[Modulating the survival and maturation system of B lymphocytes: Current and future new therapeutic strategies in systemic lupus erythematosus].

Abstract:

:Systemic lupus erythematosus is an autoimmune disease associated with an aberrant production of autoantibodies by self-reactive B lymphocytes. The study of the phenotypic characteristics of B lymphocytes and the identification of their surface receptors such as BAFF-R, TACI and BCMA, which are responsible of their survival and maturation, have contributed to the development of new therapeutic strategies in recent years.

journal_name

Med Clin (Barc)

journal_title

Medicina clinica

authors

Valor L,López-Longo FJ

doi

10.1016/j.medcli.2014.08.008

subject

Has Abstract

pub_date

2015-09-07 00:00:00

pages

206-10

issue

5

eissn

0025-7753

issn

1578-8989

pii

S0025-7753(14)00663-0

journal_volume

145

pub_type

杂志文章,评审
  • [Spironolactone in patients with resistant hypertension].

    abstract:BACKGROUND AND OBJECTIVE:The aim of the study was to assess the effect of adding spironolactone to hypertensive resistant (HTR) patients and characterize those who respond effectively. PATIENTS AND METHOD:Observational retrospective study on outpatients with HTR (being treated with at least 3 drugs at full doses, one ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13126215

    authors: Rodilla E,Costa JA,Pérez-Lahiguera F,González C,Pascual JM

    更新日期:2008-10-04 00:00:00

  • [Anxiety and depression levels in medical inpatients and their relation to the severity of illness].

    abstract:BACKGROUND AND OBJECTIVE:Anxiety and depression are common among medical inpatients. While their relation to the severity of illness is often discussed, the feeling of such severity by the patient and his/her prospects of improvement can be influenced by anxiety and depression. PATIENTS AND METHOD:Patients admitted in...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Grau Martín A,Suñer Soler R,Abulí Picart P,Comas Casanovas P

    更新日期:2003-03-22 00:00:00

  • [Global therapy of diabetic dyslipidemia: benefits and new therapeutic approaches].

    abstract::Diabetic dyslipidemia, characterized by the lipid triad (elevated plasma triglycerides, low HDL cholesterol and predominance of small, dense LDL particles), is a significant contributor to the elevated cardiovascular risk of type 2 diabetic patients. Statin monotherapy has shown, in different prospective trials, signi...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2009.10.010

    authors: Carmena R,Ascaso JF

    更新日期:2010-04-03 00:00:00

  • [Impact of sabbatical leave on hospital and university promotions].

    abstract:BACKGROUND:The aim of this study was the assessment of the scientific production and impact on academic and/or hospital promotion ob sabbatical leaves of medical staff from a University hospital. POPULATION AND METHODS:A matched case-control design was used. The Mantel-Haenszel odds ratio (ORMH) and its 95% confidence...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Asenjo MA,Vernet E,Trilla A,Rodés J,Terés J,Grau J

    更新日期:1998-10-03 00:00:00

  • [Appropriateness of admissions to an internal medicine service at a tertiary hospital].

    abstract::In the present study, clinical, epidemiological and management factors influencing the appropriateness of the 1076 admissions to a general Internal Medicine Section during one year are evaluated. 184 admissions (17%) corresponded to patients who did not meet the AEP (Appropriateness Evaluation Protocol) criteria for a...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Matorras Galán P,de Pablo Casas M,Otero García L,Alonso López F,Daroca Pérez R,Díaz-Caneja Rodríguez N

    更新日期:1990-03-03 00:00:00

  • [Determinants associated wtih the presence of risk behaviors in HIV infected patients].

    abstract:BACKGROUND:Determinants associated with risk behaviours are evaluated in a known HIV-infected population not belonging to the great metropolitan nuclei. PATIENTS AND METHODS:110 unselected HIV+ patients were interviewed, including 77 variables. Their association with sharing needles, and unprotected sex is analysed. ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Llibre JM,Bolibar I,Bleda MJ,Fábregas N,Martínez M,Juanhuix A

    更新日期:1999-04-24 00:00:00

  • [Neurologic manifestations of dissecting aneurysms of the aorta].

