[Association of VCR-5FU-CYCLO-PDN in the treatment of disseminated carcinoma of the breast (author's transl)].

Abstract:

:A group of 32 patients with disseminated breast cancer were submitted to polychemotherapy following Cooper's protocol. Vincristine, cyclophosphamide, 5-fluorouracil, and prednisone were administered. The fifth drug used by Cooper, methotrexate, was not included in the therapy program because of difficulties in obtaining it. Both the objective and subjective results were similar to those of other authors using similar drug associations, while toxicity was moderate. Although this treatment is effective to some degree, the authors feel that further research should be carried out on more potent drugs, or in different combinations, in order to get a more definite chemotherapeutic effect in patients with breast cancer.

journal_name

Med Clin (Barc)

journal_title

Medicina clinica

authors

Estapé J,Millá A,Prats M,Herranz M,Visa J

subject

Has Abstract

pub_date

1979-08-15 00:00:00

pages

136-9

issue

4

eissn

0025-7753

issn

1578-8989

journal_volume

73

pub_type

杂志文章
  • [A pancreatic pseudotumour of tuberculous etiology].

    abstract:BACKGROUND:To review the clinical findings of pancreatic tuberculosis and to establish a differential diagnosis with pancreatic tumours. PATIENTS AND METHODS:To describe three cases of pancreatic tuberculosis diagnosed in a 850 bed teaching hospital during the last two years. RESULTS:In the three case the imaging pro...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/s0025-7753(00)71592-2

    authors: Martínez-Valle F,Capdevila JA,Ribera E,Pigrau C,Pahissa A

    更新日期:2000-10-14 00:00:00

  • [Medical-legal issues of physical and pharmacological restraint].

    abstract::The use of physical and pharmacological restraint is controversial but is currently accepted as inevitable. It is indicated for controlling behavioral disorders and psychomotor agitation that put patients and third parties at risk. Its indication should be medical, and we should opt for the least restrictive measure. ...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/S0025-7753(14)70068-5

    authors: Gómez-Durán EL,Guija JA,Ortega-Monasterio L

    更新日期:2014-03-01 00:00:00

  • [Influences of hyperinsulinemia in the lipid profile of hypertensive patients].

    abstract:BACKGROUND:Hypertension and dyslipemia are associated with a greater frequency than that randomly expected. The increase in insulinic resistance hyperinsulinemia is one of the factors implicated in the pathogenesis of this association. In the present study the lipid profile of hypertensive patients is analyzed accordin...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Villar J,Muñiz O,Stiefel P,Miranda M,Jiménez L,Montilla C,Martín-Sanz V,Carneado J

    更新日期:1994-09-10 00:00:00

  • [Serum lipoprotein (a) levels during treatment with LDL apheresis for homozygous familial hypercholesterolemia].

    abstract:BACKGROUND:Due to the double atherogenic and antifibrinolytic action of lipoprotein (a) (Lp [a]) and its predictive value of cardiovascular disease in hypercholesterolemic patients, we document in the present work the changes in Lp (a) levels of a patient with homozygous familial hypercholesterolemia after one year of ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Lasunción MA,Teruel JL,Alvarez JJ,Gómez-Coronado D,Ortuño J,Herrera E

    更新日期:1992-10-31 00:00:00

  • [Acute myocardial infarction of the right ventricle: hemodynamic and electrocardiographic correlation (author's transl)].

    abstract::The electrocardiogram as a diagnostic aid in acute myocardial infarction of the right ventricle (AMI-RV) was studied prospectively in a group of 66 patients in our coronary unit. Diagnosis was AMI in all cases, divided into 29 (44%) with posterior-descending and 35 (53%) with anterior location. Electrocardiography was...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Fiol Sala M,Jaume Tomás G,Orellana Mas J,Ibáñez Juvé J,Guardiola Navarro F,García Moris S

    更新日期:1981-09-25 00:00:00

  • [Parotiditis in postvaccination period. Epidemiologic pattern and vaccine effectiveness in an epidemic outbreak].

    abstract:BACKGROUND:Upon the detection of an excess number of cases of parotiditis in La Almolda (Zaragoza) a descriptive study of the epidemic was carried out with vaccination efficacy being quantified. METHODS:The definition and system of detection of the cases was established. To calculate the rate of infection the availabl...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Guimbao Bescós J,Moreno Marín MP,Gutiérrez Colás V,Pac Sá MR,Arribas Monzón F

    更新日期:1992-09-19 00:00:00

  • Relationship between diffuse idiopathic skeletal hyperostosis, abdominal aortic calcification and associated metabolic disorders: Data from the Camargo Cohort.

