Abstract：
BACKGROUND AND OBJECTIVE:The aim of this prospective randomized trial was to compare the effectiveness and morbidity of surgical vs chemical sphincterotomy in the treatment of chronic anal fissure after a 3-year follow-up period. PATIENTS AND METHOD:Eighty patients with chronic anal fissure were treated either with close lateral internal sphincterotomy (group 1) or with chemical sphincterotomy with 25 U botulinum toxin injected into the internal sphincter (group 2). RESULTS:Overall healing was 90% in the close sphincterotomy group and 45% in the toxin botulinum group (p < 0.001). There was a group of patients with clinical factors (duration of disease over 12 months and presence of a sentinel pile before treatment) associated with a higher recurrence of anal fissure. Final percentage of incontinence was 5% in the close sphincterotomy group and 0% in the botulinum toxin group (p > 0.05). All incontinent patients were aged more than 50 years. CONCLUSIONS:We recommend surgical sphincterotomy as the first therapeutic approach in patients with clinical factors of recurrence. However, we recommend the use of botulinum toxin in patients older than 50 years or with associated risk factors of incontinence, despite the higher rate of recurrence, since it avoids the greater risk of incontinence seen with surgery.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Arroyo Sebastián A,Pérez Vicente F,Miranda Tauler E,Sánchez Romero A,Serrano Paz P,Calpena Rico Rdoi
10.1157/13074137keywords:
subject
Has Abstractpub_date
2005-04-23 00:00:00pages
573-5issue
15eissn
0025-7753issn
1578-8989pii
S0025-7753(05)71815-7journal_volume
124pub_type
临床试验,杂志文章,随机对照试验相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND:To review the series of patients with pheochromocytoma diagnosed in this institution from 1976 to 1990. METHODS:The main clinical features and presentation of 21 patients (13 women and 8 males) with mean age 40 +/- 13 years were reviewed. Urinary excretion of vanillylmandelic acid (VMA) and total catecholam...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-11-02 00:00:00
abstract：:Cephotaxime (HR 756) is a new cephalosporin antibiotic of wide spectrum and extraordinary activity, suitable for parenteral administration. It is highly resistant to the beta-lactamases of Gram negative bacilli, being thus especially active against microorganisms such as indole-positive Proteus, Serratia marcencens, a...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-11-25 00:00:00
abstract：:Glucagon-like peptide 1 (GLP-1) is secreted from enteroendocrine L-cells in response to oral nutrient intake and elicits glucose-stimulated insulin secretion while suppressing glucagon secretion. Moreover slows gastric emptying -reducing postprandial glycemic excursions-, reduces body weight, systolic blood pressure a...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(14)70103-4
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Group therapy is a widely used technique for the treatment of tobacco, alcohol and other toxic addictions. Nevertheless, its effectiveness for smoking cessation remains to be established. Our objective was to evaluate the relative effectiveness of a group intervention versus an individual intervention for sm...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0025-7753(02)73312-5
更新日期：2002-06-15 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We analyzed baseline and kinetic characteristics of lipid metabolism during the first month of bitherapy in patients with chronic hepatitis C genotype 1 (CHC-1). PATIENTS AND METHODS:A longitudinal, prospective study including 99 naïve CHC-1 patients with liver biopsy who were treated with bit...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.12.016
更新日期：2015-06-22 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The smoke fume, principal factor in the development of lung cancer, causes the expression of certain cytokines, including interleukin 4, 6, 8 and 10, which may act by inhibiting apoptosis and interfere cellular repair mechanisms and angiogenesis. To determine the possible relationship between g...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.07.034
更新日期：2014-08-04 00:00:00
abstract：BACKGROUND:We have examined the variation in the promoter region in the gene encoding UGT-1, associated with Gilbert's syndrome, in Spanish population. PATIENTS AND METHOD:Blood DNA was obtained from 100 blood donors. Polymerase chain reaction (PCR) was used to examine the A(TA)nTAA motif in the promoter region of the...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2000-10-28 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Many countries have developed screening programs for CH that bring about a normal somatic and psychological development. The aim of this study is to evaluate the evolution of cases detected by the screening program of congenital hypothyroidism in Catalonia. PATIENTS AND METHODS:The was a descr...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2009.07.048
更新日期：2010-03-13 00:00:00
abstract：:Molecular techniques have allowed the identification of new viruses in a number of patients with cryptogenic hepatitis. Whether they are clinically inapparent or true hepatitis agents remains unknown for some of them. Latest described viruses include GBV, TTV and SENV. However, based on the limited data available, the...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/s0025-7753(04)74301-8
更新日期：2004-04-17 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Sporadic inclusion body myositis (sIBM) diagnosis is frequently delayed or confused with another class of disorders, and misdiagnosis is common. Sometimes, we have problems diagnosing an sIBM in the early stages or predicting when a PM is going to become an sIBM. In this sense, we believe that...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2019.04.022
更新日期：2019-12-13 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Two different pathways for the development of tumor have been described in colorectal carcinoma: the chromosomic instability, raised by suppressor genes and proto-oncogene alterations, and the microsatellite instability (MSI), caused by alterations in DNA repairing genes. PATIENTS AND METHOD:T...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13071004
更新日期：2005-02-05 00:00:00
abstract：:Urinary tract infections are highly prevalent among women and when they are recurrent they can lead to patient discomfort and high healthcare costs, and they represent one of the most frequent causes of antibiotic consumption. There are several options to prevent RUTI which include both antibiotic treatment (continuou...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2020.04.026
更新日期：2020-08-28 00:00:00
abstract：:Familial hypophosphoremic rickets, although exceptional, is a frequent form of presentation in communities where nutritional rachitism has been eradicated. Hypophosphoremia is the biochemical defect which led to an insuffieient osseous mineralization. The real pathogenic mechanism of the disease is still unknown. Two ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-04-10 00:00:00
