In vivo imaging of calcium accumulation in fly interneurons as elicited by visual motion stimulation.

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is believed to arise through a multistep model comprised of putative precursor lesions known as pancreatic intraepithelial neoplasia (PanIN). Recent genetically engineered mouse models of PDAC demonstrate a comparable morphologic spectrum of murine PanIN (mPanIN) lesions. The hi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Habbe N,Shi G,Meguid RA,Fendrich V,Esni F,Chen H,Feldmann G,Stoffers DA,Konieczny SF,Leach SD,Maitra A

更新日期：2008-12-02 00:00:00

abstract：:Threats to species from commercial fishing are rarely identified until species have suffered large population declines, by which time remedial actions can have severe economic consequences, such as closure of fisheries. Many of the species most threatened by fishing are caught in multispecies fisheries, which can rema...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burgess MG,Polasky S,Tilman D

更新日期：2013-10-01 00:00:00

abstract：:Multiple epiphyseal dysplasia (MED) is a degenerative cartilage condition shown in some cases to be caused by mutations in genes encoding cartilage oligomeric matrix protein or type IX collagen. We studied a family with autosomal dominant MED affecting predominantly the knee joints and a mild proximal myopathy. Geneti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bönnemann CG,Cox GF,Shapiro F,Wu JJ,Feener CA,Thompson TG,Anthony DC,Eyre DR,Darras BT,Kunkel LM

更新日期：2000-02-01 00:00:00

abstract：:Rod signals in the mammalian retina are thought to reach ganglion cells over the circuit rod-->rod depolarizing bipolar cell-->AII amacrine cell-->cone bipolar cells-->ganglion cells. A possible alternative pathway involves gap junctions linking the rods and cones, the circuit being rod-->cone-->cone bipolar cells-->g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeVries SH,Baylor DA

更新日期：1995-11-07 00:00:00

abstract：:An interpretation is given of recent experiments by Brunori et al. on the binding of carbon monoxide by hemoglobin under photodissociating conditions. It is shown that their results follow directly from scalable models for hemoglobin in which the protein-modulated interactions are separable from the ligand binding. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szabo A,Karplus M

更新日期：1973-03-01 00:00:00

abstract：:Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth's magnetic field. Validation of such a mechanism has been hampered by the absence of structures of vertebrate CRYs that have funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zoltowski BD,Chelliah Y,Wickramaratne A,Jarocha L,Karki N,Xu W,Mouritsen H,Hore PJ,Hibbs RE,Green CB,Takahashi JS

更新日期：2019-09-24 00:00:00

abstract：:We have constructed a phylogenic tree for green plants by comparing 5S rRNA sequences. The tree suggests that the emergence of most of the uni- and multicellular green algae such as Chlamydomonas, Spirogyra, Ulva, and Chlorella occurred in the early stage of green plant evolution. The branching point of Nitella is a l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hori H,Lim BL,Osawa S

更新日期：1985-02-01 00:00:00

abstract：:Extraction of thylakoid membranes with cholate in the presence of ammonium sulfate inactivated oxygen evolution and liberated a managanese-containing protein. This protein could be combined with preformed liposomes containing the depleted thylakoid membranes to restore 85% of the original oxygen-evolution activity. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spector M,Winget GD

更新日期：1980-02-01 00:00:00

abstract：:X chromosome-linked severe combined immunodeficiency disease (SCIDX1) is characterized by the absence of T-cell and natural killer cell development and results from molecular mutations of the interleukin 2 receptor (IL-2R) gamma chain. The IL-2R gamma chain is a common component of the IL-2, IL-4, and IL-7 receptor sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DiSanto JP,Rieux-Laucat F,Dautry-Varsat A,Fischer A,de Saint Basile G

更新日期：1994-09-27 00:00:00

abstract：:The bidirectional self-assembly of tobacco mosaic virus (TMV, common or U1 strain) has been studied extensively in vitro. Foreign single-stranded RNA molecules containing the TMV origin-of-assembly sequence (OAS, 75-432 nt in length) are also packaged by TMV coat protein (CP) in vitro to form helical pseudovirus parti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang DJ,Roberts IM,Wilson TM

更新日期：1994-09-13 00:00:00

abstract：:Array technologies have made it straightforward to monitor simultaneously the expression pattern of thousands of genes. The challenge now is to interpret such massive data sets. The first step is to extract the fundamental patterns of gene expression inherent in the data. This paper describes the application of self-o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamayo P,Slonim D,Mesirov J,Zhu Q,Kitareewan S,Dmitrovsky E,Lander ES,Golub TR

