Abstract：
BACKGROUND:The aim of the present study was to provide information on several clinical and methodological aspects of the measurement of the contents of estrogen (ER) and progesterone (PgR) receptors in breast tumoral tissue using monoclonal antibodies. METHODS:The contents of ER and PgR were measured in 94 tumor specimens of breast carcinoma from pre- and postmenopausal women by the classical method of dextran-charcoal (DC) and an enzyme immunoassay (EIA) with monoclonal antibodies against receptors. RESULTS:The most remarkable results were: a significant difference for ER depending on the menopausal status, an increasing concentration of ER and PgR with age, a greater frequency of the phenotypes ER positive (+)-PgR (+) and ER negative (-) -PgR (-), a lower frequency of positive than negative receptors in the tumors measuring more than 10 cm, a greater presence of tumors with negative than with positive receptors in those located in the lower half of the breast, and the high diagnostic sensitivity of ER and PgR measurement with this method. CONCLUSIONS:There was a remarkable difference in contents of total ER in breast tumors from pre- and post menopausal women. This finding confirms that these tumors may have a different hormone modulation and a different capacity for protein induction depending on the menopausal status.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Navarro MA,Huguet J,Valero J,Samaniego JM,Rosel P,Sirvent JJsubject
Has Abstractpub_date
1991-06-08 00:00:00pages
41-4issue
2eissn
0025-7753issn
1578-8989journal_volume
97pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND AND OBJECTIVE:The REACH Registry is the largest worldwide designed to obtain information on cardiovascular risk factor control and preventive treatment in a population who have, or are at risk of having, symptoms of atherothrombosis. The objective of this study is to show the results of cardiovascular events...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2008.11.033
更新日期：2009-04-18 00:00:00
abstract：:The coexistence of organ-specific and nonorgan-specific autoimmune diseases is an interesting phenomenon. A 52-year-old woman was admitted with fever, general discomfort, polyarthritis, and Raynaud's phenomenon. Physical examination revealed a goiter of stony consistency, hardening, paleness, and atrophy of the skin o...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-11-10 00:00:00
abstract：BACKGROUND:The handling of upper gastrointestinal hemorrhage (UGH) usually includes the hospitalization of all patients, regardless of severity and prognosis. The aim of this paper is to assess the security of the outpatient control of some UGH, after their assessment in the hospital emergency room. PATIENTS AND METHO...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:This article provides an epidemiological description of anesthesia practice in Catalonia, Spain, in 2003. PATIENTS AND METHOD:Descriptive data on sex, age, and physical status of patients according to American Society of Anesthesiologists (ASA) classification were taken from responses to the q...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13088796
更新日期：2006-05-24 00:00:00
abstract：:The aim of a case-control design is to make a measurement of the highest possible accuracy, reducing to a minimum the possible selection, information and confusion biases. The design, methods and procedures of a multicentric study carried out in 14 hospitals from 4 autonomous communities in Spain are discussed. Overal...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1989-05-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Functional assessment is especially relevant in patients with cognitive impairment (CI). The Disability Assessment for Dementia (DAD) scale assesses functional ability and its use is becoming increasingly popular. This study aims to perform the translation and cultural adaptation of the DAD sca...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2017.03.029
更新日期：2017-09-20 00:00:00
abstract：BACKGROUND:The use of monoclonal antibodies against tumoral antigens marked with radioactive isotopes is the basis of immunoscintigraphy. The specificity of the technique is high owing to its intrinsic characteristics. METHODS:40 patients with colorectal cancer who were awaiting surgery were evaluated by immunoscintig...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-03-02 00:00:00
abstract：:The first patient with myelopathy associated with T-cell leukemia/lymphoma virus infection (HTLV-I) in Spain is reported. Although this condition is endemic in several areas from the Caribbean Sea, South America, Africa and Japan, some cases have been reported in European countries, generally in immigrant patients, re...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-02-23 00:00:00
abstract：BACKGROUND:To establish the early risk of multiple sclerosis (MS) following isolated demyelinating syndromes. PATIENTS AND METHOD:36 patients with optic neuritis, 24 with brainstem syndromes, 27 with spinal cord syndromes and 8 patients with a poliregional syndrome were included in a prospective protocol: including cl...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-05-22 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Several models for the prediction of liver fibrosis have been developed which consist of the measurement of routine laboratory data: a) a model combining platelets, gamma-glutamil-transpeptidase, cholesterol and age (Forns model), and b) a model using an aspartate-aminotransferase to platelet r...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13075845
更新日期：2005-05-28 00:00:00
abstract：:A group of 32 patients with disseminated breast cancer were submitted to polychemotherapy following Cooper's protocol. Vincristine, cyclophosphamide, 5-fluorouracil, and prednisone were administered. The fifth drug used by Cooper, methotrexate, was not included in the therapy program because of difficulties in obtaini...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-08-15 00:00:00
abstract：:The gastric emptying of solids was evaluated with radionuclide techniques in 16 patients with reflux esophagitis, demonstrated by two of the following methods: endoscopy, pathology, and/or pH measurement. The percentage of radionuclide remaining within the stomach was 80.8 +/- 17% after 45 minutes, 63.3 +/- 10% after ...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-09-30 00:00:00
abstract：:We analyzed the tissue oxygen extraction in 25 patients with acute respiratory failure. Fourteen met the clinical criteria for the adult respiratory distress syndrome (ARDS). The 11 remaining patients had acute respiratory failure with causes different from ARDS. In all cases the changes in the oxygen extraction ratio...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-01-26 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The smoke fume, principal factor in the development of lung cancer, causes the expression of certain cytokines, including interleukin 4, 6, 8 and 10, which may act by inhibiting apoptosis and interfere cellular repair mechanisms and angiogenesis. To determine the possible relationship between g...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.07.034
