[DNA arrays: a general overview and specific applications].

Abstract:

:Difficulties derived from the big complexity of the human genome (because of the great amount of genes) and difficulties at the time of performing a correct molecular diagnosis have led to the utilization of advanced technologies such as DNA arrays. By this technique, it is possible to analyze in a single experiment great sequences of genomic regions, to detect mutations or polymorphisms (characteristic of each individual), and to analyze variations in the expression of genes implicated in different disorders or in the utilization of drugs. Similarly, the use of DNA arrays-derived information has led to a considerable advance in the personalized medicine that is applied to every patient, avoiding unwanted adverse effects and the consecution of the best performance effectiveness for each drug.

journal_name

Med Clin (Barc)

journal_title

Medicina clinica

authors

Sáenz A,López de Munain A

doi

10.1157/13119504

subject

Has Abstract

pub_date

2008-04-12 00:00:00

pages

504-9

issue

13

eissn

0025-7753

issn

1578-8989

pii

S0025-7753(08)71489-1

journal_volume

130

pub_type

杂志文章,评审
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    doi:

    authors: Gil VF,Payá MA,Asensio MA,Torres MT,Pastor R,Merino J

    更新日期:1999-05-29 00:00:00

  • [The prevalence of asthma-related symptoms in 13-14-year-old children from 9 Spanish populations. The Spanish Group of the ISAAC Study (International Study of Asthma and Allergies in Childhood)].

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    journal_title:Medicina clinica

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Aguinaga Ontoso I,Arnedo Pena A,Bellido J,Guillén Grima F,Suárez Varela MM

    更新日期:1999-02-13 00:00:00

  • [Elderly patients with recurrent falls. Role of posturographic studies].

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    pub_type: 杂志文章

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    authors: Lázaro M,Cuesta F,León A,Sánchez C,Feijoo R,Montiel M,Ribera JM

    更新日期:2005-02-19 00:00:00

  • [Distribution of serotypes A and B of Candida albicans in 502 strains isolated from pathological specimens].

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    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Torres-Rodríguez JM,Nicolás MC,Madrenys N,Gallach C

    更新日期:1991-06-01 00:00:00

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    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Fiol Sala M,Abizanda Campos R,Orellana Mas J,Jaume Tomas G,Vallés J,García Moris S

    更新日期:1981-03-10 00:00:00

  • [Chronic myeloid leukemia after chemotherapy treatment for non-Hodgkin's lymphoma].

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    pub_type: 杂志文章

    doi:

    authors: Sacanella E,Cervantes F,Navarro M,Terol MJ,Estruch R,Montserrat E,Rozman C

    更新日期:1992-06-20 00:00:00

  • [Liver retransplantation: outcome analysis in 50 patients].

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    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13075442

    authors: Landaverde C,Berenguer M,Aguilera V,San Juan F,Prieto M,Berenguer J

    更新日期:2005-05-21 00:00:00

  • [Carcinomatous lymphangitis of the lung. Report of 21 cases (author's transl)].

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    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Cervantes Requena F,Costa Roma J,Vivancos Lleida J,Blajot I,Balcells Gorina A

    更新日期:1979-03-25 00:00:00

  • [Familial aggregation of lipid and lipoprotein levels: the Cuenca study].

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    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Martínez Vizcaíno V,Salcedo Aguilar F,Franquelo Gutiérrez R,Jarabo Crespo Y,Muelas Herráiz F,Domínguez Rojas V

    更新日期:1997-10-04 00:00:00

  • [Heart rate and isolated clinical tachycardia in hypertensive patients].

    abstract:BACKGROUND:There is poor information for isolated clinical tachycardia (ICT), that is to say, office tachycardia but normal ambulatory heart rate (HR). Our objective was to describe it and to know differences between hypertensive subjects with and without ICT. PATIENTS AND METHOD:Comparative study after a diagnostic i...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(00)71627-7

    authors: Vinyoles E,de la Figuera M,Bosom M,González C,Moreno N,Pacheco V

    更新日期:2000-11-04 00:00:00

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    abstract:BACKGROUND:The most appropriate methods for surveillance of nosocomial infection (NI) in hospitals with less than 250 beds remain to be elucidated. The aims of this study were to investigate the differences between the results found in a study in incidence (IS) and in another concerning prevalence (PS) carried out in a...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Javaloyas M,García D,Casasín T,Colomer J,Bonfill X,Brotons C,Rué M

    更新日期:1993-01-16 00:00:00

  • [Antenatal exposure to corticosteroids for fetal lung maturation and its repercussion on weight, length and head circumference in the newborn infant].

    abstract:BACKGROUND AND OBJECTIVE:To study the effects of antenatal corticosteroids treatment to promote fetal lung maturation, on fetal growth, depending on the number of the courses administered. PATIENTS AND METHOD:The study was based on data from the Spanish Collaborative Study of Congenital Malformations (ECEMC), analysin...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13092436

    authors: Rodríguez-Pinilla E,Prieto-Merino D,Dequino G,Mejías C,Fernández P,Martínez-Frías ML,Grupo del ECEMC.

