[Neutrophil extracellular traps: a 2-faced host defense mechanism].

Abstract:

:Neutrophils play a key role in the innate immune system, providing the first line of host defense. In addition to their ability to eliminate pathogens by phagocytosis and antimicrobial secretions, it has recently been shown that neutrophils can trap and kill microorganisms by the release of extracellular structures composed of DNA and antimicrobial proteins called neutrophil extracellular traps (NETs). Although physiological amounts of NETs are important as antimicrobial agents, high levels of NETs in circulation may result in severe tissue damage. Besides, the excessive generation of NETs or a disruption in their clearance mechanism might be associated with the development of certain autoimmune diseases. This review describes the structure, function and generation of NETs, and their possible implication in the initiation and/or progression of different diseases.

journal_name

Med Clin (Barc)

journal_title

Medicina clinica

authors

Camicia G,de Larrañaga G

doi

10.1016/j.medcli.2012.04.022

subject

Has Abstract

pub_date

2013-01-19 00:00:00

pages

70-5

issue

2

eissn

0025-7753

issn

1578-8989

pii

S0025-7753(12)00466-6

journal_volume

140

pub_type

杂志文章,评审
  • [Degenerative osteoarthritis, osteoporosis and fractures: controversies and evidences].

    abstract::Osteoarthritis and osteoporosis are both common conditions in the elderly but their association has long remained obscure. Recently published studies show that patients with osteoarthritis have higher bone mass but no corresponding decrease in fracture risk. This has been proposed to be due to an increased rate of fal...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2013.01.036

    authors: Pagès-Castellà A,Prieto Alhambra D

    更新日期:2013-09-07 00:00:00

  • [Deep venous thrombosis associated with necrotizing vasculitis].

    abstract::The association of deep vein thrombosis with systemic necrotizing vasculitis is infrequent. Herein are referred two patients with microscopic polyarteritis and one patient with overlap syndrome who developed deep vein thrombosis which complicated in two cases with pulmonary embolism. The clinical features and the path...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Cofán F,Serra A,Teixidó J,Bonet J,Bonal J,Lauzurica R,Romero R,Monreal M,Caralps A

    更新日期:1993-12-11 00:00:00

  • [Prevalence of elder abuse in Spanish dwelling in community].

    abstract:BACKGROUND AND OBJECTIVE:Although elder abuse is not a new phenomenon, it remains hidden. There have been carried out various preliminary studies about the prevalence of elder abuse in different countries. The aim of this study is to estimate the prevalence of suspicion of elder abuse in old persons without cognitive i...

    journal_title:Medicina clinica

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.medcli.2012.09.048

    authors: Pérez-Rojo G,Izal M,Montorio I,Regato P,Espinosa JM

    更新日期:2013-12-21 00:00:00

  • [Effects of aerobic exercise program and relaxation techniques on anxiety, quality of sleep, depression, and quality of life in patients with fibromyalgia: a randomized controlled trial].

    abstract:BACKGROUND AND OBJECTIVE:Fibromyalgia is considered as a combination of physical, psychological and social disabilities. The purpose of the present study was to determine the benefits of aerobic exercise program and progressive relaxation techniques on anxiety, quality of sleep, depression and quality of life in patien...

    journal_title:Medicina clinica

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.medcli.2010.09.045

    authors: Arcos-Carmona IM,Castro-Sánchez AM,Matarán-Peñarrocha GA,Gutiérrez-Rubio AB,Ramos-González E,Moreno-Lorenzo C

    更新日期:2011-10-08 00:00:00

  • [Prediction of patient outcome].

    abstract::Monitoring biomedical signals obtained from a patient generates information that processed conveniently, it has to allow detecting as soon as possible changes in the predicted evolution. The systematic register of one of these biomedical signals is named a time series. In this paper, a brief introduction appears to th...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1157/13057547

    authors: Muñoz Gracia MP

    更新日期:2004-01-01 00:00:00

  • [Detection of hepatitis B virus DNA in serum by gene amplification in patients with chronic hepatitis B and in patients chronic hepatitis C].

    abstract:BACKGROUND:The polymerase chain reaction (PCR) constitutes important methodological progress for detecting the presence of viral nucleic acids when these are found in small quantities in serum or tissues. The aim of this study was the use of PCR to detect DNA of the hepatitis B virus (HBV) in patients with chronic HBsA...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Jáuregui JI,Civeira MP,Serrano M,Camps J,Castilla A,Riezu-Boj JI,Prieto J

    更新日期:1992-01-18 00:00:00

  • [Bariatric surgery for the treatment of type 2 diabetes mellitus].

