echeverría X,Gómez-Sorribes A,Espelt-Aluja P,Pascual-Morón I

    更新日期:2005-11-19 00:00:00

  • [Uveitis as initial manifestation of sarcoidosis: study of 31 patients].

    abstract:BACKGROUND AND OBJECTIVE:Our goal was to analyze the epidemiological and clinical findings, as well as the diagnostic approach in a group of patients in whom uveitis was the first manifestation of sarcoidosis. PATIENTS AND METHOD:Retrospective study (between March 1998 and July 2002) including 31 patients diagnosed wi...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Adán A,Baget M,De Llobet JM,Segura A,Marieges MT,Casaroli-Marano R

    更新日期:2004-05-22 00:00:00

  • Type 1 autoimmune hepatitis in a patient with microscopic polyangiitis: challenges in diagnosis and treatment.

    abstract:BACKGROUND AND OBJECTIVE:Autoimmune diseases/autoantibodies tend sometimes to cumulate in the same individual, probably as a consequence of defects in immune regulation with breakdown of self-tolerance. Autoimmune hepatitis and microscopic polyangiitis have been occasionally reported with other autoimmune diseases, but...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Prieto-González S,Cardellach F,Estruch R,Miquel R,Grau JM,Cid MC

    更新日期:2011-03-26 00:00:00

  • [Cardiovascular risk factors in overweight and obesity. Changes after a weight loss treatment].

    abstract:BACKGROUND AND OBJECTIVE:For the treatment of obesity, an adecuate control of associated cardiovascular risk factors (CRF) is fundamental. The objective of this study was to assess the relationship between body mass index (BMI) and CRF, and the effect of a weight loss program on overweight subjects. PATIENTS AND METHO...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Bautista-Castaño I,Molina-Cabrillana J,Montoya-Alonso JA,Serra-Majem L

    更新日期:2003-10-18 00:00:00

  • [The health of men and women in Catalonia, Spain. Are changes occurring?].

    abstract::The aim of this work is to show the changes observed in the health profile according to gender in 2006 with respect to 1994 of the population of Catalonia, through the comparison of data obtained in 1994 and 2006 from the Encuesta de Salud de Cataluña. The increase of the level of studies of the population has tended ...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Medina-Bustos A,Mompart-Penina A,Brugulat-Guiteras P,Baranda-Areta L,Costa-Sampere D,Séculi-Sánchez E

    更新日期:2011-12-01 00:00:00

  • [Cystatin C: a protein for heart failure].

    abstract::Cystatin C (CysC) is an antiprotease useful for measuring kidney function. Beyond such property, it carries significant prognostic information in several fields of cardiovascular diseases. We review data that support CysC as a prognostic factor in cardiovascular diseases among healthy elderly, hypertensive and heart f...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审


    authors: Pérez-Calvo JI,Morales Rull JL,Ruiz Ruiz FJ

    更新日期:2011-02-19 00:00:00

  • [Determinants associated wtih the presence of risk behaviors in HIV infected patients].

    abstract:BACKGROUND:Determinants associated with risk behaviours are evaluated in a known HIV-infected population not belonging to the great metropolitan nuclei. PATIENTS AND METHODS:110 unselected HIV+ patients were interviewed, including 77 variables. Their association with sharing needles, and unprotected sex is analysed. ...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Llibre JM,Bolibar I,Bleda MJ,Fábregas N,Martínez M,Juanhuix A

    更新日期:1999-04-24 00:00:00

  • [Correlative urinary excretion of sodium-uric acid in hyperuricemia (author's transl)].

    abstract::Since uricosuria is an essential compensative factor in hyperuricemia, multiple factors exist which can influence on the uric acid excretion in the tubules. Normally, 90% of the uric acid filtered by the glomerulus is reabsorbed, and its active tubular secretion forms the greater part of the uric acid present in the u...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Pérez Ortolá R,Picardo NG,Sánchez Palacios A

    更新日期:1980-02-10 00:00:00

  • [Deep venous thrombosis associated with necrotizing vasculitis].

    abstract::The association of deep vein thrombosis with systemic necrotizing vasculitis is infrequent. Herein are referred two patients with microscopic polyarteritis and one patient with overlap syndrome who developed deep vein thrombosis which complicated in two cases with pulmonary embolism. The clinical features and the path...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Cofán F,Serra A,Teixidó J,Bonet J,Bonal J,Lauzurica R,Romero R,Monreal M,Caralps A

    更新日期:1993-12-11 00:00:00

  • [The perception of improvement in asthma].