    更新日期:2006-09-16 00:00:00

  • [New approaches for the treatment of dyslipidemia].

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    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2013.04.026

    authors: Mostaza JM,Lahoz C

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    journal_title:Medicina clinica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1157/13074137

    authors: Arroyo Sebastián A,Pérez Vicente F,Miranda Tauler E,Sánchez Romero A,Serrano Paz P,Calpena Rico R

    更新日期:2005-04-23 00:00:00

  • [Spinal cord compression in non-Hodgkin's lymphoma. A study of 10 patients].

    abstract::Spinal cord compression is an infrequent event in patients with non-Hodgkin's lymphomas (NHL) and early diagnosis and therapy are required. The main clinical and histologic characteristics as well as the response to therapy in 10 NHL patients with spinal cord compression diagnosed at a single center in a 7-year period...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Vela D,Ribera JM,Florensa R,Arellano A,Vaquero M,Batlle M,Flores A,Millá F,Feliu E

    更新日期:1997-09-27 00:00:00

  • [Spironolactone in patients with resistant hypertension].

    abstract:BACKGROUND AND OBJECTIVE:The aim of the study was to assess the effect of adding spironolactone to hypertensive resistant (HTR) patients and characterize those who respond effectively. PATIENTS AND METHOD:Observational retrospective study on outpatients with HTR (being treated with at least 3 drugs at full doses, one ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13126215

    authors: Rodilla E,Costa JA,Pérez-Lahiguera F,González C,Pascual JM

    更新日期:2008-10-04 00:00:00

  • [Diagnostic concordance between emergency room and hospitalization in medical patients].

    abstract:BACKGROUND:The purpose of this study was to know the concordance of diagnosis between emergency rooms amd hospitalization wards and to analyze the mistake index, the epidemiological characteristics and the main reasons for the mistakes. PATIENTS AND METHOD:We analyzed hospitalized patients and used a three-level conco...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(02)73485-4

    authors: Tudela P,Mòdol JM,Veny A,Tor J,Bonet M,Rego MJ

    更新日期:2002-10-26 00:00:00

  • [Infection by Borrelia burgdorferi in patients with the human immunodeficiency virus. A diagnostic problem].

    abstract:BACKGROUND:Given that Lyme's disease and HIV infection may present with similar clinical symptoms and that the serologic tests for the determination of antibodies against Borrelia burgdorferi present frequent false positives, the presence of antibodies against B. burgdorferi in patients with HIV in different evolutive ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Oteo Revuelta JA,Elías Calvo C,Martínez de Artola V,Pérez Surribas D

    更新日期:1993-07-03 00:00:00

  • [Effectiveness, safety and cost-effectiveness of the negative pressure wound therapy on the treatment of chronic wounds: a systematic review].

    abstract::Negative-pressure wound therapy (NPWT) is used to promote wound healing by using suction to drain excess fluid from wounds. A systematic literature review was undertaken to assess the effectiveness, safety and cost-effectiveness of NPWT for the treatment of chronic wounds. Medline, Embase, CENTRAL, CINAHL and the Coch...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2010.06.010

    authors: Trujillo-Martín M,García-Pérez L,Serrano-Aguilar P

    更新日期:2011-09-17 00:00:00

  • [Evaluation of ceftazidime monotherapy in Pseudomonas aeruginosa bacteremias. Prospective study].

    abstract::Twenty-six episodes of Pseudomonas aeruginosa bacteremia treated with intravenous ceftazidime, 4-6 g/day were evaluated. Treatment was begun within the first 24 hours after the isolation of the microorganism and was maintained for 10-12 days. In two patients with neutropenia amikacin was added during the initial 48-72...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Gómez J,Moldenhauer F,Ruiz J,Redondo C,Alonso JM,Canteras M,Sánchez-Gascón F

    更新日期:1989-09-16 00:00:00

  • [Effectiveness of a group therapy intervention to quit smoking. Randomized clinical trial].

    abstract:BACKGROUND:Group therapy is a widely used technique for the treatment of tobacco, alcohol and other toxic addictions. Nevertheless, its effectiveness for smoking cessation remains to be established. Our objective was to evaluate the relative effectiveness of a group intervention versus an individual intervention for sm...

    journal_title:Medicina clinica

    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Camarelles F,Asensio A,Jiménez-Ruiz C,Becerril B,Rodero D,Vidaller O

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  • [Cross-cultural validation of Antonovsky's Sense of Coherence Scale (OLQ-13) in Spanish elders aged 70 years or more].

    abstract:BACKGROUND AND OBJECTIVE:Sense of Coherence (SOC) is a construct relating to coping strategies in the face of traumatic events. SOC is defined as a personal disposition towards perceiving life experiences as understandable, manageable and meaningful. The construct has shown itself to be a predictor of self-reported and...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13100935

    authors: Virués-Ortega J,Martínez-Martín P,Del Barrio JL,Lozano LM,Grupo Español de Estudios Epidemiológicos sobre Envejecimiento.

