Abstract：
BACKGROUND AND OBJECTIVE:The aims of the GEMM Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in individuals born and living in Mexico. The authors evaluate the heritabilities (h2) of CVD risk factors in Mexicans from a preliminary cohort already studied. Heritabilities for CVD risk factor phenotypes are estimated using a variance component approach. SUBJECTS AND METHOD:As a first step in implementing a large, multi-center collaborative study, we recruited 381 individuals in 21 families at 8 regions across Mexico. Anthropometric and fasting blood samples were collected from all participants. We estimated the magnitude of the random effects of shared genes (heritability) using the genetic software SOLAR. RESULTS:We found significant heritability for phenotypes including waist circumference (0.28 [0.12]), plasma glucose (0.14 [0.08]), body mass index (BMI) (0.28 [0.10]), systolic blood pressure (BP) (0.13 [0.06]), serum cholesterol (0.31 [0.13]) and serum triglyceride (0.23 [0.10]). CONCLUSIONS:These preliminary data represent the first heritability estimates for these phenotypes in Mexico. The results indicate that this study design offers excellent power for gene discovery relative to metabolic disease.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Bastarrachea RA,Kent J Jr,Comuzzie AGdoi
10.1157/13106675subject
Has Abstractpub_date
2007-06-02 00:00:00pages
11-3issue
1eissn
0025-7753issn
1578-8989pii
S0025-7753(07)72738-0journal_volume
129pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：:Clinical trials and prospective observational registries are useful methods to gain knowledge of vascular disease. Because the design of clinical trials is mainly based on demonstrating the efficiency of therapeutic procedures, these studies cannot be widely generalized, especially in complex multifactorial diseases s...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/S0025-7753(09)71744-0
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:B-mode ultrasonography is a simple and valid method to evaluate subclinical atherosclerosis of the major superficial arteries. The aim of this study was toknow by this technique the prevalence of carotid atherosclerosisin patients with coronary disease and related factors. PATIENTS AND METHOD:In 232patients...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)71864-7
更新日期：2001-03-31 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To study the factors associated with prolonged hospitalization in patients admitted for acute heart failure (AHF) in Spanish short-stay units (SSUs). PATIENTS AND METHODS:This was a multicentre, multipurpose cohort study with prospective follow-up including all patients admitted for AHF in the...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2013.06.028
更新日期：2014-09-15 00:00:00
abstract：:Meningitis and other infectious diseases of the central nervous system are predisposing causes of the inadequate secretion syndrome of the antidiuretic hormone (ISADH). The association between the acquired immunodeficiency syndrome (AIDS) and ISADH is recognized but little studied. In AIDS patients hyponatremia is a f...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1993-03-20 00:00:00
abstract：:Difficulties derived from the big complexity of the human genome (because of the great amount of genes) and difficulties at the time of performing a correct molecular diagnosis have led to the utilization of advanced technologies such as DNA arrays. By this technique, it is possible to analyze in a single experiment g...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1157/13119504
更新日期：2008-04-12 00:00:00
abstract：BACKGROUND:In recent years there has been a change in the opportunistic diseases incidence in HIV-infected patients. The change could be related to the use antiviral therapy and chemoprophylaxis strategies. The aim of the present study was to evaluate if medical intervention is able to modificate the clinical presentat...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1998-02-07 00:00:00
abstract：OBJECTIVE:To determine if a more simplified medication regimen is associated with survival in polypathological patients. METHODS:Multicentre cohort study. We included polypathological patients admitted to internal medicine wards between March 1st and June 30rd, 2011. Patients that died during admission and readmission...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2019.06.023
更新日期：2020-04-10 00:00:00
abstract：BACKGROUND:In the present study we evaluated the influence of the observer's status--physician or nurse--on blood pressure levels and the relationship among clinic blood pressure measurement with ambulatory blood pressure and left ventricle mass. PATIENTS AND METHODS:Cross sectional study performed in seven primary ca...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-12-11 00:00:00
abstract：BACKGROUND:This study investigated the burden (incidence, mortality and serotype distribution) of pneumococcal pneumonia among older adults in the region of Tarragona (Spain). METHODS:Population-based cohort study involving 27,204 individuals ≥60 years in Tarragonès county (Southern Catalonia), who were prospectively ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2015.09.015
更新日期：2016-03-04 00:00:00
abstract：:Nesidioblastosis is an anatomopathological situation defined as the transformation or the exocrine ductal epithelium into endocrine tissue which can be hormonally active or inactive. In this study we present two cases which to our knowledge fulfil criteria for nesidioblastosis. Both patients were male (73 and 45 years...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1990-09-22 00:00:00
abstract：:The hepatitis E virus is an RNA virus with 4 genotypes. Genotypes 1 and 2 only affect humans and produce epidemic acute hepatitis in endemic regions (Asia and Africa). Genotypes 3 and 4 are considered a zoonosis and produce episodic acute hepatitis in non-endemic areas (America and Europe). However, in the last 3 year...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2011.02.003
更新日期：2012-02-04 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze the predictive factors of IDDM in first degree relatives of IDDM patients. SUBJECTS AND METHODS:From 1992 to 1994, 1,053 first degree relatives were screened for measuring islet cell antibodies (ICA) by indirect immunofluorescence (iFl). In all ICA positive subjects, bet...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：
更新日期：1996-09-28 00:00:00
abstract：:Currently, pharmacological thromboprophylaxis is frequently required in patients undergoing surgery, due to the high risk of deep venous thrombosis in the perioperative period. The administration of these anticoagulant agents (in Spain, usually low molecular weight heparins or fondaparinux, and in future, probably als...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/s0025-7753(08)76448-0