    abstract:BACKGROUND:The capacity of stable asthma patients to recognize the presence of air flow obstruction, treatment improvement and daily variations was studied. METHODS:Placebo and 500 micrograms of inhaled terbutaline for two consecutive days were administered to 39 patients. The subjective impressions were compared with...

    journal_title:Medicina clinica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Heredia JL,Rodríguez M,Quintana S,Mir I,Viñas C,Gómez L

    更新日期:1995-11-11 00:00:00

  • [Merkel cell cancer of the skin: population-based incidence and survival, 1995-2005].

    abstract:BACKGROUND AND OBJECTIVE:We aimed to assess the population-based incidence and survival of primary Merkel cell carcinoma. MATERIAL AND METHOD:From January 1995 to December 2005, 19 patients diagnosed with primary Merkel cell carcinoma were recruited in the population-based Cancer Registry of Girona. RESULTS:The age-a...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Vilar-Coromina N,Pérez Bueno F,Alsina Maqueda M,Vilardell Gil L,Izquierdo Font A,Marcos-Gragera R

    更新日期:2009-05-16 00:00:00

  • [The ''neighbourhood health'' strategy: actions focused on areas with special social and health needs].

    abstract::Through the Law 2/2004 on improving neighbourhoods, urban areas and towns requiring special attention, the Government of Catalonia set up a fund for financing projects prepared by town/city councils for the integral improvement of neighbourhoods. The Ministry of Health signed on to the strategy with The Neighbourhood ...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Sierra I,Cabezas C,Brugulat P,Mompart A

    更新日期:2008-12-01 00:00:00

  • Left endocarditis, changes in the new millennium.

    abstract:INTRODUCTION:a description of infective left endocarditis at the turn of the millennium. METHOD:A multicentre prospective study into the left endocarditis using data collected from the Andalusian cohort for the study of cardiovascular infections during 1984-2014. RESULTS:Of the 1,604 endocarditis cases collected, 382...

    journal_title:Medicina clinica

    pub_type: 杂志文章,多中心研究


    authors: Noureddine-López M,de la Torre-Lima J,Ruiz-Morales J,Gálvez-Acebal J,Hidalgo-Tenorio C,de Alarcón González CA,por el Grupo para el Estudio de las Infecciones Cardiovasculares de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI).

    更新日期:2019-07-19 00:00:00

  • [Carbapenem and multidrug-resistant Acinetobacter baumannii colonisation/infection: epidemiology and factors associated with infection].

    abstract:BACKGROUND AND OBJECTIVE:To study an outbreak of nosocomial colonisation/infection due to multidrug and carbapenem resistant A. baumannii (ABMDR-C). PATIENTS AND METHODS:Prospective study of patients with ABMDR-C colonisation/infection (January 2007-June 2008). Epidemiological and clinical variables and predictors of ...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Hernández-Torres A,García-Vázquez E,Gómez J,Canteras M,Ruiz J,Fernández-Rufete A,Herreroa JA,Yagüe G

    更新日期:2010-09-18 00:00:00

  • [The introduction of liquid oxygen as a portable source in continuous home oxygen therapy].

    abstract::The most widespread types of oxygen delivery at home in our area are bottles where the gas is stored under pressure and concentrators. Both devices can only be used at rest. We have assessed a new system for the delivery of liquid oxygen to be used at home, provided with a portable unit which permits that the patients...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Estopà R,Escarrabill J,Barbé F,Monasterio C,Manresa F

    更新日期:1990-11-10 00:00:00

  • [Appropriateness of admissions to an internal medicine service at a tertiary hospital].

    abstract::In the present study, clinical, epidemiological and management factors influencing the appropriateness of the 1076 admissions to a general Internal Medicine Section during one year are evaluated. 184 admissions (17%) corresponded to patients who did not meet the AEP (Appropriateness Evaluation Protocol) criteria for a...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Matorras Galán P,de Pablo Casas M,Otero García L,Alonso López F,Daroca Pérez R,Díaz-Caneja Rodríguez N

    更新日期:1990-03-03 00:00:00

  • [Acute lymphoblastic leukemia in adults. Comparative study of clinicobiologic characteristics and of response to treatment in terms of age in a group of 41 patients].

    abstract:BACKGROUND:The aim of this study was to analyze the influence of age on the clinical and biological features as well as the results of treatment in 41 adult patients with acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS:The patients diagnosed with ALL from January 1989 to October 1995 in a single center were s...

    journal_title:Medicina clinica

    pub_type: 杂志文章


    authors: Ribera JM,Granada I,Navarro JT,Vela D,Juncá J,Flores A,Millá F,Feliu E

    更新日期:1996-10-05 00:00:00