    abstract::Dissecting aneurysm of the aorta keeps on being nowadays a diagnostic problem, although it is a well known entity. Dissecting aneurysms may be classified into type A, dissection involving the ascending aorta, and type B, dissection involving descending aorta. The frequency of neurologic manifestations oscillates from ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Alvarez Sabín J,Vázquez J,Sala A,Ortega A,Codina Puiggrós A

    更新日期:1989-04-01 00:00:00

  • [Antibodies against hepatitis C virus in hemophiliacs: correlation with peripheral blood lymphocyte populations].

    abstract::The presence of antibodies (Abs) against hepatitis C virus (HCV) was analyzed in 26 haemophiliac patients; a prevalence of 38% was found in the total series and 56% in the treated patients. There were no cases with a positive serology among the three patients who had only received pasteurized factor. The frequency of ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Gómez E,Alberca I,Vicente V,González M,Martín AM,Corral M,Cordero M,López Borrasca A

    更新日期:1991-01-26 00:00:00

  • [Prognostic value of B-type natriuretic peptide in unstable angina and non-ST-elevation myocardial infarction].

    abstract:BACKGROUND AND OBJECTIVE:The B-type natriuretic peptide (BNP) has recently emerged as a prognostic marker in acute coronary syndromes (ACS). This role is based on results from randomized trials and other high selected population studies. The aim of this study was to determine the prognostic value of BNP in unselected p...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2009.04.057

    authors: Molina-Mora MJ,Cabrera-Bueno F,Jiménez-Navarro M,Linde-Estrella A,García-Pinilla JM,Teresa-Galván Ed

    更新日期:2009-10-24 00:00:00

  • [Study of the genetic component of cardiovascular risk phenotypes in a Mexican population].

    abstract:BACKGROUND AND OBJECTIVE:The aims of the GEMM Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in individuals born and living in Mexico. The authors evaluate the heritabilities (h2) of CVD risk factors in Mexicans from a preliminary cohort already studied. Heritabilities for CVD...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13106675

    authors: Bastarrachea RA,Kent J Jr,Comuzzie AG

    更新日期:2007-06-02 00:00:00

  • [Treatment of acute respiratory insufficiency in an intensive care unit (author's transl)].

    abstract::The clinical records of 304 patients with acute respiratory insufficiency were studied in retrospect. All of them had been treated in an Intensive Care Unit during its first year and a half of operation. One hundred and thirty-one patients suffered from chronic obstructive lung disease and acute episodes of chronic re...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Ibáñez Juvé J,Raurich Puigdevall JM,du Souich PB

    更新日期:1979-01-25 00:00:00

  • [Factors associated with the development of atopy in young adults].

    abstract:BACKGROUND:To determine the risk factors for the development of atopy in Spanish young adults. SUBJECTS AND METHODS:Case-control study over prevalent cases. Carried out in general population between the ages of 20 to 44 years old. Spanish participants of the ECRHS, a random representative sample of Spanish young adult...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(00)71231-0

    authors: Cortès X,Soriano JB,Sunyer J,Martínez-Moratalla J,Muniozgoren N,Maldonado JA,Quirós R,Antó JM

    更新日期:2000-02-12 00:00:00

  • [Cardiac tamponade and Kaposi's sarcoma].

    abstract::The case of a 31 year-old intravenous drug addict female patient with infection by the human immunodeficiency virus who had recurrent cardiac tamponade and who was diagnosed by pericardic biopsy as Kaposi's sarcoma is reported. The patient demonstrated involvement by cutaneous, mucosal, lymph node and probably pleurop...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Just M,Raventós A,Romeu J,Larrousse E,Santos J,Ojanguren I

    更新日期:1994-04-09 00:00:00

  • Vertebral osteomyelitis: Clinical, microbiological and radiological characteristics of 116 patients.

    abstract:INTRODUCTION/OBJECTIVES:To describe the clinical, radiological and microbiological characteristics of vertebral osteomyelitis patients, analysing the factors that played a role on their outcome. PATIENTS AND METHODS:Single-centre retrospective observational study including patients diagnosed with vertebral osteomyelit...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2019.12.029

    authors: Fragío Gil JJ,González Mazarío R,Salavert Lleti M,Román Ivorra JA

    更新日期:2020-10-23 00:00:00

  • [Antibiotic sensitivity, serology and typing by pyocine in 154 cultures of Pseudomonas aeruginosa (author's transl)].