abstract：:Transfer factor (TF) consists of messenger peptides produced by activated T lymphocytes as part of cellular immunity, and it acts in virgin lymphocytes through TF inducers, suppressors and specific antigens. TF is not immunogenic because it is not species-specific, since it contains a consensus sequence of amino acids...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2010.05.002
更新日期：2011-09-10 00:00:00
abstract：BACKGROUND:The aim of the present study was to provide information on several clinical and methodological aspects of the measurement of the contents of estrogen (ER) and progesterone (PgR) receptors in breast tumoral tissue using monoclonal antibodies. METHODS:The contents of ER and PgR were measured in 94 tumor speci...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-06-08 00:00:00
abstract：BACKGROUND:The administration of factor VIII (FVIII) in continuous infusion (CI) to hemophiliac inpatients is a therapeutic approach made possible by the development of new commercial preparations. METHODS:In the present study the outcome of 14 treatment courses of FVIII in CI to 12 patients with hemophilia A (2 of th...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-03-16 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The PROCES (Programa de Reanimació Cardiopulmonar Orientat a Centres d'Ensenyament Secundari) program is aimed at teaching basic cardiopulmonary resuscitation (b-CPR) to teenagers within high school. Our aim was to analyze the results obtained from the pilot program. SUBJECTS AND METHOD:PROCES...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1157/13070434
更新日期：2005-01-15 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Although elder abuse is not a new phenomenon, it remains hidden. There have been carried out various preliminary studies about the prevalence of elder abuse in different countries. The aim of this study is to estimate the prevalence of suspicion of elder abuse in old persons without cognitive i...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2012.09.048
更新日期：2013-12-21 00:00:00
abstract：:Pituitary apoplexy (PA) is currently considered as one of the causes of empty sella (ES). However, in most reported cases the diagnosis of PA was based on anamnesis. A prospective study of three patients diagnosed during the PA episode was carried out. Periodical evaluations of hormone concentrations and cerebral comp...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-06-15 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Highly active antiretroviral therapy (HAART) has been considered to be ineffective in controlling hepatitis C viremia in the first year of treatment. The present study evaluates the effect of prolonged HAART upon HCV-VL. PATIENTS AND METHOD:We selected those cases with positive serology for HC...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(03)73970-0
更新日期：2003-10-04 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The correct management of patients with chronic renal disease depends on an early diagnosis. The aim of this study was to evaluate the usefulness, in the daily clinical practice, of the weight/creatinine formula as an indirect measurement of glomerular filtration. PATIENTS AND METHOD:1,025 amb...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(03)73751-8
更新日期：2003-04-12 00:00:00
abstract：:The follow-up of the Mediterranean Diet (MD) has been associated with lower mortality and morbidity from cardiovascular diseases. However, it is important to evaluate the scientific evidence provided by published articles. Therefore, in order to analyze the literature on the overall effects of MD on intermediate and f...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2009.01.033
更新日期：2010-01-23 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Hypertension is the most prevalent risk factor in the community. The aim of this study was to describe the risk factors for the progression of blood pressure (BP) from correct values. SUBJECTS AND METHODS:Prospective and observational study with 7 years follow-up. BP>140/90 mmHg was considered...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.09.026
更新日期：2013-06-04 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Rounded atelectasis (RA) is an unusual form of pulmonary lesion often confounded with pulmonary neoplasia. We studied the main diagnostic and evolutive characteristics of a series of patients diagnosed with RA. PATIENTS AND METHOD:Twenty patients diagnosed of RA in a tertiary hospital in Catal...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13072036
更新日期：2005-02-26 00:00:00
abstract：OBJECTIVE:To determine if a more simplified medication regimen is associated with survival in polypathological patients. METHODS:Multicentre cohort study. We included polypathological patients admitted to internal medicine wards between March 1st and June 30rd, 2011. Patients that died during admission and readmission...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2019.06.023
更新日期：2020-04-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of our study was to identify the rate of diabetic patients treated for hypothyroidism and compare them with a group without type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:We reviewed the computerized clinical records of 5161 patients. We identified diabetic patients treated with...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2011.08.009
更新日期：2012-04-28 00:00:00
abstract：BACKGROUND:The poor phenotype/genotype correlation in Gaucher's disease makes difficult therapy-decision-making and prevention of complications. Gaucher's cells and tissue fibrosis are the earliest findings of the disease. Transforming growth factor ss (TGF-beta1) is the key cytokine involved in the regulation of tissu...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71637-x
更新日期：2000-11-11 00:00:00
abstract：BACKGROUND AND AIMS:It has been recently shown that psychiatric disorders are associated with obesity. However this association has not been studied in overweight/obese patients at a hospital setting in our country. PATIENTS AND METHODS:We have studied 333 consecutive patients who were referred to our hospital outpati...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13115025
更新日期：2008-01-26 00:00:00
abstract：BACKGROUND AND OBJECTIVES:To evaluate the association between high levels of glycemia and low serum uric acid levels in two independent population-based samples. PATIENTS AND METHODS:The first sample was taken from the Pizarra Study, a population-based prospective study of 1.226 persons classified according to their g...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2010.09.044
更新日期：2011-04-23 00:00:00
abstract：:The authors report a case of hepatorenal polycystic disease discovered in the course of a routine physical examination. The patient was asymptomatic and the progression of the disease was extremely low. The existence of the disorder, however, was confirmed in the autopsy. Although hepatorenal polycystic disease is a r...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-02-10 00:00:00
