Abstract：
:In this study, we review the efficacy and safety limitations of insulin-dependent oral antidiabetic agents. In terms of efficiency, the main drawback of metformin, sulfonylureas, gliptins and -to a lesser extent-glitazones is durability. No drug per se is able to maintain stable blood glucose control for years. Metformin, sulfonylureas and gliptins have demonstrated safety. Experience with the first two drug groups is more extensive. The main adverse effect of metformin is gastrointestinal discomfort. Major concerns related to the use of sulfonylureas are hypoglycemia and weight gain. The use of pioglitazone has been associated with an increased risk of bladder cancer, edema, heart failure, weight gain, and distal bone fractures in postmenopausal women. The most common adverse reactions associated with glucagon-like peptide-1 agonists are gastrointestinal discomfort that sometimes leads to treatment discontinuation.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Valerón PF,de Pablos-Velasco PLdoi
10.1016/S0025-7753(13)70059-9subject
Has Abstractpub_date
2013-09-01 00:00:00pages
20-5eissn
0025-7753issn
1578-8989pii
S0025-7753(13)70059-9journal_volume
141 Suppl 2pub_type
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