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:Due to the double atherogenic and antifibrinolytic action of lipoprotein (a) (Lp [a]) and its predictive value of cardiovascular disease in hypercholesterolemic patients, we document in the present work the changes in Lp (a) levels of a patient with homozygous familial hypercholesterolemia after one year of ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-10-31 00:00:00
abstract：UNLABELLED:This was a study aimed to know the knowledge about asthma. SUBJECTS AND METHOD:933 teachers of 27 schools from 7 cities (children aged between 4 and 15 years) using a self-administered questionnaire Half of them knew asthma prevalence and its hereditary nature. Nearly all related asthma with allergy, 38% wi...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)72142-2
更新日期：2001-10-20 00:00:00
abstract：:Uterine fibroids are the most common benign tumours that affect women of reproductive age and they represent the main indication for surgery for benign uterine pathology. In 25% of cases, they become clinically apparent, causing heavy menstrual bleeding, pelvic pain and/or infertility. Therefore, fibroids have a notab...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(13)70045-9
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Since 1992 conservative treatment of breast cancer (stage I and II: clinical TNM) has been established as an alternative to mastectomy in our hospital. The aim of this retrospective study was to analyse locoregional recurrence features and to compare prognosis with regard to to site of recurrence. METHOD:Be...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)72321-x
更新日期：2002-02-16 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Left ventricular hypertrophy (LVH) is the most frequent manifestation of cardiac damage in hypertension. The objective of this study was to evaluate the prevalence of LVH in hypertensive patients of long evolution at Primary Care (PC) and to describe their epidemiological profile. PATIENTS AND...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1157/13106936
更新日期：2007-06-09 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The pprevalence of extended-spectrum beta-lactamase (ESBL) producing gram-negative bacilli has increased in recent years. The aim of this study is to estimate the prevalence of infection/colonization due to theses microorganisms per 100 admissions and its trend during the period 2007-2010. PAT...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.03.034
更新日期：2013-07-07 00:00:00
abstract：:A group of 32 patients with disseminated breast cancer were submitted to polychemotherapy following Cooper's protocol. Vincristine, cyclophosphamide, 5-fluorouracil, and prednisone were administered. The fifth drug used by Cooper, methotrexate, was not included in the therapy program because of difficulties in obtaini...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-08-15 00:00:00
abstract：BACKGROUND:The aim of the present study was to determine the prevalence and diagnostic usefulness of antineutrophil cytoplasmic antibodies (ANCA) in a Spanish population of patients with inflammatory bowel disease from the province of Tarragona. PATIENTS AND METHODS:One hundred and fifty-six sera obtained from 116 pat...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1998-01-17 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze the influence of age on the clinical and biological features as well as the results of treatment in 41 adult patients with acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS:The patients diagnosed with ALL from January 1989 to October 1995 in a single center were s...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1996-10-05 00:00:00
abstract：BACKGROUND AND OBJECTIVE:An important input to decision-making and health planning is a consistent and comparative description of the population health status. The purpose of this study was to describe the burden of disease in the Region of Valencia (Spain). MATERIAL AND METHODS:Disability-adjusted life years (DALYs) ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.01.028
更新日期：2013-04-20 00:00:00
abstract：:Neutrophils play a key role in the innate immune system, providing the first line of host defense. In addition to their ability to eliminate pathogens by phagocytosis and antimicrobial secretions, it has recently been shown that neutrophils can trap and kill microorganisms by the release of extracellular structures co...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2012.04.022
更新日期：2013-01-19 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Information about the prevalence of chronic kidney disease (CKD) in the population treated in primary care is scarce. The aim of this study was to assess the prevalence of CKD in Spanish hypertensive women aged 64 years or older, and to determine possible associated factors. PATIENTS AND METH...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2011.03.038
更新日期：2012-05-05 00:00:00
abstract：:Osteoarthritis and osteoporosis are both common conditions in the elderly but their association has long remained obscure. Recently published studies show that patients with osteoarthritis have higher bone mass but no corresponding decrease in fracture risk. This has been proposed to be due to an increased rate of fal...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2013.01.036
更新日期：2013-09-07 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) are excellent predictive factors of tissue damage, inflammation and infection. However, there is not sufficient data about their usefulness in elderly patients with acute septic pathology. Our objective was to identify the cytokines related ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(03)73952-9
更新日期：2003-09-27 00:00:00
abstract：:Epstein-Barr virus (EBV) infection is ubiquitous and may result in multiple and widely different clinical features; the most common of these is infectious mononucleosis (IM). Recently, a group of patients has been included in the chronic EBV infection syndrome (EBVIS), with a sustained nonspecific syndrome consisting ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1989-04-29 00:00:00
abstract：BACKGROUND:In the last few years a marked increase has been observed in the use of statistical techniques in biomedical publications. Some characteristics of the statistical quality of the first 100 articles consecutively published in 1993 in the section of originals and surveys of the journal MEDICINA CLINICA are pres...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-06-03 00:00:00
abstract：:The REACH registry allows the degree of control of risk factors associated with atherothrombosis to be evaluated. Although 90% were taking at least one antihypertensive agent, hypertension was controlled in only 42.9% of the patients with vascular disease. This inadequate control may have multiple causes but the main ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/S0025-7753(09)71754-3
更新日期：2009-09-01 00:00:00