    更新日期:2007-04-07 00:00:00

  • [Determinants associated wtih the presence of risk behaviors in HIV infected patients].

    abstract:BACKGROUND:Determinants associated with risk behaviours are evaluated in a known HIV-infected population not belonging to the great metropolitan nuclei. PATIENTS AND METHODS:110 unselected HIV+ patients were interviewed, including 77 variables. Their association with sharing needles, and unprotected sex is analysed. ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Llibre JM,Bolibar I,Bleda MJ,Fábregas N,Martínez M,Juanhuix A

    更新日期:1999-04-24 00:00:00

  • Shared decision-making in advanced chronic kidney disease in the elderly.

    abstract::Chronic kidney disease is common in people >65years of age. The development and improvement of dialysis techniques has allowed its generalisation to the entire population, when there is a situation of terminal nephropathy, without limit of use due to chronological age. Decision making in elderly patients with advanced...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2018.07.011

    authors: Heras Benito M,Fernández-Reyes Luis MJ

    更新日期:2019-03-01 00:00:00

  • [Hyporeninemic hypoaldosteronism. Case report and attempt at pathophysiological classification (author's transl)].

    abstract::A 75 year-old male presented with hyperkalemia unexplained by a moderate renal insufficiency, low basal levels of aldosterone and renin with a subnormal response to walking and saline depletion, and normal glucocorticoid function. The hyperkalemia was corrected by fluorocortisone administration. The concept of hypoald...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Cuervas-Mons V,Moya Mir MS,Martín Martín F,Barbadillo García de Velasco R,Sánchez Miró I,Martín Jiménez T,Lorenz Pérez P

    更新日期:1980-11-10 00:00:00

  • [Differential diagnosis of parkinsonism using dopamine transporters brain SPECT].

    abstract:BACKGROUND AND OBJECTIVE:Parkinsonism is a group of neurological disorders characterized by extrapiramidal signs. Often, the differential diagnosis between parkinsonism, essential tremor and drug-induced parkinsonism is difficult. The aim of the study was to evaluate the utility of (123I)-FP-CIT SPECT in patients with ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(04)74224-4

    authors: Lorenzo Bosquet C,Miquel Rodríguez F,Roca Bielsa I,Milà M,Aguadé Bruix S,Castell Conesa J

    更新日期:2004-03-13 00:00:00

  • [Mediterranean diet improves low density lipoprotein susceptibility to oxidative modifications].

    abstract:UNLABELLED:Most experts, specially from Anglo-Saxon countries, recommend a low fat diet in order to prevent cardiovascular diseases. However, mortality rate by ischemic cardiopathy is low in Mediterranean countries, probably because of the consumption of a Mediterranean diet, with a high level of monounsaturated fats p...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(00)71561-2

    authors: López-Miranda J,Gómez P,Castro P,Marín C,Paz E,Bravo MD,Blanco J,Jiménez-Perepérez J,Fuentes F,Pérez-Jiménez F

    更新日期:2000-09-30 00:00:00

  • [Terminal heart failure].

    abstract::Heart failure (HF) is a cardiovascular disease with a permanent increase in prevalence, incidence and mortality. Current optimal therapies for HF are effective only for slowing, but not stopping, its progression. HF-related mortality is high, even at the time of the disease onset. Approximately 40% of HF-attributable ...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/s0025-7753(07)72555-1

    authors: Formiga F,Manito N,Pujol R

    更新日期:2007-02-24 00:00:00

  • [Outpatient care of upper gastrointestinal hemorrhage not related to portal hypertension].

    abstract:BACKGROUND:The handling of upper gastrointestinal hemorrhage (UGH) usually includes the hospitalization of all patients, regardless of severity and prognosis. The aim of this paper is to assess the security of the outpatient control of some UGH, after their assessment in the hospital emergency room. PATIENTS AND METHO...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Almela P,Benages A,Peiró S,Grau F,Mínguez M,Peña A,Pascual I,Mora F

    更新日期:2000-01-01 00:00:00

  • [Clinical and biological prognostic factors in relapsed acute myeloid leukemia patients].

    abstract:BACKGROUND AND OBJECTIVE:Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common cause of treatment failure. Leukaemia relapse occurs due to clonal evo...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2016.05.015

    authors: Yébenes-Ramírez M,Serrano J,Martínez-Losada C,Sánchez-García J

    更新日期:2016-09-02 00:00:00