    abstract::Pseudomonas infections continue to be an important problem in the hospital environment. Serious infections are always invariably associated with severe underlying conditions or with diminished host resistance. The increasingly resistance of strains and hospital epidemics favour the organism prevalence. During 1978, Ps...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Cantos de la Casa A,García Curiel A,Gómez Fernández MV,Arroyo Trillo A,Díaz Sánchez JA,Dueñas P

    更新日期:1980-07-15 00:00:00

  • [Clinical and epidemiological features of imported dengue in Spain].

    abstract:BACKGROUND AND OBJECTIVE:Dengue is the most common imported arbovirus infection in Europe. International travel and an increasing incidence of dengue fever in tropical areas have defined the disease as an emerging infection in returning travellers. We describe the clinical and microbiological features of imported dengu...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13123037

    authors: Muñoz J,Puente S,López-Vélez R,Domingo C,Ruiz J,Ramírez G,Navarro M,de Orye F,Sanz S,Rivas P,Turrientes MC,Tenorio A,Gascon J

    更新日期:2008-06-07 00:00:00

  • Recurrent urinary tract infections: from pathogenesis to prevention.

    abstract::Urinary tract infections are highly prevalent among women and when they are recurrent they can lead to patient discomfort and high healthcare costs, and they represent one of the most frequent causes of antibiotic consumption. There are several options to prevent RUTI which include both antibiotic treatment (continuou...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2020.04.026

    authors: Pigrau C,Escolà-Vergé L

    更新日期:2020-08-28 00:00:00

  • Effectiveness of a self-management programme in the treatment of antivitamin K oral anticoagulants. A feasibility study.

    abstract:BACKGROUND AND OBJECTIVES:To compare the efficacy of a self-monitoring programme vs. the conventional method used before the intervention in maintaining the international normalised ratio (INR) in the therapeutic range in patients receiving oral anticoagulants, as well as complications, quality of life and the time inv...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2019.06.016

    authors: Vall Vargas A,Altes Hernandez A,Arnau A,Constans Cots M,Gallart Fernández-Puebla A,de Juan Pardo MÁ

    更新日期:2020-05-22 00:00:00

  • [Effect of HAART on HCV viral load in the first three years of follow-up].

    abstract:BACKGROUND AND OBJECTIVE:Highly active antiretroviral therapy (HAART) has been considered to be ineffective in controlling hepatitis C viremia in the first year of treatment. The present study evaluates the effect of prolonged HAART upon HCV-VL. PATIENTS AND METHOD:We selected those cases with positive serology for HC...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(03)73970-0

    authors: Tornero C,Gimeno C,Igual R,Santamaría A,Gil E,Rull S

    更新日期:2003-10-04 00:00:00

  • [Cutaneous larva migrans in travelers].

    abstract::Fifteen cases of cutaneous larva migrans (CLM) diagnosed in transcontinental travellers over a period of 4 years in the Department of Tropical Medicine in Hospital Clinic i Provincial of Barcelona were reviewed. The frequency of this disease as an imported pathology is on the increase and is related to the greater mob...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:

    authors: Rubio S,Ruiz L,Gascón J,Corachán M

    更新日期:1992-02-15 00:00:00

  • Health-related quality of life according to the main caregiver in patients with home nutritional support.

    abstract:BACKGROUND AND OBJECTIVE:We intended to know the degree of agreement between the quality of life's perception of patients with home nutritional support and that of their main caregiver in the different dimensions. We also aimed to establish the predictive ability of the health-related quality of life (HRQL) punctuation...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(08)72258-9

    authors: Wanden-Berghe C,Nolasco A,Planas M,Sanz-Valero J,Rodríguez T,Cuerda C,Guardiola R,Castelló-Botia I,Grupo NADYA-SENPE.

