Abstract：
BACKGROUND AND OBJECTIVE:The association between the presence of the allele APOE*epsilon4 (apolipoprotein E) and sporadic Alzheimer disease (AD) has been long established. However, the possible influence of other genetic factors is still under debate. This study investigated the role of the a 1-antichymotrypsin (ACT) gene as a susceptibility factor for developing late-onset AD in the population of Navarra. PATIENTS AND METHODS:The study group included 98 patients with late-onset AD and 188 control individuals 70-71 years of age. APOE*epsilon2,*epsilon3,*epsilon4 and ACT codon -17*A,*T polymorphisms were analyzed by PCR-RFLP. Statistical analyses were performed determining the chi-square test, using 2 x 2 contingency tables and logistic regression to calculate odds ratios. RESULTS:APOE*epsilon4 allele frequency was significantly higher in AD patients than in controls (odds ratio [OR] = 3.02; 95% confidence interval [CI], 1.59-5.73; p < 0.001 in heterozygous carriers, and OR = 9.40; 95% CI, 1.84-64.43; p = 0.001 in homozygous individuals). We found no significant differences in the distribution of ACT polymorphisms between AD cases and controls. However, APOE*epsilon4 carriers had a 2.5-fold increased risk of developing AD in the presence of the ACT/AA genotype (OR = 10.13; 95% CI, 1.98-97.81; p < 0.001). The risk difference, however, did not reach statistical significance (p = 0.271). CONCLUSIONS:APOE*epsilon4 heterozygous and homozygous carriers have a 3 and 9 times higher risk, respectively, of developing AD. We could not demonstrate an effect of ACT polymorphisms as a independent risk factor for this disease; however, the ACT/AA genotype seems to act as an additional susceptibility factor, duplicating the APOE*epsilon4-associated AD risk.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Hernández-Charro B,Moreno S,Valiente A,Manubens JM,Villar MD,Ramos-Arroyo MAdoi
10.1016/s0025-7753(04)74479-6keywords:
subject
Has Abstractpub_date
2004-09-04 00:00:00pages
251-4issue
7eissn
0025-7753issn
1578-8989pii
S0025-7753(04)74479-6journal_volume
123pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND:The purpose of this study was to know the concordance of diagnosis between emergency rooms amd hospitalization wards and to analyze the mistake index, the epidemiological characteristics and the main reasons for the mistakes. PATIENTS AND METHOD:We analyzed hospitalized patients and used a three-level conco...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)73485-4
更新日期：2002-10-26 00:00:00
abstract：BACKGROUND:To study the evolution of the diet and the nutritional intake between 1983 and 1999, by age and sex. SUBJECTS AND METHODS:We performed a series of analysis of the food intake on a representative sample of the population of Reus (aged 10-69 years). Dietary intake was estimated using the 24-hours recall metho...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71448-5
更新日期：2000-06-03 00:00:00
abstract：BACKGROUND:In the context of the COVID-19 pandemic the risk of misdiagnosis of other causes of respiratory infection is likely. In this work we aim to describe the clinical characteristics, treatment and outcome of pneumococcal infection in COVID-19 patients. PATIENTS AND METHODS:Every COVID-19 patient presenting with...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2020.05.022
更新日期：2020-12-11 00:00:00
abstract：:A woman who had recently become infected with HIV-1 after sexual relations with a seropositive subject presented a rapid fall in CD4+ T lymphocytes and evolved to AIDS 13 months after primoinfection. The most plausible cause for the rapid disease progression in this patient was the observation of a viral syncytium for...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-06-17 00:00:00
abstract：:Heart failure is a complex syndrome that affects almost all organs and systems of the body. Signs and symptoms of organ dysfunction, in particular kidney dysfunction, may be accentuated or become evident for the first time during acute decompensation of heart failure. Cardiorenal syndrome has been defined as the simul...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(14)70079-X
更新日期：2014-03-01 00:00:00
abstract：:Transfer factor (TF) consists of messenger peptides produced by activated T lymphocytes as part of cellular immunity, and it acts in virgin lymphocytes through TF inducers, suppressors and specific antigens. TF is not immunogenic because it is not species-specific, since it contains a consensus sequence of amino acids...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2010.05.002
更新日期：2011-09-10 00:00:00
abstract：BACKGROUND:In order to plan the objectives of the rehabilitation treatment after a stroke, it is necessary to know the functional prognosis of the patient. The main prognostic factors of disability in the hemiplegic patient, by means of an analysis of his neurological deficits (aphasia, disorientation, urinary incontin...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71602-2
更新日期：2000-10-21 00:00:00
abstract：:Twenty-six episodes of Pseudomonas aeruginosa bacteremia treated with intravenous ceftazidime, 4-6 g/day were evaluated. Treatment was begun within the first 24 hours after the isolation of the microorganism and was maintained for 10-12 days. In two patients with neutropenia amikacin was added during the initial 48-72...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1989-09-16 00:00:00
abstract：INTRODUCTION:The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis with renal involvement are associated with high morbi-mortality. In this study we analyse if the prognosis of these diseases have improved in recent years, and which factors influence the outcomes. MATERIAL AND METHODS:Retrospective sin...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2016.09.015
更新日期：2017-01-06 00:00:00
abstract：:During a period of 29 months positive hemocultures to Streptococcus agalactiae corresponding to eight adult patients have been observed. These bacteria were apparently responsible for the clinical picture in five patients. In other two patients S. agalactiae appeared in the course of a sepsis caused by other germ. The...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-09-25 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Our objective was to assess the frequency of fungal colonization and/or infection in critically ill patients admitted to intensive care units (ICUs) and to describe the characteristics and risk factors of those patients in whom fungi had been isolated. PATIENTS AND METHOD:Observational, multic...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/s0025-7753(03)73891-3
更新日期：2003-07-05 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with la...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2017.02.025
