Abstract：
BACKGROUND:This study investigated the burden (incidence, mortality and serotype distribution) of pneumococcal pneumonia among older adults in the region of Tarragona (Spain). METHODS:Population-based cohort study involving 27,204 individuals ≥60 years in Tarragonès county (Southern Catalonia), who were prospectively followed between 01/12/2008 and 30/11/2011. Bacteremic and nonbacteremic (positive sputum culture and/or urinary antigen test) pneumococcal pneumonias were recruited. RESULTS:A total of 125 pneumococcal pneumonias (16 bacteremic and 109 nonbacteremic) was observed. Incidence rates (per 1000 person-years) were 0.21 (95% confidence interval [CI]: 0.13-0.35) for bacteremic cases and 1.45 (95% CI: 1.20-1.75) for nonbacteremic cases. Case-fatality rate was 10.4% (12.5% in bacteremic and 10.1% in nonbacteremic cases). Five serotypes (types 3, 6C, 19A, 22F and 35B) were the most common serotypes, accounting for 64.3% of overall isolated serotypes. 73.1% of cases were due to the strains included in the 23-valent vaccine whereas 53.6% were due to the strains included in the 13-valent vaccine. CONCLUSION:The burden of pneumococcal pneumonia remains considerable (especially among oldest people and nursing-home residents) despite a publicly funded anti-pneumococcal vaccination program operative for several years.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Vila-Corcoles A,Ansa X,Ochoa-Gondar O,Satue E,de Diego C,Rodriguez-Blanco T,EPIVAC Research Team.doi
10.1016/j.medcli.2015.09.015subject
Has Abstractpub_date
2016-03-04 00:00:00pages
199-202issue
5eissn
0025-7753issn
1578-8989pii
S0025-7753(15)00566-7journal_volume
146pub_type
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