Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling.

abstract：:Translation of injected mRNA in oocytes of Xenopus laevis has been used as a highly sensitive and quantitative assay for interferon mRNA. Injection into oocytes of polyadenylylated RNA extracted from poly(I).poly(C)-induced human diploid fibroblasts (FS-4) leads to the synthesis of biologically active human fibroblast...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sehgal PB,Dobberstein B,Tamm I

更新日期：1977-08-01 00:00:00

abstract：:The free radicals nitric oxide and superoxide anion react to form peroxynitrite (ONOO-), a highly toxic oxidant species. In vivo formation of ONOO- has been demonstrated in shock and inflammation. Herein we provide evidence that cytotoxicity in cells exposed to ONOO- is mediated by DNA strand breakage and the subseque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szabó C,Zingarelli B,O'Connor M,Salzman AL

更新日期：1996-03-05 00:00:00

abstract：:Two-dimensional electron gases (2DEGs) are at the base of current nanoelectronics because of their exceptional mobilities. Often the accumulation layer forms at polar interfaces with longitudinal optical (LO) modes. In most cases, the many-body screening of the quasi-2DEGs dramatically reduces the Fröhlich scattering ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Sjakste J,Dong J,Taleb-Ibrahimi A,Rueff JP,Shukla A,Peretti J,Papalazarou E,Marsi M,Perfetti L

更新日期：2020-09-08 00:00:00

abstract：:Nitric oxide-releasing compounds were shown to activate an ADP-ribosyltransferase activity in the cytosol of Dictyostelium discoideum. The enzyme ADP-ribosylated a cytosolic protein of approximately 41 kDa, p41. Neither cGMP nor GTP and its analogues affected this ADP-ribosylation. p41 differs from other substrates AD...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao Y,Howlett A,Klein C

更新日期：1992-07-01 00:00:00

abstract：:Chemical coding in the sympathetic nervous system involves both noradrenergic and, for a minority of neurons, cholinergic neurotransmission. The expression of the cholinergic phenotype in the developing sympathetic nervous system was examined to determine if coding for cholinergic transmission occurs before or after i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schäfer MK,Schütz B,Weihe E,Eiden LE

更新日期：1997-04-15 00:00:00

abstract：:Misalignment between internal circadian rhythmicity and externally imposed behavioral schedules, such as occurs in shift workers, has been implicated in elevated risk of metabolic disorders. To determine underlying mechanisms, it is essential to assess whether and how peripheral clocks are disturbed during shift work ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skene DJ,Skornyakov E,Chowdhury NR,Gajula RP,Middleton B,Satterfield BC,Porter KI,Van Dongen HPA,Gaddameedhi S

更新日期：2018-07-24 00:00:00

abstract：:The growth or decay of population of a single species interacting with a large number of other species (or environment) according to the Volterra-Lotka model is investigated. When the environment is initially very close to its equilibrium level, the growth of a single species follows a generalized Verhulst law, contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zwanzig R

更新日期：1973-11-01 00:00:00

abstract：:Hydrogen atoms constitute about half of all atoms in proteins and play a critical role in enzyme mechanisms and macromolecular and solvent structure. Hydrogen atom positions can readily be determined by neutron diffraction, and as such, neutron diffraction is an invaluable tool for elucidating molecular mechanisms. Jo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blum MM,Mustyakimov M,Rüterjans H,Kehe K,Schoenborn BP,Langan P,Chen JC

更新日期：2009-01-20 00:00:00

abstract：:The androgen receptor (AR) plays an essential role in prostate cancer, and suppression of its signaling with androgen deprivation therapy (ADT) has been the mainstay of treatment for metastatic hormone-sensitive prostate cancer for more than 70 y. Chemotherapy has been reserved for metastatic castration-resistant pros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Komura K,Jeong SH,Hinohara K,Qu F,Wang X,Hiraki M,Azuma H,Lee GS,Kantoff PW,Sweeney CJ

更新日期：2016-05-31 00:00:00

abstract：:Nonesterified fatty acids accumulate at sites of tissue injury and necrosis. In cardiac tissue the concentrations of oleic acid, arachidonic acid, leukotrienes, and other fatty acids increase greatly during ischemia due to receptor or nonreceptor-mediated activation of phospholipases and/or diminished reacylation. In ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang JM,Xian H,Bacaner M

