Abstract：
:GLP-1 receptors agonists have been a substantial change in treatment of type 2 diabetes mellitus, and its weekly administration has broken pre-established schemes. Daily exenatide is administered every 12 hours (BID) subcutaneously, while weekly exenatide is administered once a week. Both molecules share a common mechanism of action but have differential effects on basal and postprandial glucose. We review the major clinical trials with both exenatide BID and weekly exenatide. It can be concluded that exenatide BID shows a hypoglycemic effect similar to other treatments for type 2 DM but adding significant weight loss with low incidence of hypoglycemia. Weekly exenatide decreases HbA1c similar to liraglutide but larger than exenatide BID, both glargine and biphasic insulin, sitagliptin, and pioglitazone, maintaining weight loss and adding to gastrointestinal intolerance the induration at the injection site as a side effect.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Lecube A,Bueno M,Suárez Xdoi
10.1016/S0025-7753(14)70105-8subject
Has Abstractpub_date
2014-01-01 00:00:00pages
23-7eissn
0025-7753issn
1578-8989pii
S0025-7753(14)70105-8journal_volume
143 Suppl 2pub_type
杂志文章,评审相关文献
MEDICINA CLINICA文献大全abstract：:Since uricosuria is an essential compensative factor in hyperuricemia, multiple factors exist which can influence on the uric acid excretion in the tubules. Normally, 90% of the uric acid filtered by the glomerulus is reabsorbed, and its active tubular secretion forms the greater part of the uric acid present in the u...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-02-10 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) consists of an excessive depositing of fat in the liver, which can end up by causing inflammation, fibrosis and also cirrhosis with the corresponding complications including liver cancer. NAFLD has become the most common liver disease worldwide. The incidence has increased in ...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2017.06.026
更新日期：2017-12-20 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To estimate the prevalence of risk behaviors related to drug use and to identify factors associated with of accepting and passing on used syringes among intravenous drug users (IDU) recruited in Barcelona city and other surrounding areas in 2004. SUBJECTS AND METHOD:A cross-sectional study of ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13093723
更新日期：2006-10-14 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Although health risks associated to excessive body fat increase with small increases in body weight, measurement of body fat is usually grouped in very few categories. The aim of our study was to assess whether the risk for a combined end-point including the incidence of either hypertension an...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2009.02.016
更新日期：2009-05-09 00:00:00
abstract：FOUNDATIONS AND AIM:The aim of this study is to analyze the CHADS2 score as a marker of the risk of mortality in hypertensive patients, with and without the presence of atrial fibrillation. METHODS:We included 1,003 hypertensive patients≥65 years. Risk factors, and CHADS2 score were recorded among other factors, as we...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2016.03.015
更新日期：2016-06-03 00:00:00
abstract：:The coexistence of organ-specific and nonorgan-specific autoimmune diseases is an interesting phenomenon. A 52-year-old woman was admitted with fever, general discomfort, polyarthritis, and Raynaud's phenomenon. Physical examination revealed a goiter of stony consistency, hardening, paleness, and atrophy of the skin o...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-11-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Hypertension is highly prevalent in the very elderly. We studied control rates of hypertension according to clinic blood pressure (BP) and ambulatory BP monitoring (ABPM) in treated hypertensives aged > or =80 years. PATIENTS AND METHOD:Data came from the Spanish Society of Hypertension ABPM R...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2009.04.056
更新日期：2009-11-28 00:00:00
abstract：BACKGROUND:The aim of this study was to assess the familial aggregation of lipid levels in schoolchildren of Cuenca city, Spain. SUBJECTS AND METHODS:A cross sectional study was made including 307 both sexes schoolchildren 9-12 years old recruited in three schools of Cuenca city, and 346 of their parents. Sociodemogra...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1997-10-04 00:00:00
abstract：BACKGROUND:In the context of the COVID-19 pandemic the risk of misdiagnosis of other causes of respiratory infection is likely. In this work we aim to describe the clinical characteristics, treatment and outcome of pneumococcal infection in COVID-19 patients. PATIENTS AND METHODS:Every COVID-19 patient presenting with...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2020.05.022
更新日期：2020-12-11 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate the risk factors of complications in lower limbs in diabetic patients. PATIENTS AND METHODS:We evaluated 270 patients with diabetes followed in Hospital la Paz from 2000 to 2008.We measured the ankle-brachial index (ABI), toe-brachial index (TBII), and toe blood pressure (BP). We d...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2010.05.032
更新日期：2011-04-09 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Several models for the prediction of liver fibrosis have been developed which consist of the measurement of routine laboratory data: a) a model combining platelets, gamma-glutamil-transpeptidase, cholesterol and age (Forns model), and b) a model using an aspartate-aminotransferase to platelet r...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13075845
更新日期：2005-05-28 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The association of an exaggerated systolic blood pressure increase with exercise (EBPIE) with cardiovascular events remains controversial. Our aim was to determine the possible association of an EBPIE with survival and risk of serious cardiac events in patients with hypertension and known or su...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2016.09.016
更新日期：2017-01-20 00:00:00
abstract：BACKGROUND:Vertebral bone metastases represent the most frequently affected region within the skeleton. They are of important relevance because of the risk of medullar compression. The diagnosis of medullar canal invasion is of particular interest in order to prevent neurological dysfunction. A prospective study was ca...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-09-26 00:00:00
abstract：:The serum levels of cholesterol bound to high density lipoproteins (HDL-C) were determined by the heparin-manganese chloride precipitation method in 306 subjects, 182 male with ages ranging from 11 to 81 years, and 124 female with ages ranging from 7 to 78 years. Twenty six subjects belonged to a lacto-vegetarian comm...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-03-25 00:00:00