更新日期：2017-10-11 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The REACH Registry is the largest worldwide designed to obtain information on cardiovascular risk factor control and preventive treatment in a population who have, or are at risk of having, symptoms of atherothrombosis. The objective of this study is to show the results of cardiovascular events...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2008.11.033
更新日期：2009-04-18 00:00:00
abstract：BACKGROUND:The aim of the present was to determine the levels of the tumor necrosis factor (TNF)-alpha in patients with HIV infection to study the relationship with the concentration of triglycerides (TG), CD4 lymphocyte count and clinical diagnosis. METHODS:Seventy-eight HIV-infected patients (58 males, 20 females); ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-03-18 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common cause of treatment failure. Leukaemia relapse occurs due to clonal evo...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2016.05.015
更新日期：2016-09-02 00:00:00
abstract：BACKGROUND:Using the data available from the Cancer Registry of Zaragoza, the incidence of breast cancer in women from 1961 to 1985 was analyzed with future evolution being predicted up to the year 2000. METHODS:The age, period and birth cohort effects, in addition to the place of residence (capital/rest of province) ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-05-29 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We pursued here to determine the incidence of blood-stream infections. PATIENTS AND METHOD:Longitudinal descriptive study. All patients admitted to hospital from January 1999 to December 2000 were included. Blood-stream infection episodes were defined according to CDC criteria. Blood-stream in...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(03)73654-9
更新日期：2003-02-22 00:00:00
abstract：BACKGROUND:Our main goals were to know the actual degree of oral anticoagulation and antiaggregation in hypertensive patients with atrial fibrillation in the daily clinical practice in Spain and to analyze any differences between primary care physicians and cardiologists. PATIENTS AND METHOD:32,051 outpatients attende...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)72375-0
更新日期：2002-03-16 00:00:00
abstract：BACKGROUND:The cytogenetic analysis of the fragile X affected shows a break point in the q27.3 region of chromosome X. However many carrier females and normal carrier males remain refractory to cytogenetic diagnosis. New DNA probes tightly linked to the fragile X point are now available allowing by the familiar RFLP an...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：BACKGROUND:The renin-angiotensin system (RAS) plays an important role in blood pressure (BP) regulation. A number of RAS polymorphisms have been linked to essential hypertension (EH), but there is uncertainty about this association in other studies. We examined whether the insertion/deletion (I/D) polymorphism of the a...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1999-05-01 00:00:00
abstract：:Noninvasive ventilation (NIV) utilization has experienced an exponential growth in the last 25 years immediately after the introduction of the positive pressure and the nasal mask. Patients with acute, chronic and acute on chronic respiratory failure are candidates to be treated by this therapeutic modality. Its utili...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2011.10.003
更新日期：2011-12-10 00:00:00
abstract：BACKGROUND:To evaluate differences in the temporal profile of acute phase response (APR) between ischemic stroke (IS) and intracerebral hemorrhage (ICH). PATIENTS AND METHOD:We studied APR parameters (< 24 h and 3-5 day) in 88 consecutive patients (43 ICH and 45 IS). The increase/decrease of the parameters between bot...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)71717-4
更新日期：2001-01-20 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The ankle-brachial index allows for the detection of subclinical cardiovascular disease and risk, by diagnosing peripheral arterial disease and arterial calcification. Asymptomatic hypertensive men, between 45-55 years and with the suspicion of low risk, could be an important population group t...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2014.02.028
更新日期：2015-05-21 00:00:00
abstract：:Three cases of encrusted cystitis caused by Corynebacterium group D2 are described. The vesical damage previous to the establishment of this bacteria is noteworthy and the very rapid increase in urease activity explains the pathogenesis of the situation. Thus allowing for its identification and is relevant to treatmen...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-03-21 00:00:00
abstract：:The usefulness of two alpha-2 adrenergic agonists (clonidine and guanfacine) and their comparative effectiveness were evaluated regarding the control of the opiates abstinence syndrome and the secondary effects, including development of cardiovascular abnormalities, in 88 parenteral heroin abusers admitted to two hosp...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-02-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The pprevalence of extended-spectrum beta-lactamase (ESBL) producing gram-negative bacilli has increased in recent years. The aim of this study is to estimate the prevalence of infection/colonization due to theses microorganisms per 100 admissions and its trend during the period 2007-2010. PAT...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.03.034
更新日期：2013-07-07 00:00:00
abstract：:Due to a combination of ingested ethanol and inhaled trichloroethylene (Tri) a 28 year old man developed toxic hepatitis and acute oliguric renal failure, both of which had a favorable evolution. Tri has been described as a cause of hepatic disfunction and acute renal failure due to acute tubular necrosis, although so...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-06-25 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of this study was to evaluate the ability of long-term highly active antiretroviral therapy (HAART) to fully reconstitute the immune system in children with severe AIDS. PATIENT AND METHOD:Lymphoproliferative responses (LPR) were evaluated by incorporation of [3H]-thymidine. Cytokine p...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(03)73723-3
更新日期：2003-03-29 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Functional assessment is especially relevant in patients with cognitive impairment (CI). The Disability Assessment for Dementia (DAD) scale assesses functional ability and its use is becoming increasingly popular. This study aims to perform the translation and cultural adaptation of the DAD sca...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2017.03.029
更新日期：2017-09-20 00:00:00
abstract：BACKGROUND:Incidence analysis of tuberculosis in a series of 562 patients with chronic myeloproliferative syndrome (CMPS). 344 had chronic myelocytic leukemia, 91 polycythemia vera, 70 idiopathic myelofibrosis and 57 essential thrombocythemia. METHODS:The association between CMPS and tuberculosis was evaluated with th...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-03-09 00:00:00