    abstract::Weight loss can improve metabolic control in patients with type 2 diabetes mellitus but the results of conventional therapy in this respect have been discouraging. Besides achieving significant and sustained weight loss, bariatric surgery can improve or resolve type 2 diabetes mellitus in the majority of patients. Ana...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2011.04.009

    authors: Benaiges Boix D,Goday Arno A,Pedro-Botet J

    更新日期:2012-04-14 00:00:00

  • [The inappropriate antidiuretic hormone secretion syndrome associated with cryptococcal meningitis in a patient with the acquired immunodeficiency syndrome].

    abstract::Meningitis and other infectious diseases of the central nervous system are predisposing causes of the inadequate secretion syndrome of the antidiuretic hormone (ISADH). The association between the acquired immunodeficiency syndrome (AIDS) and ISADH is recognized but little studied. In AIDS patients hyponatremia is a f...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:

    authors: Brea Hernando AI,Bandrés Franco E,Aguirre Miñana T,Ezquerra Lezcano M,Borque de Larrea L

    更新日期:1993-03-20 00:00:00

  • Usefulness of a risk scale based on procalcitonin for early discrimination between necrotising fasciitis and cellulitis of the extremities.

    abstract:BACKGROUND AND OBJECTIVE:To assess the usefulness of a risk scale based on serum procalcitonin (PCT) compared to the Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) scale in the early discrimination between necrotising fasciitis (NF) and cellulitis of the extremities. MATERIALS AND METHODS:Retrospective s...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2019.01.032

    authors: Novoa-Parra CD,Wadhwani J,Puig-Conca MA,Lizaur-Utrilla A,Montaner-Alonso D,Rodrigo-Pérez JL,Morales-Suárez-Varela M

    更新日期:2019-11-15 00:00:00

  • [Influences of hyperinsulinemia in the lipid profile of hypertensive patients].

    abstract:BACKGROUND:Hypertension and dyslipemia are associated with a greater frequency than that randomly expected. The increase in insulinic resistance hyperinsulinemia is one of the factors implicated in the pathogenesis of this association. In the present study the lipid profile of hypertensive patients is analyzed accordin...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Villar J,Muñiz O,Stiefel P,Miranda M,Jiménez L,Montilla C,Martín-Sanz V,Carneado J

    更新日期:1994-09-10 00:00:00

  • [Self care of common health disorders: results of a telephone survey of the general population].

    abstract:BACKGROUND:Self-care of health problems including self-medication, constitutes the most frequent response to the most common acute symptoms in several studies carried out in other countries. Indeed there are few data concerning the scope of self-care in Spain. METHODS:A telephone survey was carried out by a questionna...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Nebot M,Llauger MA

    更新日期:1992-10-10 00:00:00

  • [Characteristics and types of GLP-1 receptor agonists. An opportunity for individualized therapy].

    abstract::Glucagon-like peptide 1 (GLP-1) is secreted from enteroendocrine L-cells in response to oral nutrient intake and elicits glucose-stimulated insulin secretion while suppressing glucagon secretion. Moreover slows gastric emptying -reducing postprandial glycemic excursions-, reduces body weight, systolic blood pressure a...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/S0025-7753(14)70103-4

    authors: Jódar E

    更新日期:2014-09-01 00:00:00

  • [Prevalence of infections by hepatitis A, B, C and E viruses in two different socioeconomic groups of children from Santa Cruz, Bolivia].

    abstract:BACKGROUND AND OBJECTIVES:The epidemiology of hepatitis A, E, B and C was analyzed in 1,393 children living in Santa Cruz de la Sierra, Bolivia. They were distributed in two groups according to the social condition. MATERIALS AND METHOD:1,393 children were selected from two different schools: one attended by children ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(03)73826-3

    authors: Gandolfo GM,Ferri GM,Conti L,Antenucci A,Marrone R,Frasca AM,Vitelli G

    更新日期:2003-05-24 00:00:00

  • Non-alcoholic fatty liver disease: A poorly known pandemic.

    abstract::Non-alcoholic fatty liver disease (NAFLD) consists of an excessive depositing of fat in the liver, which can end up by causing inflammation, fibrosis and also cirrhosis with the corresponding complications including liver cancer. NAFLD has become the most common liver disease worldwide. The incidence has increased in ...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2017.06.026

    authors: Augustin S,Graupera I,Caballeria J,en nombre del grupo de trabajo sobre «Hígado graso no alcohólico» de la Societat Catalana de Digestologia.