    abstract:BACKGROUND AND OBJECTIVE:Diffuse idiopathic skeletal hyperostosis (DISH) and abdominal aortic calcification (AAC) are related to an increased cardiovascular risk. The aim of this study was to analyse a possible relationship between both entities and also the association between metabolic disorders and DISH. PATIENTS A...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2017.01.030

    authors: Pariente-Rodrigo E,Sgaramella GA,Olmos-Martínez JM,Pini-Valdivieso SF,Landeras-Alvaro R,Hernández-Hernández JL

    更新日期:2017-09-08 00:00:00

  • [Research on prognostic factors in large-cell lymphomas].

    abstract:BACKGROUND:To carry out a study on the prognostic factors in large cell lymphomas (LCL) treated during the last decade and validate the international prognostic index (IPI). METHODS:One hundred twenty-four cases of newly diagnosed LCL, treated from 1978 to 1990, with a mean follow up of 27 months (1-142) were included...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Gandarillas MA,Conde E,Mazorra F,Cuadrado MA,Baro J,Garijo J,Recio M,Richard C,Iriondo A,Castro F

    更新日期:1995-04-29 00:00:00

  • Burden of disease assessment with summary measures of population health for the Region of Valencia, Spain: a population-based study.

    abstract:BACKGROUND AND OBJECTIVE:An important input to decision-making and health planning is a consistent and comparative description of the population health status. The purpose of this study was to describe the burden of disease in the Region of Valencia (Spain). MATERIAL AND METHODS:Disability-adjusted life years (DALYs) ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2012.01.028

    authors: Catalá-López F,Gènova-Maleras R,Ridao M,Álvarez E,Sanfélix-Gimeno G,Morant C,Peiró S

    更新日期:2013-04-20 00:00:00

  • [Delirium in an elderly population admitted at a general hospital].

    abstract:BACKGROUND:Delirium is an organic mental disorder frequently seen in elderly patients admitted to hospital for medical or surgical diseases. The prevalence, triggering factors, the relationship with prior existence of dementia and the evolution of delirium were studied. METHODS:One hundred eight elderly patients admit...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Lázaro L,Marcos T,Cirera E,Pujol J

    更新日期:1995-03-11 00:00:00

  • [Transforming growth factor beta (TGF-beta) in Gaucher's disease. Preliminary results in a group of patients and their carrier and non-carrier relatives].

    abstract:BACKGROUND:The poor phenotype/genotype correlation in Gaucher's disease makes difficult therapy-decision-making and prevention of complications. Gaucher's cells and tissue fibrosis are the earliest findings of the disease. Transforming growth factor ss (TGF-beta1) is the key cytokine involved in the regulation of tissu...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(00)71637-x

    authors: Pérez Calvo JI,Iñigo Gil P,Giraldo Castellano P,Torralba Cabeza MA,Civeira F,Lario García S,Pocoví M

    更新日期:2000-11-11 00:00:00

  • [Analysis of Spanish hospital's reputation: relationship with their scientific production in different subspecialities].

    abstract:BACKGROUND AND OBJECTIVE:To assess the relationship between reputation of hospitals, as determined by specialists' opinion, and their scientific production. MATERIAL AND METHOD:A questionnaire was sent to a sample of members of the Spanish Societies of Cardiology, Digestive Diseases, Neurology and Otorhinolaryngology....

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13089112

    authors: Asenjo MA,Bertrán MJ,Guinovart C,Llach M,Prat A,Trilla A

    更新日期:2006-05-27 00:00:00

  • [Costs of known diabetes mellitus in Spain].

    abstract:BACKGROUND:Diabetes mellitus is an important cause of mortality and morbidity in western nations with high costs for both patients and health care systems. MATERIAL AND METHODS:Based on the latest epidemiological studies and in combination with Spanish demographic data the direct health care costs of known diabetes me...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Hart WM,Espinosa C,Rovira J

    更新日期:1997-09-13 00:00:00

  • [Guidelines for the rational use of endoscopy to improve the detection of relevant lesions in an open-access endoscopy unit: a prospective study].

    abstract:BACKGROUND AND OBJECTIVE:Almost 50% of gastrointestinal endoscopies performed in our Unit correspond to patients coming from primary care. Since resources are finite, adherence to appropriate indications for these procedures is essential. We prospectively assessed the appropriateness of gastrointestinal endoscopies ref...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13107917

    authors: Fernández-Esparrach G,Gimeno-García AZ,Llach J,Pellisé M,Ginès A,Balaguer F,Mata A,Castells A,Bordas JM

    更新日期:2007-07-07 00:00:00

  • [Atherothrombosis: an excessively globalizing concept?].

