Abstract：
BACKGROUND AND OBJECTIVE:Obesity is characterized by a generalized increase of adipose tissue, high production of adipocytokines and presence of oxidative systemic stress. The objective of this study was to evaluate the changes generated in the oxidative stress and anthropometric parameters in obese subjects by the prescription of a hypocaloric diet in combination with moderate aerobic exercise and supplementation with antioxidants. PATIENTS AND METHODS:Oxidative damage was determined in the plasma from 30 normal weight and 30 obese subjects. Three groups of treatment were established: Hypocaloric diet (HD), HD plus moderate aerobic exercise (HDE) and HDE plus antioxidants (DHEA). Biomarkers of oxidative stress (thiobarbituric acid reactive substances [TBARS], carbonyl groups, dityrosine) and anthropometric parameters were determined. RESULTS:Higher values of biomarkers of oxidative damage were observed in obese (TBARS 13.74 ± 1.2 μM; carbonyl groups 0.89 ± 0.04 nmol of osazone/mg of protein; dityrosine 478.9 ± 27.4 RFU/mg of protein) in comparison to normal weight subjects (TBARS 7.08 ± 0.8 μM; carbonyl groups 0.65 ± 0.04 nmol of osazone/mg of protein; dityrosine 126.3 ± 12.6 RFU/mg of protein), thus showing the presence of an oxidative damage. The prescription of HD decreased the oxidative damage and anthropometric parameters in the obese subjects. We did not observe additional benefit effects on these determinations with HDE or HDEA treatments. CONCLUSIONS:We demonstrated that an HD decreases the oxidative damage in obese subjects. Oxidative stress is an important factor in the development of comorbidity in obesity. Therefore, the prescription of a HD could be a key issue in the treatment of the disease.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Gutiérrez L,García JR,Rincón Mde J,Ceballos GM,Olivares IMdoi
10.1016/j.medcli.2013.12.015subject
Has Abstractpub_date
2015-07-06 00:00:00pages
1-6issue
1eissn
0025-7753issn
1578-8989pii
S0025-7753(14)00083-9journal_volume
145pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：:We report the case of a female aged 67 years suffering a Waldenström's macroglobulinemia which began with arthritis at the knee and pleural effusion. In both locations the anatomopathological examination showed infiltration by typical lympho-plasmatic cells. Other possible etiologies such as amyloid, infection or arth...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1990-10-27 00:00:00
abstract：:In the present article we describe the activity of the admissions service on the day of the terrorist attacks, 11 March, 2004. Firstly, we try to describe the objectives and lines of intervention that we believe should be covered by our service. Subsequently, we describe how we organized ourselves into teams in order ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13072650
更新日期：2005-03-01 00:00:00
abstract：:Clinical journals often publish economic evaluation studies of health technologies and programs. To improve the peer review process and, hence, the quality and validity of published studies, the British Medical Journal (BMJ) established publication guidelines for the publication of economic evaluations aimed at author...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(05)72212-0
更新日期：2005-12-01 00:00:00
abstract：:Dissecting aneurysm of the aorta keeps on being nowadays a diagnostic problem, although it is a well known entity. Dissecting aneurysms may be classified into type A, dissection involving the ascending aorta, and type B, dissection involving descending aorta. The frequency of neurologic manifestations oscillates from ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：BACKGROUND:The Kveim-Siltzbach test has been widely used in the diagnosis of sarcoidosis. This reactive is currently available in the authors' hospitals. Previous experience with this test in the same centers was reviewed to know its diagnostic usefulness. The present is the first series described in Spain. METHODS:Fr...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-05-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The REACH Registry is the largest worldwide designed to obtain information on cardiovascular risk factor control and preventive treatment in a population who have, or are at risk of having, symptoms of atherothrombosis. The objective of this study is to show the results of cardiovascular events...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2008.11.033
更新日期：2009-04-18 00:00:00
abstract：INTRODUCTION:Recently diagnosis of latent tuberculosis infection (LTBI) can be made using the tuberculin skin test (TST) or by techniques known as interferon-γ release assays (IGRAS), being QuantiFERON(®)-TB Gold In-Tube (QF-G-IT) the most used. The IGRAS avoid some drawbacks of the TST, especially cross-reaction with ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2014.11.027
