Abstract：
BACKGROUND AND OBJECTIVE:The effects of rosiglitazone on the lipid profile are controversial, with related increases in the concentration of total and LDL cholesterol. Our objective is to evaluate the evolution of the concentration and size of LDL particles in a group of patients with type 2 diabetes mellitus taking rosiglitazone. PATIENTS AND METHODS:We studied 30 patients under treatment with oral antidiabetics to whom rosiglitazone was added to their initial therapy. The following tests were determined before and after 6 months of treatment: glucose, total cholesterol, HDL, LDL, triglycerides, C reactive protein, lipoprotein (a) and glycosylated haemoglobin. The average diameter of the particles LDL was also estimated, as well as the probability of cardiovascular events up to ten years, according to the Framingham and SCORE model. RESULTS:Statistically significant reductions of glucose, HbA(1C) and CRP levels, and an increase of total cholesterol, cholesterol LDL and triglycerides concentrations were observed, with statistical significance for total cholesterol. A significant increase in the estimation of cardiovascular risk up to ten years was found. No modifications either in the concentrations of HDL-c and Lp (a) or in the average size of LDL particles were detected. CONCLUSIONS:After treatment with rosiglitazone, there is an increase of total cholesterol concentrations without variation in the mean size of LDL particles. Nevertheless, the reduction of CRP, and thus of inflammation is clear, with prevention of the progression of atherosclerosis.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Albaladejo Otón MD,Calle Luna JG,Granero Fernández E,Hernández Martínez AM,Parra Pallarés S,Martínez Hernández Pdoi
10.1016/j.medcli.2008.05.001subject
Has Abstractpub_date
2009-01-31 00:00:00pages
98-101issue
3eissn
0025-7753issn
1578-8989pii
S0025-7753(08)00037-7journal_volume
132pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：OBJECTIVES:To describe 11 patients with cardiofaciocutaneous syndrome (CFC) and compare them with 130 patients with other RAS-MAPK syndromes (111 Noonan syndrome patients [NS] and 19 patients with LEOPARD syndrome). PATIENTS AND METHODS:Clinical data from patients submitted for genetic analysis were collected. Bidirec...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2014.06.009
更新日期：2015-01-20 00:00:00
abstract：BACKGROUND AND OBJECTIVES:To compare the efficacy of a self-monitoring programme vs. the conventional method used before the intervention in maintaining the international normalised ratio (INR) in the therapeutic range in patients receiving oral anticoagulants, as well as complications, quality of life and the time inv...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2019.06.016
更新日期：2020-05-22 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Obstructive sleep apnoea (OSA) is associated with an increased risk of cardiovascular disease. Our objective was to evaluate subclinical atherosclerosis in OSA patients and the effect of continuous positive airway pressure (CPAP) treatment on carotid intima-media thickness (cIMT). PATIENTS AND...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2016.03.032
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:There are few epidemiological studies on massive transfusion (MT), although they may be important to evaluate possible strategies to reduce the number of transfused units, as well as transfusion side-effects. We, therefore, retrospectively assessed the incidence of MT at our institution (a 700-...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13110210
更新日期：2007-09-22 00:00:00
abstract：:The electrocardiogram as a diagnostic aid in acute myocardial infarction of the right ventricle (AMI-RV) was studied prospectively in a group of 66 patients in our coronary unit. Diagnosis was AMI in all cases, divided into 29 (44%) with posterior-descending and 35 (53%) with anterior location. Electrocardiography was...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-09-25 00:00:00
abstract：:The dual antiplatelet therapy with acetylsalicylic acid and clopidogrel has been the mainstay of both acute and chronic phase coronary artery disease, reducing importantly the risk of adverse events. Despite a correct compliance, a non-negligible rate of adverse events still happens. New compounds, with improved prope...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2013.12.006
更新日期：2014-12-09 00:00:00
abstract：:A woman who had recently become infected with HIV-1 after sexual relations with a seropositive subject presented a rapid fall in CD4+ T lymphocytes and evolved to AIDS 13 months after primoinfection. The most plausible cause for the rapid disease progression in this patient was the observation of a viral syncytium for...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-06-17 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Urban air pollutants are composed of a heterogeneous mixture of substances in gas and aerosol states. The aim of this study was to compare the effects caused by exposure to contaminants in the gas phase and atmospheric particles in ambient air in patients hospitalized for acute coronary syndro...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.05.040
更新日期：2013-06-18 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:Dilatation of the ascending aorta associated with bicuspid aortic valve is a major cause of morbidity and mortality in adults. The main objective was to recognize the aortic involvement in children, its characteristics and risk factors. METHODS:Aortic measures of all pediatric patients with...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2017.03.041
更新日期：2017-11-09 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The standard treatment of the obstructive sleep apnea syndrome (OSAS) is the nCPAP. There is evidence that its use improves the quality of life of patients. The objective of the study is to measure the effect of nCPAP on the quality of life of patients in a Spanish cohort. PATIENTS AND METHOD:...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13080827
更新日期：2005-11-05 00:00:00
abstract：:The hemophagocytosis or the process of ingestion of blood cells by phagocytes and macrophages of the mononuclear phagocytic system (MFS), is a phenomenon that rarely could be observed in the morphological examination of the bone marrow aspirate. Occasionally it is present in certain pathologic conditions such as, mali...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-12-15 00:00:00
abstract：BACKGROUND:To analyze the relationship between length of hospitalary stay and early readmission rate. To assess the hypothesis that those admissions with the lowest length of stay are associated with higher early readmission rate. PATIENTS AND METHODS:Retrospective study of 35,902 hospital admissions. A single admissi...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1996-11-02 00:00:00
abstract：BACKGROUND:The aim of this study was to know the opinion of the professionals (physicians and nursing staff) of intensive medicine concerning aspects such as informed consent, family participation in health care decisions, the possibility of not undertaking resuscitation manoeuvers and limiting care in determined cases...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1994-04-16 00:00:00
