Abstract:
BACKGROUND AND OBJECTIVE:Although constipation affects quality of life, questionnaires hardly exist for its evaluation. We aimed to develop and validate a questionnaire able to measure the quality of life in patients with constipation. PATIENTS AND METHOD:A Spanish multicenter study was performed in 2 stages: a) questionnaire development (open interview to patients with constipation, pilot questionnaire, quantitative and factorial analysis, Rasch analysis, and specific questionnaire design), and b) questionnaire validation in 136 patients. These patients were divided in 2 groups: a) reliability group (n = 55; no need to begin or change treatment; re-tested after 15 days), and b) sensibility to change group (n = 81; need to begin or change treatment; re-tested after 3 months). We collected clinical and socio-demographic data and we evaluated the quality of life through the general questionnaire EuroQoL-5D (EQ-5D) and the specific one, design in the previous stage (25 items). After that, we analysed feasibility, reliability and validity (of content, convergent and longitudinal). RESULTS:The trial questionnaire was obtained during the development stage and the results were 51 items that were later reduced to 25 in the validation stage. A total of 126 patients (93% women; mean age [standard deviation]: 43.4 [1] years) completed the study properly. The answer average time was 12 min. The content validity process reduced the questionnaire to 20 items (CVE-20) within 4 domains: emotional, general physical, rectal physical and social. The reliability was good in relation to the general punctuation (Cronbach alpha coefficient = 0.87), being in the different domains of 0.79, 0.73, 0.75 and 0.60, respectively. The construct validity showed a good correlation between the CVE-20 results and constipation severity. The CVE-20 score positively correlated with EQ -5D changes. The test and re-test reliability were good: interclass correlation coefficient = 0.89 (ranging from 0.80 to 0.88 in the different domains). The clinically relevant and minimal difference was 17 points (95% confidence interval, 11-23). The content validity showed a strong correlation between CVE-20 and constipation severity. CONCLUSIONS:The CVE-20 is the first specific questionnaire in Spanish language for constipated patients; it is valid, reliable, sensitive to changes and it meets the psychometric requirements to be applied in daily practice and clinical trials.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Perona M,Mearin F,Guilera M,Mínguez M,Ortiz V,Montoro M,Serra J,Casanova C,Rey E,Alarcón O,Bujanda L,Lima A,Andreu M,Castro M,López A,Carrillo R,Sempere L,Badia X,Study group on functional gastrointestinal disorders fdoi
10.1016/s0025-7753(08)72285-1subject
Has Abstractpub_date
2008-09-27 00:00:00pages
371-7issue
10eissn
0025-7753issn
1578-8989pii
S0025-7753(08)72285-1journal_volume
131pub_type
杂志文章,多中心研究相关文献
MEDICINA CLINICA文献大全abstract:BACKGROUND:Hypertension and dyslipemia are associated with a greater frequency than that randomly expected. The increase in insulinic resistance hyperinsulinemia is one of the factors implicated in the pathogenesis of this association. In the present study the lipid profile of hypertensive patients is analyzed accordin...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1994-09-10 00:00:00
abstract:BACKGROUND:To assess how patients with diabetes experience their condition. PATIENTS AND METHOD:Pilot study conducted in 10 selected patients with type 1 diabetes. A structured interview guide was prepared including physical, social and emotional areas. The information provided was analyzed qualitatively, key statemen...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis with renal involvement are associated with high morbi-mortality. In this study we analyse if the prognosis of these diseases have improved in recent years, and which factors influence the outcomes. MATERIAL AND METHODS:Retrospective sin...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2016.09.015
更新日期:2017-01-06 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The association between the presence of the allele APOE*epsilon4 (apolipoprotein E) and sporadic Alzheimer disease (AD) has been long established. However, the possible influence of other genetic factors is still under debate. This study investigated the role of the a 1-antichymotrypsin (ACT) g...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(04)74479-6
更新日期:2004-09-04 00:00:00
abstract::Several heritable disorders of glucose transport across cellular membranes have been recently characterized both genetically and pathophysiologically. Diseases such as glucose-galactose malabsorption, Fanconi-Bickel syndrome and GLUT1 deficiency syndrome are caused by mutation of transporters located in bowel, liver a...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13095099
更新日期:2006-11-11 00:00:00
abstract::The gastric emptying of solids was evaluated with radionuclide techniques in 16 patients with reflux esophagitis, demonstrated by two of the following methods: endoscopy, pathology, and/or pH measurement. The percentage of radionuclide remaining within the stomach was 80.8 +/- 17% after 45 minutes, 63.3 +/- 10% after ...
