Abstract：
BACKGROUND AND OBJECTIVE:The plasma protein leakage produced in the bronchial mucose of patients with acute asthma might be associated to the quickness of the onset exacerbation. The aim of this study was to study this association. PATIENTS AND METHOD:22 patients with acute asthma were recruited, and the magnitude of plasma protein leakage was measured by the concentrations of albumin and alpha2-macroglobulin in sputum. RESULTS:Days of onset in acute asthma correlated negatively with albumin sputum concentration (r = -0.563; p = 0.006), alpha2-macroglobulin sputum concentration (r = -0.603; p = 0.003), and related relative coefficients of albumin sputum/serum (r = -0.538; p = 0.01) and alpha2-macroglobulin sputum/serum (r = -0.514; p = 0.014). When the sample was divided by the following daily cutoff: < or = 4, patients suffering from a shorter onset of acute asthma showed a higher concentration of alpha2-macroglobulin in sputum: mean (standard deviation) of 14.4 (18) versus 5.3 (5.4) (p = 0.028). CONCLUSIONS:Plasma protein leakage seems to play an important role in the inflammatory pathogenesis of asthma exacerbation. The quicker onset of asthma the more plasma protein extravasation to the bronchial lumen.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Bellido-Casado J,Plaza V,Belda J,Martínez-Brú C,Torrejón M,Sanchis Jdoi
10.1157/13093055subject
Has Abstractpub_date
2006-09-30 00:00:00pages
451-3issue
12eissn
0025-7753issn
1578-8989pii
S0025-7753(06)72291-6journal_volume
127pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND:The aim of this study was to assess the familial aggregation of lipid levels in schoolchildren of Cuenca city, Spain. SUBJECTS AND METHODS:A cross sectional study was made including 307 both sexes schoolchildren 9-12 years old recruited in three schools of Cuenca city, and 346 of their parents. Sociodemogra...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1997-10-04 00:00:00
abstract：:To evaluate the clinical and microbiological features of infective endocarditis in patients with cirrhosis we compared 18 episodes of endocarditis in these patients with a control group of patients without liver disease. In 61% of patients with cirrhosis the origin of infection was unknown. Four patients developed end...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1989-11-11 00:00:00
abstract：:The coexistence of organ-specific and nonorgan-specific autoimmune diseases is an interesting phenomenon. A 52-year-old woman was admitted with fever, general discomfort, polyarthritis, and Raynaud's phenomenon. Physical examination revealed a goiter of stony consistency, hardening, paleness, and atrophy of the skin o...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-11-10 00:00:00
abstract：:GLP-1 receptors agonists have been a substantial change in treatment of type 2 diabetes mellitus, and its weekly administration has broken pre-established schemes. Daily exenatide is administered every 12 hours (BID) subcutaneously, while weekly exenatide is administered once a week. Both molecules share a common mech...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(14)70105-8
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To assess the usefulness of a risk scale based on serum procalcitonin (PCT) compared to the Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) scale in the early discrimination between necrotising fasciitis (NF) and cellulitis of the extremities. MATERIALS AND METHODS:Retrospective s...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2019.01.032
更新日期：2019-11-15 00:00:00
abstract：:In the present study, clinical, epidemiological and management factors influencing the appropriateness of the 1076 admissions to a general Internal Medicine Section during one year are evaluated. 184 admissions (17%) corresponded to patients who did not meet the AEP (Appropriateness Evaluation Protocol) criteria for a...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1990-03-03 00:00:00
abstract：:The case of a dysbaric accident with occurred in a professional athlete during a national competition is herein reported. The clinical symptoms and response to treatment in a depressurization chamber in addition to CT controls should alert physicians in coastal areas in which this sport is carried out in order to take...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-05-20 00:00:00
abstract：:Since its inception in 2006, the Alliance for Patient Safety in Catalonia has played a major role in promoting and shaping a series of projects related to the strategy of the Ministry of Health, Social Services and Equality, for improving patient safety. One such project was the creation of functional units or committ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2014.07.011
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Growth hormone binding protein (GHBP), insuline-like growth factor 1 (IGF-1) and insuline-like growth factor binding protein 3 (IGFBP-3) serum concentrations were studied in familial short-statured patients (FSS) and age-matched normal-statured subjects. The aim of the study was to ascertain wh...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13067086
更新日期：2004-10-09 00:00:00
abstract：BACKGROUND:To evaluate the efficacy of methotrexate in patients with systemic lupus erythematosus (SLE) without major organ involvement resistant to medium-high doses of prednisone. METHODS:Crossover, open clinical trial with two treatment periods, the first of 3 months and the second of 6 months, an intermediate cont...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章
doi：
更新日期：1993-10-02 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The B-type natriuretic peptide (BNP) has recently emerged as a prognostic marker in acute coronary syndromes (ACS). This role is based on results from randomized trials and other high selected population studies. The aim of this study was to determine the prognostic value of BNP in unselected p...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2009.04.057
更新日期：2009-10-24 00:00:00
abstract：BACKGROUND:The aim of this study is to assess the prevalence of Parvovirus B19 infection in a group of patients affected by congenital coagulation disorders and its association with epidemiological aspects. PATIENTS AND METHODS:We have analyzed a group of 50 patients (median age 28) diagnosed with haemophilia or any o...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1997-05-03 00:00:00
abstract：BACKGROUND:In recent years there has been a change in the opportunistic diseases incidence in HIV-infected patients. The change could be related to the use antiviral therapy and chemoprophylaxis strategies. The aim of the present study was to evaluate if medical intervention is able to modificate the clinical presentat...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1998-02-07 00:00:00
abstract：:The measurement of health-related quality of life (HRQOL) plays a very important role in the study of health outcomes, particularly in effectiveness studies. Nevertheless, the nature of these studies implies a series of challenges in the use of HRQOL instruments, due to the type of comparisons made, the heterogeneity ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Given that Lyme's disease and HIV infection may present with similar clinical symptoms and that the serologic tests for the determination of antibodies against Borrelia burgdorferi present frequent false positives, the presence of antibodies against B. burgdorferi in patients with HIV in different evolutive ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-07-03 00:00:00
abstract：BACKGROUND:Hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) is a disorder diagnosed with low frequency, that produces a very prolonged and recurrent fever with other symptoms and analytical markers of inflammation. Its origin seems to be hereditary with a recessive autosomic pattern, but its pathogenic mech...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71331-5
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We decided to assess the overall prevalence of exposure to environmental tobacco smoke (ETS) both in general and according to the settings of exposure (home, workplace and leisure time). SUBJECTS AND METHOD:We analyzed cross-sectional data of ETS exposure in 1,059 non-smokers included in the C...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(04)74570-4
更新日期：2004-10-16 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We aimed to test a new telerehabilitation device for stress urinary incontinence (SUI) in order to make an initial assessment of its effectiveness. PATIENTS AND METHOD:Randomized, controlled pilot study. INTERVENTION:experimental group (10 patients): pelvic floor muscle training, device train...