更新日期：1999-03-16 00:00:00

abstract：:Insect damage on fossil leaves from the Central Rocky Mountains, United States, documents the response of herbivores to changing regional climates and vegetation during the late Paleocene (humid, warm temperate to subtropical, predominantly deciduous), early Eocene (humid subtropical, mixed deciduous and evergreen), a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilf P,Labandeira CC,Johnson KR,Coley PD,Cutter AD

更新日期：2001-05-22 00:00:00

abstract：:Spectrin (betaISigma*) and ankyrin (AnkG119) associate with Golgi membranes and the dynactin complex, but their role in vesicle trafficking remains uncertain. We find that the actin-binding domain and membrane-association domain 1 (MAD1) of betaI spectrin together form a constitutive Golgi targeting signal in transfec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devarajan P,Stabach PR,De Matteis MA,Morrow JS

更新日期：1997-09-30 00:00:00

abstract：:Mate attraction in Aplysia involves a long-distance water-borne signal (the protein pheromone attractin), which is released during egg laying. Aplysia californica attractin attracts species that produce closely related attractins, such as Aplysia brasiliana, whose geographic distribution does not overlap that of A. ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Painter SD,Cummins SF,Nichols AE,Akalal DB,Schein CH,Braun W,Smith JS,Susswein AJ,Levy M,de Boer PA,ter Maat A,Miller MW,Scanlan C,Milberg RM,Sweedler JV,Nagle GT

更新日期：2004-05-04 00:00:00

abstract：:Upon cytosolic viral DNA stimulation, cGMP-AMP synthase (cGAS) catalyzes synthesis of 2'3'cGMP-AMP (cGAMP), which binds to the adaptor protein MITA (mediator of IRF3 activation, also called STING, stimulator of IFN genes) and induces innate antiviral response. How the activity of MITA/STING is regulated to avoid exces...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia T,Yi XM,Wu X,Shang J,Shu HB

更新日期：2019-10-01 00:00:00

abstract：:Infant maltreatment increases vulnerability to physical and mental disorders, yet specific mechanisms embedded within this complex infant experience that induce this vulnerability remain elusive. To define critical features of maltreatment-induced vulnerability, rat pups were reared from postnatal day 8 (PN8) with a m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raineki C,Opendak M,Sarro E,Showler A,Bui K,McEwen BS,Wilson DA,Sullivan RM

更新日期：2019-11-05 00:00:00

abstract：:We have generated RANK (receptor activator of NF-kappaB) nullizygous mice to determine the molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK during bone resorption and remodeling processes. RANK(-/-) mice lack osteoclasts and have a profound defect in bone resorption and remodeli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Sarosi I,Yan XQ,Morony S,Capparelli C,Tan HL,McCabe S,Elliott R,Scully S,Van G,Kaufman S,Juan SC,Sun Y,Tarpley J,Martin L,Christensen K,McCabe J,Kostenuik P,Hsu H,Fletcher F,Dunstan CR,Lacey DL,Boyle WJ

更新日期：2000-02-15 00:00:00

abstract：:The mechanisms regulating expression of mouse mammary tumor virus (MMTV)-encoded superantigens from the viral sag gene are largely unknown, due to problems with detection and quantification of these low-abundance proteins. To study the expression and regulation of the MMTV sag gene, we have developed a sensitive and q...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reuss FU,Coffin JM

更新日期：1995-09-26 00:00:00

abstract：:Spumaviruses, commonly called foamy viruses (FV), are complex retroviruses that establish lifelong persistent infections without any accompanying pathologies. In tissue culture, cells can be either lytically or latently infected, depending on cell type. Regulation of FV replication is controlled by two promoters: the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meiering CD,Linial ML

更新日期：2002-11-12 00:00:00

abstract：:Mice with a targeted deletion of beta3 integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of beta3+/+ mice by 14 days. In contrast, only 4% of beta3-/- mice developed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bakewell SJ,Nestor P,Prasad S,Tomasson MH,Dowland N,Mehrotra M,Scarborough R,Kanter J,Abe K,Phillips D,Weilbaecher KN

