Abstract：
BACKGROUND AND OBJECTIVES:Primary biliary cirrhosis (PBC) is associated to any systemic autoimmune disease (SAD), in particular systemic sclerosis (SSc). To investigate the prevalence of SAD in a cohort of patients with PBC, specifically the prevalence of SSc and its clinical subtypes, and determining the clinical and biological profile of patients with associated PBC and SSc. METHODS:Observational study of 62 patients with PBC following a protocol that included an anamnesis and physical examination to detect the presence of SAD as well as a nailfold capillaroscopy and an immunological study with specific SSc autoantibodies. A comparative analysis was conducted between patients with isolated PBC and patients with PBC and an associated SAD. RESULTS:SAD was associated to PBC in 22 patients (35,4%), and SSc was the most frequent illness, identified in 13 cases (21%). Five patients (8%) without previous diagnosis of SAD fulfilled pre-scleroderma criteria, according to LeRoy and Medsger criteria. The presence of anticentromere antibodies (54,5% vs. 5%, P<.001) was the unique immunological determination identified more frequently in patients with PBC-SAD. The SSc suggestive capillary pattern was visualized in 11 patients (20,4%), mainly the slow pattern. No factors associated with greater morbi-mortality were identified in the PBC-SAD group. CONCLUSIONS:It does exist a subgroup of patients with PBC and clinical-biological features suggestive of an SAD, which advise a protocolized study to detect early the association to an SAD.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Marí-Alfonso B,Amengual-Guedan MJ,Vergara-Gómez M,Simeón-Aznar CP,Fonollosa-Plà V,Jove-Buxeda E,Oliva-Morera J,Tolosa-Vilella Cdoi
10.1016/j.medcli.2015.02.026subject
Has Abstractpub_date
2016-01-01 00:00:00pages
8-15issue
1eissn
0025-7753issn
1578-8989pii
S0025-7753(15)00191-8journal_volume
146pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND AND OBJECTIVE:The aim of the present study was to investigate the factors influencing CRP serum levels in the diabetic population. PATIENTS AND METHOD:Eighty-six patients with type 2 diabetes mellitus were prospectively included. The following variables were considered: age, gender, smoking habit, body mass...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13072422
更新日期：2005-03-12 00:00:00
abstract：:Uterine fibroids are the most common benign tumours that affect women of reproductive age and they represent the main indication for surgery for benign uterine pathology. In 25% of cases, they become clinically apparent, causing heavy menstrual bleeding, pelvic pain and/or infertility. Therefore, fibroids have a notab...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(13)70045-9
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:A low folic acid (FA) intake may increase the risk of neural tube defects (NTD). We estimated the proportion of women with a FA intake < 400 micrograms/day, at the Valencian Region, exploring those factors associated with a FA intake < 400 micrograms/day. SUBJECTS AND METHOD:Daily FA intake was estimated fo...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71316-9
更新日期：2000-03-25 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Anxiety and depression are common among medical inpatients. While their relation to the severity of illness is often discussed, the feeling of such severity by the patient and his/her prospects of improvement can be influenced by anxiety and depression. PATIENTS AND METHOD:Patients admitted in...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2003-03-22 00:00:00
abstract：BACKGROUND:Advanced atrioventricular block (AB) during acute myocardial infarction (AMI), characterizes a high-risk subgroup of patients. Our aim was to determine the prognostic significance of AB and its possible peculiarities in relation to infarction localization and/or the thrombolytic therapy. PATIENTS AND METHOD...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71282-6
更新日期：2000-03-11 00:00:00
abstract：BACKGROUND:The aim of the present study was to follow for a year all the osteoporotic proximal femoral fractures that happened in the island of Gran Canaria during 1990 and to analyze: a) mortality; b) the degree of functional capacity; c) their destination after being attended from the fracture. METHODS:Personal inte...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-10-23 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Information about the prevalence of chronic kidney disease (CKD) in the population treated in primary care is scarce. The aim of this study was to assess the prevalence of CKD in Spanish hypertensive women aged 64 years or older, and to determine possible associated factors. PATIENTS AND METH...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2011.03.038
更新日期：2012-05-05 00:00:00
abstract：BACKGROUND AND OBJECTIVE:There is a bidirectional association between neoplasia and venous thromboembolism (VTE). However, whether this association has an impact in tumor recurrence is unknown. The aim of the study is to assess the incidence of cancer recurrence after diagnosis of VTE and determine if VTE could be a ma...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2009.04.054
更新日期：2009-10-17 00:00:00
abstract：:Tumor necrosis factor (TNF) alpha plays a central role in both the inflammatory response and that of the immune system. Thus, its blockade with the so-called anti-TNF agents (infliximab, etanercept and adalimumab) represents an important tool for the management of a variety of disorders, such as rheumatoid arthritis, ...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1157/13126958
更新日期：2008-10-11 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Endoscopy is the gold standard to assess disease severity in inflammatory bowel disease, although it is an invasive procedure. Clinical activity and biological markers have been routinely used to determine disease activity in a non-invasive manner. The aim of this study was to determine concor...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.09.047
更新日期：2015-01-06 00:00:00
abstract：:Hereditary angioedema (HAE) is due to a deficit of the C1 inhibitor (C1 INH) of a dominant autosomic inheritance. Seven patients are presented from a family with HAE, four of whom with poor prognosis due to the frequency and site of the angioedema. Prophylaxis was obtained with long-term danazol since antifibrinolytic...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-03-14 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Since World Health Organization (WHO) recommends brief interventions for smoking cessation to be included systematically in daily practise as a part of clinical work, the main aim of this study is to know if this intervention is done by health professionals working in hospital wards in a genera...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13106128
更新日期：2007-05-19 00:00:00
abstract：BACKGROUND:To review the clinical findings of pancreatic tuberculosis and to establish a differential diagnosis with pancreatic tumours. PATIENTS AND METHODS:To describe three cases of pancreatic tuberculosis diagnosed in a 850 bed teaching hospital during the last two years. RESULTS:In the three case the imaging pro...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/s0025-7753(00)71592-2
更新日期：2000-10-14 00:00:00
abstract：:Calcified aortic valve disease (CAVD) is a prevalent condition, affecting 25% of people older than 65 years. CAVD and atherosclerosis share common risk factors and pathogenic mechanisms. Nevertheless, they present different pathologic lesions. The main factors involved in the pathogenesis of CAVD are genetic predispos...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2010.02.019
更新日期：2011-05-14 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the clinical-microbiological characteristics presented in the area of influence of the Hospital de Bellvitge-Prínceps d'Espanya, of articular infection induced by pyogenic germs in patients without intravenous drug addiction. METHODS:All the cases of microbiologically c...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-04-11 00:00:00
abstract：:A woman who had recently become infected with HIV-1 after sexual relations with a seropositive subject presented a rapid fall in CD4+ T lymphocytes and evolved to AIDS 13 months after primoinfection. The most plausible cause for the rapid disease progression in this patient was the observation of a viral syncytium for...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-06-17 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In recent years, many studies have investigated metformin and its effects on lung cancer. However, since previous studies have shown that the relationship between metformin and lung cancer is complicated, we performed a meta-analysis to analyze this relationship. MATERIAL AND METHODS:An electr...