    更新日期:2017-12-20 00:00:00

  • [Transfer factors in medical therapy].

    abstract::Transfer factor (TF) consists of messenger peptides produced by activated T lymphocytes as part of cellular immunity, and it acts in virgin lymphocytes through TF inducers, suppressors and specific antigens. TF is not immunogenic because it is not species-specific, since it contains a consensus sequence of amino acids...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2010.05.002

    authors: Sánchez-González DJ,Sosa-Luna CA,Vásquez-Moctezuma I

    更新日期:2011-09-10 00:00:00

  • [Mediterranean diet improves low density lipoprotein susceptibility to oxidative modifications].

    abstract:UNLABELLED:Most experts, specially from Anglo-Saxon countries, recommend a low fat diet in order to prevent cardiovascular diseases. However, mortality rate by ischemic cardiopathy is low in Mediterranean countries, probably because of the consumption of a Mediterranean diet, with a high level of monounsaturated fats p...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(00)71561-2

    authors: López-Miranda J,Gómez P,Castro P,Marín C,Paz E,Bravo MD,Blanco J,Jiménez-Perepérez J,Fuentes F,Pérez-Jiménez F

    更新日期:2000-09-30 00:00:00

  • [Terminal heart failure].

    abstract::Heart failure (HF) is a cardiovascular disease with a permanent increase in prevalence, incidence and mortality. Current optimal therapies for HF are effective only for slowing, but not stopping, its progression. HF-related mortality is high, even at the time of the disease onset. Approximately 40% of HF-attributable ...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/s0025-7753(07)72555-1

    authors: Formiga F,Manito N,Pujol R

    更新日期:2007-02-24 00:00:00

  • [Hemolytic anemia due to cold-reacting antibodies: association with human immunodeficiency virus infection and non-Hodgkin's lymphoma].

    abstract::Hemolytic disease by cold-reacting antibodies is a rare form of hemolytic anemia. In most cases a subjacent cause is found. This disease is generally related with reactive lymphoproliferative processes (infections by the Epstein-Barr virus and cytomegalovirus) or uncontrolled lymphoproliferative disorders (lymphomas, ...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: López Dupla JM,Rodríguez Pérez A,Martínez Martínez P,de Castro Carpeño J,Lavilla Uriol P,Gil Aguado A

    更新日期:1992-04-04 00:00:00

  • [Hereditary angioedema. Control and treatment in 7 cases].

    abstract::Hereditary angioedema (HAE) is due to a deficit of the C1 inhibitor (C1 INH) of a dominant autosomic inheritance. Seven patients are presented from a family with HAE, four of whom with poor prognosis due to the frequency and site of the angioedema. Prophylaxis was obtained with long-term danazol since antifibrinolytic...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Marqués L,Dordal T,Baltasar M,Guspi R,Nogueiras C,Cadahia A

    更新日期:1992-03-14 00:00:00

  • [Hemolytic-uremic syndrome in the adult (author's transl)].

    abstract::This article presents six cases of hemolytic-uremic syndrome, defined as the combination of acute renal insufficiency, microangiopathic hemolytic anemia, and thrombocytopenia, in six adult patients, two men and four women, between 20 and 52 years old. Three of the cases were considered idiopathic, two secondary to the...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: Montoliu J,Darnell A,Torras A,Botey A,Revert L

    更新日期:1980-01-10 00:00:00

  • [Smoking cessation after 12 months follow-up at a smoking cessation unit].

    abstract:BACKGROUND AND OBJECTIVE:To assess the cessation and relapse rates of smoking, and analyze the associated variables in a 12-month follow-up study at a smoking cessation unit. SUBJECTS AND METHOD:Patients from the Area de Salud 19 of the Conselleria de Sanitat of the Generalitat Valenciana, coming to a smoking cessatio...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13087715

    authors: Pascual-Lledó JF,De la Cruz-Amorós E,Bustamante-Navarro R,Buades-Sánchez MR,Contreras-Santos C,Castillo-Aguilar C

    更新日期:2006-04-29 00:00:00

  • [Perceptions of clinical safety after hospital discharge].

    abstract:OBJECTIVE:Patient perception of clinical safety has been scantly studied. This study describes the frequency of clinical errors from a patient point of view, their perception of safety and its relationship with the information received. MATERIAL AND METHODS:Descriptive study based on a postal survey to 336 surgical pa...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(08)76458-3

    authors: Mira JJ,Aranaz JM,Vitaller J,Ziadi M,Lorenzo S,Rebasa P,Aibar-Remón C

    更新日期:2008-12-01 00:00:00

  • [Low prevalence of the Leu7/Pro polymorphism in the signal peptide of preproneuropeptide Y in the Spanish Mediterranean population].