更新日期：2014-08-04 00:00:00
abstract：BACKGROUND:The purpose of this study was to know the concordance of diagnosis between emergency rooms amd hospitalization wards and to analyze the mistake index, the epidemiological characteristics and the main reasons for the mistakes. PATIENTS AND METHOD:We analyzed hospitalized patients and used a three-level conco...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)73485-4
更新日期：2002-10-26 00:00:00
abstract：INTRODUCTION:There are gaps in our knowledge of the normative levels of haemoglobin and the prevalence of anaemia in our geographical area, and in certain population subgroups. OBJECTIVES:To study the mean values of haemoglobin in a mountainous Spanish region, according to sex, age range and residence altitude, and th...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2019.02.002
更新日期：2019-12-13 00:00:00
abstract：:Through the Law 2/2004 on improving neighbourhoods, urban areas and towns requiring special attention, the Government of Catalonia set up a fund for financing projects prepared by town/city councils for the integral improvement of neighbourhoods. The Ministry of Health signed on to the strategy with The Neighbourhood ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(08)76477-7
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Infliximab is a chimeric monoclonal antibody that binds to tumor necrosis factor alpha and blocks the inflammatory response. The purpose of this study was to assess the effects of infliximab in patients with severe and refractory psoriasis. PATIENTS AND METHOD:Eleven patients with severe and r...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章
doi：10.1016/s0025-7753(04)74634-5
更新日期：2004-11-13 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The association between the presence of the allele APOE*epsilon4 (apolipoprotein E) and sporadic Alzheimer disease (AD) has been long established. However, the possible influence of other genetic factors is still under debate. This study investigated the role of the a 1-antichymotrypsin (ACT) g...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(04)74479-6
更新日期：2004-09-04 00:00:00
abstract：:We performed a systematic review to assess the efficacy and safety of extracorporeal albumin dialysis systems in patients with liver failure. After screening 436 references, 10 controlled trials were detected. The analyzed interventions were MARS, Prometheus and Biologic-DT. Efficacy was proven by a reduction in bilir...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2010.01.032
更新日期：2011-04-23 00:00:00
abstract：:The usefulness of two alpha-2 adrenergic agonists (clonidine and guanfacine) and their comparative effectiveness were evaluated regarding the control of the opiates abstinence syndrome and the secondary effects, including development of cardiovascular abnormalities, in 88 parenteral heroin abusers admitted to two hosp...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-02-10 00:00:00
abstract：:Monitoring biomedical signals obtained from a patient generates information that processed conveniently, it has to allow detecting as soon as possible changes in the predicted evolution. The systematic register of one of these biomedical signals is named a time series. In this paper, a brief introduction appears to th...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1157/13057547
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The effects of rosiglitazone on the lipid profile are controversial, with related increases in the concentration of total and LDL cholesterol. Our objective is to evaluate the evolution of the concentration and size of LDL particles in a group of patients with type 2 diabetes mellitus taking ro...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2008.05.001
更新日期：2009-01-31 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Our goal was to know if the diagnosis of metabolic syndrome (MS) as defined by International Diabetes Federation (IDF) criteria 2005 identifies more subjects with atherogenic dyslipidemia and high cardiovascular risk than the National Cholesterol Education Program-Adult Treatment Panel III (NCE...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13092312
更新日期：2006-09-09 00:00:00
abstract：BACKGROUND AND OBJECTIVE:There is a bidirectional association between neoplasia and venous thromboembolism (VTE). However, whether this association has an impact in tumor recurrence is unknown. The aim of the study is to assess the incidence of cancer recurrence after diagnosis of VTE and determine if VTE could be a ma...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2009.04.054
更新日期：2009-10-17 00:00:00
abstract：:Coronary heart disease is one of the major causes of death in developed countries. The hypothesis that peroxidation of low density lipoproteins (LDL) may be the initial step of the atherosclerotic process has promoted numerous studies aimed at investigating the mechanisms by which the body protects itself from such ox...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/s0025-7753(03)74011-1
更新日期：2003-10-25 00:00:00
abstract：FOUNDATIONS AND AIM:The aim of this study is to analyze the CHADS2 score as a marker of the risk of mortality in hypertensive patients, with and without the presence of atrial fibrillation. METHODS:We included 1,003 hypertensive patients≥65 years. Risk factors, and CHADS2 score were recorded among other factors, as we...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2016.03.015
更新日期：2016-06-03 00:00:00
abstract：:A series of eight patients with cerebral tuberculoma seen between 1980 and 1990 is reported. Headache was the leading clinical finding, followed by focal neurological findings and seizures. Papilledema was the most uniform examination finding associated with intracranial hypertension. Five patients had another localiz...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-07-06 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Strategies to improve the efficiency of bronchoalveolar lavage (BAL) are needed. We conducted a study to establish the diagnostic value of BAL in patients with hematological malignancies and pulmonary infiltrates. PATIENTS AND METHODS:The correlation of cytologic and flow cytometric study of ...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章
doi：10.1016/j.medcli.2016.10.045
更新日期：2017-04-07 00:00:00
abstract：:Since uricosuria is an essential compensative factor in hyperuricemia, multiple factors exist which can influence on the uric acid excretion in the tubules. Normally, 90% of the uric acid filtered by the glomerulus is reabsorbed, and its active tubular secretion forms the greater part of the uric acid present in the u...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-02-10 00:00:00