更新日期：1992-07-15 00:00:00

abstract：:The alternative adaptive immune system of jawless vertebrates is based on different isotypes of variable lymphocyte receptors (VLRs) that are composed of leucine-rich repeats (LRRs) and expressed by distinct B- and T-like lymphocyte lineages. VLRB is expressed by B-like cells, whereas VLRA and VLRC are expressed by tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holland SJ,Gao M,Hirano M,Iyer LM,Luo M,Schorpp M,Cooper MD,Aravind L,Mariuzza RA,Boehm T

更新日期：2014-10-14 00:00:00

abstract：:Lissencephaly is a severe brain malformation in humans. To study the function of the gene mutated in lissencephaly (LIS1), we deleted the first coding exon from the mouse Lis1 gene. The deletion resulted in a shorter protein (sLIS1) that initiates from the second methionine, a unique situation because most LIS1 mutati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cahana A,Escamez T,Nowakowski RS,Hayes NL,Giacobini M,von Holst A,Shmueli O,Sapir T,McConnell SK,Wurst W,Martinez S,Reiner O

更新日期：2001-05-22 00:00:00

abstract：:To initiate fertilization, mouse sperm bind to Ser- (O-) linked oligosaccharides located at the sperm combining site of zona pellucida glycoprotein mZP3. Apparently, the oligosaccharides are present on one or more of five Ser residues clustered in the carboxyl-terminal region of the mZP3 polypeptide. Here, each of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen J,Litscher ES,Wassarman PM

更新日期：1998-05-26 00:00:00

abstract：:The central nitrogen metabolic circuit in enteric bacteria consists of three enzymes: glutamine synthetase, glutamate synthase (GOGAT), and glutamate dehydrogenase (GDH). With the carbon skeleton provided by 2-oxoglutarate, ammonia/ammonium (NH(4)(+)) is assimilated into two central nitrogen intermediates, glutamate a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan D

更新日期：2007-05-29 00:00:00

abstract：:By indirect immunofluorescence techniques, microtubules and mitochondria were localized in normal rat kidney cells, human WI38 fibroblasts, mouse peritoneal macrophages, and a putative smooth muscle rat cell line, in monolayer culture. The mitochondria were found to be arranged along the cytoplasmic microtubules in ea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heggeness MH,Simon M,Singer SJ

更新日期：1978-08-01 00:00:00

abstract：:A fraction obtained by gel filtration at neutral pH of the extracellular Hb of Lumbricus terrestris dissociated either at pH 9.8 or at pH 4.0, consisting of the three subunits D1 (31 kDa), D2 (37 kDa), and T (50 kDa), was found to produce two peaks when subjected to gel filtration on Superose 6 at pH 7. The first peak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kapp OH,Mainwaring MG,Vinogradov SN,Crewe AV

更新日期：1987-11-01 00:00:00

abstract：:It has been proposed that the causative agent of scrapie represents a class of infectious particle that is devoid of nucleic acid and that an altered form of the endogenous prion protein (PrP) is the agent. However, it has been difficult to exclude the possibility that PrP purified from scrapie tissues might be contam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caughey B,Race RE,Vogel M,Buchmeier MJ,Chesebro B

更新日期：1988-07-01 00:00:00

abstract：:The action of cyclin-dependent kinases (CDKs) is regulated by phosphorylation, cyclin levels, the abundance of CDK inhibitors, and, as recently has been shown for cyclin B/cdc2, their localization. It is unclear how localization regulates the action of cyclin E/Cdk2 and its inhibitors. Here, we show that the closest k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson C,Ross J,Jackson PK

更新日期：2000-07-05 00:00:00

abstract：:Sexual arousal is a dynamical, highly coordinated neurophysiological process that is often induced by visual stimuli. Numerous studies have proposed that the cognitive processing stage of responding to sexual stimuli is the first stage, in which sex differences occur, and the divergence between men and women has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitricheva E,Kimura R,Logothetis NK,Noori HR

更新日期：2019-07-30 00:00:00

abstract：:The mode of action of "allogeneic supernatant" (the culture supernatant of a 24-hr mixedlymphocyte reaction), has been studied. This factor stimulates the response of spleen cell cultures depleted in thymus-derived lymphoid cells (T-cells) to antigens that elicit a thymus-dependent response. We used a limiting dilutio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunter P,Kettman JR