journal_title：Medicina clinica
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.medcli.2014.05.036
更新日期：2015-05-21 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The association of an exaggerated systolic blood pressure increase with exercise (EBPIE) with cardiovascular events remains controversial. Our aim was to determine the possible association of an EBPIE with survival and risk of serious cardiac events in patients with hypertension and known or su...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2016.09.016
更新日期：2017-01-20 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of this cross-sectional study was to compare the prevalence of target organ damage (TOD) and established cardiovascular disease (CVD) in a cohort of nondiabetic hypertensive patients with 3 or more cardiovascular risk factors (CVRF) against a group of hypertensives with type 2 diabetes....
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.05.032
更新日期：2013-10-05 00:00:00
abstract：BACKGROUND:Recent advances in sensitivity and specificity of hormone immunoanalysis and their automatization have brought about changes in clinical laboratories that led us to review the need for some endocrine dynamic tests. The specific aim of this study was to determine the basal cortisol values predicting a normal ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)72415-9
更新日期：2002-04-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Although elder abuse is not a new phenomenon, it remains hidden. There have been carried out various preliminary studies about the prevalence of elder abuse in different countries. The aim of this study is to estimate the prevalence of suspicion of elder abuse in old persons without cognitive i...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2012.09.048
更新日期：2013-12-21 00:00:00
abstract：BACKGROUND:The aim of this study was to know the opinion of the professionals (physicians and nursing staff) of intensive medicine concerning aspects such as informed consent, family participation in health care decisions, the possibility of not undertaking resuscitation manoeuvers and limiting care in determined cases...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1994-04-16 00:00:00
abstract：OBJECTIVE:Fibromyalgia (FM) is a chronic pain syndrome of unknown etiology, which affects predominantly women. Among the alterations that have been implicated in the pathophysiology of FM, there have been postulated disturbances in serotonin levels and metabolism, and their implication in symptoms. The aim of the prese...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2010.05.009
更新日期：2010-11-13 00:00:00
abstract：BACKGROUND:In our society advertising compaigns promote consumption of superfluous foods, such as sweets and snacks, displacing the intake of other basic nutrients. The aim of this study is to assess the intake of these foods by children, their relative contribution to overall macronutrient intake and their effects on ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1997-06-14 00:00:00
abstract：BACKGROUND:Evaluation of the therapy with high-dose 131I in solitary toxic thyroid adenoma, with particular attention to the effects on thyroid function and on the nodular size. METHODS:A retrospective study of 43 patients with solitary thyroid nodule treated with radioactive iodine (mean dose 26.6 mCi, range 10-35) a...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1991-05-18 00:00:00
abstract：:A series of eight patients with cerebral tuberculoma seen between 1980 and 1990 is reported. Headache was the leading clinical finding, followed by focal neurological findings and seizures. Papilledema was the most uniform examination finding associated with intracranial hypertension. Five patients had another localiz...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-07-06 00:00:00
abstract：BACKGROUND:Diagnosis of mycobacterioses in HIV infected patients is sometimes difficult because of atypical findings. The aim of this study was to assess the utility of gallium scintigraphy in diagnosis of AIDS related mycobacterioses in patients with fever of unknown origin. PATIENTS AND METHODS:We retrospectively re...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1998-05-02 00:00:00
abstract：UNLABELLED:BACKGROUND AND OJECTIVE: Tobacco attributable mortality offers a complementary view to smoking prevalence, giving an estimate of its impact at population level. The purpose of this study is to measure the impact, using mortality figures, of tobacco consumption in the Galician population over 34 years from 19...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2010.10.009
更新日期：2011-09-10 00:00:00
abstract：:Friedreich's ataxia (FA) is a progressive degenerative disease involving both central and peripheral nervous system. It is an autosomal recessive hereditary disorder, which begins around puberty and has an unknown genetic basis and biochemical defect. The recent mapping of FA locus in human chromosome 9 by means of th...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1990-05-05 00:00:00