    abstract:BACKGROUND AND OBJECTIVE:A common Leu7Pro polymorphism in the signal peptide of neuropeptide Y has been associated with increased plasma cholesterol and accelerated atherosclerosis in the Finnish population. SUBJECTS AND METHOD:A cross-sectional design was carried out in 1,000 individuals from the Mediterranean Spanis...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/s0025-7753(03)73695-1

    authors: Portolés O,Sorlí JV,González JI,Ruiz de la Fuente S,Ramírez JB,Corella D

    更新日期:2003-03-15 00:00:00

  • [Q fever outbreak in an urban area following a school-farm visit].

    abstract:BACKGROUND AND OBJECTIVE:The aim of this study was to describe an outbreak of Q fever in a group of people (day care centre for mental-handicapped individuals) previously exposed to animals in a school-farm. PATIENTS AND METHOD:A retrospective cohort study among the 25 mental-handicapped individuals and the 30 workers...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13087697

    authors: de los Ríos-Martín R,Sanz-Moreno JC,Martín-Martínez F,Tébar-Betegón MA,Cortés-García M,Escudero-Nieto R

    更新日期:2006-04-22 00:00:00

  • [Effectiveness, safety and cost-effectiveness of the negative pressure wound therapy on the treatment of chronic wounds: a systematic review].

    abstract::Negative-pressure wound therapy (NPWT) is used to promote wound healing by using suction to drain excess fluid from wounds. A systematic literature review was undertaken to assess the effectiveness, safety and cost-effectiveness of NPWT for the treatment of chronic wounds. Medline, Embase, CENTRAL, CINAHL and the Coch...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.medcli.2010.06.010

    authors: Trujillo-Martín M,García-Pérez L,Serrano-Aguilar P

    更新日期:2011-09-17 00:00:00

  • [Atherothrombosis: an excessively globalizing concept?].

    abstract::Clinical trials and prospective observational registries are useful methods to gain knowledge of vascular disease. Because the design of clinical trials is mainly based on demonstrating the efficiency of therapeutic procedures, these studies cannot be widely generalized, especially in complex multifactorial diseases s...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/S0025-7753(09)71744-0

    authors: Castillo J,Blanco M

    更新日期:2009-09-01 00:00:00

  • [Microsatellite instability predicts better outcome in colorectal cancer patients].

    abstract:BACKGROUND AND OBJECTIVE:Two different pathways for the development of tumor have been described in colorectal carcinoma: the chromosomic instability, raised by suppressor genes and proto-oncogene alterations, and the microsatellite instability (MSI), caused by alterations in DNA repairing genes. PATIENTS AND METHOD:T...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1157/13071004

    authors: Vidaurreta M,Sanz-Casla MT,Maestro ML,Rafael S,Jiménez F,Arroyo M,Fernández C,Cerdán J

    更新日期:2005-02-05 00:00:00

  • [Cathepsin K as a biomarker of bone involvement in type 1 Gaucher disease].

    abstract:BACKGROUND AND OBJECTIVE:Gaucher disease is an inherited disorder caused by deficit of acid β-glucocerebrosidase, responsible for the degradation of glucosylceramide to ceramide and glucose. Although the disorder is primarily hematologic, bone is the second most commonly affected structure. Cathepsin K (CATK) is an enz...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:10.1016/j.medcli.2014.11.018

    authors: Bobillo Lobato J,Durán Parejo P,Núñez Vázquez RJ,Jiménez Jiménez LM

    更新日期:2015-10-05 00:00:00

  • [Lost opportunities for preventing tuberculosis and derived costs; comment].

    abstract:BACKGROUND:We determined the extent to which opportunities for prevention were missed among patients with tuberculosis and the costs derived from the lack of prevention. METHOD:Descriptive study of patients with active tuberculosis were studied in the hospital ward of tuberculosis at the A. Marcide-Novoa Santos Centre...

    journal_title:Medicina clinica

    pub_type: 杂志文章

    doi:

    authors: García Rodríguez JF,Mariño Callejo A,Lorenzo García MV,de Juan Prego J,Díaz Peromingo JA,Sesema Sánchez P

    更新日期:1997-06-07 00:00:00

  • [The fibroid as clinical problem].

    abstract::Uterine fibroids are the most common benign tumours that affect women of reproductive age and they represent the main indication for surgery for benign uterine pathology. In 25% of cases, they become clinically apparent, causing heavy menstrual bleeding, pelvic pain and/or infertility. Therefore, fibroids have a notab...

    journal_title:Medicina clinica

    pub_type: 杂志文章,评审

    doi:10.1016/S0025-7753(13)70045-9

    authors: Calaf J,Arqué M,Porta O,D'Angelo E

    更新日期:2013-07-01 00:00:00