[Influences of hyperinsulinemia in the lipid profile of hypertensive patients].

Abstract:

BACKGROUND:Hypertension and dyslipemia are associated with a greater frequency than that randomly expected. The increase in insulinic resistance hyperinsulinemia is one of the factors implicated in the pathogenesis of this association. In the present study the lipid profile of hypertensive patients is analyzed according to the degree of insulinemia. METHODS:The lipid profile (total cholesterol, fraction linked to low density lipoproteins cLDL, high density cHDL, triglycerides and plasma apolipoproteins A1 and B were determined in 87 patients with essential high blood pressure. Moreover an oral overdose of 75 g of glucose was administered with determinations of glycemia, insulinemia and C peptide at the time of glucose administration, 60 and 120 minutes. RESULTS:Upon separation of the hypertense patients into two groups according to the insulinemia achieved following an oral overload of glucose, those hypertensives with a greater degree of insulinemia showed a significant increase in triglycerides (p < 0.05) and also a significant decrease in cHDL (p < 0.001). The hypertensive patients with lower insulinemia showed a significant increase in total cholesterol (p < 0.05) and fraction linked to LDL although the latter was not significant. CONCLUSIONS:Two different lipid profiles may be observed in hypertensive patients: one linked to hyperinsulinemia and characterized by an increase in triglycerides and a decrease in cHDL and another with no relation with hyperinsulinemia which is manifested by an increase in total cholesterol and cholesterol transported by the LDL.

journal_name

Med Clin (Barc)

journal_title

Medicina clinica

authors

Villar J,Muñiz O,Stiefel P,Miranda M,Jiménez L,Montilla C,Martín-Sanz V,Carneado J

subject

Has Abstract

pub_date

1994-09-10 00:00:00

pages

241-5

issue

7

eissn

0025-7753

issn

1578-8989

journal_volume

103

pub_type

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    doi:

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    doi:

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  • [Effect of a hypocaloric diet in the oxidative stress in obese subjects without prescription of exercise and antioxidants].

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    doi:

    authors: Just M,Raventós A,Romeu J,Larrousse E,Santos J,Ojanguren I

    更新日期:1994-04-09 00:00:00

  • [Influenza vaccination and mortality in the elderly].

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    doi:

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  • [Sleep apnea in arterial hypertension].

    abstract:BACKGROUND:The sleep apnea syndrome (SAS) and high blood pressure (HBP) present multiple relations. Apnea culminates with an increase in arterial pressure, and a high percentage of apneic patients have HBP. It has also been reported that SAS is more frequent among hypertensive patients than among the general population...

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    更新日期:1993-02-27 00:00:00

  • [Emergency hospital admission in medical services: causes, justification, social factors, and their differences in function of age].

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    pub_type: 杂志文章

    doi:

    authors: González-Montalvo JI,Baztán JJ,Rodríguez-Mañas L,San Cristóbal E,Gato A,Ballesteros P,Salgado A

    更新日期:1994-10-15 00:00:00

  • [Usefulness of PSA and its fractions in the diagnosis of prostate cancer].

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    pub_type: 杂志文章

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    更新日期:2004-02-28 00:00:00

  • [Surveillance of nosocomial infection at a regional++ hospital. Results of incidence and prevalence studies in a 2 years' experience].

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    doi:

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    pub_type: 杂志文章

    doi:

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