journal_title：Medicina clinica
pub_type： 杂志文章,meta分析
doi：10.1016/j.medcli.2018.06.026
更新日期：2019-04-18 00:00:00
abstract：:Vitamin K antagonists were the only choice for chronic oral anticoagulation for more than half a century. Over the past few years, direct oral anticoagulants have emerged, including one direct thrombin inhibitor (dabigatran etexilate) and three factor Xa inhibitors (apixaban, edoxaban and rivaroxaban). In randomised c...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2017.11.042
更新日期：2018-09-14 00:00:00
abstract：BACKGROUND:The aim of this study was to know the prevalence of previous infection markers for hepatitis A and B viruses in a pediatric-juvenile population from Gijón, Spain. PATIENTS AND METHODS:A representative (according to the census) transversal randomized sample of a population from 6 to 25 years in age from Gijó...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1996-04-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common cause of treatment failure. Leukaemia relapse occurs due to clonal evo...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2016.05.015
更新日期：2016-09-02 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with la...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2017.02.025
更新日期：2017-10-11 00:00:00
abstract：:During a period of 29 months positive hemocultures to Streptococcus agalactiae corresponding to eight adult patients have been observed. These bacteria were apparently responsible for the clinical picture in five patients. In other two patients S. agalactiae appeared in the course of a sepsis caused by other germ. The...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-09-25 00:00:00
abstract：:A patient is reported with meningoencephalomyelitis with polyradiculitis caused by Borrelia burgdorferi infection. Neurological features developed without previously known tick bite nor the characteristic skin lesion, chronic migratory erythema (CME). The vector of the disease (the tick Ixodes ricinus) exists in Spain...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1989-09-09 00:00:00
abstract：BACKGROUND:The aim of the present was to study the prevalence of infection and tuberculous disease as well as the fulfillment of secondary antituberculin chemoprophylaxis in immigrants according to their geographic origin. PATIENTS AND METHODS:A descriptive study was carried out of 1,489 immigrants under the age of 35...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1996-04-13 00:00:00
abstract：BACKGROUND:The aim of this study is to assess the prevalence of Parvovirus B19 infection in a group of patients affected by congenital coagulation disorders and its association with epidemiological aspects. PATIENTS AND METHODS:We have analyzed a group of 50 patients (median age 28) diagnosed with haemophilia or any o...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1997-05-03 00:00:00
abstract：BACKGROUND:Reimplantation disease (RD) is a postoperative complication in lung transplantation. It is defined as hypoxemia (PaO2/FiO2 ratio < 150 mmHg), radiologic infiltrates and decrease of lung compliance. The aim of the study was to analyze the incidence, predictive factors, prognosis and outcome of the patients wi...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-06-26 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The impact and burden of disease of the rare diseases (RD) is not known, also the type of disability that entail. The objective of the work is to analyze the socio-sanitary impact of the RD in Spain. PATIENTS AND METHOD:This is a nationwide study. The dimensions used were mobility, personal ca...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13112096
更新日期：2007-11-10 00:00:00
abstract：:The possible development of the dawn phenomenon in three gestational stages was investigated in 9 pregnant women with type I diabetes mellitus and 10 with gestational diabetes. To this end, the overnight intravenous insulin infusion was evaluated with the artificial pancreas (Biostator). In none of the two clinical co...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1990-01-20 00:00:00
abstract：BACKGROUND:In this study the prescription of drugs in an outpatients geriatric population was evaluated in terms of age and body weight. METHODS:From a wide survey carried out on 500 geriatric outpatients, all the prescriptions corresponding to H-2 antagonists, digoxin, theophylline, bromazepam, diazepam, lorazepam an...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-03-07 00:00:00
abstract：:The case of a dysbaric accident with occurred in a professional athlete during a national competition is herein reported. The clinical symptoms and response to treatment in a depressurization chamber in addition to CT controls should alert physicians in coastal areas in which this sport is carried out in order to take...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-05-20 00:00:00