    abstract::Clinical trials and prospective observational registries are useful methods to gain knowledge of vascular disease. Because the design of clinical trials is mainly based on demonstrating the efficiency of therapeutic procedures, these studies cannot be widely generalized, especially in complex multifactorial diseases s...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/S0025-7753(09)71744-0

    authors: Castillo J,Blanco M

    更新日期:2009-09-01 00:00:00

  • [Microsatellite instability predicts better outcome in colorectal cancer patients].

    abstract:BACKGROUND AND OBJECTIVE:Two different pathways for the development of tumor have been described in colorectal carcinoma: the chromosomic instability, raised by suppressor genes and proto-oncogene alterations, and the microsatellite instability (MSI), caused by alterations in DNA repairing genes. PATIENTS AND METHOD:T...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13071004

    authors: Vidaurreta M,Sanz-Casla MT,Maestro ML,Rafael S,Jiménez F,Arroyo M,Fernández C,Cerdán J

    更新日期:2005-02-05 00:00:00

  • [Fetal microchimerism in patients with primary biliary cirrhosis].

    abstract:BACKGROUND:Fetal microchimerism (FM) has been implicated in the pathogenesis of primary biliary cirrhosis (PBC). The aim of the study was to investigate the presence of FM in PBC patients. PATIENTS AND METHOD:FM was studied in 28 women, 14 with PBC and 14 healthy controls.DNA was extracted from peripheral blood cells,...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(02)73575-6

    authors: Selva O'Callaghan A,Balada Prades E,Castells Fusté L,Vargas Blasco V,Solans Laque R,Vilardell Tarrés M

    更新日期:2002-12-07 00:00:00

  • [Clinical and methodological considerations in the quantification of estrogen and progesterone receptors using monoclonal antibodies in breast cancer].

    abstract:BACKGROUND:The aim of the present study was to provide information on several clinical and methodological aspects of the measurement of the contents of estrogen (ER) and progesterone (PgR) receptors in breast tumoral tissue using monoclonal antibodies. METHODS:The contents of ER and PgR were measured in 94 tumor speci...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Navarro MA,Huguet J,Valero J,Samaniego JM,Rosel P,Sirvent JJ

    更新日期:1991-06-08 00:00:00

  • [Diagnosis of renovascular disease by heart catheterization].

    abstract::Atherosclerotic renovascular disease is a common entity, particularly in persons older than 50 years of age and especially in those patients with other evidence of atherosclerotic vascular disease. The illness clearly progresses in some patients, and progression rate appears to be highly variable. Taken into account t...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: de Sequera P,Abad J,Albalate M,Torres M,Vázquez A,Sierra MP,Casado S

    更新日期:1997-04-12 00:00:00

  • [Treatment and control of patients with phenylketonuria: results from the Collaborative Group of Spanish Follow-up Units].

    abstract:BACKGROUND AND OBJECTIVE:To evaluate the management of phenylketonuria (PKU) in Spanish metabolic units and to develop a patients registry. PATIENTS AND METHODS:PKU patients diagnosed and/or followed up in Spain, with phenylalanine values before treatment > 360 μmol/L. Registered anonymous data are those yielded by th...

    journal_title:Medicina clinica

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.medcli.2011.03.037

    authors: Campistol J,González MJ,Gutiérrez AP,Vilaseca MA,Grupo Colaborativo de Unidades de Seguimiento Españolas.

    更新日期:2012-03-03 00:00:00

  • [Clinical and biological prognostic factors in relapsed acute myeloid leukemia patients].

    abstract:BACKGROUND AND OBJECTIVE:Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common cause of treatment failure. Leukaemia relapse occurs due to clonal evo...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2016.05.015

    authors: Yébenes-Ramírez M,Serrano J,Martínez-Losada C,Sánchez-García J

    更新日期:2016-09-02 00:00:00

  • [Incidence and mortality of massive transfusion in a university hospital: study of the period 2001-2005].

    abstract:BACKGROUND AND OBJECTIVE:There are few epidemiological studies on massive transfusion (MT), although they may be important to evaluate possible strategies to reduce the number of transfused units, as well as transfusion side-effects. We, therefore, retrospectively assessed the incidence of MT at our institution (a 700-...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13110210

    authors: Campos A,Muñoz M,García-Erce JA,Ramírez G

    更新日期:2007-09-22 00:00:00

  • [Nontraumatic cerebral hematoma in young adults: a study of 42 cases].

    abstract:BACKGROUND:Cerebrovascular disease has particular features in young adults (15-45 years). In this context, non-traumatic intracranial hematoma (NTICH) has received little attention. Therefore, its analysis has been attempted focusing on etiology, localization and short term prognosis. METHODS:42 patients aged 15-45 ye...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Martínez Menéndez B,Pérez Sempere A,Cabeza Alvarez CI,Villaverde Amundaraín FJ,Calandre Hoenigsfeld L