journal_title:Medicina clinica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-09-30 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Several models for the prediction of liver fibrosis have been developed which consist of the measurement of routine laboratory data: a) a model combining platelets, gamma-glutamil-transpeptidase, cholesterol and age (Forns model), and b) a model using an aspartate-aminotransferase to platelet r...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13075845
更新日期:2005-05-28 00:00:00
abstract:BACKGROUND:Whether or not performing cardiopulmonary resuscitation (CPR) is a complex decision that requires taking account of several factors. The aim of this study was to analyse the preferences of elderly people with regard to CPR. SUBJECTS AND METHOD:Survey administered to 181 elderly subjects from nursing homes a...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(02)72296-3
更新日期:2002-02-02 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The pprevalence of extended-spectrum beta-lactamase (ESBL) producing gram-negative bacilli has increased in recent years. The aim of this study is to estimate the prevalence of infection/colonization due to theses microorganisms per 100 admissions and its trend during the period 2007-2010. PAT...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2012.03.034
更新日期:2013-07-07 00:00:00
abstract:BACKGROUND:There is poor information for isolated clinical tachycardia (ICT), that is to say, office tachycardia but normal ambulatory heart rate (HR). Our objective was to describe it and to know differences between hypertensive subjects with and without ICT. PATIENTS AND METHOD:Comparative study after a diagnostic i...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(00)71627-7
更新日期:2000-11-04 00:00:00
abstract::The use of physical and pharmacological restraint is controversial but is currently accepted as inevitable. It is indicated for controlling behavioral disorders and psychomotor agitation that put patients and third parties at risk. Its indication should be medical, and we should opt for the least restrictive measure. ...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/S0025-7753(14)70068-5
更新日期:2014-03-01 00:00:00
abstract::Pseudomonas infections continue to be an important problem in the hospital environment. Serious infections are always invariably associated with severe underlying conditions or with diminished host resistance. The increasingly resistance of strains and hospital epidemics favour the organism prevalence. During 1978, Ps...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1980-07-15 00:00:00
abstract::The most widespread types of oxygen delivery at home in our area are bottles where the gas is stored under pressure and concentrators. Both devices can only be used at rest. We have assessed a new system for the delivery of liquid oxygen to be used at home, provided with a portable unit which permits that the patients...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1990-11-10 00:00:00
abstract:BACKGROUND:To evaluate the evolution of the HIV infection in the drug addicts of Madrid. PATIENTS AND METHODS:Data of 2,234 patients that entered for the first time in a Psychiatric Hospital Detoxication Unit of Madrid from October 1985 to december 1996 were recorded. RESULTS:There was a reduction of the percentage o...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1998-09-12 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Common laboratory parameters are crucial in aiding coronavirus disease 2019 (COVID-19) case detection. This study aimed to determine the differences between laboratory parameters in (1) COVID-19 versus non-COVID-19 pneumonia, and (2) severe versus non-severe COVID-19 cases. METHODS:Studies ...
journal_title:Medicina clinica
pub_type: 杂志文章,meta分析
doi:10.1016/j.medcli.2020.05.017
更新日期:2020-08-28 00:00:00
abstract::The presence of antibodies (Abs) against hepatitis C virus (HCV) was analyzed in 26 haemophiliac patients; a prevalence of 38% was found in the total series and 56% in the treated patients. There were no cases with a positive serology among the three patients who had only received pasteurized factor. The frequency of ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1991-01-26 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To determine the accuracy of clinical gestalt to identify patients with acute symptomatic pulmonary embolism (PE) at low-risk for short-term complications. PATIENTS AND METHODS:This study included a total of 154 consecutive patients diagnosed with acute symptomatic PE in a tertiary university ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2017.11.023
更新日期:2018-08-22 00:00:00
abstract:BACKGROUND:The sleep apnea syndrome (SAS) and high blood pressure (HBP) present multiple relations. Apnea culminates with an increase in arterial pressure, and a high percentage of apneic patients have HBP. It has also been reported that SAS is more frequent among hypertensive patients than among the general population...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1993-02-27 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To evaluate the adherence to the recommendations in clinical practice performed by the Therapeutic Positioning Report (TPR) of the Spanish Agency of Medicines and Sanitary Products about the treatment with oral anticoagulants in patients aged≥75 years old with nonvalvular atrial fibrillation (N...