abstract：BACKGROUND:To identify which clinical factors can modify the probability of the appearance of the psychotic syndromes in patients with idiopathic Parkinson's disease treated with levodopa. PATIENTS AND METHODS:214 patients were retrospectively studied to evaluate the appearance of hallucinosis, delusions or mental con...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-02-27 00:00:00
abstract：BACKGROUND:The aim of the present was to determine the levels of the tumor necrosis factor (TNF)-alpha in patients with HIV infection to study the relationship with the concentration of triglycerides (TG), CD4 lymphocyte count and clinical diagnosis. METHODS:Seventy-eight HIV-infected patients (58 males, 20 females); ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-03-18 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Sporadic inclusion body myositis (sIBM) diagnosis is frequently delayed or confused with another class of disorders, and misdiagnosis is common. Sometimes, we have problems diagnosing an sIBM in the early stages or predicting when a PM is going to become an sIBM. In this sense, we believe that...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2019.04.022
更新日期：2019-12-13 00:00:00
abstract：BACKGROUND:To examine whether provincial mortality from ischaemic heart disease and cerebrovascular disease in Spain in 1991-1995 is associated with infant mortality in 1930-1934, independently of illiteracy (an estimator of socioeconomic status) in 1991. MATERIAL AND METHODS:Population-correlation study. RESULTS:Inf...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-10-16 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Two different pathways for the development of tumor have been described in colorectal carcinoma: the chromosomic instability, raised by suppressor genes and proto-oncogene alterations, and the microsatellite instability (MSI), caused by alterations in DNA repairing genes. PATIENTS AND METHOD:T...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13071004
更新日期：2005-02-05 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Gaucher disease is an inherited disorder caused by deficit of acid β-glucocerebrosidase, responsible for the degradation of glucosylceramide to ceramide and glucose. Although the disorder is primarily hematologic, bone is the second most commonly affected structure. Cathepsin K (CATK) is an enz...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2014.11.018
更新日期：2015-10-05 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To analyze the effects of an aquatic biodance based therapy on sleep quality, anxiety, depression, pain and quality of life in fibromyalgia patients. PATIENTS AND METHOD:Randomized controlled trial with 2 groups. Fifty-nine patients were assigned to 2 groups: experimental group (aquatic biodan...
journal_title：Medicina clinica
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.medcli.2012.09.036
更新日期：2013-12-07 00:00:00
abstract：BACKGROUND:This study investigated the burden (incidence, mortality and serotype distribution) of pneumococcal pneumonia among older adults in the region of Tarragona (Spain). METHODS:Population-based cohort study involving 27,204 individuals ≥60 years in Tarragonès county (Southern Catalonia), who were prospectively ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2015.09.015
更新日期：2016-03-04 00:00:00
abstract：:The case of a 74-year-old woman with a carotid-cavernous fistula is reported. She was admitted to hospital with oliguria and generalized edema. After improvement of the edematous condition she suddenly presented intense, pulsatile, frontal cephalea. It was more intense on the right side and was accompanied by nausea a...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-03-25 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To describe the evolution of food, energy and nutritional consumption at preconception, weeks 6, 10, 26 and 38 of pregnancy, and 6 and 26 weeks after birth. SUBJECTS AND METHOD:Longitudinal evaluation of the nutritional status in 80 healthy volunteers with the intention of immediate conception...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(04)74395-x
更新日期：2004-06-05 00:00:00
abstract：:Several heritable disorders of glucose transport across cellular membranes have been recently characterized both genetically and pathophysiologically. Diseases such as glucose-galactose malabsorption, Fanconi-Bickel syndrome and GLUT1 deficiency syndrome are caused by mutation of transporters located in bowel, liver a...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13095099
更新日期：2006-11-11 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate the adherence to the recommendations in clinical practice performed by the Therapeutic Positioning Report (TPR) of the Spanish Agency of Medicines and Sanitary Products about the treatment with oral anticoagulants in patients aged≥75 years old with nonvalvular atrial fibrillation (N...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2017.07.025
更新日期：2018-07-13 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Obesity is characterized by a generalized increase of adipose tissue, high production of adipocytokines and presence of oxidative systemic stress. The objective of this study was to evaluate the changes generated in the oxidative stress and anthropometric parameters in obese subjects by the pre...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.12.015
更新日期：2015-07-06 00:00:00
abstract：:The first patient with myelopathy associated with T-cell leukemia/lymphoma virus infection (HTLV-I) in Spain is reported. Although this condition is endemic in several areas from the Caribbean Sea, South America, Africa and Japan, some cases have been reported in European countries, generally in immigrant patients, re...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-02-23 00:00:00
abstract：:The ANESCAT 2003 survey has provided reliable information on all practices within the specialty of anesthesiology in a community comprising 6.7 million inhabitants (namely Catalonia, Spain). In a situation in which official statistics are lacking, the findings allow us to make predictions and plan the clinical and org...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13088807
更新日期：2006-05-24 00:00:00
abstract：BACKGROUND AND OBJECTIVE:White coat effect (WCE) (i.e., the difference between office blood pressure [OBP] and awake ambulatory blood pressure monitoring [ABPM]) may be present in hypertensive individuals. The relationship between occurrence of WCE and target organ damage (TOD) has not yet been assessed in true resista...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.04.031
更新日期：2013-01-05 00:00:00
