Abstract：
BACKGROUND:Cytogenetic studies of meningiomas suggest that loss of (or parts of) chromosome 22 is a primary event in the development of these tumors; later on, other chromosomal changes would occur in the caryotypes. All these secondary changes are observed mainly in cases with high clinical aggressivity. However, in a few cases of meningiomas disomy 22 coexists, but with other chromosomic anomalies. We present clinical, histopathological and cytogenetic findings in a group of meningiomas with disomy of chromosome 22. PATIENTS AND METHODS:We collected 10 meningiomas from nine patients which ages ranged between 28-70 years. Fresh tumoral specimens were divided for histologic examination and cytogenetic study, performed after short-term culture. RESULTS:At microscopic examination 5 tumors were classified as benign meningiomas, four as atypical and one as malignant meningioma. Four cases were recurrent tumors. The cytogenetic studies showed that all tumors presented two chromosomes 22 and other chromosome abnormalities. Losses in chromosomes 4, 7, 10, 14, 16, 17 and 20 were frequent; cytogenetics rearrangements of chromosomes 1, 4, 5, 7, 14, 19 and 22 were frequently involved. CONCLUSIONS:In karyotypic evolution of meningiomas, secondary anomalies of chromosomes 1p, 10 and 14 are the most common and appear to be associated with a more aggressive clinical course. In this group of meningiomas with disomy 22, these anomalies were also frequently found, and were related in 50% of cases with atypical or malignant morphologies and of them with recurrent tumors in the 40%.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
López-Ginés C,Cerdá-Nicolás M,Pérez-Bacete M,Barcia-Salorio JL,Llombart-Bosch Asubject
Has Abstractpub_date
1998-11-21 00:00:00pages
663-6issue
17eissn
0025-7753issn
1578-8989journal_volume
111pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND:The aim of the present was to determine the levels of the tumor necrosis factor (TNF)-alpha in patients with HIV infection to study the relationship with the concentration of triglycerides (TG), CD4 lymphocyte count and clinical diagnosis. METHODS:Seventy-eight HIV-infected patients (58 males, 20 females); ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1995-03-18 00:00:00
abstract：BACKGROUND:To evaluate the evolution of the HIV infection in the drug addicts of Madrid. PATIENTS AND METHODS:Data of 2,234 patients that entered for the first time in a Psychiatric Hospital Detoxication Unit of Madrid from October 1985 to december 1996 were recorded. RESULTS:There was a reduction of the percentage o...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1998-09-12 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Our purpose was to provide information about static and dynamic balance posturographic disorders in elderly people with recurrent falls, and to compare the results with a healthy elderly group. PATIENTS AND METHOD:We included 95 subjects: 57 patients who fell (86% women; age, 78.1 years) and 3...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13071759
更新日期：2005-02-19 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Sense of Coherence (SOC) is a construct relating to coping strategies in the face of traumatic events. SOC is defined as a personal disposition towards perceiving life experiences as understandable, manageable and meaningful. The construct has shown itself to be a predictor of self-reported and...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13100935
更新日期：2007-04-07 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To determine whether in the Mexican population the spouses of patients with type 2 diabetes mellitus (DM2) have an increased risk of any degree of glucose intolerance compared with spouses of subjects without diabetes. SUBJECTS AND METHOD:An analytical cross-sectional study was made in the Fam...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13127917
更新日期：2008-11-08 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The suitable antibiotic(s) and duration of treatment for hip prosthesis acute infections (HPAIs) has not been clearly defined. PATIENTS AND METHOD:We studied 32 patients whose HPAI was diagnosed within 2 months after surgery. All patients underwent debridement and samples were taken for cultur...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(03)73863-9
更新日期：2003-06-21 00:00:00
abstract：BACKGROUND:Human immunodeficiency virus (HIV) increases the risk for anal premalignant lesions associated to human papillomavirus infection (HPV). The aim of this study was to compare the prevalence of HPV and squamous intraepithelial lesions (SIL) in patients with anal warts, with and without anti-HIV antibodies. PAT...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-06-12 00:00:00