更新日期：2015-11-20 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To ascertain if a bilaterally lung transplanted patient can climb a mountain higher than 4,000 metres and to compare the evolution of his physiological parameters during the ascent with those of healthy mountaineers. SUBJECTS AND METHOD:Heart rate, blood pressure, arterial oxygen saturation (S...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(07)72845-2
更新日期：2007-09-15 00:00:00
abstract：:Bacterial vaginosis is a widely spread health problem with multiple connotations. It has been the subject of many studies and work during decades and it still remains a polemic entity, with contradictory finding. The polymicrobian etiology, unsolved epidemiology, obstetrico-gynecological complications and high recurre...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2008.11.043
更新日期：2009-11-28 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Forced respiratory volume in first second spirometry is currently used to diagnose chronic obstructive pulmonary disease. However, this technique does not always provide a reliable short-term prognosis, especially in patients with associated morbidity. We propose that specific health-related qu...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13058683
更新日期：2004-03-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Left ventricular hypertrophy (LVH) is the most frequent manifestation of cardiac damage in hypertension. The objective of this study was to evaluate the prevalence of LVH in hypertensive patients of long evolution at Primary Care (PC) and to describe their epidemiological profile. PATIENTS AND...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1157/13106936
更新日期：2007-06-09 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Sense of Coherence (SOC) is a construct relating to coping strategies in the face of traumatic events. SOC is defined as a personal disposition towards perceiving life experiences as understandable, manageable and meaningful. The construct has shown itself to be a predictor of self-reported and...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13100935
更新日期：2007-04-07 00:00:00
abstract：BACKGROUND:Given that Lyme's disease and HIV infection may present with similar clinical symptoms and that the serologic tests for the determination of antibodies against Borrelia burgdorferi present frequent false positives, the presence of antibodies against B. burgdorferi in patients with HIV in different evolutive ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-07-03 00:00:00
abstract：:Cephotaxime (HR 756) is a new cephalosporin antibiotic of wide spectrum and extraordinary activity, suitable for parenteral administration. It is highly resistant to the beta-lactamases of Gram negative bacilli, being thus especially active against microorganisms such as indole-positive Proteus, Serratia marcencens, a...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-11-25 00:00:00
abstract：BACKGROUND:Bone mineral density (BMD) has been related with age, hormonal status, body mass index (BMI) and life style. We have evaluated the influence of these factors on BMD in healthy women, without risk factors for osteoporosis, using ultrasound measures. PATIENTS AND METHODS:We have selected 255 women (136 premen...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-09-18 00:00:00
abstract：:The aim of a case-control design is to make a measurement of the highest possible accuracy, reducing to a minimum the possible selection, information and confusion biases. The design, methods and procedures of a multicentric study carried out in 14 hospitals from 4 autonomous communities in Spain are discussed. Overal...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1989-05-06 00:00:00
abstract：:A case of rapidly progressive glomerular disease with 100% of epithelial crescents completely enveloping each glomerulus, prolonged anuria and renal failure requiring dialysis. There were no indications of either streptococcal etiology or systemic disease. Improvement in renal function in response to plasmapheresis an...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-06-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We aimed to know the prevalence of classical cardiovascular risk factors, hyperinsulinism, insulin resistance and metabolic syndrome (MS) in a population with coronary heart disease (CHD) as compared with a population without personal or familial history of cardiovascular risk factors. SUBJECT...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(03)73907-4
更新日期：2003-07-12 00:00:00
