Abstract：
BACKGROUND AND OBJECTIVE:Highly active antiretroviral therapy (HAART) has been considered to be ineffective in controlling hepatitis C viremia in the first year of treatment. The present study evaluates the effect of prolonged HAART upon HCV-VL. PATIENTS AND METHOD:We selected those cases with positive serology for HCV, never been treated with protease inhibitors (PIs) at baseline, which after the introduction of HAART maintained undetectable HIV viral loads (HIV-VL) uninterruptedly for at least three years. Determinations were made of HCV-VL at baseline and after two and three years of HIV-VL suppression. Spearman coefficient and Friedman test were used. RESULTS:Of these patients, 21 satisfied the inclusion criteria. HCV-VL remained without significant changes and with relatively stable levels throughout the three-year follow-up period. However, two patients showed HCV-VL negative conversion after two years, that persisted after three years. CONCLUSIONS:Patients who respond to HAART maintain stable HCV-VL. Some subjects may exhibit HCV RNA clearance in the first two years of treatment, maintaining this situation after three years.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Tornero C,Gimeno C,Igual R,Santamaría A,Gil E,Rull Sdoi
10.1016/s0025-7753(03)73970-0keywords:
subject
Has Abstractpub_date
2003-10-04 00:00:00pages
408-9issue
11eissn
0025-7753issn
1578-8989pii
S0025-7753(03)73970-0journal_volume
121pub_type
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