Abstract:
BACKGROUND:The aim of this study was to analyze the influence of age on the clinical and biological features as well as the results of treatment in 41 adult patients with acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS:The patients diagnosed with ALL from January 1989 to October 1995 in a single center were studied. Two groups of patients were analyzed based on age. The main clinical, hematologic and biochemical parameters, morphologic subtype and immunologic phenotype and the results of the cytogenetic study were analyzed. Likewise, the attainment of complete remission (CR), its duration and overall survival (OS) were also studied. Comparison of the cited variables and the results of treatment among the two groups of patients was performed. RESULTS:Group I was made of 19 (11 males, 8 females) patients > or = 50 years of age (mean age 65 +/- 9 years). Group II included 22 patients (11 males and 11 females) with a mean age of 28 +/- 11 years. Significant differences were only observed between the two groups in regard to the proportion of peripheral blood blasts (p < 0.02), serum LDH values (p = 0.05) and the performance status at the time of diagnosis ( p < 0.00007). In the patients in group 1 cytogenetic alterations were more frequent (10/16 vs 4/20, p < 0.02), being mainly pseudodiploid. Complete remission was achieved in 7/16 patients in group I and in 17/22 in group II (p < 0.02). The median duration of CR was 34 and 18 months, respectively. The median OS was 7 months in group 1 and 15 months in group II with an estimated survival at 5 years of 0% in group I and 38% in group II (p < 0.05). CONCLUSIONS:Patients with acute lymphoblastic leukemia over the age of 50 years have a worse general status and more cytogenetic alterations (particularly structural) than younger adult patients, presenting a lower probability of achieving complete remission and a shorter survival.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Ribera JM,Granada I,Navarro JT,Vela D,Juncá J,Flores A,Millá F,Feliu Esubject
Has Abstractpub_date
1996-10-05 00:00:00pages
401-4issue
11eissn
0025-7753issn
1578-8989journal_volume
107pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract:BACKGROUND AND OBJECTIVES:To validate four instruments to detect domestic violence in health-care settings against external criteria -Index of Spouse Abuse (ISA), Psychological Maltreatment of Women Inventory short form (PMWI-SF), Woman Abuse Screening Tool (WAST), Partner Violence Screen (PVS)- and to assess the conco...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2010.11.038
更新日期:2011-10-08 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Our goal was to analyze the epidemiological and clinical findings, as well as the diagnostic approach in a group of patients in whom uveitis was the first manifestation of sarcoidosis. PATIENTS AND METHOD:Retrospective study (between March 1998 and July 2002) including 31 patients diagnosed wi...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(04)74374-2
更新日期:2004-05-22 00:00:00
abstract:BACKGROUND:To identify and to compare the recommendations of the currently existing clinical protocols for arterial hypertension (HT) screening, diagnosis and baseline study in the Murcia Region, Spain, in order to assess their validity and reliability. MATERIAL AND METHODS:Structured comparative description of guidel...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Primary hyperparathyroidism (PH) is now considered a common condition. Its frequency and the deleterious long-term effects of hypercalcemia make a correct diagnosis mandatory. We attempted to evaluate the usefulness of the indexes of parathyroid function and hormone measurements more commonly used in the diagnosis of ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1989-04-08 00:00:00
abstract:BACKGROUND:To establish the early risk of multiple sclerosis (MS) following isolated demyelinating syndromes. PATIENTS AND METHOD:36 patients with optic neuritis, 24 with brainstem syndromes, 27 with spinal cord syndromes and 8 patients with a poliregional syndrome were included in a prospective protocol: including cl...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1999-05-22 00:00:00
abstract::Bile acids play a fundamental role in the degradation and absorption of intestinal lipids. The primary ones are cholic acid and chenodeoxycholic acid which are synthesized from cholesterol in the liver and conjugate with taurine and glycine amino acids. The secondary bile acids are derived from the primary ones by the...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1979-04-10 00:00:00
abstract:BACKGROUND:To analyze the relationship between length of hospitalary stay and early readmission rate. To assess the hypothesis that those admissions with the lowest length of stay are associated with higher early readmission rate. PATIENTS AND METHODS:Retrospective study of 35,902 hospital admissions. A single admissi...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1996-11-02 00:00:00
abstract::The health information system in Catalonia has experienced an important evolution but obtaining integrated data to evaluate the health services is still difficult. At the end of 2008 the basis of the information system of the "Center of Results" and a first set of indicators has been approved by the health system stak...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/S0025-7753(10)70006-3
更新日期:2010-02-01 00:00:00
abstract::Meningitis and other infectious diseases of the central nervous system are predisposing causes of the inadequate secretion syndrome of the antidiuretic hormone (ISADH). The association between the acquired immunodeficiency syndrome (AIDS) and ISADH is recognized but little studied. In AIDS patients hyponatremia is a f...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:
更新日期:1993-03-20 00:00:00
abstract:BACKGROUND AND OBJECTIVE:There is a bidirectional association between neoplasia and venous thromboembolism (VTE). However, whether this association has an impact in tumor recurrence is unknown. The aim of the study is to assess the incidence of cancer recurrence after diagnosis of VTE and determine if VTE could be a ma...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2009.04.054
更新日期:2009-10-17 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The plasma protein leakage produced in the bronchial mucose of patients with acute asthma might be associated to the quickness of the onset exacerbation. The aim of this study was to study this association. PATIENTS AND METHOD:22 patients with acute asthma were recruited, and the magnitude of ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13093055
更新日期:2006-09-30 00:00:00
abstract::Giant cell myocarditis is a rare disease of unknown etiology, which develops as a myocardial isolated affection or associated to different diseases. Its characteristics are such as necrosis, inflammation and giant cell presence in the myocardium. We present the case of a woman who suffered of giant cell myocarditis, t...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:
