Abstract：
BACKGROUND AND OBJECTIVE:The smoke fume, principal factor in the development of lung cancer, causes the expression of certain cytokines, including interleukin 4, 6, 8 and 10, which may act by inhibiting apoptosis and interfere cellular repair mechanisms and angiogenesis. To determine the possible relationship between gene polymorphisms of these cytokines and lung cancer. PATIENTS AND METHOD:To achieve this objective we designed a case-control study, which included 400 patients who had come to the consultation for rapid diagnosis of lung cancer at the Pneumology Department, University Hospital of Salamanca, and whose main criterion exclusion was the lack of active contact with smoke fume. Patients were divided into 2 groups, each consisting of 200 patients: cases (patients diagnosed with lung cancer) and controls (patients without lung cancer). RESULTS:A percentage of 62.8 of men were former smokers at diagnosis compared with 55.5% of women, although the former still had a greater cumulative consumption. Squamous cell carcinoma predominated in diagnosis (48.9% of patients) and more than half were in advanced stages (28.5% in stage iiiB and 25.5% in stage iv). No statistical significance was observed by linking the existence of tumor to the prevalence of any of the analyzed polymorphisms. CONCLUSIONS:Polymorphisms in the study did not modify the risk of developing lung cancer.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Jiménez-Massa AE,Alonso-Sardón M,Menacho-Miguel JA,Mirón-Canelo JA,González-Sarmiento Rdoi
10.1016/j.medcli.2013.07.034subject
Has Abstractpub_date
2014-08-04 00:00:00pages
97-103issue
3eissn
0025-7753issn
1578-8989pii
S0025-7753(13)00923-8journal_volume
143pub_type
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