Abstract：
BACKGROUND:To determine the risk factors for the development of atopy in Spanish young adults. SUBJECTS AND METHODS:Case-control study over prevalent cases. Carried out in general population between the ages of 20 to 44 years old. Spanish participants of the ECRHS, a random representative sample of Spanish young adults (n = 16,884), and a 20% randomised subsample made by those who answered to a short respiratory questionnaire and had atopy assessed, was studied. Atopy was defined as having serum specific IgE positivity to the following aeroallergnes: cat dander, Cladosporium herbarum, Dermatophagoides pteronyssinus, Parietaria judaica and Phleum pratense. RESULTS:Several factors had a statistically significant effect. In addition to male gender and lower age, maternal allergy (OR = 1.63; 95% CI = 1.11-2.40), having allergic siblings (OR = 1.40; 95% CI = 1.06-1.90) and a higher educational level (OR = 1.69; 95% CI = 1.22-2.34) were associated with the presence of high levels of specific IgE in our sample. Moreover, having had older siblings, especially older brothers appears to be a protective factor to the development of atopy but not in a statistically significant way, while having had pet birds during childhood appears to enhance the risk. CONCLUSIONS:In addition to the familial variables that indicates both environmental and genetic factors, educational level seems to have low degree of association with atopy; this feature shows that variables related with life style are involved in atopy development.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Cortès X,Soriano JB,Sunyer J,Martínez-Moratalla J,Muniozgoren N,Maldonado JA,Quirós R,Antó JMdoi
10.1016/s0025-7753(00)71231-0keywords:
subject
Has Abstractpub_date
2000-02-12 00:00:00pages
165-8issue
5eissn
0025-7753issn
1578-8989pii
S0025-7753(00)71231-0journal_volume
114pub_type
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