Abstract：
:Vitamin K antagonists were the only choice for chronic oral anticoagulation for more than half a century. Over the past few years, direct oral anticoagulants have emerged, including one direct thrombin inhibitor (dabigatran etexilate) and three factor Xa inhibitors (apixaban, edoxaban and rivaroxaban). In randomised controlled trials comparing direct oral anticoagulants with traditional vitamin K antagonists, the direct oral anticoagulants all showed a favourable benefit-risk balance in their safety and efficacy profile, in prevention of thromboembolic events in patients with atrial fibrillation and in the prevention and treatment of venous thromboembolism and acute coronary syndrome. In 2008, dabigatran was the first direct oral anticoagulant approved by the European Medicine Agency. Subsequently, rivaroxaban, apixaban and edoxaban were also authorised. This article reviews the evidence related to the use of these drugs.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Franco Moreno AI,Martín Díaz RM,García Navarro MJdoi
10.1016/j.medcli.2017.11.042subject
Has Abstractpub_date
2018-09-14 00:00:00pages
198-206issue
5eissn
0025-7753issn
1578-8989pii
S0025-7753(17)30926-0journal_volume
151pub_type
杂志文章,评审相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND:We determined the extent to which opportunities for prevention were missed among patients with tuberculosis and the costs derived from the lack of prevention. METHOD:Descriptive study of patients with active tuberculosis were studied in the hospital ward of tuberculosis at the A. Marcide-Novoa Santos Centre...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1997-06-07 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) consists of an excessive depositing of fat in the liver, which can end up by causing inflammation, fibrosis and also cirrhosis with the corresponding complications including liver cancer. NAFLD has become the most common liver disease worldwide. The incidence has increased in ...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2017.06.026
更新日期：2017-12-20 00:00:00
abstract：:A case of primary amyloidosis in which multinucleated giant cells occurred in relation to amyloid deposits in the renal-glomerulus and in multiple other organs is reported. The ubiquity of multinucleated giant cells distinguishes the present case from those previously described in the literature. It is felt that the f...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-11-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The effects of rosiglitazone on the lipid profile are controversial, with related increases in the concentration of total and LDL cholesterol. Our objective is to evaluate the evolution of the concentration and size of LDL particles in a group of patients with type 2 diabetes mellitus taking ro...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2008.05.001
更新日期：2009-01-31 00:00:00
abstract：:Tumor necrosis factor (TNF) alpha plays a central role in both the inflammatory response and that of the immune system. Thus, its blockade with the so-called anti-TNF agents (infliximab, etanercept and adalimumab) represents an important tool for the management of a variety of disorders, such as rheumatoid arthritis, ...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1157/13126958
更新日期：2008-10-11 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Endoscopy is the gold standard to assess disease severity in inflammatory bowel disease, although it is an invasive procedure. Clinical activity and biological markers have been routinely used to determine disease activity in a non-invasive manner. The aim of this study was to determine concor...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.09.047
更新日期：2015-01-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In the last years, a study is being conducted about exposure to asbestos among shipyards workers in order to know the diagnosis of the diseases associated with the exposure. Our goal was to know the asbestos pulmonary contents in this population. MATERIAL AND METHODS:We obtained autopsy pulmon...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.01.023
更新日期：2013-02-16 00:00:00
abstract：BACKGROUND:The handling of upper gastrointestinal hemorrhage (UGH) usually includes the hospitalization of all patients, regardless of severity and prognosis. The aim of this paper is to assess the security of the outpatient control of some UGH, after their assessment in the hospital emergency room. PATIENTS AND METHO...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:The possible development of the dawn phenomenon in three gestational stages was investigated in 9 pregnant women with type I diabetes mellitus and 10 with gestational diabetes. To this end, the overnight intravenous insulin infusion was evaluated with the artificial pancreas (Biostator). In none of the two clinical co...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1990-01-20 00:00:00
abstract：:Twenty-one cases of carcinomatous lymphangitis of the lung are reported. In diagnosing them clinical, roentgenologic, and histopathologic criteria were used and the clinical, roentgenologic and evolutive findins were considered in order to emphasize the origin of the primitive neoplasm. From this point of view the pri...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-03-25 00:00:00
abstract：BACKGROUND:We describe the characteristics of people with a recent diagnosis of HIV infection. PATIENTS AND METHOD:Series of 126 new cases of HIV infection diagnosed in an infectious diseases Service. RESULTS:Sexual transmission was the commonest form of infection (74%). Fifteen percent of individuals were aged over ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)72211-7
更新日期：2001-11-24 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Left ventricular hypertrophy (LVH) is the most frequent manifestation of cardiac damage in hypertension. The objective of this study was to evaluate the prevalence of LVH in hypertensive patients of long evolution at Primary Care (PC) and to describe their epidemiological profile. PATIENTS AND...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1157/13106936
更新日期：2007-06-09 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Our goal was to determine the incidence of infection due to Mycobacterium kansasii in Elche, Spain over the last 10 years and to study the activity of new antibiotics against the strains isolated. MATERIAL AND METHODS:A retrospective study of patients and study of antibiotic susceptibility in ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Information about the prevalence of chronic kidney disease (CKD) in the population treated in primary care is scarce. The aim of this study was to assess the prevalence of CKD in Spanish hypertensive women aged 64 years or older, and to determine possible associated factors. PATIENTS AND METH...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2011.03.038