    更新日期:1991-11-30 00:00:00

  • [The prevalence of markers for the hepatitis A and B viruses in the population of Gijón between 6 and 25 years old].

    abstract:BACKGROUND:The aim of this study was to know the prevalence of previous infection markers for hepatitis A and B viruses in a pediatric-juvenile population from Gijón, Spain. PATIENTS AND METHODS:A representative (according to the census) transversal randomized sample of a population from 6 to 25 years in age from Gijó...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Suárez A,Navascués CA,García R,Peredo B,Miguel D,Menéndez MT,Saro C,Román F

    更新日期:1996-04-06 00:00:00

  • Adherence to recommendations of the Therapeutic Positioning Report about treatment with oral anticoagulants in elderly patients with atrial fibrillation. The ESPARTA study.

    abstract:BACKGROUND AND OBJECTIVE:To evaluate the adherence to the recommendations in clinical practice performed by the Therapeutic Positioning Report (TPR) of the Spanish Agency of Medicines and Sanitary Products about the treatment with oral anticoagulants in patients aged≥75 years old with nonvalvular atrial fibrillation (N...

    journal_title:Medicina clinica

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.medcli.2017.07.025

    authors: Suárez Fernández C,Mostaza JM,Castilla Guerra L,Cantero Hinojosa J,Suriñach JM,Acosta de Bilbao F,Tamarit JJ,Diaz Diaz JL,Hernandez JL,Cazorla D,Ràfols C,en nombre de los Investigadores del Estudio ESPARTA.

    更新日期:2018-07-13 00:00:00

  • [Cardiomyopathy and inborn errors of metabolism in children. Study of 12 cases].

    abstract:BACKGROUND AND OBJECTIVE:Cardiomyopathy in childhood is a rare entity. Inborn errors of metabolism can cause myocardial involvement by several mechanisms. PATIENTS AND METHODS:Patients under 16 years diagnosed with cardiomyopathy and EIM in a period of 11 years (1998-2009) were included. RESULTS:A total of 12 patient...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2011.06.019

    authors: Sabaté Rotés A,Del Toro Riera M,Albert Brotons DC,Arranz Amo JA,Carrascosa Lezcano A,Girona Comas J

    更新日期:2011-11-19 00:00:00

  • [Characteristics of patients with familial adenomatous polyposis in Spain. First results of the Spanish Registry of Familial Adenomatous Polyposis].

    abstract:BACKGROUND AND OBJECTIVES:Familial adenomatous polyposis is an inherited disorder characterized by the presence of multiple colorectal adenomas (more than 100 in the classic form and between 10 and 100 in the attenuated one), with a high risk of colorectal cancer development. To improve the diagnostic and therapeutic m...

    journal_title:Medicina clinica

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.medcli.2009.09.054

    authors: Alfaro I,Ocaña T,Castells A,Cordero C,Ponce M,Ramón Y Cajal T,Andreu M,Bujanda L,Herráiz M,Hervás Molina AJ,Fernández-Bañares F,Riestra-Menéndez S,Gargallo C,Ruiz A,Bustamante M,Blanco I,Martínez de Juan F,Registro Espa

    更新日期:2010-06-19 00:00:00

  • [Postacute care].

    abstract::The aging of the population and changes in family and social structures have led to increasing care needs for elderly persons following an acute disease or accident, with consequent concerns regarding costs and sustainability within the public health system. The main objective of postacute care (PAC) is to restore the...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2013.05.032

    authors: Admetlla Falgueras M,Fusté Sugrañes J

    更新日期:2014-07-07 00:00:00

  • [Clinical factors associated with bone mass loss previous cardiac transplantation].

    abstract:BACKGROUND:A high prevalence of osteoporosis has been described in patients before and after cardiac transplantation. But clinical factors involved in previous bone loss in this condition are not well known. The purpose has been to study bone mineral density (BMD) in patients subject to cardiac transplantation, analyzi...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(00)71430-8

    authors: García Delgado I,Gil-Fraguas L,Robles E,Martínez G,Hawkins F

    更新日期:2000-05-27 00:00:00

  • [Impact of sabbatical leave on hospital and university promotions].

    abstract:BACKGROUND:The aim of this study was the assessment of the scientific production and impact on academic and/or hospital promotion ob sabbatical leaves of medical staff from a University hospital. POPULATION AND METHODS:A matched case-control design was used. The Mantel-Haenszel odds ratio (ORMH) and its 95% confidence...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Asenjo MA,Vernet E,Trilla A,Rodés J,Terés J,Grau J

    更新日期:1998-10-03 00:00:00