Abstract：
BACKGROUND:Fetal microchimerism (FM) has been implicated in the pathogenesis of primary biliary cirrhosis (PBC). The aim of the study was to investigate the presence of FM in PBC patients. PATIENTS AND METHOD:FM was studied in 28 women, 14 with PBC and 14 healthy controls.DNA was extracted from peripheral blood cells, and a PCR analysis to detect a specific Y-chromosome sequence was performed. Specificity was confirmed by Southern-blot analysis. RESULTS:The Y-chromosome sequence was amplified from peripheral-blood cell DNA in only one PBC patient and in none of the controls. CONCLUSIONS:FM does not seem to play a major role in patients with PBC.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Selva O'Callaghan A,Balada Prades E,Castells Fusté L,Vargas Blasco V,Solans Laque R,Vilardell Tarrés Mdoi
10.1016/s0025-7753(02)73575-6keywords:
subject
Has Abstractpub_date
2002-12-07 00:00:00pages
770-2issue
20eissn
0025-7753issn
1578-8989pii
S0025-7753(02)73575-6journal_volume
119pub_type
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