更新日期：2012-05-05 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Primary biliary cirrhosis (PBC) is associated to any systemic autoimmune disease (SAD), in particular systemic sclerosis (SSc). To investigate the prevalence of SAD in a cohort of patients with PBC, specifically the prevalence of SSc and its clinical subtypes, and determining the clinical and ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2015.02.026
更新日期：2016-01-01 00:00:00
abstract：:The follow-up of the Mediterranean Diet (MD) has been associated with lower mortality and morbidity from cardiovascular diseases. However, it is important to evaluate the scientific evidence provided by published articles. Therefore, in order to analyze the literature on the overall effects of MD on intermediate and f...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2009.01.033
更新日期：2010-01-23 00:00:00
abstract：BACKGROUND:The purpose of this study was to know the concordance of diagnosis between emergency rooms amd hospitalization wards and to analyze the mistake index, the epidemiological characteristics and the main reasons for the mistakes. PATIENTS AND METHOD:We analyzed hospitalized patients and used a three-level conco...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)73485-4
更新日期：2002-10-26 00:00:00
abstract：:The case of a 19 year old patient with Takayasu arteritis with exclusive involvement of the abdominal aorta and without involvement of the renal arteries who presented severe arterial hypertension during the acute phase of the disease is referred. The administration of a dose of 20 mg of enalapril maleate was followed...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-22 00:00:00
abstract：:We performed a systematic review to assess the efficacy and safety of extracorporeal albumin dialysis systems in patients with liver failure. After screening 436 references, 10 controlled trials were detected. The analyzed interventions were MARS, Prometheus and Biologic-DT. Efficacy was proven by a reduction in bilir...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2010.01.032
更新日期：2011-04-23 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The REACH Registry is the largest worldwide designed to obtain information on cardiovascular risk factor control and preventive treatment in a population who have, or are at risk of having, symptoms of atherothrombosis. The objective of this study is to show the results of cardiovascular events...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2008.11.033
更新日期：2009-04-18 00:00:00
abstract：BACKGROUND:Bone mineral density (BMD) has been related with age, hormonal status, body mass index (BMI) and life style. We have evaluated the influence of these factors on BMD in healthy women, without risk factors for osteoporosis, using ultrasound measures. PATIENTS AND METHODS:We have selected 255 women (136 premen...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-09-18 00:00:00
abstract：BACKGROUND:Sentinel-node biopsy is meant to excise the first-echelon node from a primary tumor, which is the one that most probably harbors early metastases. PATIENTS AND METHODS:We report our results in 35 patients with breast cancer, using a radiotracer by peri-tumoral injection, pre-surgical scintigraphy and intrao...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-06-19 00:00:00
abstract：:Uterine fibroids are the most common benign tumours that affect women of reproductive age and they represent the main indication for surgery for benign uterine pathology. In 25% of cases, they become clinically apparent, causing heavy menstrual bleeding, pelvic pain and/or infertility. Therefore, fibroids have a notab...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(13)70045-9
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:The objective of this study was to identify the risk factors associated with the nosocomial sepsis syndrome according to the criteria of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. PATIENTS AND METHOD:A 1-year prospective case-control study matched for se...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2001-06-02 00:00:00
abstract：:The aim of this work is to show the changes observed in the health profile according to gender in 2006 with respect to 1994 of the population of Catalonia, through the comparison of data obtained in 1994 and 2006 from the Encuesta de Salud de Cataluña. The increase of the level of studies of the population has tended ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/S0025-7753(11)70025-2
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To determine whether in the Mexican population the spouses of patients with type 2 diabetes mellitus (DM2) have an increased risk of any degree of glucose intolerance compared with spouses of subjects without diabetes. SUBJECTS AND METHOD:An analytical cross-sectional study was made in the Fam...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13127917
更新日期：2008-11-08 00:00:00
abstract：BACKGROUND:The renin-angiotensin system (RAS) plays an important role in blood pressure (BP) regulation. A number of RAS polymorphisms have been linked to essential hypertension (EH), but there is uncertainty about this association in other studies. We examined whether the insertion/deletion (I/D) polymorphism of the a...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:To review the clinical findings of pancreatic tuberculosis and to establish a differential diagnosis with pancreatic tumours. PATIENTS AND METHODS:To describe three cases of pancreatic tuberculosis diagnosed in a 850 bed teaching hospital during the last two years. RESULTS:In the three case the imaging pro...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/s0025-7753(00)71592-2
更新日期：2000-10-14 00:00:00
abstract：BACKGROUND:The use of statistical techniques has become strongly consolidated in biomedical investigation. The present study analyzes the statistical repertoire of the original articles published in 1993 in four general medicine journals: Med Clin (Barc), Rev Clin Esp, Lancet and N Engl J Med. METHODS:A single reviewe...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1996-03-30 00:00:00
abstract：BACKGROUND:The incorrect use of statistical techniques in medical articles may seriously compromise the validity of conclusions. This finding otherwise is relatively common. METHODS:A total of 84 original articles published in Medicina Clínica between 1962 and 1992 were reviewed with the aim of assessing the use and a...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
