Abstract：
BACKGROUND AND OBJECTIVE:The influence of homocysteine metabolism on the prognosis of acute coronary syndrome without ST elevation is controversial. PATIENTS AND METHOD:Prospective study of 109 patients admitted because of acute coronary syndrome without ST elevation. Basal plasmatic levels of homocysteine and folates were obtained. Clinical features and survival data on follow-up were registered. RESULTS:Both two years-free-of-events and total survival were lower in patients with low folate levels (36.5% vs 72.5%, p = 0.02; 48% vs 94%, p < .001). Patients with high homocysteine levels had lower two years-free-of-events survival (57.4% vs 89.1%, p < .01); but no difference in the total survival was observed (86.3% vs 97.3%, p = 0.11). The multivariate analysis showed that low folate levels was an independent predictor of mortality (odds ratio [OR] = 8.33; 95% confidence interval [CI], 1.88-33.33; p < 0.01), and moderate high homocysteine was an independent predictor of events on follow-up (OR = 4.34; 95% CI, 1.47-12.50; p < 0.01). CONCLUSIONS:Patients with high homocysteine or low folate levels have a poor prognosis compared with those with normal levels. On the other hand, low folate levels and moderate hyiperhomocysteinemia are independent predictors of bad prognosis in the follow-up.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
García-Pinilla JM,Espinosa-Caliani S,Gómez-Doblas JJ,Jiménez-Navarro MF,Cabrera-Bueno F,Muñoz Morán E,Ruiz-Galdón M,Reyes-Engel A,de Teresa Galván Edoi
10.1157/13109705subject
Has Abstractpub_date
2007-09-08 00:00:00pages
281-6issue
8eissn
0025-7753issn
1578-8989pii
S0025-7753(07)72826-9journal_volume
129pub_type
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