    更新日期:2008-09-13 00:00:00

  • [Direct genotypic analysis of myotonic dystrophy: detection of an unstable DNA fragment in carriers].

    abstract:BACKGROUND:Myotonic dystrophy (DM) is an inherited autosomal dominant disorder. The molecular defect responsible for the disease is the expansion of a CTG triplet at the 3' end of the DM gene. We report the analysis of the gene expansion, its correlation with the clinical severity and with the phenomenon of anticipatio...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Cobo AM,Martorell L,López de Munain A,Basauri B,Martínez JM,Johnson K,Baiget M

    更新日期:1993-03-13 00:00:00

  • [Perception of safety culture in Spanish intensive care units].

    abstract:BACKGROUND AND OBJECTIVE:Promoting a safety culture in intensive care units (ICUs) is a basic strategy to improve patient safety. The aim of this study was to measure the safety culture in Spanish ICUs. METHOD:We drafted a questionnaire based on the Safety Climate Survey (SCS) and the Safety Attitude Questionnaire-ICU...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/S0025-7753(10)70019-1

    authors: Gutiérrez-Cía I,de Cos PM,Juan AY,Obón-Azuara B,Alonso-Ovies Á,Martin-Delgado MC,Álvarez-Rodríguez J,Aibar-Remón C

    更新日期:2010-07-01 00:00:00

  • [Liver retransplantation: outcome analysis in 50 patients].

    abstract:BACKGROUND AND OBJECTIVE:Liver re-transplantation (re-LT) is an accepted indication for some (technical problems, primary non-function [PNF]) but not all indications, particularly recurrence of the original disease, such as hepatitis C. We aimed to determine in our center: a) the rate of survival following re-transplan...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13075442

    authors: Landaverde C,Berenguer M,Aguilera V,San Juan F,Prieto M,Berenguer J

    更新日期:2005-05-21 00:00:00

  • [Glucose transport hereditary diseases].

    abstract::Several heritable disorders of glucose transport across cellular membranes have been recently characterized both genetically and pathophysiologically. Diseases such as glucose-galactose malabsorption, Fanconi-Bickel syndrome and GLUT1 deficiency syndrome are caused by mutation of transporters located in bowel, liver a...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13095099

    authors: Pascual JM

    更新日期:2006-11-11 00:00:00

  • [Number needed to treat: Interpretation and estimation in multivariable analyses and censored data].

    abstract::Number needed to treat has been recommended as an easy way to transmit results from a trial, especially controlled clinical trials. Most articles estimate it from a 2×2 table, as the inverse of the absolute risk reduction. However, some limitations have been pointed out: The interpretation is not as easy as claimed, c...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2013.05.003

    authors: Gómez-Acebo I,Dierssen-Sotos T,Llorca J

    更新日期:2014-05-20 00:00:00

  • Metabolic risk factors in a cohort of young adults and their association with a body-mass index between 22 and 25 kg/m2.

    abstract:BACKGROUND AND OBJECTIVES:Although health risks associated to excessive body fat increase with small increases in body weight, measurement of body fat is usually grouped in very few categories. The aim of our study was to assess whether the risk for a combined end-point including the incidence of either hypertension an...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2009.02.016

    authors: Toledo E,Beunza JJ,Núñez-Córdoba JM,Bes-Rastrollo M,Basterra-Gortari FJ,Martínez-González MA

    更新日期:2009-05-09 00:00:00

  • [Usefulness of the basic exploration of the upper airways and neighbor structures in patients with adult obstructive sleep apnea-hypopnea syndrome].

    abstract::Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a prevalent disease in the general population, associated with an increase in the cardiovascular morbimortality. A basic and/or standardized otolaryngologic exploration could help us to detect the structural abnormalities that alter the upper airway collapsibility a...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2013.04.035

    authors: Ferré A,Vila J,Arcalís N

    更新日期:2014-04-07 00:00:00

  • [Lung transplanted patient climbing a mountain higher than 4,000 metres. Comparison with healthy climbers].

    abstract:BACKGROUND AND OBJECTIVE:To ascertain if a bilaterally lung transplanted patient can climb a mountain higher than 4,000 metres and to compare the evolution of his physiological parameters during the ascent with those of healthy mountaineers. SUBJECTS AND METHOD:Heart rate, blood pressure, arterial oxygen saturation (S...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(07)72845-2

    authors: Botella de Maglia J,Fuster Escrivà A

    更新日期:2007-09-15 00:00:00

  • [Renal vasculitis without hematuria in senile patients].

    abstract::Systemic vasculitis is a disease whose prognosis has improved considerably with steroid and immunosuppressive treatment, which points up the importance of early diagnosis. In elderly, diagnosis is made more difficult because the frequent onset in the form of a febrile syndrome with non-specific disturbances in general...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Poveda R,Díaz-Gallo C,Carrera M,González MT,Pac V,Vidaller A,Carreras L,Alsina J

    更新日期:1992-04-18 00:00:00