abstract：BACKGROUND:Autopsies may be used to know the causes of death in population. In Navarra, the number of patients who died by cancer and were autopsied has increased. A similar pattern appeared in other communities. METHODS:We reviewed 2,643 autopsies performed in the main hospitals of Navarra. In each autopsy, age, sex,...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-04-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Our goal was to analyze the epidemiological and clinical findings, as well as the diagnostic approach in a group of patients in whom uveitis was the first manifestation of sarcoidosis. PATIENTS AND METHOD:Retrospective study (between March 1998 and July 2002) including 31 patients diagnosed wi...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(04)74374-2
更新日期：2004-05-22 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To study the effect of clinical and demographic variables on mortality in patients with probable Alzheimer's disease treated with the cholinesterase inhibitor galantamine. PATIENTS AND METHOD:This retrospective cohort study reviewed 172 medical records, gathering information such as demographi...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13091012
更新日期：2006-07-08 00:00:00
abstract：INTRODUCTION:The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis with renal involvement are associated with high morbi-mortality. In this study we analyse if the prognosis of these diseases have improved in recent years, and which factors influence the outcomes. MATERIAL AND METHODS:Retrospective sin...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2016.09.015
更新日期：2017-01-06 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Pertussis remains an important cause of morbimortality despite current vaccination strategies. This study was designed to describe the results and characteristics of close contacts of pertussis cases diagnosed in children less than 16 years in a tertiary hospital in Barcelona. PATIENTS AND ME...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.09.017
更新日期：2013-11-02 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The description of different forms of PSA has opened a new strategy in the diagnosis of prostate cancer. The measurement of the ratio between free PSA and PSA in the group of patients with a PSA level between 4 and 10 ng/ml decreases the number of negative biopsies. The aim of our study was to ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(04)75311-7
更新日期：2004-02-28 00:00:00
abstract：:In this study, we review the efficacy and safety limitations of insulin-dependent oral antidiabetic agents. In terms of efficiency, the main drawback of metformin, sulfonylureas, gliptins and -to a lesser extent-glitazones is durability. No drug per se is able to maintain stable blood glucose control for years. Metfor...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(13)70059-9
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Pleural mesothelioma is a tumor of low incidence whose relation with the exposure to asbestos has been widely demonstrated. This exposure is generally occupational, but may also be domestic and there is the possibility of environmental exposure. METHODS:By death certifications all the cases of death by pleu...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-11-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aims of the GEMM Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in individuals born and living in Mexico. The authors evaluate the heritabilities (h2) of CVD risk factors in Mexicans from a preliminary cohort already studied. Heritabilities for CVD...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13106675
更新日期：2007-06-02 00:00:00
abstract：:This article presents six cases of hemolytic-uremic syndrome, defined as the combination of acute renal insufficiency, microangiopathic hemolytic anemia, and thrombocytopenia, in six adult patients, two men and four women, between 20 and 52 years old. Three of the cases were considered idiopathic, two secondary to the...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-01-10 00:00:00
abstract：:The aim of this article is to discuss the implications of the results obtained in the latest large-scale clinical trials designed to evaluate the effect of intensive glycemic control on the vascular complications associated with type 2 diabetes mellitus. The current scientific evidence is reviewed and the implications...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(10)70025-7
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Patients identified as risk drinkers usually fill a questionnaire in order to assess their alcohol dependence. In our setting, the Münchner Alkoholismus Test (MALT) has been recommended, but there are not enough data about its validity and accuracy, particularly in women. The aim of this study ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13079611
更新日期：2005-10-08 00:00:00
abstract：:Three cases of encrusted cystitis caused by Corynebacterium group D2 are described. The vesical damage previous to the establishment of this bacteria is noteworthy and the very rapid increase in urease activity explains the pathogenesis of the situation. Thus allowing for its identification and is relevant to treatmen...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-03-21 00:00:00
abstract：BACKGROUND:Few reports have analysed the transmission of tuberculosis in rural areas with a low incidence of disease. PATIENTS AND METHOD:A population-based molecular epidemiological study of patients with tuberculosis, diagnosed by culture, was conducted in Segovia (Spain) between 1995 and 1999. Clinical, demographic...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)72484-6
更新日期：2002-05-11 00:00:00
abstract：BACKGROUND:Clinical observation ratifies the existence of commonly accepted erroneous beliefs (EB) in relation to sexuality. In the health care sector, reinforcing factors of these beliefs are the professionals who are not specifically trained to manage, or detect the same in addition to the variability of the criteria...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-11-25 00:00:00
abstract：BACKGROUND:It is estimated that 5-10% of breast cancers have an hereditary origin, germline mutations of BRCA1 and BRCA2 genes causing a predisposition. In the present study we analyzed BRCA1 and BRCA2 mutations in moderate to high risk breast cancer patients in order to find out the types and frequency of these mutati...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)73450-7
更新日期：2002-10-12 00:00:00
abstract：BACKGROUND:B-mode ultrasonography is a simple and valid method to evaluate subclinical atherosclerosis of the major superficial arteries. The aim of this study was toknow by this technique the prevalence of carotid atherosclerosisin patients with coronary disease and related factors. PATIENTS AND METHOD:In 232patients...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)71864-7
更新日期：2001-03-31 00:00:00