更新日期：2003-11-25 00:00:00

abstract：:We have generated mutants of Escherichia coli formylmethionine initiator tRNA in which one, two, and all three G X C base pairs in the GGGCCC sequence in the anticodon stem are changed to those found in E. coli elongator methionine tRNA. Overproduction of the mutant tRNAs using M13 recombinants as an expression vector...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seong BL,RajBhandary UL

更新日期：1987-01-01 00:00:00

abstract：:Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain. Differences between the two strains include changes in the light-harvesting capacity, which is lower in OTH95, and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cardol P,Bailleul B,Rappaport F,Derelle E,Béal D,Breyton C,Bailey S,Wollman FA,Grossman A,Moreau H,Finazzi G

更新日期：2008-06-03 00:00:00

abstract：:Bacterial RNases catalyze the turnover of RNA and are essential for gene expression and quality surveillance of transcripts. In Escherichia coli, the exoribonucleases RNase R and polynucleotide phosphorylase (PNPase) play critical roles in degrading RNA. Here, we developed an optical-trapping assay to monitor the tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fazal FM,Koslover DJ,Luisi BF,Block SM

更新日期：2015-12-08 00:00:00

abstract：:Although ghrelin has been demonstrated to stimulate energy intake and storage through a central mechanism, its effect on hepatic lipid metabolism remains largely uncharacterized. Ghrelin receptor antagonism or gene deletion significantly decreased obesity-associated hepatic steatosis by suppression of de novo lipogene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Xu G,Qin Y,Zhang C,Tang H,Yin Y,Xiang X,Li Y,Zhao J,Mulholland M,Zhang W

更新日期：2014-09-09 00:00:00

abstract：:The calcium-activated K(+) channel KCa3.1 plays an important role in T lymphocyte Ca(2+) signaling by helping to maintain a negative membrane potential, which provides an electrochemical gradient to drive Ca(2+) influx. To assess the role of KCa3.1 channels in lymphocyte activation in vivo, we studied T cell function ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di L,Srivastava S,Zhdanova O,Ding Y,Li Z,Wulff H,Lafaille M,Skolnik EY

更新日期：2010-01-26 00:00:00

abstract：:IFN-alpha/beta plays an essential role in innate immunity against viral and bacterial infection. Among the proteins induced by IFN-alpha/beta are the ubiquitin-like ISG15 protein and its E1- (Ube1L) and E2- (UbcH8) conjugating enzymes, leading to the conjugation of ISG15 to cellular proteins. It is likely that ISG15 c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao C,Denison C,Huibregtse JM,Gygi S,Krug RM

更新日期：2005-07-19 00:00:00

abstract：:Platelet-derived growth factor (PDGF) isoforms lead to mitogenic, survival, and chemotactic responses in a variety of mesenchymal cell types during development and in the adult. We have studied the importance of phosphatidylinositol-3' kinase (PI3K) signaling in these responses by mutating the PI3K-binding sites in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heuchel R,Berg A,Tallquist M,Ahlén K,Reed RK,Rubin K,Claesson-Welsh L,Heldin CH,Soriano P

更新日期：1999-09-28 00:00:00

abstract：:5 alpha-Cholest-8(14)-en-3 beta-ol-15-one has been found to have significant hypocholesterolemic activity upon oral administration at a daily dosage of 75 mg/kg of body weight to Rhesus monkeys fed a diet of moderate cholesterol (Chol) content [0.19 mg/kcal (1 cal = 4.184 J) of diet]. The reductions in total serum Cho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schroepfer GJ Jr,Sherrill BC,Wang KS,Wilson WK,Kisic A,Clarkson TB

更新日期：1984-11-01 00:00:00

abstract：:It recently has been shown that epithelial Na(+) channels are controlled by a receptor for intracellular Na(+), a G protein (G(o)), and a ubiquitin-protein ligase (Nedd4). Furthermore, mutations in the epithelial Na(+) channel that underlie the autosomal dominant form of hypertension known as Liddle's syndrome inhibit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishibashi H,Dinudom A,Harvey KF,Kumar S,Young JA,Cook DI

更新日期：1999-08-17 00:00:00

abstract：:A 105-kilobase bacterial artificial chromosome (BAC) clone from the ovate-containing region of tomato chromosome 2 was sequenced and annotated. The tomato BAC sequence was then compared, gene by gene, with the sequenced portions of the Arabidopsis thaliana genome. Rather than matching a single portion of the Arabidops...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ku HM,Vision T,Liu J,Tanksley SD

更新日期：2000-08-01 00:00:00