更新日期：1974-02-01 00:00:00

abstract：:The CuAAC reaction (click chemistry) has been used in conjunction with solid-phase synthesis to produce catalytically active hairpin ribozymes around 100 nucleotides in length. Cross-strand ligation through neighboring nucleobases was successful in covalently linking presynthesized RNA strands with high efficiency (tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El-Sagheer AH,Brown T

更新日期：2010-08-31 00:00:00

abstract：:Eukaryotic transcriptional activators may function by stimulating formation of RNA polymerase II preinitiation complexes at the core promoter of genes. In this case, their mode of action will intrinsically depend on how these complexes assemble on promoters in living cells, an issue that remains largely unexplored. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez-Couto E,Klages N,Strubin M

更新日期：1997-07-22 00:00:00

abstract：:The N,N'-diacetyllactosediamine (lacdiNAc) pathway of complex-type oligosaccharide synthesis is controlled by a UDP-GalNAc:GlcNAc beta-R beta 1-->4-N-acetylgalac-tesaminyltransferase (beta 4-GalNAcT) that acts analogously to the common UDP-Gal:GlcNAc beta-R beta 1-->4-galactosyltransferase (beta 4-GalT). LacdiNAc-base...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neeleman AP,van de Eijnden DH

更新日期：1996-09-17 00:00:00

abstract：:Enhanced transductional recombination between specialized transducing phage lambda plac5 and plasmid F42lac depends on cis- and trans-acting factors. By constructing a series of recombinant molecules, the cis-acting site required for enhanced recombination has been identified as oriT, the origin of conjugational trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seifert HS,Porter RD

更新日期：1984-12-01 00:00:00

abstract：:The complete nucleotide sequence of the gene for the specific glycoprotein (gp55) of the polycythemic strain of Friend spleen focus-forming virus (SFFV) was derived from the cloned SFFV DNA intermediate. The gp55 gene is present within 1.4 kilobases of the 5' side of the 3'long terminal repeat sequence. The open readi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amanuma H,Katori A,Obata M,Sagata N,Ikawa Y

更新日期：1983-07-01 00:00:00

abstract：:T cells are essential for immune defenses against pathogens, such that viability of naïve T cells before antigen encounter is critical to preserve a polyclonal repertoire and prevent immunodeficiencies. The viability of naïve T cells before antigen recognition is ensured by IL-7, which drives expression of the prosurv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller ML,Mashayekhi M,Chen L,Zhou P,Liu X,Michelotti M,Tramontini Gunn N,Powers S,Zhu X,Evaristo C,Alegre ML,Molinero LL

更新日期：2014-05-20 00:00:00

abstract：:Subtractive library construction and differential screening were used to identify a cDNA for a cell type-specific immediate early gene induced in rat PC12 pheochromocytoma cells. Sequencing identified the protein product of this gene as rat synaptotagmin IV (SytIV). Synaptotagmins are synaptic vesicle proteins thought...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vician L,Lim IK,Ferguson G,Tocco G,Baudry M,Herschman HR

更新日期：1995-03-14 00:00:00

abstract：:Hematologic malignancies are frequently associated with cardiac pathologies. Mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a subset of acute myeloid leukemia patients, causing metabolic and epigenetic derangements. We have now discovered that altered metabolism in leukemic cells has a profound effect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karlstaedt A,Zhang X,Vitrac H,Harmancey R,Vasquez H,Wang JH,Goodell MA,Taegtmeyer H

更新日期：2016-09-13 00:00:00

abstract：:Lipid interactions with the integral membrane protein Na,K-ATPase (ATP phosphohydrolase, EC 3.6.1.3) purified from the electric organ of Electrophorus electricus were studied by spin labeling. A protein-associated component (boundary layer) in equilibrium with the fluid bilayer is clearly evident in the electron spin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brotherus JR,Jost PC,Griffith OH,Keana JF,Hokin LE

更新日期：1980-01-01 00:00:00

abstract：:Angiogenesis restores blood flow to healing tissues, a process that is inhibited by high doses of glucocorticoids. However, the role of endogenous glucocorticoids and the potential for antiglucocorticoid therapy to enhance angiogenesis is unknown. Using in vitro and in vivo models of angiogenesis in mice, we examined ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Small GR,Hadoke PW,Sharif I,Dover AR,Armour D,Kenyon CJ,Gray GA,Walker BR

更新日期：2005-08-23 00:00:00