journal_title:Medicina clinica
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medcli.2017.07.025
更新日期:2018-07-13 00:00:00
abstract:BACKGROUND:Advanced atrioventricular block (AB) during acute myocardial infarction (AMI), characterizes a high-risk subgroup of patients. Our aim was to determine the prognostic significance of AB and its possible peculiarities in relation to infarction localization and/or the thrombolytic therapy. PATIENTS AND METHOD...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(00)71282-6
更新日期:2000-03-11 00:00:00
abstract::In February 2014, the autonomous government in Catalonia, the Generalitat de Catalunya, approved the Catalan Public Health System Interdepartmental Plan (PINSAP, as per the Catalan acronym), responsible for the strategy in Catalonia for Health in All Policies, as recommended by the WHO and other international institut...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/S0025-7753(15)30036-1
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Our objective was to assess the frequency of fungal colonization and/or infection in critically ill patients admitted to intensive care units (ICUs) and to describe the characteristics and risk factors of those patients in whom fungi had been isolated. PATIENTS AND METHOD:Observational, multic...
journal_title:Medicina clinica
pub_type: 杂志文章,多中心研究
doi:10.1016/s0025-7753(03)73891-3
更新日期:2003-07-05 00:00:00
abstract:BACKGROUND:Incidence analysis of tuberculosis in a series of 562 patients with chronic myeloproliferative syndrome (CMPS). 344 had chronic myelocytic leukemia, 91 polycythemia vera, 70 idiopathic myelofibrosis and 57 essential thrombocythemia. METHODS:The association between CMPS and tuberculosis was evaluated with th...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1991-03-09 00:00:00
abstract:BACKGROUND AND OBJECTIVE:We aimed to evaluate the prognostic impact of the degree and time-point of arterial recanalization during the first 24h after tPA administration in patients with acute middle cerebral artery (MCA) occlusions. PATIENTS AND METHOD:We prospectively studied consecutive ischemic stroke patients tre...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2008.06.029
更新日期:2009-05-02 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To assess the safety and efficacy of insulin analogues versus human insulin in pregnant women with pregestational diabetes. PATIENTS AND METHODS:We collected data on pregnant women with type 1 or type 2 diabetes who were attended at the Diabetes and Pregnancy Unit between January 1998 and Apri...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2010.11.021
更新日期:2011-11-19 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Alcohol and drug dependent patients present a higher psychiatric comorbidity, which increases according to the number of drugs. Moreover, there are complications from the treatment and the prognosis is aggravated. We aimed to observe the differences regarding personality disorders (PD) and cogn...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13120771
更新日期:2008-05-17 00:00:00
abstract:BACKGROUND:To review the clinical findings of pancreatic tuberculosis and to establish a differential diagnosis with pancreatic tumours. PATIENTS AND METHODS:To describe three cases of pancreatic tuberculosis diagnosed in a 850 bed teaching hospital during the last two years. RESULTS:In the three case the imaging pro...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/s0025-7753(00)71592-2
更新日期:2000-10-14 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Although elder abuse is not a new phenomenon, it remains hidden. There have been carried out various preliminary studies about the prevalence of elder abuse in different countries. The aim of this study is to estimate the prevalence of suspicion of elder abuse in old persons without cognitive i...
journal_title:Medicina clinica
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medcli.2012.09.048
更新日期:2013-12-21 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To establish the factors associated with the presence of non-alcoholic fatty liver disease (NAFLD) and evaluate the influence of each component constituting the metabolic syndrome (MS) and the risk of developing NAFLD. PATIENTS AND METHODS:We performed a multicenter, population-based, observa...
journal_title:Medicina clinica
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medcli.2012.11.034
更新日期:2013-09-21 00:00:00
abstract:BACKGROUND:We determined the extent to which opportunities for prevention were missed among patients with tuberculosis and the costs derived from the lack of prevention. METHOD:Descriptive study of patients with active tuberculosis were studied in the hospital ward of tuberculosis at the A. Marcide-Novoa Santos Centre...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1997-06-07 00:00:00