更新日期:1993-10-16 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To compare the efficacy of a self-monitoring programme vs. the conventional method used before the intervention in maintaining the international normalised ratio (INR) in the therapeutic range in patients receiving oral anticoagulants, as well as complications, quality of life and the time inv...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2019.06.016
更新日期:2020-05-22 00:00:00
abstract::Autoinflammatory syndromes are characterised by recurrent or persistent inflammation with no increase in the antibody titers or antigen-specific T lymphocytes, and absence of infection. Initially, they included the hereditary periodic fever syndromes, a group of innate immune system monogenic diseases characterised by...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/S0025-7753(11)70002-1
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with la...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2017.02.025
更新日期:2017-10-11 00:00:00
abstract:BACKGROUND AND OBJECTIVE:We decided to assess the overall prevalence of exposure to environmental tobacco smoke (ETS) both in general and according to the settings of exposure (home, workplace and leisure time). SUBJECTS AND METHOD:We analyzed cross-sectional data of ETS exposure in 1,059 non-smokers included in the C...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(04)74570-4
更新日期:2004-10-16 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Many studies have been performed on the ability of bone turnover markers (BTM) for the prediction of bone loss and to assess the correlation of BTM with bone mineral density (BMD). However, the results from these studies have been mixed. The aim of this study was to assess the usefulness of BTM...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(08)72271-1
更新日期:2008-09-20 00:00:00
abstract:BACKGROUND:To assess how patients with diabetes experience their condition. PATIENTS AND METHOD:Pilot study conducted in 10 selected patients with type 1 diabetes. A structured interview guide was prepared including physical, social and emotional areas. The information provided was analyzed qualitatively, key statemen...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Bacillary angiomatosis (epithelioid) is a recently described clinicopathologic syndrome, principally associated to infection by the human immunodeficiency virus. The case of a patient who was seen for fever and the appearance of four painful, erythematous and indurated subcutaneous nodules on the anteroexternal face o...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:
更新日期:1993-06-12 00:00:00
abstract::Obesity is an ever-increasing disease in our environment, and a major risk factor for the development of other chronic diseases that increase morbidity and mortality. Bariatric surgery is an effective treatment for obesity, since it not only allows a significant and sustained loss of weight, but also an important redu...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2009.12.020
更新日期:2011-02-26 00:00:00
abstract:BACKGROUND:"Stroke Code" is a system for the rapid identification, pre-notification and transport of acute ischemic stroke patients. The objective of this study was to evaluate the impact of delay reduction for thrombolytic therapy in these patients. SUBJECTS AND METHODS:We evaluated acute ischemic stroke patients adm...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1999-10-23 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Although health risks associated to excessive body fat increase with small increases in body weight, measurement of body fat is usually grouped in very few categories. The aim of our study was to assess whether the risk for a combined end-point including the incidence of either hypertension an...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2009.02.016
更新日期:2009-05-09 00:00:00
abstract:BACKGROUND:Increasing attention has been given to the care to elderly patients in emergency departments (ED). Moreover, few data are available about final phase of the process, that is hospital admission from ED. This study was conducted to establish appropriateness, reasons and social factors related to hospital admis...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1994-10-15 00:00:00
abstract::Molecular techniques have allowed the identification of new viruses in a number of patients with cryptogenic hepatitis. Whether they are clinically inapparent or true hepatitis agents remains unknown for some of them. Latest described viruses include GBV, TTV and SENV. However, based on the limited data available, the...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/s0025-7753(04)74301-8
更新日期:2004-04-17 00:00:00
abstract::The first patient with myelopathy associated with T-cell leukemia/lymphoma virus infection (HTLV-I) in Spain is reported. Although this condition is endemic in several areas from the Caribbean Sea, South America, Africa and Japan, some cases have been reported in European countries, generally in immigrant patients, re...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1991-02-23 00:00:00
abstract::A prospective, open and uncontrolled study of effectiveness and side effects of intravenous 6-methylprednisolone megadoses was carried out in 20 patients with systemic vasculitis with rapidly progressive renal failure. The results showed a favorable response of renal function in 80% of patients and a control of pulmon...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Exercise tests has been used in the diagnosis of metabolic myopathies. If there is an abnormal response pattern in mild mitochondrial myopathy (MM) and her role in the initial suspect diagnostic is unknown. SUBJECTS AND METHODS:Prospective study of 26 patients with mitochondrial myopathy (15 men, 11 women) ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(00)71216-4
更新日期:2000-02-05 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The effectiveness of the treatment of latent tuberculosis infection depends on its efficacy, the adherence to treatment and patient's risk of tuberculosis. The objective of this study was to evaluate the adherence to treatment with daily isoniazid for 9 months, its effectiviness and equivalent ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13116320
更新日期:2008-02-16 00:00:00
abstract::Transfer factor (TF) consists of messenger peptides produced by activated T lymphocytes as part of cellular immunity, and it acts in virgin lymphocytes through TF inducers, suppressors and specific antigens. TF is not immunogenic because it is not species-specific, since it contains a consensus sequence of amino acids...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2010.05.002
更新日期:2011-09-10 00:00:00
abstract::A group of 39 patients has been divided in three categories according to their plasmatic renine activity and the correlation of the hipotensive answer to the Timolol Maleate (betadrenergic blocking). The control is more favourable in the normorreninemic than in the hiporreninemic patients and, paradoxically, even more...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1980-09-10 00:00:00