abstract：:The plasma level of neuron-specific enolase (NSE) was measured in 55 patients with small cell bronchial carcinoma (SCC) with cytohistological confirmation to evaluate its diagnostic usefulness. As a control group, 132 patients with non-small cell bronchial carcinoma, 81 with non-neoplastic disease and 37 healthy indiv...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1990-06-02 00:00:00
abstract：BACKGROUND:The differences in clinical presentation, morphology, phenotype and genetic changes between lymphomas originating in the gastrointestinal tract and the lymph nodes justified the proposal of a system of specific classification for lymphomas originating in lymphoid tissue associated to mucosa (MALT). Neverthel...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-10-24 00:00:00
abstract：:The coexistence of organ-specific and nonorgan-specific autoimmune diseases is an interesting phenomenon. A 52-year-old woman was admitted with fever, general discomfort, polyarthritis, and Raynaud's phenomenon. Physical examination revealed a goiter of stony consistency, hardening, paleness, and atrophy of the skin o...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-11-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Parkinsonism is a group of neurological disorders characterized by extrapiramidal signs. Often, the differential diagnosis between parkinsonism, essential tremor and drug-induced parkinsonism is difficult. The aim of the study was to evaluate the utility of (123I)-FP-CIT SPECT in patients with ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(04)74224-4
更新日期：2004-03-13 00:00:00
abstract：:Since Perrinaud in 2006 first described three patients with hemorrhagic bullae in relation to the use of heparins, numerous cases have been published. Currently, this entity has been established as a clearly defined pathology. We review all reported cases, diagnostic features and features that differentiate it from ot...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2015.10.017
更新日期：2016-05-06 00:00:00
abstract：BACKGROUND:Upon the detection of an excess number of cases of parotiditis in La Almolda (Zaragoza) a descriptive study of the epidemic was carried out with vaccination efficacy being quantified. METHODS:The definition and system of detection of the cases was established. To calculate the rate of infection the availabl...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-09-19 00:00:00
abstract：INTRODUCTION:There are gaps in our knowledge of the normative levels of haemoglobin and the prevalence of anaemia in our geographical area, and in certain population subgroups. OBJECTIVES:To study the mean values of haemoglobin in a mountainous Spanish region, according to sex, age range and residence altitude, and th...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2019.02.002
更新日期：2019-12-13 00:00:00
abstract：:The authors report a case of hepatorenal polycystic disease discovered in the course of a routine physical examination. The patient was asymptomatic and the progression of the disease was extremely low. The existence of the disorder, however, was confirmed in the autopsy. Although hepatorenal polycystic disease is a r...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-02-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Our goal was to determine the incidence of infection due to Mycobacterium kansasii in Elche, Spain over the last 10 years and to study the activity of new antibiotics against the strains isolated. MATERIAL AND METHODS:A retrospective study of patients and study of antibiotic susceptibility in ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:Twenty-one cases of carcinomatous lymphangitis of the lung are reported. In diagnosing them clinical, roentgenologic, and histopathologic criteria were used and the clinical, roentgenologic and evolutive findins were considered in order to emphasize the origin of the primitive neoplasm. From this point of view the pri...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-03-25 00:00:00
abstract：BACKGROUND:Community-acquired pneumonia (CAP) is one of the most frequent infectious disease conditions. With the aim of knowing the diagnostic and therapeutic strategies of CAP in Spanish hospitals we performed a prospective, observational and multicenter study. PATIENTS AND METHOD:Observational study of 468 patients...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/s0025-7753(02)73405-2
更新日期：2002-09-21 00:00:00
abstract：BACKGROUND:To establish the early risk of multiple sclerosis (MS) following isolated demyelinating syndromes. PATIENTS AND METHOD:36 patients with optic neuritis, 24 with brainstem syndromes, 27 with spinal cord syndromes and 8 patients with a poliregional syndrome were included in a prospective protocol: including cl...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-05-22 00:00:00