abstract：FOUNDATIONS AND AIM:The aim of this study is to analyze the CHADS2 score as a marker of the risk of mortality in hypertensive patients, with and without the presence of atrial fibrillation. METHODS:We included 1,003 hypertensive patients≥65 years. Risk factors, and CHADS2 score were recorded among other factors, as we...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2016.03.015
更新日期：2016-06-03 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Primary biliary cirrhosis (PBC) is associated to any systemic autoimmune disease (SAD), in particular systemic sclerosis (SSc). To investigate the prevalence of SAD in a cohort of patients with PBC, specifically the prevalence of SSc and its clinical subtypes, and determining the clinical and ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2015.02.026
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aims of the present study were to analyze the prognosis after resuscitation from out-of-hospital sudden cardiac death in patients admitted to the coronary care unit, and to identify the predictor variables of morbi-mortality. PATIENTS AND METHOD:From November 1999 to January 2004 we analyz...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(06)72232-1
更新日期：2006-09-02 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate the management of phenylketonuria (PKU) in Spanish metabolic units and to develop a patients registry. PATIENTS AND METHODS:PKU patients diagnosed and/or followed up in Spain, with phenylalanine values before treatment > 360 μmol/L. Registered anonymous data are those yielded by th...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2011.03.037
更新日期：2012-03-03 00:00:00
abstract：:We discuss different interpretations of the term poison as well as the need of bringing up to date the changes in this matter according to the science progress. A clear and exact definition is proposed after analysing the factors that affect the relativity of the concept and its boundaries. The proposal for a definiti...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2011.02.002
更新日期：2012-02-18 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Strategies to improve the efficiency of bronchoalveolar lavage (BAL) are needed. We conducted a study to establish the diagnostic value of BAL in patients with hematological malignancies and pulmonary infiltrates. PATIENTS AND METHODS:The correlation of cytologic and flow cytometric study of ...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章
doi：10.1016/j.medcli.2016.10.045
更新日期：2017-04-07 00:00:00
abstract：BACKGROUND:In this study the prescription of drugs in an outpatients geriatric population was evaluated in terms of age and body weight. METHODS:From a wide survey carried out on 500 geriatric outpatients, all the prescriptions corresponding to H-2 antagonists, digoxin, theophylline, bromazepam, diazepam, lorazepam an...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-03-07 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of this study was to describe an outbreak of Q fever in a group of people (day care centre for mental-handicapped individuals) previously exposed to animals in a school-farm. PATIENTS AND METHOD:A retrospective cohort study among the 25 mental-handicapped individuals and the 30 workers...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13087697
更新日期：2006-04-22 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The Chronic Kidney Disease Epidemiology Collaboration (CDK-EPI) equation has been proposed as a replacement for the Modification of Diet in Renal Disease (MDRD) equation to estimate the glomerular filtration rate, but this equation has not yet been evaluated in the general population. PATIENTS...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2009.07.055
更新日期：2010-05-15 00:00:00
abstract：BACKGROUND:Cerebrovascular disease has particular features in young adults (15-45 years). In this context, non-traumatic intracranial hematoma (NTICH) has received little attention. Therefore, its analysis has been attempted focusing on etiology, localization and short term prognosis. METHODS:42 patients aged 15-45 ye...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-11-30 00:00:00
abstract：:Several heritable disorders of glucose transport across cellular membranes have been recently characterized both genetically and pathophysiologically. Diseases such as glucose-galactose malabsorption, Fanconi-Bickel syndrome and GLUT1 deficiency syndrome are caused by mutation of transporters located in bowel, liver a...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13095099
更新日期：2006-11-11 00:00:00
abstract：BACKGROUND:The prognosis of sarcoidosis is difficult to predict. In general, sarcoidosis is considered as chronic when it remains active for over 2 years. The aim of this study was to analyze predictive factors in the persistence of sarcoidosis activity 2 years after diagnosis. METHODS:One hundred fifty-five patients ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-12-07 00:00:00