abstract：BACKGROUND:To relate the renal hemodynamic changes, as assessed by Doppler ultrasonography,with the development of ascites, renal function, and endogenous vasoactive systems in patients with liver cirrhosis. PATIENTS AND METHODS:60 cirrhotic patients were studied prospectively, 31 of these compensated and 29 with asci...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)71906-9
更新日期：2001-04-28 00:00:00
abstract：:Currently, pharmacological thromboprophylaxis is frequently required in patients undergoing surgery, due to the high risk of deep venous thrombosis in the perioperative period. The administration of these anticoagulant agents (in Spain, usually low molecular weight heparins or fondaparinux, and in future, probably als...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/s0025-7753(08)76448-0
更新日期：2008-11-01 00:00:00
abstract：:Osteoporosis is a major cause of fractures in elderly women. Bone densitometry is used in order to detect osteoporosis. It has been observed can also be analyzed in the jawbone. The osteoporosis may be associated with resorption of the residual ridge, periodontitis and tooth loss; also the same treatments can affect t...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2012.05.029
更新日期：2013-02-16 00:00:00
abstract：BACKGROUND AND OBJECTIVE:There are few epidemiological studies on massive transfusion (MT), although they may be important to evaluate possible strategies to reduce the number of transfused units, as well as transfusion side-effects. We, therefore, retrospectively assessed the incidence of MT at our institution (a 700-...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13110210
更新日期：2007-09-22 00:00:00
abstract：:The serum levels of cholesterol bound to high density lipoproteins (HDL-C) were determined by the heparin-manganese chloride precipitation method in 306 subjects, 182 male with ages ranging from 11 to 81 years, and 124 female with ages ranging from 7 to 78 years. Twenty six subjects belonged to a lacto-vegetarian comm...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-03-25 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Many studies have been performed on the ability of bone turnover markers (BTM) for the prediction of bone loss and to assess the correlation of BTM with bone mineral density (BMD). However, the results from these studies have been mixed. The aim of this study was to assess the usefulness of BTM...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(08)72271-1
更新日期：2008-09-20 00:00:00
abstract：:To evaluate the clinical and microbiological features of infective endocarditis in patients with cirrhosis we compared 18 episodes of endocarditis in these patients with a control group of patients without liver disease. In 61% of patients with cirrhosis the origin of infection was unknown. Four patients developed end...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1989-11-11 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The myocardial infarction (MI) with ST elevation and angiographically normal coronary arteries isn't frequent. The aim of this study is to describe clinical characteristic and mid-term follow-up of those patients. PATIENTS AND METHOD:Between January 1997 and December 2004 we identified 75 pati...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13112511
更新日期：2007-11-17 00:00:00
abstract：BACKGROUND:We aimed at assessing the pulmonary function and life quality of patients with bronchiectasis not caused by cystic fibrosis (CF) on the basis of the presence or absence of colonization (with Pseudomonas or other microorganisms). PATIENTS AND METHOD:Prospective, randomised control-case study of patients with...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)72308-7
更新日期：2002-02-09 00:00:00
abstract：:Number needed to treat has been recommended as an easy way to transmit results from a trial, especially controlled clinical trials. Most articles estimate it from a 2×2 table, as the inverse of the absolute risk reduction. However, some limitations have been pointed out: The interpretation is not as easy as claimed, c...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2013.05.003
更新日期：2014-05-20 00:00:00
abstract：BACKGROUND:To evaluate differences in the temporal profile of acute phase response (APR) between ischemic stroke (IS) and intracerebral hemorrhage (ICH). PATIENTS AND METHOD:We studied APR parameters (< 24 h and 3-5 day) in 88 consecutive patients (43 ICH and 45 IS). The increase/decrease of the parameters between bot...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)71717-4
更新日期：2001-01-20 00:00:00
